Reposted by MILO LabYahaya Yabo @yahayayabo.bsky.social · 24/09/2026A great start to #EANO26! 🧠 Glad to have presented our work in the very first session. Looking forward to the next few days of great talks and catching up with colleagues! #NeuroOncology @milolab.bsky.social 041
Reposted by MILO LabYahaya Yabo @yahayayabo.bsky.social · 28/06/2026🧠 NEW PAPER ALERT from the @milolab.bsky.social and the #SonabendLab 🚨 Why do some glioblastomas (GBM) respond to immunotherapy while others don't? Our study reveals a surprising driver of treatment success: the tumor's own MAPK/ERK signaling pathway! 🧵 👇 www.nature.com/articles/s41...nature.comGlioma-intrinsic MAPK/ERK signaling promotes immunotherapy efficacy through T cell infiltration and interferon responses - Nature CommunicationsActivation of the MAPK/ERK signaling pathway is known to influence glioma biology. Here the authors report that MAPK/ERK signaling activation drives interferon responses in glioma cells, enhancing ant... 122
MILO Lab @milolab.bsky.social · 08/06/2026Brain cancer is one of medicine’s most complex challenges. At the MILO Lab, we are working on decoding this complexity, from cellular interactions to computational patterns, to map the path to a breakthrough. 🧠✨ 011
MILO Lab @milolab.bsky.social · 30/05/2026A wonderful lab retreat bringing together scientific discussion, new ideas, collaboration, and plenty of laughter. Grateful for the opportunity to step away from the bench, reflect on our research, and strengthen the connections that make science possible! ✨🧬🔬 011
Reposted by MILO LabYahaya Yabo @yahayayabo.bsky.social · 19/03/2026🧵 1/8 Hot off the press! 🔥 link.springer.com/article/10.1... CAR-T cells show promising results in preclinical glioblastoma models, yet clinical benefit in patients has been limited. To understand why, we used a human brain slice model that preserves the native human GBM tumor microenvironment. 🧠 262
Reposted by MILO LabYahaya Yabo @yahayayabo.bsky.social · 20/12/2025www.biorxiv.org/content/10.6...biorxiv.orgSerotonergic neuron-glioma interactions drive high-grade glioma pathophysiologyHigh-grade gliomas are lethal brain cancers that are powerfully regulated by glutamatergic neurons through activity-dependent paracrine factors and functional neuron-to-glioma synapses. Here, we repor... 041
Reposted by MILO LabDieter Henrik Heiland @heilandhenrik.bsky.social · 24/11/2025Very proud and truly honored to have taken part in this year’s SNO in Hawaii. Inspiring science, outstanding discussions, and my incredible lab pushing the boundaries @milolab.bsky.social Grateful for the beautiful setting that made this meeting unforgettable #SNO2025 #KeynoteSpeaker #NeuroOncology 093
MILO Lab @milolab.bsky.social · 22/11/2025Amazing Keynote talk by @heilandhenrik.bsky.social on "Translational Data Integration and Technological Developments in Neuro-Oncology" at the ongoing #SNO2025 in Hawaii.🧠 081
MILO Lab @milolab.bsky.social · 19/11/2025If you are at #SNO2025 be sure to check @milolab.bsky.social talks and posters including a keynote talk by @heilandhenrik.bsky.social #Hawaii🏖️🌊 #glioblastoma 051
MILO Lab @milolab.bsky.social · 10/11/2025✨ Early holiday vibes from the microscope! ✨ Live calcium imaging of glioblastoma cells at full confluence — bursting with spontaneous activity and glowing with waves of intracellular signaling. You can even spot a few cells dividing amidst the flicker. #CalciumImaging #Glioblastoma 050
MILO Lab @milolab.bsky.social · 20/10/2025Just wrapped up an incredible few days in Prague for the @eanoassociation.bsky.social meeting! Truly inspiring sessions, great discussions, and exciting new collaborations. The MILO Lab shined with engaging talks and eye-catching posters! Ready to keep pushing the boundaries of science together! 041
Reposted by MILO LabFAU Erlangen-Nbg @fau.de · 16/09/2025Oliver Schnell untersucht Hirntumore in ihrer Entstehung. Mit seinen Erkenntnissen möchte der Direktor der neurochirurgischen Klinik des Uniklinikums Operationen besser und sicherer machen. FAU-Präsdient @hornegger.bsky.social war zu Besuch: www.fau.de/2025/09/news...fau.deA cup with the President - Episode 33: Prof. Dr. Oliver SchnellFAU-Präsident Prof. Dr. Joachim Hornegger besucht in jedem Semester Professorinnen und Professoren in ihren Instituten. Dort möchte er mit ihnen ins Gespräch über ihre Forschung kommen… 0224
Reposted by MILO LabRoel Verhaak @roelverhaak.bsky.social · 16/07/2025New preprint on longitudinal treatment response signatures in IDH-mutant glioma from the GLASS Consortium www.biorxiv.org/content/10.1...biorxiv.orgTumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomasAstrocytomas and oligodendrogliomas are slow-growing and treatment-sensitive IDH-mutant gliomas diagnosed at ages 30-50. Local tumor regrowth and treatment resistance is inevitable resulting in 3-10 y... 2214
Reposted by MILO LabYahaya Yabo @yahayayabo.bsky.social · 05/07/2025Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...nature.comCombining spatial transcriptomics and AI to enhance brain tumour diagnosis - Nature Reviews CancerIn this Tools of the Trade article, Yahaya A. Yabo describes the development of neuropathology spatial transcriptomic analysis (NePSTA), an artificial intelligence (AI)-based tool to identify and map ... 172
Reposted by MILO LabEANO @eanoassociation.bsky.social · 08/06/2025🧠 June 8 is #WorldBrainTumorDay — raising awareness & understanding of brain tumors. EANO supports progress in #NeuroOncology through research, education & collaboration. 🔗 Learn more: www.eano.eu #btsm #BrainTumor #Oncology 0116
MILO Lab @milolab.bsky.social · 05/06/2025Thank you for the opportunity to present our work at #DGNC2025 in Hannover. 030
Reposted by MILO LabNature Neuroscience @natneuro.nature.com · 20/05/2025A Perspective on a dynamic and multimodal framework to define microglial states from @rsankowski.bsky.social and Marco Prinz www.nature.com/articles/s41...nature.comA dynamic and multimodal framework to define microglial states - Nature NeuroscienceSankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a robust terminology with biol... 0114
Reposted by MILO LabDieter Henrik Heiland @heilandhenrik.bsky.social · 07/04/2025We had an amazing lab retreat Spring 2025! Best team of the world! 041
Reposted by MILO LabYahaya Yabo @yahayayabo.bsky.social · 07/04/2025The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group. Great people, great science. #glioblastoma #spatialtranscriptomics #scRNA-seq 031
Reposted by MILO LabTy Miller Lab @tymillerlab.bsky.social · 27/02/2025Grade = microenvironment under a microscope, so we looked to see what specific environments in the tumor were associated w/specific myeloid activities using 10X Visium data from @milolab.bsky.social .Our Scavenger Suppressive program was only in hypoxia. The Complement Suppressive? Everywhere else 111
Reposted by MILO LabTy Miller Lab @tymillerlab.bsky.social · 27/02/2025Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...nature.comPrograms, origins and immunomodulatory functions of myeloid cells in glioma - NatureA study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell... 4289
Reposted by MILO LabMichelle Monje @michellemonje.bsky.social · 19/02/2025Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵 Open access link: www.nature.com/articles/s41... 27423
Reposted by MILO LabThomas Daubon pro - GBmetabo @thomasdaubon.bsky.social · 04/02/20251/5 Excited to share our latest paper published in EMBO Molecular Medicine!🎉 🎉 embopress.org/doi/full/10.... This collaborative work brings together Team1 BRIC_Bordeaux, @ahmadsharanek.bsky.social, Andreas Bikfalvi, Lucie Brisson, Thomas Mathivet and our GBmetabo Team with Audrey Burbanembopress.orgExploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile | EMBO Molecular MedicineimageimageIn patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting mitochondrial respiration. Combination with the current standard of ... 1133
MILO Lab @milolab.bsky.social · 30/01/2025Ever wondered what makes brain tumors tick? Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content! www.instagram.com/the_milolab/...instagram.comLogin • InstagramWelcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world. 011
MILO Lab @milolab.bsky.social · 30/01/2025Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors. @10xGenomics 🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs t.co/GmA9MLNKy1 031
MILO Lab @milolab.bsky.social · 30/01/2025Happy to share your latest collaboration with @sahm_lab leveraging spatial transcriptomics @10xGenomics for neuropathology diagnosis #DeepLearning ! 107 patients across 15 CNS tumors! www.nature.com/articles/s43...nature.comSpatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature CancerRitter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ... 153
Reposted by MILO LabVarun Venkataramani @venkataramanilab.bsky.social · 06/12/2024🧵Just in time for : New research from the Venkataramani lab @CellCellPress maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S... @ekinreyhan.bsky.social @svenjaktetzlaff.bsky.social 1/15 25116
Reposted by MILO LabYahaya Yabo @yahayayabo.bsky.social · 22/11/2024Amazing talk by Henrik Heiland on using #spatialtranscriptomics data to model glioblastoma evolution #SNO2024 082
