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Alex Cope, PhD (he/him)

@alexcope241.bsky.social
405 followers 953 following 54 posts

Unemployed postdoc. Collaborating with Rokas lab at Vandy and Pennell lab at Cornell. Studying the evolution of gene expression and its impact on protein evolution. Opinions my own. #FirstGen

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Reposted by Alex Cope, PhD (he/him)
Silas Tittes @silastittes.bsky.social · 12/10/2026
Final version of Gabby Coffing’s last chapter! Reviewer’s made some good suggestions. Nice paper I’m proud to have played a role on! 🐙 academic.oup.com/mbe/advance-...
academic.oup.com
Diversity and divergence of two sympatric, sibling octopus species
Abstract. Coleoid cephalopods have convergently evolved many traits shared with vertebrates, including camera-type eyes, large brain-to-body size ratios, a
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Reposted by Alex Cope, PhD (he/him)
Matthew Hahn @3rdreviewer.bsky.social · 12/10/2026
New version of our paper on gene tree topologies under duplication, loss, and coalescence. (Led by @smishra677.bsky.social) 1st version was wrong: we should have been conditioning all our expected branch lengths on seeing a duplication at all. Now fixed! www.biorxiv.org/content/10.6...
biorxiv.org
Distribution of Gene Tree Topologies with Duplication, Loss, and Coalescence
Motivation: Many methods can be used to infer the number and timing of gene duplication and loss events from gene trees. Most such reconciliation methods use a model of gene duplication that does not ...
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Reposted by Alex Cope, PhD (he/him)
Mark Copelovitch @mcopelov.bsky.social · 09/10/2026
Again, you (& I) live in a country where there are concentration camps & people are being disappeared. We can argue about what exactly to call this particular form of partially autocratic political regime, but it’s not a full democracy.
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Reposted by Alex Cope, PhD (he/him)
Aide Macias-Muñoz @aidemm.bsky.social · 06/10/2026
Please share! My lab is recruiting a postdoctoral scholar in evolutionary development. For more details feel free to email me.
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Reposted by Alex Cope, PhD (he/him)
Roshni Patel @roshnipatel.bsky.social · 06/10/2026
So excited about this work with @nasalab.bsky.social! Led by Stephanie Gogarten & with help from @daphmarts.bsky.social, we use LLMs as judges to evaluate the use of population descriptors in the entirety of the GWAS Catalog (~4,000 papers published 2007-2025) www.biorxiv.org/content/10.6...
biorxiv.org
Large language model-based bibliometric evaluation of population descriptors in human genetics
As the use of population descriptors such as race, ethnicity, and ancestry have become increasingly common in modern genetics research, there have been growing calls to critically examine their use. M...
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Reposted by Alex Cope, PhD (he/him)
Casey Dunn @caseywdunn.bsky.social · 05/10/2026
Interested in joining our lab (dunnlab.org) and YIBS as a postdoc? I'm looking for someone to work on siphonophores, diversity in the open ocean, or natural history. If that's you, please reach out this week to discuss a nomination for the Donnelley Postdoc Fellowship - yibs.yale.edu/donnelley-fe...
dunnlab.org
The Dunn Lab
Casey Dunn's laboratory in the Department of Ecology and Evolutionary Biology at Yale University.
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Reposted by Alex Cope, PhD (he/him)
Josef Uyeda @pseudacris.bsky.social · 23/09/2026
Two positions in my department at Virginia Tech in Molecular Microbiology. Come be my colleague! jobs.apply.vt.edu/jobs/assista...
jobs.apply.vt.edu
Assistant/Associate Professor - Blacksburg, Virginia, United States
Job Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ...
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Reposted by Alex Cope, PhD (he/him)
Dan Schrider @samurscicop.bsky.social · 21/09/2026
The (literal) closing of a chapter, former Schrider Lab student Amjad Dabi's paper where he simulates evolutionary rescue scenarios to model the dynamics of treatment resistance in sequential cancer therapy is now published in PLoS Comp Bio: journals.plos.org/ploscompbiol... (1/5)
journals.plos.org
Evolutionary rescue model informs strategies for driving cancer cell populations to extinction
Author summary Cancer cells often evolve resistance to treatments during therapy by acquiring specific mutations, leading to eventual relapse and treatment failure. While using multiple treatments in ...
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Reposted by Alex Cope, PhD (he/him)
Alex Cope, PhD (he/him) @alexcope241.bsky.social · 08/07/2026
If anyone is looking for a postdoc/staff scientist with experience in evolutionary genetics, computational biology/bioinformatics, and/or various omics methods (RNA-seq, Ribo-seq, LC-MS/MS), I'm still looking! (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas... (3) doi.org/10.1371/jour...
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 08/07/2026
If anyone is looking for a postdoc/staff scientist with experience in evolutionary genetics, computational biology/bioinformatics, and/or various omics methods (RNA-seq, Ribo-seq, LC-MS/MS), I'm still looking! (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas... (3) doi.org/10.1371/jour...
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Reposted by Alex Cope, PhD (he/him)
Roshni Patel @roshnipatel.bsky.social · 14/09/2026
These are of course very old questions with tremendous recent progress; we focus mostly on the recent progress and what it offers for the next era of studying human genetics in biobanks. Excited this preprint is out and we'd of course love to hear any thoughts!
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Reposted by Alex Cope, PhD (he/him)
Manuel Kleiner @manuelkleiner.bsky.social · 08/09/2026
We are looking to hire a microbiology laboratory research technician here at NC State in Raleigh, NC. If you have experience in microbiology and/or LC-MS/MS please consider applying. Please repost! jobs.ncsu.edu/postings/234...
jobs.ncsu.edu
Microbiology Laboratory Research Technician
The Kleiner Lab at North Carolina State University is seeking a Research Technician to support research focused on complex microbial communities, microbial symbioses, and metaproteomics. Reporting to ...
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Reposted by Alex Cope, PhD (he/him)
Matthew Hahn @3rdreviewer.bsky.social · 08/09/2026
NSF Biology Postdoc Fellowships are back! Good news for everyone...great news for someone who wants to work in our group? Just reach out if interested. www.nsf.gov/funding/oppo...
nsf.gov
Postdoctoral Research Fellowships in Biology (PRFB)
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 04/09/2026
This looks awesome. Very much looking forward to reading it!
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Reposted by Alex Cope, PhD (he/him)
Will Shoemaker @shoestrapped.bsky.social · 04/09/2026
Self-reposting (re-skeeting?) as I may be teaching this sooner than expected.
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Reposted by Alex Cope, PhD (he/him)
Edward Wallace @ewjwallace.bsky.social · 14/07/2026
Postdoc/staff scientist/ in computational biology and evolutionary genetics? Alex Cope is very good. I've collaborated with him for years. First author publications, all technically great, some in glam journals. A great team player and nice guy too. scholar.google.com/citations?us...
scholar.google.com
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Reposted by Alex Cope, PhD (he/him)
Haoran Cai @haorancai.bsky.social · 27/08/2026
Now out @molbioevol.bsky.socialGenetic correlations summarize how traits covary, but they can hide different underlying architectures. Distinguishing those architectures can reveal distinct mechanisms generating—and potentially constraining—trait–trait relationships. academic.oup.com/mbe/advance-...
academic.oup.com
Consistent and idiosyncratic pleiotropy in shaping genetic correlations
Abstract. Pleiotropy, the phenomenon where a single mutation influences multiple phenotypic traits, creates genetic correlations that can constrain evoluti
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Reposted by Alex Cope, PhD (he/him)
Maitreya Dunham @maitreya.bsky.social · 28/08/2026
If you are thinking of applying to the @uwgenome.bsky.social PhD program this fall, we have a couple of zoom info sessions set up for Oct 6 and Oct 22. Please register at the link. Our website also has a ton of useful information about crafting your application. www.gs.washington.edu/news/graduat...
gs.washington.edu
Graduate Program Information Sessions – UW Genome Sciences
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 29/07/2026
Congrats, Allan!
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Reposted by Alex Cope, PhD (he/him)
Alison Feder @alisonfeder.bsky.social · 28/07/2026
A few months ago, @elena-romero.bsky.social published a paper showing that HIV escape from broadly neutralizing antibody 10-1074 is driven by very recurrent mutation. In her latest, she asks - just how soft are the signatures of these sweeps? www.biorxiv.org/content/10.6...
biorxiv.org
Haplotype and diversity signatures of ultra-soft selective sweeps in HIV-1
Many urgent medical and agricultural challenges are driven by resistance evolution via soft selective sweeps of multiple simultaneous mutations. Standard approaches to detect these mutations involve g...
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 14/07/2026
Thank you, Edward!
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Reposted by Alex Cope, PhD (he/him)
Roman (he/il) @trcava.bsky.social · 13/07/2026
This is so sad… Thousands of deaths in just two years with an estimated remaining population size <13,000… I’m no marine biologist but it seems like the Pacific gray whale is at serious risk of extinction. I can only imagine the dismantling of the ESA will hasten their decline.
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Reposted by Alex Cope, PhD (he/him)
Rob Calver @robcalver.bsky.social · 02/07/2026
I am giving away a free copy of the #BayesianWorkflow book by @statmodeling.bsky.social, @avehtari.bsky.social, @rmcelreath.bsky.social et al!! Please like, repost, and follow to enter. I will randomly draw the winner next Weds July 8. 😀 routledge.com/9780367490140 #RStats #DataScience #Bayesian
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Reposted by Alex Cope, PhD (he/him)
Jeff Spence @jeffspence.github.io · 22/06/2026
Excited to see @jonj-udd.bsky.social's fantastic work out @genetics-gsa.bsky.social. Selection in _heterozygotes_ is the primary force shaping allele frequencies of loss-of-function mutations in humans, even in genes only associated with purely recessive diseases. 🧪🧬 doi.org/10.1093/gene...
doi.org
Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes
Abstract. The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model pred
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 22/06/2026
Speaking as a postdoc still striving for a tenure-track job, it gets harder and harder every day to justify sticking around academia.
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 19/06/2026
New paper from a project I started working on during my final few months of grad school (...6 years ago): doi.org/10.1371/jour.... Here, we estimate codon ribosome drop-off rates from ribo-seq in yeast, as well as quantify the impact of selection against drop-off on coding-sequence evolution.
doi.org
The importance of nonsense errors: Estimating the rates and implications of ribosome drop-off during protein synthesis
Author summary The process of translating mRNA into a protein is both energetically expensive and relatively error-prone. As such, natural selection is thought to shape the evolution of protein-coding...
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Reposted by Alex Cope, PhD (he/him)
The Rokas Lab at Vanderbilt University @rokaslab.bsky.social · 11/06/2026
Interested in how #fungi came about on this planet? If so, take a look at my new article that just came out in @annualreviews.bsky.social. doi.org/10.1146/annu...
doi.org
The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles
Fungi are widespread on our planet and essential for life as we know it, but how did they come about? Their last common ancestor lived hundreds of millions of years ago, but its characteristics, and t...
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Reposted by Alex Cope, PhD (he/him)
Alex Cope, PhD (he/him) @alexcope241.bsky.social · 13/05/2026
I'm looking for postdoc opportunities for the 2026-2027 academic year. If you're looking for a postdoc with a broad skill set spanning evolutionary genetics, bioinformatics, and various omics methods, feel free to reach out. Some recent pubs: (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas...
doi.org
Macroevolutionary divergence of gene expression driven by selection on protein abundance
The regulation of messenger RNA (mRNA) and protein abundances is well-studied, but less is known about the evolutionary processes shaping their relationship. To address this, we derived a new phylogen...
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 13/05/2026
I'm looking for postdoc opportunities for the 2026-2027 academic year. If you're looking for a postdoc with a broad skill set spanning evolutionary genetics, bioinformatics, and various omics methods, feel free to reach out. Some recent pubs: (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas...
doi.org
Macroevolutionary divergence of gene expression driven by selection on protein abundance
The regulation of messenger RNA (mRNA) and protein abundances is well-studied, but less is known about the evolutionary processes shaping their relationship. To address this, we derived a new phylogen...
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Reposted by Alex Cope, PhD (he/him)
Dan Schrider @samurscicop.bsky.social · 20/05/2026
Update! The posting for the postdoc opening in my lab is up! Apply here: unc.peopleadmin.com/postings/319...
unc.peopleadmin.com
Post-Doc Research Associate (Schrider)
The Schrider Lab at the University of North Carolina at Chapel Hill is hiring a postdoc in population genetics and/or phylogenetics. The successful candidate will help design and carry out projects re...
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Reposted by Alex Cope, PhD (he/him)
Maureen Barr @barrlab.bsky.social · 12/05/2026
POSTDOC OPPORTUNITY!!! The Rutgers IRACDA program is phenomenal: 70% of postdoctoral fellows land faculty positions. Martha Soto (LinkedIn below) is the amazing director and leader of this program. Please apply or reach out if you have questions. www.linkedin.com/posts/martha...
linkedin.com
INSPIRE is recruiting! Please share broadly with senior graduate students and beginning postdocs. INSPIRE, the NIH-funded Rutgers-IRACDA, offers postdoctoral training for individuals interested in… | ...
INSPIRE is recruiting! Please share broadly with senior graduate students and beginning postdocs. INSPIRE, the NIH-funded Rutgers-IRACDA, offers postdoctoral training for individuals interested in com...
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Reposted by Alex Cope, PhD (he/him)
Dominique Baker @bakerdphd.bsky.social · 18/10/2025
Props and planning, great work!
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Reposted by Alex Cope, PhD (he/him)
Zeteo @zeteo.com · 18/10/2025
“Donald Trump, the man who uses Palestinian as a pejorative, as a slur, has no plan for Palestinian freedom.” @mehdirhasan.bsky.social slams Donald Trump at the ‘No Kings’ rally in Washington, DC over his Gaza ‘peace-plan.’ Watch his full speech: zeteo.com/p/no-kings-p...
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Reposted by Alex Cope, PhD (he/him)
Acyn @acyn.bsky.social · 18/10/2025
Sanders: In my state, people received notices from insurance companies that their health care premiums in some cases would triple or quadruple. That is going on all over the country, at a time when we already pay by far the highest prices in the world for health care…
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Reposted by Alex Cope, PhD (he/him)
Roshni Patel @roshnipatel.bsky.social · 15/10/2025
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
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Reposted by Alex Cope, PhD (he/him)
Genetics Society of America @genetics-gsa.bsky.social · 13/10/2025
New in #GENETICS: Using deep mutational scanning to create a mutant library and measuring protein–protein interactions, @christianlandry.bsky.social and the team determined the in vivo binding strength of motifs that bind to the SH3 domain in #yeast mutants. buff.ly/uOXTpZG
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Reposted by Alex Cope, PhD (he/him)
Taulby Edmondson @taulby.bsky.social · 09/10/2025
Students successful in TPUSA (via recruitment and harassing people) are in line for cushy positions in the right-wing think tank industry or Republican politics upon graduation. That is what the most outspoken ones work for, and ruining lives is a plus.
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Reposted by Alex Cope, PhD (he/him)
Kevin M. Kruse @kevinmkruse.bsky.social · 09/10/2025
The Rutgers TPUSA chapter — whose characterization of a historian there as a “outspoken, well-known antifa member” led to death threats and moving his family to Europe — think *other* people are being “blatantly defamatory.” Not them, though. They’re doing politics the right way.
foxnews.com
Rutgers TPUSA officers slam petition to shut down chapter, ‘Blatantly defamatory’
Alexander Di Filippo accuses Turning Point USA of inciting violence against Antifa handbook author Mark Bray.
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Reposted by Alex Cope, PhD (he/him)
Julian Sanchez @normative.bsky.social · 09/10/2025
Brett Kavanaugh assures me this is the sort of minor inconvenience that shouldn't disturb anyone.
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Reposted by Alex Cope, PhD (he/him)
Chicago Sun-Times @chicago.suntimes.com · 06/10/2025
Body-camera video appears to contradict the government’s claim that Marimar Martinez, 30, drove toward officers before one of them opened fire at her late Saturday morning in Brighton Park, her attorney claimed. trib.al/9Sxu9IN
trib.al
Attorney for woman shot by Border Patrol claims officer said 'Do something b-----' before shooting
Body-camera video appears to contradict the government's claim that Marimar Martinez, 30, drove toward officers before one of them opened fire at her late Saturday morning in Brighton Park, her attorney claimed. A judge ordered Martinez and a co-defendant released pending trial.
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Reposted by Alex Cope, PhD (he/him)
Vincent J Lynch 🐘🦣🦥 🦇🐋🐢🐍 @devoevomed.bsky.social · 06/10/2025
#MammothMonday factoids: A comparison of 23 woolly mammoths (how cool is it to have that many mammoth genomes!) and 28 living elephants identified at least 1.2 million mammoth-specific genetic changes, including 4,786 amino acid substitutions in 3,097 genes 1/n 🧪 🐘 🦣 PMID: 37030294
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Reposted by Alex Cope, PhD (he/him)
Matthew Hahn @3rdreviewer.bsky.social · 06/10/2025
The most important paper in evolutionary biology I'd never heard of: 1/ www.sciencedirect.com/science/arti...
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Reposted by Alex Cope, PhD (he/him)
Don Moynihan @donmoyn.bsky.social · 03/10/2025
Elected officials questioning the legality of ICE processes being arrested
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Melissa Herman @melissaherman.bsky.social · 02/10/2025
This is a fantastic program and a great opportunity 👇👇👇👇👇
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I Scare You Like Sound Dog @chadstanton.blacksky.app · 30/09/2025
““We should use some of these dangerous cities as training grounds for our military.”” They’re not being coy about their vision for the future.
nytimes.com
Trump Administration Live Updates: President Tells Top Brass American Cities Should Be ‘Training Grounds’ for Military
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Reposted by Alex Cope, PhD (he/him)
jamelle @jamellebouie.net · 30/09/2025
the president of the united states wants to use the american military to kill american citizens on american soil. that's the whole story!
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Reposted by Alex Cope, PhD (he/him)
Kevin M. Kruse @kevinmkruse.bsky.social · 27/09/2025
The two middle aged joggers on the side street are TERRIFYING.
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Reposted by Alex Cope, PhD (he/him)
Bill Kristol @billkristolbulwark.bsky.social · 27/09/2025
“Oregon is our home. Keep troops off our streets.”
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 26/09/2025
I was a completely normal graduate student until my PhD advisor made me write in LaTeX. Now I habitually add '\' every time I type out a percentage.
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