The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...

Nature Cell Biology - Keeping time with protein turnover

Small gene regulatory circuits can encode a surprising diversity of dynamical behaviors. A biophysical model of the AC-DC motif reveals over thirty distinct bifurcation structures and shows how molecu...

Why do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipu...

In this issue of Developmental Cell, Matsuda et al. and Nakanoh et al. reveal that global protein turnover rate controls species-specific developmental clocks. Their findings demonstrate how translati...

Are cardiac progenitors committed to fixed lineages, or do they carry probability distributions over heart regions in the epiblast that resolve during gastrulation? Reanalyzing mouse retrospective cl...

Letter to the Editor

Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…

Why do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipu...

We seek a highly motivated Postdoctoral Research Associate to join the laboratory of Professor Kathy Niakan. We are based in the Loke Centre for Trophoblast Research (LCTR), in the Department of Physi...

Certain shallow-water species carry a mutation that reduces translation errors and prevents toxic protein buildup

Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and soph...

Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...

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A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

I wanted to like QED's new 1% ranking. I don't.