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Victor Dubach

@vicsnor.bsky.social
138 followers 236 following 1 posts

PhD student @bjmurphylab.bsky.social @mpibp.bsky.social with @imprs-cbp.bsky.social Interested in #cryoEM 🔬❄️, redox and membrane proteins

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Reposted by Victor Dubach
Murphy Lab @bjmurphylab.bsky.social · 03/09/2026
Check out our newest preprint! tinyurl.com/mttvaed3 Max was able to resolve cryo-EM structures of the DsrMKJOP complex, which catalyzes a critical step in sulfur metabolism and sulfide production is sulfate-reducing microbes. The main findings are summarized in the video below 📽️
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Murphy Lab @bjmurphylab.bsky.social · 17/08/2026
We enjoyed the last bit of German summer and had a great time at our lab bbq last week! 🍔 🍻
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Katharina Geißler @kgeissler.bsky.social · 26/06/2026
What is the best way to distribute the electron dose across your tilt series in cryo ET? Thanks to Maarten Tuijtel, we finally know --> head over to eLife for the publication! doi.org/10.7554/eLif...
doi.org
Optimising the tilt-increment for in situ cryo-electron tomography
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Roger Castells @rcastellsg.bsky.social · 31/05/2026
Excited to share our latest research on leveraging machine learning with helical fusions for the design of novel protein cages! Preprint: “Design and structure of protein cages based on helical fusion and machine learning” Link: www.biorxiv.org/content/10.6...
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Sonja Welsch @sonjawelsch.bsky.social · 29/05/2026
If it fits, it sits, #cryoEM version. Rear door of Krios at @mpibp.bsky.social has a cat flap now🚪
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Reposted by Victor Dubach
Murphy Lab @bjmurphylab.bsky.social · 09/05/2026
We had a great time having Michael Elbaum from the Weizmann Institute visit our institute (@mpibp.bsky.social)! Had an insightful seminar and a fun time at the Krios doing STEM 🔬 Our Krios is upside down according to material scientists so instead of turning our microscope, we turned ourselves!
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Max Planck Institute of Biophysics @mpibp.bsky.social · 20/04/2026
That’s a wrap on our @embo.org #cryoFIB & #cryoET course! It was an incredible week of hands-on learning, collaboration, and shared expertise, made possible by dedicated organizers, incredible trainers, and an engaged group of participants.
A large diverse group of people waving and smiling at the camera in front of scientific posters displayed on a wall.
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Reposted by Victor Dubach
Max Planck Institute of Biophysics @mpibp.bsky.social · 17/04/2026
We are having a very hands-on week at the @embo.org #cryoFIB & #cryoET course 🔬 Our participants are learning about sample vitrification, lamella milling, FLM, lift-out, data acquisition and more! We are learning by doing, troubleshooting, and sharing expertise across labs. 🧪
Three female researchers discuss data displayed on dual monitors in a microscopy workspace with keyboards, mouse, and electronic equipment on the desk.Two female researchers working at a computer displaying a 3D scientific visualization on a large curved monitor in a modern office.Two young researchers examining an object with tweezers in a lab setting near a sink and hygiene supplies.Group of participants in a lab setting reviewing microscopy images on computer screens and looking at printed diagrams during a practical course.
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Reposted by Victor Dubach
Max Planck Institute of Biophysics @mpibp.bsky.social · 15/04/2026
Participants shared their work and ideas in our poster session at the @embo.org Practical Course on “In-situ structural biology by Cryo-FIB and Cryo-ET” at our institute! It was a great chance to connect, discuss, and get new perspectives on #cryoFIB and #cryoET. 🌍
Three young researchers—two women and one man—stand in front of a poster at a poster session, holding drinks and smiling as they chat. Other people stand in the background.Female researcher pointing at a scientific poster on a borad while two others observe in an indoor setting.Female researcher pointing at a scientific poster on a borad while two others observe in an indoor setting.Two female researchers at the poster session are standing in front of a poster board, holding drinks and chatting, whilst other people stand in the background.
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Reposted by Victor Dubach
Joe Greener @jgreener64.bsky.social · 01/04/2026
On this 1st April I'm happy to release a technical report from our startup MirageBio, describing a new protein structure model with state-of-the-art performance. jgreener64.github.io/posts/techni...
jgreener64.github.io
MirageBio technical report
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Max Planck Institute of Biophysics @mpibp.bsky.social · 12/02/2026
Ready to TANGO? 💃 In our new publication, Beata Turoňová & Markus Schreiber (@ms314.bsky.social, @becklab.bsky.social) present TANGO: the first cryoET framework to analyze the relation between particle positions and orientations 🪩 All in a single user-friendly package! #CryoET #OpenScience
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Murphy Lab @bjmurphylab.bsky.social · 27/01/2026
Enjoying long incubation times and snowy days in Frankfurt ☃️
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Wilfling Lab @wilflinglab.bsky.social · 20/01/2026
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET
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Sergio Cruz-León @sergiocruzleon.bsky.social · 13/01/2026
We resolved the molecular architecture of a condensate—inside cells. 🤯 By combining in situ cryoET with multiscale simulations, we show how a single point mutation modifies molecular interactions, shifts the condensate’s material properties, and alters its biological function. Preprint 👇
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Katharina Geißler @kgeissler.bsky.social · 16/12/2025
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
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Jenny Sachweh @jennysachweh.bsky.social · 07/11/2025
Yesterday I finally defended my PhD thesis - time to say thank you to all those who were part of this journey as mentors, collaborators, colleagues and friends!
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Desislava Glushkova @deglushk.bsky.social · 06/11/2025
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
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Reposted by Victor Dubach
Murphy Lab @bjmurphylab.bsky.social · 05/11/2025
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
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Melanie McDowell @melaniemcdowell.bsky.social · 30/10/2025
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
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Max Planck Institute of Biophysics @mpibp.bsky.social · 30/10/2025
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
Structure of the ribosome-bound SND3 translocon complex from the heat-tolerant fungus Chaetomium thermophilum. The SND3 translocon inserts proteins into the endoplasmic reticulum membrane as they are produced by the ribosome.
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Max Planck Institute of Biophysics @mpibp.bsky.social · 16/10/2025
Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence
Bonnie Murphy and Ralf Steinhilper stand together, smiling at the camera. Ralf is wearing a creatively handcrafted doctor’s hat.
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Ralf Steinhilper @ralfsteinhilper.bsky.social · 16/10/2025
Big thanks to everyone at @bjmurphylab.bsky.social and @mpibp.bsky.social for your support and for making this such an unforgettable time!
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IMPRS on Cellular Biophysics @imprs-cbp.bsky.social · 13/10/2025
Our yearly retreat brought together our PhD students 👩‍🔬from Frankfurt and Mainz for a journey of science and community building in the mountains of Switzerland! 🏔️ #gradschool #imprs_cbp Photos: Vinay Singh
Group of people looking at camera with a nature green background.
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Jan Philipp Kreysing @jpkreysing.bsky.social · 10/10/2025
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
nature.com
cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology
Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.
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Reposted by Victor Dubach
Max Planck Institute of Biophysics @mpibp.bsky.social · 29/09/2025
🎉 Congratulations to our postdoc @sergiocruzleon.bsky.social for receiving the 2026 Theory & Computation Postdoctoral Research Award from the Biophysical Society! 🎉 Sergio will present his work at the Theory & Computation subgroup Symposium during the 2026 Biophysical Society meeting.
Photo of Sergio Cruz and text: Sergio Cruz-León receives the 2026 Theory & Computation Postdoctoral Research Award
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Max Planck Institute of Biophysics @mpibp.bsky.social · 21/07/2025
🔬 Check out our new article on the mitochondrial TOM complex! Researchers from the Structural Biology Department have resolved a high-resolution structure of the main entry point for proteins into mitochondria. 🚪 🤩 Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019
biophys.mpg.de
Visualizing the Main Gate into Mitochondria
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Melanie McDowell @melaniemcdowell.bsky.social · 12/07/2025
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 11/07/2025
SND3 is the membrane insertase within a fungal multipass translocon www.biorxiv.org/content/10.1101/202…
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SCALE - SubCellular Architecture of LifE @scale-cluster-ffm.bsky.social · 05/06/2025
🎉We’re celebrating the #SCALE-it-Best-PhD-Awards-2025, honoring exceptional researchers! 🎓 This year, three remarkable dissertations were recognized, selected from a highly competitive and multidisciplinary pool of candidates. 🧵
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Jan Philipp Kreysing @jpkreysing.bsky.social · 12/04/2025
Looking for a tool to measure membrane thicknesses in tomograms (#TeamTomo)? Or curious about thickness differences within and across organelles? Check out my fellow @becklab.bsky.social PhD student @deglushk.bsky.social's excellent preprint: www.biorxiv.org/content/10.1...
biorxiv.org
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Jan Philipp Kreysing @jpkreysing.bsky.social · 11/04/2025
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
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Olivia Pfeil-Gardiner @zoliviapg.bsky.social · 28/03/2025
Get yourself a supervisor with whom you can laugh! …So this happened two days ago… Incredibly grateful for all the fun and support over the years with @bjmurphylab.bsky.social and all the great people at @mpibp.bsky.social 🎓
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evlodinsky.bsky.social @evlodinsky.bsky.social · 11/02/2025
Happy International Women and Girls in STEM Day! Every mentor and act makes a difference - when we support a girl's curiosity or champion a female colleague, we inspire the next generation and one another. Let’s make STEM a place where all women & girls can thrive 🔬👩🏼‍🔬#WomenInSTEM
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Sonja Welsch @sonjawelsch.bsky.social · 04/02/2025
In case you wondered what it looks like "in real life" when the FluScreen of a Krios cryoEM is retracted/inserted: here you go. ❄️🔬
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Max Planck Institute of Biophysics @mpibp.bsky.social · 31/01/2025
Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩‍🔬 🔗 www.biophys.mpg.de/2844976/micr...
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Murphy Lab @bjmurphylab.bsky.social · 31/01/2025
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
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Bianca Introini @bianca-introini.bsky.social · 27/01/2025
I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬 You can find the paper in open access in Nature Structural and Molecular Biology: www.nature.com/articles/s41...
nature.com
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea - Nature Structural & Molecular Biology
Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interacti...
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Wilfling Lab @wilflinglab.bsky.social · 08/01/2025
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with ‪@kraftlabfr.bsky.social‬ www.nature.com/articles/s41... Short teaser below 👇👇👇
nature.com
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
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Murphy Lab @bjmurphylab.bsky.social · 05/12/2024
Hello bluesky, we’re excited to be here! To start off, we want to share our latest work on the FDX2-bound core ISC complex, which is now published in Nature Comms. Congrats to @ralfsteinhilper.bsky.social and everyone else involved! 🎉 www.nature.com/articles/s41...
nature.com
Two-stage binding of mitochondrial ferredoxin-2 to the core iron-sulfur cluster assembly complex - Nature Communications
De novo [2Fe-2S] cluster synthesis by the mitochondrial ISC complex requires electrons from ferredoxin-2 (FDX2). The authors map FDX2 binding to the core ISC complex, showing that FDX2 can bind in two...
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Victor Dubach @vicsnor.bsky.social · 03/12/2024
Congratulations Bis!!🎉
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Biswajit Pradhan @bislightyear.bsky.social · 03/12/2024
It's awesome that most of the coauthors are on Bluesky! 🤩 I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab. Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
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