Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

Chromosome conformation analysis in Drosophila wing discs reveals the requirement of specific meta-loops during regeneration.

Zirkel et al. use three distinct primary human cell types to show that nuclear depletion of HMGB2 constitutes an early event on the path to replicative senescence controlling heterochromatic and trans...

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.