What are the ethics of human enhancement? Given the breadth of this question, this is an excerpt of a discussion held between the six of us addressing this topic. Although we are certainly not experts...

Genome-wide analyses indicate that accumulation of mitochondrial DNA mutations, a hallmark of ageing, may be caused by cryptic replication errors, which act as passenger mutations that eventually become detectable with age owing to age-related somatic mosaicism, rather than oxidative damage.

Have you ever thought about what makes someone an “expert” at something? Is it their ability to carefully and correctly respond to a scenario, or is it their ability to complete a task intuitively and...

Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse p...

One of the most challenging questions in all of biology is how to make sense of complex systems. This question is becoming increasingly relevant as advances in sequencing technologies decrease the cos...

One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, ab...

Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...