Tom Kindlon
@tomkindlon.bsky.social
7.4K followers 216 following 8.9K posts
95% of posts on #MyalgicEncephalomyelitis, #LongCovid or #chronicillness. With ME/CFS 37 years, severe ME 32 years. @IrishMECFSAssoc trustee 29 years 26 publications in peer-reviewed journals Social media: me-pedia.org/wiki/Tom_Kindlon
![SLEEP DYSFUNCTION IN ME/CFS
Sleep dysfunction is a relentless and life-disrupting feature of ME/CFS. It takes many forms and can exacerbate already challenging symptoms, such as fatigue and cognitive dysfunction.
ME/CFS research highlights: • Disrupted glymphatic system -brain's waste clearance tool -associated with more severe symptoms, including sleep dysfunction. • Reduced heart rate variability during sleep, indicating inability of autonomic nervous system to de-arouse/recover. • Greater impairment across symptom/functional domains when sleep reversal is present. Although the studies have limitations, they provide a foundation for future research. INFORM. INFLUENCE. INVEST.
unrefreshing sleep broken/shallow sleep prolonged sleep/excessive daytime sleepiness
altered sleep pattern ken RESEARCH UK SCO36942
Full overview and references at [tinyurl.com/sleepdyssymptomsat]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:43rudsv62fuwsmnk7oppgtdy/bafkreicanfi6c2ruhzzu562wdmyzsn3qxtpmv4qqjfcw3humxwtclo2eau)
![COGNITIVE DYSFUNCTION "BRAIN FOG" IN ME/CFS
Cognitive dysfunction, "brain fog", includes issues with mental processing, verbalising, and memory. This symptom profoundly impacts the lives of individuals with ME/CFS.
ME/CFS research highlights: • Impaired communication between different brain areas and disrupted brain waste clearance system. • Links with dysautonomia (autonomic nervous system dysfunction) and orthostatic stress (associated with moving to an upright posture). • Low grade inflammation and impairment of blood flow to brain as contributory factors. Whilst several studies have limitations, such as small cohorts, they lay a foundation for further research. INFORM. INFLUENtrIVEST. Full overview and references at [tinyurl.com/brainfogsymptomsat]
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RESEARCH UK SCO36942](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:43rudsv62fuwsmnk7oppgtdy/bafkreidj2crovqrqnpkvh52a6ofthca3nh2ct6j32p62flqjb3wl5maymu)
![POST-EXERTIONAL MALAISE (PEM) IN ME/CFS
PEM is the delayed worsening of symptoms, such as cognitive dysfunction and fatigue, following minimal physical and/or mental exertion. It often has a profound impact on daily activities.
ME/CFS research highlights:
• Lower threshold for anaerobic respiration / lactic acid (lactate) production. Elevated lactate at rest associated with more severe PEM.
• Sodium-potassium pump dysfunction in skeletal muscle may impair mitochondria and contribute to PEM.
• Increased activation of certain brain regions post-exercise may be associated with PEM.
Although these studies have limitations, they provide a foundation for future research.
PEM is the hallmark feature of ME/CFS
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INFORM. INFLUENCE. INVEST. Full overview and references at [tinyurl.com/PEMsymptomsat]
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