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Olga Sigalova

@olgasigalova.bsky.social
98 followers 260 following 1 posts

Postdoc @ KU Leuven (Stein Aerts lab) PhD @ EMBL Heidelberg (Eileen Furlong and Judith Zaugg labs) Interested in computational genomics, gene regulation, evolution and marine biology

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Reposted by Olga Sigalova
Arnau Sebé-Pedrós @arnausebe.bsky.social · 20/07/2026
The third chapter in our coral single-cell trilogy is here. After mapping cell type diversity in Stylophora (Levy 2021) and exploring facultative symbiosis in Oculina (Levy 2025), we now uncover cell type-specific responses to heat stress. Find out more in @xgrau.bsky.social's thread below.
biorxiv.org
Cell-resolved transcriptional responses during heat-induced coral bleaching and recovery
Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causing coral bleaching. Yet how these responses are dis...
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Reposted by Olga Sigalova
VIB.AI @vibai.bsky.social · 30/06/2026
The @steinaerts.bsky.social lab received an ERC Proof of Concept Grant to develop CellTuned: an AI platform that combines sequence-to-function models with single-cell regulatory networks to uncover the mechanisms driving disease, and translate them into new therapeutic opportunities. 👏 celltuned.ai
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Reposted by Olga Sigalova
Nicholas Bellono @nbellono.bsky.social · 16/06/2026
How did animal senses evolve? Max Coyle et al. used choanoflagellates to uncover TRPW, ancient ion channels predating animal somatosensory receptors. TRPW links microbial prey ecology to evolution of receptor structure, sensory organelles, & multicellular processing. www.biorxiv.org/content/10.6...
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Reposted by Olga Sigalova
Arnau Sebé-Pedrós @arnausebe.bsky.social · 10/06/2026
Long-term aggregation induced by bacteria in the filasteran Ministeria, with increased mating frequency inside aggregates. Truly remarkable observations by JP Gerdt, @multicellgenome.bsky.social and team! www.nature.com/articles/s41...
nature.com
A unicellular relative links aggregative multicellularity to animal origins - Nature
Nature - A unicellular relative links aggregative multicellularity to animal origins
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Reposted by Olga Sigalova
Pawel Burkhardt @pawelburkhardt.bsky.social · 23/05/2026
A fossil nervous system meets modern neurobiology. We found that a living comb jelly preserves neural architecture remarkably similar to those inferred from Cambrian fossils over 500 million years old 🤩. www.biorxiv.org/content/10.6...
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Reposted by Olga Sigalova
Marie Kieseler, Ph.D. @mlkieseler.bsky.social · 03/06/2026
Excited to share that our paper on mirror use in octopuses is published today in @currentbiology.bsky.social! This is the first time mirror-mediated spatial navigation has been demonstrated in an invertebrate. 🐙 www.sciencedirect.com/science/arti...
sciencedirect.com
Octopus bimaculoides can learn to utilize a mirror to localize a reward outside the line of sight
Mirror-mediated localization of hidden objects is well documented in vertebrates1,2,3,4,5,6,7,8,9,10,11,12 but has never been demonstrated in inverteb…
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Reposted by Olga Sigalova
preLights @prelights.bsky.social · 02/06/2026
As marine heatwaves intensify, who survives - and why? Maitri Manjunath highlights work from @zoe-meziere.bsky.social & team who studied the variation in coral thermal stress responses during a real-time marine heatwave 🪸 #preprint #ecology #preLight: prelights.biologists.com/highlights/h...
prelights.biologists.com
Heatwave winners and losers: cryptic coral holobionts differ in thermal tolerance - preLights
Beating the heat isn’t about place, it’s about partnership.
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Reposted by Olga Sigalova
c0nc0rdance @c0nc0rdance.bsky.social · 30/05/2026
Magnolias evolved before bees existed. 95 million years ago, their ancestors shared the planet with the dinosaurs of the Cretaceous, but no bees. So they made a messy partnership with beetles that continues today & it explains why they're such unusual flowering plants. Let's talk about it.
mymodernmet.com
Magnolias Are So Old That They’re Pollinated by Beetles
Why beetles? You'll need to read to beelieve it.
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Reposted by Olga Sigalova
Chema Martin @chemamd.bsky.social · 19/05/2026
🚨 We discovered a new mode of Hox gene regulation in annelids! 🪱 A distal enhancer acts as a "global control region", lifting Hox genes from Polycomb repression. This is reminiscent of Hox gene control in vertebrates, but the two modes likely evolved convergently. www.biorxiv.org/content/10.6...
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Reposted by Olga Sigalova
Konrad @konradjk.bsky.social · 13/05/2026
🧬 New preprint! We present an All by All analysis in All of Us: common and rare variant association testing across 392,030 whole genomes and 3,602 phenotypes. 1.337 trillion tests, ~50k significant signals, all publicly browseable. www.medrxiv.org/content/10.6...
medrxiv.org
Systematic common and rare variant association testing in 392,030 whole genomes in All of Us
Large-scale genome-wide association studies (GWAS) and rare variant association studies (RVAS) from population biobanks provide valuable resources for gene discovery in complex human traits. We presen...
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Reposted by Olga Sigalova
MPI for Evolutionary Biology @mpi-evolbio.bsky.social · 07/05/2026
Facial diversity in birds and mammals doesn’t just come from different signals – but from how cells respond to them. A new study in Science Advances shows evolution acts on both: signal placement and cellular interpretation. More Info: www.evolbio.mpg.de/3879733/news... @marketa-kau.bsky.social
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Reposted by Olga Sigalova
Nature @nature.com · 29/04/2026
Octopuses and squid have elaborate brains. How did their intelligence evolve? go.nature.com/4tIg5Mw
go.nature.com
Do octopus brains work like humans’ — or is there another way to be smart?
Just like vertebrates, cephalopods — such as octopuses and squid — have elaborate brains. Neuroscientists are flocking to them for insights into how intelligence evolved.
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Olga Sigalova @olgasigalova.bsky.social · 16/04/2026
Happy to share our new preprint on non-coding genetic variation in the human brain and Parkinson's disease. Great team effort with @alexanrna.bsky.social, @juliedeman.bsky.social, Koen Theunis, and all co-authors, supervised by @steinaerts.bsky.social and @jdemeul.bsky.social. Thread below:
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