Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Speaker : Morgane THION, College de France"Microglia in the developing brain: from colonization to functions"

Nature - Learned risk-taking behaviours can persist for years after leaving the lab — and even after taking on a new research topic.

Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...

A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.

B-1 cells are innate-like lymphocytes that play a critical role in homeostasis by secreting natural antibodies, typically IgM, and immunosuppressive molecules such as IL-10. However, the regulation of...

The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...

Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Liver-restricted viral infection in mice results in secondary lymphoid organ dormancy and the compensatory induction of specialized lymphoid tissue in the liver, the structural features and functional outputs of which are closely mirrored in humans.

By learning a differentiation potential using an optimal transport-based approach, STORIES models and infers cell fate trajectories using spatiotemporal omics data.

This essay uses immunology to illuminate human relationships. Moving beyond self/non-self toward danger-based models, it draws parallels between cytokine communication and language, tolerance and forgiveness, microbiota diversity and coexistence. Recognizing these metaphors reveals pathways toward healthier connections within individuals, communities, and societies.

Immune activity at the cerebrospinal fluid (CSF)–dura–brain interface regulates key functions of brain physiology. In two back-to-back papers, Mamuladze et al. and Kothari et al. show that dural mast cells (MCs) are strategically positioned to coordinate this regulation, controlling CSF flow dynamics and immune cell trafficking in allergy, meningitis, and stroke.

Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.

Pioneering project uses “rapid autopsies” to find virus hideouts in infected people

The causes of early-life eczema have been unclear, but evidence indicates that changes to fetal immune cells and sensory neurons during pregnancy play a key part.

An unprecedented situation has arisen this summer, with the first locally acquired cases of chikungunya detected as early as June, notably affecting the Grand Est region for the very first time. Chiku...

From the tiger mosquito, now well established in Europe, to endemic species in the tropics or Pacific region, these insects have colonized vast areas of the planet and play a key role in local ecosyst...

Humanities and Social Sciences Communications - The innovation trade-off: how following superstars shapes academic novelty