The second messenger, cyclic adenosine monophosphate (cAMP), plays a crucial role in regulating cellular function, including in vascular smooth muscle (VSM). While extensive research has focused on th...

Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at th...

Exciting results from multiple design campaigns on challenging targets with my awesome lab and collaborators using the Latent Labs platform! Looking forward to sharing our journey at the Latent-Y lau...

The regulation of vascular tone underlies normal cardiovascular homeostasis, ensuring appropriate distribution of blood flow to tissues and maintenance of blood pressure. Computational modeling and si...

Abstract. Efficient interpretation of the structural, functional, and clinical impact of protein variants remains a longstanding challenge. This difficulty

G-protein-coupled receptors (GPCRs) are pivotal in cellular signal transduction and serve as key drug targets. Among them, the β-adrenergic receptors (β₁AR and β₂AR) regulate car...

The School of Medicine recently announced Laura Borodinsky, professor in the Department of Physiology & Membrane Biology and Clifford Pereira, professor in the Department of Surgery, as the 2026 recip...

Summary: Temporal disruption of sonic hedgehog signaling reveals stage-specific roles in eye cup patterning and in regulating proliferation, progenitor competence and fate specification during retinal...

Metabolic syndrome (MetS) encompasses an interconnected set of risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and systemic inflammation, all of which signif...