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Research at UHN

@uhnresearch.ca
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Research news from Canada's largest research hospital. 🔗 uhnresearch.ca

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Research at UHN @uhnresearch.ca · 17h
#GairdnerScienceWeek is back October 19 to 23. Join world-leading scientists for free public events celebrating cutting-edge research, global health innovation, and the brilliant 2026 Gairdner Awards laureates. 🔗 Register today: www.gairdner.org/event-item/g... -- @gairdnerawards.bsky.social
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Research at UHN @uhnresearch.ca · 30/09/2026
@uhn.ca @pmresearch-uhn.bsky.social @kiteuhn.bsky.social @kbi-uhn.bsky.social @dkjei-uhn.bsky.social @schroeder-uhn.bsky.social @tier-uhn.bsky.social
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Research at UHN @uhnresearch.ca · 30/09/2026
Read about the latest findings from Canada’s largest #research hospital in @uhn.ca ’s Research Spotlight newsletter: ▶️ New treatment for bipolar depression ▶️ #AI tool for cancer treatment ▶️ Retaining registered practical nurses + More 🔗: www.uhnresearch.ca/nrx_newslett...
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Research at UHN @uhnresearch.ca · 30/09/2026
🚨Out today in @natimmunol.nature.com, a study from @pmresearch-uhn.bsky.social’s Dr. Anastasia Tikhonova identifies distinctive early changes in the bone marrow environment in people with age-related blood #StemCell mutations, before blood cancer develops. ⬇️
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Research at UHN @uhnresearch.ca · 28/09/2026
(2/2) #ICYMI: Another recent study from Dr. Li’s lab on a new class of non-viral therapies for genetic diseases that restores protein function without altering the genome. 🔗 www.uhnresearch.ca/news/8-27-20...
uhnresearch.ca
A New Class of RNA Therapies | UHN Research
University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care.
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Research at UHN @uhnresearch.ca · 28/09/2026
Out today in @natbiotech.nature.com, a study from Dr. Bowen Li (@pmresearch-uhn.bsky.social) shows a new strategy for improving the non-viral delivery of large mRNA cargo for gene editing—an approach with the potential to expand the reach of gene editing therapies. 🔗: www.nature.com/articles/s41...
nature.com
Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing - Nature Biotechnology
Lipid nanoparticles are improved by including RNA cargo size in the design process.
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Research at UHN @uhnresearch.ca · 25/09/2026
Congratulations to Dr. Tak Mak, Senior Scientist at @pmresearch-uhn.bsky.social, on receiving the German Society of Immunology's German Immunology Prize. 🎉 As the Society's highest scientific honour, the award recognizes outstanding contributions to immunology. 🔗: idw-online.de/en/news877636
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Research at UHN @uhnresearch.ca · 25/09/2026
#PostdocAppreciationWeek 👋 Meet Fernanda Yamamato Ricardo da Silva, a postdoctoral researcher at @transplant-uhn.bsky.social, whose research focuses on improving lung transplantation outcomes. Learn why she is excited about the future of health research. 🔗: www.uhnresearch.ca/news/9-24-20...
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Research at UHN @uhnresearch.ca · 23/09/2026
#PostdocAppreciationWeek 👋 Meet Ambika Bansal, a postdoctoral researcher at @kiteuhn.bsky.social and a recruit from @uhn.ca's Canada Leads program. Learn about her sensory-motor research that can be applied to areas such as aging and rehabilitation technology. 🔗: www.uhnresearch.ca/news/9-23-20...
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Research at UHN @uhnresearch.ca · 22/09/2026
#PostdocAppreciationWeek 👋 Meet Francesco Rugolo, a postdoctoral researcher at @uhn.ca. Learn about his work studying genetic kidney diseases and his thoughts on how #AI can be involved in the future of health research. 🔗: www.uhnresearch.ca/news/9-22-20...
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Research at UHN @uhnresearch.ca · 21/09/2026
#PostdocAppreciationWeek 👋 Meet Rachel Shum, a postdoctoral researcher at @pmresearch-uhn.bsky.social. Learn how her research is helping advance radiation dose measurement to support more precise #cancer treatment. 🔗: www.uhnresearch.ca/news/9-21-20...
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Research at UHN @uhnresearch.ca · 21/09/2026
Postdoctoral researchers play an important role in advancing discovery and innovation at @uhn.ca. During #PostdocAppreciationWeek, we're highlighting members of UHN's postdoctoral community and the work they're leading across a range of research areas. 🧵⬇️
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Research at UHN @uhnresearch.ca · 18/09/2026
2/ First author: Ximing Li Senior author: Dr. Anastasia Tikhonova Featured on the cover of @bloodjournals.hematology.org: ashpublications.org/blood/articl... -- @uhn.ca @oicr.on.ca @stemcellnetwork.ca
ashpublications.org
IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy
Key PointsDOX remodels the BM niche, inducing arteriolar damage, MSC dysfunction, and sustained expansion of phenotypic HSCs.IFN-γ signaling from CD8+ T ce
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Research at UHN @uhnresearch.ca · 18/09/2026
New research from @pmresearch-uhn.bsky.social shows how chemotherapy can cause long-term damage to bone & and blood-forming cells in the bone marrow by triggering inflammation—offering insight into why many cancer survivors face lasting health challenges. 🔗: www.uhnresearch.ca/news/9-18-20...
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Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 17/09/2026
Congratulations to Dr. Long Nguyen on being named Canada's Top 40 Under 40 by @financialpost.com for leading a research program uncovering how cancer cells evolve, adapt, and develop resistance to treatment, to improve patient outcomes. @uhnresearch.ca @uhn.ca
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Research at UHN @uhnresearch.ca · 17/09/2026
2/ First author: Derrick Lim Senior author: Dr. Kei Masani -- @uhn.ca
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Research at UHN @uhnresearch.ca · 17/09/2026
Can a low-cost depth camera make balance rehabilitation more accessible? Researchers at @kiteuhn.bsky.social found a depth camera performed similarly to traditional force plates used in balance training, suggesting a more accessible rehabilitation approach. 🔗: www.uhnresearch.ca/news/9-16-20...
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Research at UHN @uhnresearch.ca · 17/09/2026
Congratulations on this well-deserved recognition! 👏
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Research at UHN @uhnresearch.ca · 16/09/2026
2/ First authors: Dr. Michael St. Paul and Dr. Liam Hendrikse Senior authors: Dr. Tak Mak and Dr. Suzanne Trudel -- @uhn.ca @nature.com @uoftmedicine.bsky.social
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Research at UHN @uhnresearch.ca · 16/09/2026
#NewPublication🚨 Researchers at @pmresearch-uhn.bsky.social have developed a new #AI tool that can identify rare immune cells with the ability to recognize and respond to #cancer. 🔗 Read more: www.uhnresearch.ca/news/9-16-20...
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UHN Research & Innovation Cores @uhncores.bsky.social · 11/09/2026
The Princess Margaret Living Biobank is celebrating 10 years of advancing cancer research through patient-derived models. Join researchers, collaborators, and the UHN community on October 8 for food, refreshments, remarks, and a celebration of impact, discovery, and innovation. @uhnresearch.ca
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Research at UHN @uhnresearch.ca · 10/09/2026
2/ First author: Dr. Brendan Santyr Senior authors: Drs. Andres Lozano & Alfonso Fasano (@alfonsofasano.bsky.social) -- @uhn.ca @parkinsoncanada.bsky.social @uoftmedicine.bsky.social
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Research at UHN @uhnresearch.ca · 10/09/2026
1/ Why does deep brain stimulation (DBS) affect people with #Parkinsons differently? Researchers at @kbi-uhn.bsky.social found that DBS affects brain-wide networks and that outcomes differ across two common targets. The findings could help personalize care. 🔗: www.uhnresearch.ca/news/9-07-20...
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Research at UHN @uhnresearch.ca · 09/09/2026
@src-rsc.bsky.social @uoftmedicine.bsky.social @pmresearch-uhn.bsky.social
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Research at UHN @uhnresearch.ca · 09/09/2026
Congratulations to @uhn.ca’s Drs. Laura Dawson and Jan Seuntjens, who have been elected to the Royal Society of Canada—Canada’s leading body of scholars, researchers & artists! 🎉 Their transformative work in radiation oncology is shaping the future of health. 🔗 : www.uhnresearch.ca/news/9-09-20...
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Research at UHN @uhnresearch.ca · 08/09/2026
2/ Principal investigators: Dr. Joanne Goldman and Dr. Stella Ng -- @uhn.ca @uoftmedicine.bsky.social
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Research at UHN @uhnresearch.ca · 08/09/2026
1/ Improving care goes beyond clinical expertise. A @tier-uhn.bsky.social study identified ways continuing professional development programs can improve teaching on topics such as health equity and power dynamics to advance collaboration and patient care. 🔗: www.uhnresearch.ca/news/9-08-20...
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Research at UHN @uhnresearch.ca · 04/09/2026
2/ First author: Dr. Steven R. Botts Senior authors: Drs. Kathryn Howe and Jason Fish -- @uoftmedicine.bsky.social @natcomms.nature.com @innovation.ca
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Research at UHN @uhnresearch.ca · 04/09/2026
A new study from @uhn.ca’s Peter Munk Cardiac Centre shows that the protein ERG helps protect blood vessels from changes that drive atherosclerosis—the buildup of plaque in the arteries. Findings could point to future therapeutic strategies to protect arteries. 🔗: www.uhnresearch.ca/news/9-04-20...
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Research at UHN @uhnresearch.ca · 03/09/2026
3/ Learn how clinical trial participant Greg Rennie experienced this treatment and what the findings could mean for bipolar depression care: www.ctvnews.ca/health/artic...
ctvnews.ca
Clinical trial patient says ketamine treatment for bipolar depression changed his life
Rennie, who has had bipolar depression for almost 30 years, was one of the 68 participants in a University Health Network clinical trial evaluating the safety and effectiveness of repeated ketamine in...
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Research at UHN @uhnresearch.ca · 03/09/2026
2/ First author: Diana Orsini Senior author: Dr. Joshua Rosenblat -- @kbi-uhn.bsky.social @uoftmedicine.bsky.social @jamanetworkopen.com @uoftpsychology.bsky.social @ontarioshores.bsky.social
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Research at UHN @uhnresearch.ca · 03/09/2026
1/ Four infusions. Two weeks. One important step toward expanding treatment options. A @uhn.ca-led clinical trial found that ketamine reduced symptoms in adults with treatment-resistant #BipolarDepression and was well tolerated throughout the study. 🔗: www.uhnresearch.ca/news/9-02-20...
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Research at UHN @uhnresearch.ca · 27/08/2026
2/ First authors: Jingan Chen, Dr. Muye Zhou, and Dr. Songtao Dong Senior authors: Dr. Bowen Li and Dr. Haissi Cui @uhn.ca | @pharmacy.utoronto.ca
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Research at UHN @uhnresearch.ca · 27/08/2026
1/ Researchers at @pmresearch-uhn.bsky.social have developed an RNA-based therapy that can repair disease-causing genetic "stop" signals. Out today in @science.org, the approach has the potential to treat certain genetic disorders such as cystic fibrosis. 🔗: www.uhnresearch.ca/news/8-27-20...
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Research at UHN @uhnresearch.ca · 25/08/2026
Congratulations to @uhn.ca’s Drs. Niall Ferguson, Jennie Johnstone, Michael Milosevic, & Gang Zheng on being elected as Fellows of the Canadian Academy of Health Sciences. Their research is improving health outcomes in Canada and beyond. 🔗: www.uhnresearch.ca/news/8-25-20...
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Research at UHN @uhnresearch.ca · 25/08/2026
2/ First author: Anna Huynh Senior author: Dr. Yana Yunusova -- @uhn.ca @braincanada.bsky.social
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Research at UHN @uhnresearch.ca · 25/08/2026
People with #ALS often face uncertainty about disease progression and care management. @kiteuhn.bsky.social researchers found that access to personalized information and more patient-centred support may help people make more informed choices about their care. 🔗: www.uhnresearch.ca/news/8-25-20...
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Research at UHN @uhnresearch.ca · 24/08/2026
@uhn.ca @uoftmedicine.bsky.social @terryfoxresearch.bsky.social
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Research at UHN @uhnresearch.ca · 24/08/2026
2/ This study was done in collaboration with scientists at Tabriz University of Medical Sciences and Istanbul Rumeli University. First author: Nasim Bakhtiyari Corresponding authors: Dr. Sushant Kumar, Dr. Safar Farajnia, Dr. Yosef Masoudi-Sobhanzadeh
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Research at UHN @uhnresearch.ca · 24/08/2026
1/ A new study from @pmresearch-uhn.bsky.social introduces a new #AI model that could make gene editing more effective. DeepCC9 predicts which CRISPR-Cas9 guide RNAs will perform best while revealing the sequence patterns behind successful gene editing. 🔗: www.uhnresearch.ca/news/8-24-20...
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Krembil Brain Institute 🧠 @kbi-uhn.bsky.social · 18/08/2026
Get a behind-the-scenes look as some of this year's summer students @kbi-uhn.bsky.social @dkjei-uhn.bsky.social @schroeder-uhn.bsky.social as they share what it was like working in the lab and reflect on their research experiences this summer >> bit.ly/4gflcOG @uhn.ca @uhnresearch.ca
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Ajmera Transplant Centre UHN @transplant-uhn.bsky.social · 14/08/2026
Ajmera Transplant Centre Research Day 2026 brought our transplant community together to share discoveries, celebrate excellence, and advance the future of transplantation. Read more: ow.ly/Pyc250ZzQ6N #Transplantation #Research #UHN
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Research at UHN @uhnresearch.ca · 13/08/2026
2/ First authors: Dr. Sasha Main, Mitchell Elliott, & Althaf Singhawansa Senior author: Dr. David Cescon -- @uhn.ca @aacrjournals.bsky.social @uoftmedicine.bsky.social @ccsresearch.bsky.social
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Research at UHN @uhnresearch.ca · 13/08/2026
1/ A new blood test-based method developed by researchers at @pmresearch-uhn.bsky.social could detect and classify metastatic breast cancer without the need for invasive tissue biopsies. 🔗 Read more: www.uhnresearch.ca/news/8-04-20...
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Donald K. Johnson Eye Institute @dkjei-uhn.bsky.social · 12/08/2026
We are pleased to announce the Vision Research Symposium 2026: Innovations in Retina, bringing together Toronto's vision science community to share knowledge, celebrate research, and foster collaboration across disciplines. @uhn.ca @uhnresearch.ca @kbi-uhn.bsky.social @uoftmedicine.bsky.social
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Research at UHN @uhnresearch.ca · 12/08/2026
@pmresearch-uhn.bsky.social @kiteuhn.bsky.social @kbi-uhn.bsky.social @schroeder-uhn.bsky.social @dkjei-uhn.bsky.social @tier-uhn.bsky.social
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Research at UHN @uhnresearch.ca · 12/08/2026
Through UHN STEM Pathways, 37 high school students gained hands-on research experience and explored their future STEM aspirations. 🔗 This #YouthDay, learn about 4 of these summer students and their experiences at @uhn.ca: www.uhnresearch.ca/news/8-12-20... #NextGenUHN
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Research at UHN @uhnresearch.ca · 11/08/2026
#ICYMI Recently, the Hon. Nolan Quinn, Michelle Cooper, and Mohamed Firin joined us to learn about transplant innovations and advanced MRI technologies at @uhn.ca, which are shaping the future of patient care. Watch some of the highlights from the visit below ⬇️
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Research at UHN @uhnresearch.ca · 07/08/2026
@pmresearch-uhn.bsky.social @kbi-uhn.bsky.social @schroeder-uhn.bsky.social @dkjei-uhn.bsky.social @kiteuhn.bsky.social @tier-uhn.bsky.social @transplant-uhn.bsky.social
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Research at UHN @uhnresearch.ca · 07/08/2026
#ICYMI: With $20.7 million from the Canadian Institutes of Health Research's Spring 2026 Project Grant Competition, 26 @uhn.ca-led projects will advance research and help shape the future of health care across Canada. 🔗 Learn more about these impactful projects: www.uhnresearch.ca/news/8-07-20...
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