Akis (Argyris) Papantonis @akispapantonis.bsky.social · 25/08/2026Newest from the lab - and the only of our manuscripts since the introduction of bioRxiv that we did not preprint (it will become obvious why). "Targeting addiction to HMGB2-driven transcriptional programs in pancreatic cancer" A thread... 44012 0
Akis (Argyris) Papantonis @akispapantonis.bsky.social · 25/08/2026We have long been working with the highly abundant, but functionally elusive HMGB2 chromatin binder. And work from 2018 (Zirkel et al, Mol Cell), but also from this year (Palikyras et al, Nat Aging; www.nature.com/articles/s43...) have consolidated that its loss from cell nuclei induces senescence.nature.comSenescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature AgingPalikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin... 120 0
Akis (Argyris) Papantonis @akispapantonis.bsky.social · 25/08/2026...and few years back I proposed that HMGB2 should perhaps be viewed as a "rheostat" of chromatin and cell homeostasis: www.sciencedirect.com/science/arti... 110 0
