The second messenger, cyclic adenosine monophosphate (cAMP), plays a crucial role in regulating cellular function, including in vascular smooth muscle (VSM). While extensive research has focused on th...

Metabolic syndrome (MetS) encompasses an interconnected set of risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and systemic inflammation, all of which signif...

The L-type voltage-gated Ca2+ channel (CaV1.2) controls gene expression, cardiac function, and neuronal excitability. Mutations in CaV1.2 that disrupt channel function are implicated in cardiac arrhyt...

Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for acce....

Abstract figure legend Amyloid-β1-42 (Aβ1-42) triggers a male-specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway invol...

Dopamine-induced phosphorylation of an L-type Ca2+ channel supports working memory in mice.

Primary Work Address: One Shields Avenue, Davis, CA, 95616 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and s...

These results suggest a key role for Panx1 in controlling ATP signaling through the P2Y_11L/AC5/AKAP5/PKA/Ca_V1.2 axis in arterial myocytes. This Panx1-led complex modulates cAMP levels, Ca_V1.2 activity, and vascular reactivity in response to diabetic hyperglycemia. Th …

Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar.

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

Lee et al. show that OCT3 and PMAT transport norepinephrine (NE) into neurons to stimulate β2ARs that are in their interior. The ensuing phosphorylation of GluA1 on S845 by PKA drives AMPARs to the su...

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

YouTube video by UC Davis Graduate Studies

UC Davis PMB—Physiology Talks · Episode

The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate contraction force in the heart. Based on recent advancements and the historical literature, we propose new persp...

The importance of biological sex on disease etiology and outcomes has long been underinvestigated. While recent focus on characterizing sex differences in cardiac pathophysiology has led to improved i...

Electrifying the brain capillary Ca2+ signal

Graduate student Nathaniel (Nate) Herrera has used his last year at UC Davis to springboard a career in STEM teaching. Herrera, who joined UC Davis in 2021, studies sex differences in cardiac physiolo...

Donald M. Bers, chair of the Department of Pharmacology, received an Honorary Fellowship from The Physiological Society, the group's highest honor presented to an individual.

Attention, researchers from Germany! The Feodor Lynen Research Fellowship supports you – postdoctoral and experienced researchers– with your research abroad.

Postdoctoral ResearcherSalary Range: $67,000-$79,000 USD per yearLocation: Onsite, UC DavisApplication Deadline: November 29, 2024