iiinova — where your digital self keeps evolving

Reposted by Nachiket Vartak

Anirban Banerjee @banirbn.bsky.social · 21/06/2026

How palmitoylation regulates protein function and structure beyond membrane localization is very poorly understood. Human organic solute transporter (OST) α/β uses palmitoylation to facilitate substrate transport. #proteinlipidation #proteinpalmitoylation #OST #transporter rdcu.be/fpxyI

rdcu.be

Structural insights into OSTα/β-mediated transport of bile acids and steroid conjugates

Nature Structural & Molecular Biology - OSTα/β regulates bile acid and steroid conjugate homeostasis. Sun, Tian, Low and colleagues reveal structures of the human OSTα/β...

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Nachiket Vartak @vartak.bioimaging.tech · 27/05/2026

I really hate language like 'we show x that could potentially contribute to y'. This usually means we wanted to do y, but we did not get there, and are hoping someone else in the future might solve this problem. This language is tolerable only in the discussion and speculation part of a paper.

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Nachiket Vartak @vartak.bioimaging.tech · 12/05/2026

"Bhuri" for fair-skinned foreigners. "Tori" for restless bustle. British surveyors mapped a continent from this ridge. From here came numbers that measured the world's tallest mountain. Mount Everest entered history but Bhuri Tori slipped out of it. The name lingered and science faded. #india

timesofindia.indiatimes.com

Mount Everest: Observatory that put Mount Everest in record books now lies in ruins | India News - The Times of India

India News: SIRONJ: \"Bhuri\" for fair-skinned foreigners. \"Tori\" for restless bustle. British surveyors mapped a continent from this ridge. From here came numbers .

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Reposted by Nachiket Vartak

Ilya Kashnitsky @ikashnitsky.phd · 13/07/2025

SmothCSV -- the tool I always wanted smoothcsv.com Picture this: You need to explore visually some CSV data. So you double-slick the file and... wait for 20 seconds for Excel to boot up... Agggr. Instead, SmoothCSV does the job blazing fast (written in rust). FOSS, quick, sleek, beautiful 😍

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Cameron Blevins @cblevins.bsky.social · 03/04/2026

This is so, so well-articulated.

People call this friction "grunt work." Schwartz uses exactly that phrase, and he's right that LLMs can remove it. What he doesn't say, because he already has decades of hard-won intuition and doesn't need the grunt work anymore, is that for someone who doesn't yet have that intuition, the grunt work is the work. The boring parts and the important parts are tangled together in a way that you can't separate in advance. You don't know which afternoon of debugging was the one that taught you something fundamental about your data until three years later, when you're working on a completely different problem and the insight surfaces. Serendipity doesn't come from efficiency. It comes from spending time in the space where the problem lives, getting your hands dirty, making mistakes that nobody asked you to make and learning things nobody assigned you to learn.

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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 08/01/2026

By Betrand Russell _New York American_, 10 May 1933 #superstupidity

Fulltext:
https://archive.org/stream/the-triumph-of-stupidity-russell/The%20Triumph%20of%20Stupidity_Russell_djvu.txt

The Triumph of Stupidity
Bertrand Russell

Originally published under the title 'Stupidity Rules' in the New York American,
10 May 1933.

Republished as 'The Triumph of Stupidity," in
Russell, B. (1998) Mortals and Others, Volume II: American Essays 1931-1935.
Edited by Harry Ruja, pages 27-28, Routledge, London and New York.

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Nachiket Vartak @vartak.bioimaging.tech · 08/01/2026

Over on #X, some people want Grok to apologise for generating offending images. The cognitive dissonance is astounding. #Grok is a LLM. It is nothing but an elaborate database of affinities between arrangements of letters and arrangements of pixels. It has no agency.

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Nachiket Vartak @vartak.bioimaging.tech · 28/10/2025

@bsky.app Ok. New theme from Bluesky makes everything less legible in dark mode because the deep almost benthic blue accent color. And the new icon is ugly. It does not have a dark version on iOS. Fail much.

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Rino Pescitelli @rinopescitelli.bsky.social · 09/09/2025

our paper rebutting claim that Raman can distinguish enantiomers is finally out onlinelibrary.wiley.com/doi/10.1002/... Never accepted by Spectrochimica Acta A despite 2 positive reviews, withdrawn after 2 months... while the flawed paper is still on their website #chemsky #researchintegrity 🧪

onlinelibrary.wiley.com

May Two Enantiomers Have Different Raman Spectra?

May two enantiomers have different Raman spectra? Of course, no! despite what was claimed in a recent publication (Kopec et al., Spectrochim. Acta A 341 (2025):126423). In keeping with the theoretica...

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Kagi HQ @kagi.com · 25/09/2025

Liquid glass for Orion Desktop and Orion Mobile is coming in a few days 🥰

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Itai Yanai @itaiyanai.bsky.social · 24/09/2025

The reality in science is that creativity is not treated as a core skill while hypothesis testing is, and that is the imbalance that we want correct through the Night Science Institute! www.technologynetworks.com/genomics/art... www.night-science.org

technologynetworks.com

The Night Science Institute Is Changing How Science Teaches Creativity

In this interview with Professors Itai Yanai and Martin Lercher, explore how night science brings creativity, ideation and collaboration back into the heart of modern science.

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Reposted by Nachiket Vartak

Wonder of Science @wonderofscience.bsky.social · 07/05/2025

These boxes are not moving. A mind-bending optical illusion by Japanese artist Jagarikin.

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Nachiket Vartak @vartak.bioimaging.tech · 22/04/2025

@bsky.app has started its downhill journey to X-fication. Domain #verification prevents anonymous malicious actors because a domain name is identifiable at ICANN. #Bluecheckmarks that can only be given by select entities (including Bluesky) inevitably creates 2 classes of users. This is a fail.

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Ming Tommy Tang @tommytang.bsky.social · 20/04/2025

1/15 Every wet lab uses spreadsheets. But sloppy spreadsheets waste time, break code, and can cost you $450,000 a year. Here's how to fix that 🧵

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Reposted by Nachiket Vartak

Journal of Cell Biology @jcb.org · 15/04/2025

Rab #GTPases are evolutionarily conserved signals mediating selective #autophagy, say Pengwei Zhao, Rui Tian, Dandan Song, Qi Zhu, Xianming Ding, Wei Zou, Qiming Sun and colleagues @ZJU_China: rupress.org/jcb/article/... #Trafficking #Biochemistry #Mitophagy #Lipophagy #Xenophagy

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MPI Dortmund @mpi-dortmund.bsky.social · 10/04/2025

🚨Paper alert🚨 The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning - Published in @embojournal.org by the Peter Bieling Group & William Bement Group & Scott Hansen Group www.embopress.org/doi/full/10....

embopress.org

The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning | The EMBO Journal

imageimageFormation of Rho GTPase activity patterns on the plasma membrane is key to numerous morphogenic processes in eukaryotic cells. This study employs a reconstitution approach to reveal the bioc...

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Nachiket Vartak @vartak.bioimaging.tech · 14/03/2025

@leising.bsky.social I saw with much interest your interview on DW over the skewed power structure in academia. I wanted to ask you if you are aware of specific oversight bodies that exist in order to regulate, mitigate individual cases.

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Nachiket Vartak @vartak.bioimaging.tech · 26/02/2025

I use an app called @obsidian.md to keep my notes from meetings, conferences, as well as a lab book. I used to think it is a pretty niche program. But seeing their enterprise supporter list , it obviously isn't : obsidian.md/enterprise/ I just wish their pricing for sync and publish was reasonable.

obsidian.md

Meet the teams that trust Obsidian

Organizations that demand the highest security trust Obsidian. Their teams rely on Obsidian to think more effectively and keep total ownership over private data.

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Nachiket Vartak @vartak.bioimaging.tech · 08/02/2025

I just spent the whole day wondering why my email was filling up, why it was so quiet at the institute. Talking with the wife was the first time I realised when she informed me that it was a Saturday, not a Friday.

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Nachiket Vartak @vartak.bioimaging.tech · 08/02/2025

Dear @microsoft.com , no one wants a "Co-pilot" . What people want is a "servant" who will do all the tedious tasks involved in everyday computing.

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Reposted by Nachiket Vartak

Waggoner Lab @labwaggoner.bsky.social · 19/12/2024

Cellular RNAs directly regulate the activity of an antiviral immune signaling complex www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @science.org @nandangokhale.bsky.social @ramlabuw.bsky.social

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Nachiket Vartak @vartak.bioimaging.tech · 13/12/2024

Is the solution to #gallstones simply increasing water flow through the #biliary system? A paper by Huo et al. shows increasing activity of #aquaporins may help. But the answer may not be so simple - we wrote an invited editorial at the Journal of #Hepatology authors.elsevier.com/c/1kEtjcOnAU...

authors.elsevier.com

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Thomas Arnesen @natmachinery.bsky.social · 04/12/2024

The expanding landscape of canonical and non-canonical protein phosphorylation. New review out in TiBS @cellpress.bsky.social www.cell.com/trends/bioch...

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Alexander Titus @alexandertitus.com · 26/11/2024

I don’t get the whole corporate “Alumni” thing. I don’t care if you’ve worked at McKinsey, Google, Goldman Sachs, or anywhere else. I care if you can do the job and do it well. That's it. I’ve met plenty of name-brand idiots and even more no-name geniuses.

media.tenor.com

a puppet in a suit and tie is talking about his " qualifications "

ALT: a puppet in a suit and tie is talking about his " qualifications "

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Christophe 🔬 Leterrier @christlet.bsky.social · 25/11/2024

Something to keep in mind... I'm happy to use English as my work language, but frustrated by how this is often a blind spot among supporters of inclusivity stuck in a US-centric view of research

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Nicolas Chiaruttini @nkiaru.bsky.social · 20/11/2024

Direct streaming of an #OMERO dataset in #BigDataViewer from the public server omero-tim.gerbi-gmb.de (dataset from the Workshop 35). Thank you Tom and @gerbi.bsky.social !

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Oded Rechavi @odedrechavi.bsky.social · 19/11/2024

Hope I'm the first to post this all time classic on this platform

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Wyoming Wormboy @wyomingwormboy.bsky.social · 17/11/2024

From the vaults...

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Kate Coldwell @katecoldwell.bsky.social · 15/11/2024

I'm putting together a primary sclerosing cholangitis starter pack to make us easier to find. I think it's the first of it's kind. Comment or message if you belong there or want to nominate. #PSC #liversky #hepatology #gastroenterology

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Nachiket Vartak @vartak.bioimaging.tech · 14/11/2024

I know we are all jumping on to #Bluesky. But given that there are almost no alternative Bluesky instances or third party clients, this is just Twitter 2.0. I have a hunch that Bluesky will soon launch premium subscriptions that will include things like an iPad client.

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Nachiket Vartak @vartak.bioimaging.tech · 25/10/2024

It would save a huge amount of time for researchers if #JHEP #Journal of #Hepatology would provide a proper official CSL file for citation formatting. I had to modify the upodate JHEP CSL file available for Zotero. The upgraded version can be obtained from cumulus.ifado.de/f/7f705cf50a...

cumulus.ifado.de

JHEP_mod.csl

Share link for JHEP_mod.csl.

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Ian Martin @ianmartin.bsky.social · 13/02/2024

There's an absolutely adorable child on this train reciting the alphabet and after K, he keeps going "ello mello P" and honestly his lusty affirmation of life, of hope, reminds me that once again I have forgotten to bring my fucking headphones.

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Nachiket Vartak @vartak.bioimaging.tech · 10/02/2024

Genuine question: #RCS basically makes the functionality of messaging apps like Whatsapp redundant. So why are we still using Whatsapp, Signal, Telegram etc.?

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Nachiket Vartak @vartak.bioimaging.tech · 24/11/2023

Intermittent Bsky user. Is discoverabiliy here significantly better than Mastodon now?

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Nachiket Vartak @vartak.bioimaging.tech · 07/11/2023

#TIL the word “Veda” , referring to the ancient Hindu texts comes from the same root - ‘vid’ - to know by observing/seeing. This is also the root of Latin ‘videre’ - to see, Greek ‘uida’ - to know/see, English - ‘wisdom’ and ‘wit’, and in the modern world ‘video’.

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Nachiket Vartak @vartak.bioimaging.tech · 04/10/2023

Ibrahim Cisse shows that the range at which RNA-bursting during transcription can be modulated at is greater in the range of a micron. Does a dynamic and transient condensate regulate this ? #EESImaging

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Nachiket Vartak @vartak.bioimaging.tech · 21/09/2023

Why does Bluesky insist on blinding me by showing me the splash screen of the sunniest sky when I am in Dark mode?

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Sebastian S. Cocioba @atinygreencell.bsky.social · 18/09/2023

Rage Rage against the vinyl in the night

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Pavel @spavel.bsky.social · 10/07/2023

Do not go gentle into that good night

Refuse to be stored in black plastic sacks and placed in the containers provided

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Nachiket Vartak @vartak.bioimaging.tech · 13/09/2023

Just realised when editing a dossier for work that my #English has Americanized. In school, we used British English (Wren & Martin for grammar, remember?). And today, 'standardised' feels a little off compared to 'standardized'.

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Nachiket Vartak @vartak.bioimaging.tech · 11/09/2023

Shower thought: Text is compression. A word is a compressed form of a very complicated idea eg: 'science'. Does text effectively increase the capacity to hold information in our brain? Do literate people have a higher data capacity because they have a way make zip files in the brain?

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Nachiket Vartak @vartak.bioimaging.tech · 06/09/2023

Shower thought: In the ancient past, there must have been violet blood, an intermediate the blue and green blood of invertebrates, and the red blood of vertebrates. Turns out there exists violet blood even today, but not for the reason I thought. #Evolution surprises as usual. #science #colors

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Joachim Goedhart @joachimgoedhart.bsky.social · 03/09/2023

qMaLioffG: A single yellow fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP www.biorxiv.org/content/10.1...

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