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Svenja Tetzlaff

@svenjaktetzlaff.bsky.social
79 followers 87 following 1 posts

MD student at Heidelberg University | Cancer Neuroscience @ Venkataramani lab🔬🧠

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Reposted by Svenja Tetzlaff
neurooncologyhd.bsky.social @neurooncologyhd.bsky.social · 15/05/2025
The organizing committee of the UNITE conference would like to thank all speakers for their excellent presentations and all participants for the valuable discussions. @wickwolfgang.bsky.social @michael-platten.bsky.social
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neurooncologyhd.bsky.social @neurooncologyhd.bsky.social · 15/05/2025
The second day of the UNITE conference. Today there will also be a contribution from a patient on the book “Alles gut? Alles gut.” by Marlene Assmann. www.jacobystuart.de/buecher-von-...
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Cell Chemical Biology @cp-cellchembiol.bsky.social · 20/03/2025
Spotlight @svenjaktetzlaff.bsky.social, @venkataramanilab.bsky.social et al @cp-cell.bsky.social paper: Disrupting neuron-tumor networking connections by C.-E. Shen, A. Echeandía Marrero, Yuan Pan at @mdanderson.bsky.social dlvr.it/TJfRwt
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Michelle Monje @michellemonje.bsky.social · 21/03/2025
#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler. www.nature.com/articles/s41...
nature.com
Cancer research needs neuroscience and neuroscientists - Nature Neuroscience
The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...
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Matthia Karreman @matthiakarreman.bsky.social · 20/03/2025
It was my pleasure to write a Preview of the paper www.sciencedirect.com/science/arti... together with @venkataramanilab.bsky.social ! 🧠 #cancerneuroscience #glioblastoma The preview is now online @cp-neuron.bsky.social 👇
sciencedirect.com
Calm in the chaos: Targeting mTOR to reduce glioma-driven neuronal hyperexcitability
Primary brain tumors induce neuronal hyperexcitability, leading to epileptic seizures. In this issue of Neuron, Goldberg et al.1 demonstrate genetic, …
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Cancer Neuroscience Heidelberg @cn-hd.bsky.social · 11/03/2025
We are thrilled to welcome #thebrainprize2025 winner Prof. Winkler @winklerlab.bsky.social as a speaker on #cancerneuroscience at the UNITE Conference 2025! Join us on May 14-15, 2025, in Heidelberg, Germany! 📢 Register now and submit your abstracts here: www.unite-glioblastoma.de/unite-confer...
unite-glioblastoma.de
UNITE CONFERENCE - UNITE Glioblastoma
Conference
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Cancer Neuroscience Heidelberg @cn-hd.bsky.social · 24/01/2025
Enjoy the early bird rate with 25 Euros discount on the registration fee until January 31st! Abstract submission deadline: February 23rd.
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Adlung Lab @adlunglab.com · 25/01/2025
🤯 Glioblastoma tumours form connections with neurons, driving their own progression! 😱 The lab of my good friend @venkataramanilab.bsky.social back from the days at Studienstiftung des deutschen Volkes e.V. just dropped that screamer of a paper! 1/3
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Adlung Lab @adlunglab.com · 25/01/2025
🕸️ This study maps glioblastoma’s integration into neural circuits using rabies-virus tracing, revealing neuron-tumour networks as key therapeutic targets. 🗞️ The paper by @svenjaktetzlaff.bsky.social et al. is out now in @cp-cell.bsky.social 🔗 www.cell.com/cell/fu... 🧪 🔓 3/3
cell.com
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.
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Wolfgang Wick @wickwolfgang.bsky.social · 12/12/2024
🎉Es ist ein Riesenprivileg, wenn man mit so leistungsstarken und kreativen Wissenschaftler:innen wie @svenjatetzlaff.bsky.social und @venkataramanilab.bsky.social zusammenarbeiten darf. Der Schritt pathologische Netzwerke in Hirntumoren als Routen für Therapie zu explorieren,ist hochinnovativ.
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Sam Connell @samuelconnell.3i.social · 10/12/2024
🧪🧵🔬🔥Amazing microscopy here from the Venkataramani lab!
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Maria Puschhof @mariapuschhof.bsky.social · 08/12/2024
Great to see the study published! Congrats to all co-authors and thanks very much for having us @juliosaezrod.bsky.social @saezlab.bsky.social on the team. A nice example of how the @aihcluster.bsky.social makes new collaborations possible.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 07/12/2024
Beautiful work & insightful BlueSkytorial by @venkataramanilab.bsky.social. Using modified rabies viruses, they show that glioblastoma tumor cells rapidly make connections with neurons & these interactions represent targetable vulnerabilities that could open therapeutic avenues for brain cancers.
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Emmanuelle Huillard @emmanuellehuillard.bsky.social · 07/12/2024
🔥 Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing: Beautiful work by @venkataramanilab.bsky.social, congratulations !! www.cell.com/cell/fulltex...
cell.com
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.
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Winkler Laboratory @winklerlab.bsky.social · 07/12/2024
Important #cancerneuroscience work from the amazing @venkataramanilab.bsky.social and as shared first @svenjaktetzlaff.bsky.social and @ekinreyhan.bsky.social ! Check it out 👇
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Matthia Karreman @matthiakarreman.bsky.social · 07/12/2024
Fantastic work by the amazing @svenjaktetzlaff.bsky.social , @ekinreyhan.bsky.social and the @venkataramanilab.bsky.social !! Important and beautiful study 🤩 and I am happy and honored to have played a small part in it!
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Ekin Reyhan @ekinreyhan.bsky.social · 06/12/2024
Thrilled to share our latest work on how glioblastoma integrates into brain-wide networks using rabies-mediated retrograde tracing!🧠 So grateful to have been part of such a big team effort! @svenjaktetzlaff.bsky.social @venkataramanilab.bsky.social
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
We are incredibly grateful for the patients, their families and the funding agencies for enabling this research!
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
Sonja Hänzelmann, @matthiakarreman.bsky.social, Felix Kurz, Manuel Schröter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna, @saezlab.bsky.social , Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland
arreman.bsky.social
Bluesky
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
@atefehpourkhalili.bsky.social @ninadrewa.bsky.social @afaymonville.bsky.social ville.bsky.social @ekeifert.bsky.social eifert.bsky.social, Julia Wagner, @stellasoyka.bsky.social @marccschubert.bsky.social @nirosansivapalan.bsky.social
ville.bsky.social
Andres Villegas (@ville.bsky.social)
Systems are life
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
So proud of the shared first authors @ekinreyhan.bsky.social sky.social @svenjaktetzlaff.bsky.social etzlaff.bsky.social and the entire team of amazing collaborators @layern.bsky.social Peter Bengtson, Alina Heuer, @julianschroers.bsky.social @afaymonville.bsky.social
bsky.social
Bluesky
Social media as it should be. Find your community among millions of users, unleash your creativity, and have some fun again.
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🔗 This research showcases the importance of bespoke methods development for Cancer Neuroscience, how it will advance our understanding of (brain) cancer circuits and the development of novel therapeutics for yet incurable tumors. 14/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
📊 Beyond just mapping, this work provides new therapeutic targets and a platform for testing treatments against these aggressive brain tumors. 13/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
📡 Radiation therapy revealed something unexpected: It increased neuronal activity and subsequently connections between neurons and tumor cells. 9/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🧬 Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🌐 These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
⚡️ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🔬 Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
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Varun Venkataramani @venkataramanilab.bsky.social · 06/12/2024
🧪 How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
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Svenja Tetzlaff @svenjaktetzlaff.bsky.social · 06/12/2024
So happy this is finally out😊 thank you for the amazing supervision @venkataramanilab.bsky.social, to the best partner-in-crime @ekinreyhan.bsky.social and everyone who contributed, such a team effort!🧠🔬
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Jeremy Borniger @jborniger.bsky.social · 06/12/2024
www.cell.com/cell/fulltex... from the immensely talented Venkataramani group, essential work for cancer neuroscience.
cell.com
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.
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Reposted by Svenja Tetzlaff
Varun Venkataramani @venkataramanilab.bsky.social · 26/11/2024
The Venkataramani lab had an incredible time at #SNO2024! Very proud of Ekin Reyhan presenting our work during the Plenary Session, and so proud of Svenja Tetzlaff @svenjaktetzlaff.bsky.social & Julia Wagner for their poster presentations. Can’t wait for next year’s conference in Hawaii!
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