The regulation of vascular tone underlies normal cardiovascular homeostasis, ensuring appropriate distribution of blood flow to tissues and maintenance of blood pressure. Computational modeling and si...

Abstract. Efficient interpretation of the structural, functional, and clinical impact of protein variants remains a longstanding challenge. This difficulty

To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to solve has been the re...

The integration of digital health technologies is revolutionizing health care quality and patient safety by shifting from reactive to proactive care models. Advances in electronic health records, clin...

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In this article, Sun and colleagues develop a humanized engineered heart tissue platform by integrating human ventricular extracellular matrix with GCaMP6f-expressing hiPSC-derived cardiomyocytes. Thi...

Longitudinal phenomapping resulted in echocardiographic trajectories of cardiac structure and function with different clinical, laboratory, and survival characteristics. HFpEF is a dynamic condition, ...

Abstract figure legend Dose-dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate ....

On January 14, the Data Science Seminar Series is tackling an intersection of two critical data science concepts in cancer research: theranostics and digital twins. By combining computational and clin...

GenScript Life Science Research Grant Program is a new initiative dedicated to supporting breakthroughs in life science research areas. This program is designed to empower researchers by providing gra...

Digital twins are well established in industrial settings, but there has not been wide adoption in biomedical settings. Digital twins for biomedical applications are now possible with the inclusion of...

Lopez-Mateos et al.’s study demonstrates AlphaFold2’s potential to sample multiple states of human NaV channels. Additionally, NaV α-subunit interactions w

The integration of digital health technologies is revolutionizing health care quality and patient safety by shifting from reactive to proactive care models. Advances in electronic health records, clinical decision support systems, data analytics, artificial intelligence (AI), mobile applications, an …