Integrating spatial and single-cell data from 100 patients, the authors define conserved cellular communities and communications in glioblastoma, revealing distinct mesenchymal-like tumor subtypes and...

Glioblastoma, the most aggressive malignant brain tumor in adults, remains one of the most challenging cancers to treat because of limited treatment options and a poor prognosis. Patient outcomes have...

PDGFRA is commonly altered in pediatric HGG. Mayr et al. report that the PDGFRA/KIT inhibitor avapritinib demonstrates on-target activity, brain penetrance, and survival benefit in pre-clinical H3K27M...

Synthetic super-enhancers enable specific delivery of anticancer payloads, achieving tumour elimination after a single dose in a mouse model of aggressive glioblastoma.

Organoids provide a useful model to capture the heterogeneity of brain tumours. Here, the authors assess current methodologies for generating organoids from various types of brain tumour and discuss h...

In this Review, Golebiewska and colleagues summarize the main features of the immunosuppressive microenvironment in glioblastoma (GBM) and discuss how different therapeutic approaches reshape GBM immu...

Brain tumors represent a unique challenge for cancer immunotherapies because of their location in an immune privileged site. However, the brain tumor immune microenvironment is dictated more by tumor type than the location within the brain per se. This feature is reflected by the higher immunogenici …

Candidatez à l'édition 2025 de ComSciCon France ! Les candidatures sont ouvertes aux doctorant·e·s de toutes disciplines !

Neuroscientists probing the boundary between sleep and awareness are finding many types of liminal states, which help explain the sleep disorders that can result when sleep transitions go wrong.

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