Excess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic reprogramming, yet wheth...

Abstract. Intergenerational and transgenerational fitness effects can shape evolutionary processes. Theoretically, however, intergenerational and transgene

New Canadian data suggest an explanation for long COVID symptoms such as fatigue, lack of motivation, slowed movement, and memory problems.

Here they use killifish to reveal a stark genetic trade-off in aging. They found that disrupting the vgll3 gene accelerates early-life maturation and growth but directly increases the risk of age-rela...

Telomerase is a ribonucleoprotein complex that elongates telomeric DNA, ensuring germline immortality. In this study, we identified the Caenorhabditis elegans telomerase RNA component 1 (terc-1), as t...

New research shows that dialing down an overactive immune sensor can restore tissue health in severe genetic disorders, reshaping how scientists think about aging and DNA damage.

Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

Mobile DNA - A new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted...

High-energy particles streaming through space can damage DNA and increase cancer risk, but antioxidants, tardigrades and hibernation could help astronauts make the journey safely.

In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated ...

In multicellular organisms, sensory perception affects many aspects of behavior and physiology. Perception of environmental stressors like food sca...

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Jane Goodall, who died on Wednesday at the age of 91, followed several principles that geriatricians recommend for a long

An team has developed a new technique that will speed up the design of drugs targeting ion channels, a type of cell membrane protein

The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

Author summary Humans are not the only species suffering from cancer, yet cancer does not impact all life equally. Body size is relevant because maintaining a large number of cells in a tumour-free st...

Scientists compared diet, rapamycin and metformin in search for longevity boost.

The authors provide evidence that, together with Dietary Restriction, Rapamcyin and not Metformin, provides a significant lifespan extension in vertebrates.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Intermittent fasting has gained a following, in part because of tantalizing hints that it can boost cognition, fend off cancer and even slow ageing.

Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and...