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Thomas Luo

@thomas-zhihao-luo.bsky.social
294 followers 331 following 17 posts

Assistant Professor, University of Utah Neural population dynamics in decision, attention & learning theluolab.org | biology.utah.edu/faculty/thomas-zhihao-luo

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Reposted by Thomas Luo
Arman Behrad @armanbehrad.bsky.social · 22/09/2026
How do internal states shape foraging, decisions, and adaptation in a changing world? 🧠🌍 @clairesturgill.bsky.social and I are organizing a #BernsteinConference satellite workshop bringing together lab and wild perspectives on adaptive behavior. Join us 😉
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COSYNE @cosynemeeting.bsky.social · 11/09/2026
📢Have work to share with the computational and systems neuroscience community? Abstract submissions for #COSYNE2027 are now open. Deadline: 18 October 2026, 11:59 p.m. AoE Submit your abstract: www.cosyne.org/abstracts-su... #Neuroscience
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SchottdorfLab @schottdorflab.bsky.social · 25/08/2026
New preprint from the lab: We reproduced our 2p data in the accumulating towers task with e-phys and found low-dimensional neural manifolds in the frontal cortex that were aligned timepoint-by-timepoint with the hippocampus. www.biorxiv.org/content/10.6...
biorxiv.org
The geometry of knowledge in the hippocampal-prefrontal system
Decision making is associated with frontal brain circuits and spatial navigation with the hippocampus. In addition, recent work in spatial decision making tasks found single neurons in both areas enco...
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Brian DePasquale @briandepasquale.bsky.social · 11/06/2026
🚨 New preprint from the lab! 🚨 We introduce BiXformer, a bidirectional cross-attention transformer for disentangling inter-regional neural dynamics. Recordings from multiple regions superimpose feedforward & feedback signals 🔁, offset in time, making it difficult to tease these signals apart. 🧠 🔁
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Gouki Okazawa @gouki-okazawa.bsky.social · 31/05/2026
New review with Cheng Xue at U Chicago @cxue.bsky.social in Trends Neurosci@cp-trendsneuro.bsky.social! We discuss the neural geometry of task-dependent computation: disentangled encoding, RNN modeling, switch cost, etc. www.cell.com/trends/neuro...
cell.com
The ‘neat’ and ‘messy’ in task-dependent neural geometry and computation
To solve diverse real-world tasks, the brain must flexibly switch between task rules and adjust computations. Recent advances in analyzing neural data and modeling neural networks have revealed their ...
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Cheng Xue @cxue.bsky.social · 01/06/2026
Excited to share our new review in Trends in Neuroscience with Gouki Okazawa @gouki-okazawa.bsky.social : "The 'neat' and 'messy' in task-dependent neural geometry and computation" where we reviewed what we know about the 'task-manager' in the brain. A thread 👇
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Athena Akrami @athenaakrami.bsky.social · 13/04/2026
New preprint! 🧠 How do RNNs learn abstract rules from sequences, independent of specific stimuli? By Vezha Boboeva, with Alberto Pezzotta & George Dimitriadis "From sequences to schemas: low-rank recurrent dynamics underlie abstract relational representations" www.biorxiv.org/content/10.6...
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Constantinople lab @constantinoplelab.bsky.social · 25/03/2026
Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...
nature.com
Acetylcholine demixes heterogeneous dopamine signals for learning and moving
Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...
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Athena Akrami @athenaakrami.bsky.social · 10/03/2026
Thanks @natmesanash.bsky.social for covering our new work, in @thetransmitter.bsky.social!
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Chunyu Ann Duan @annduan.bsky.social · 14/12/2025
New preprint from the lab! A frontal motor circuit for economic decisions and actions: www.biorxiv.org/content/10.6... We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
biorxiv.org
A frontal motor circuit for economic decisions and actions
Flexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu...
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Jim Heys @jim-heys.bsky.social · 09/12/2025
Neuro grad students! Applications for the 6th annual - Rising Stars in Neuroscience - due Jan 9! Don’t miss this chance to present research, sharpen science communication skills and connect with peers & faculty. Plus you’ll get to experience stunning Utah! medicine.utah.edu/neurobiology...
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SchottdorfLab @schottdorflab.bsky.social · 01/12/2025
*Fully funded PhD student positions available to discover what changes in 🧠 when we learn something new.* You think virtual reality + laser scanning microscopy are cool? You like 💻 and 🐭? Come join us! Apply either through www.udel.edu/academics/co... or www.udel.edu/academics/co...
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Carla Golden @goldenneurons.bsky.social · 26/11/2025
Thank you for the great summary, @thetransmitter.bsky.social, and the shout-outs from scientists we admire. There is so much we don’t know about how sex hormones modulate behavior and we’ll keep exploring!
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Dan Levenstein @dlevenstein.bsky.social · 23/11/2025
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
biorxiv.org
Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification
Most behaviors involve neural dynamics in high-dimensional activity spaces. A common approach is to extract dimensions that capture task-related variability, such as those separating stimuli or choice...
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Thomas Luo @thomas-zhihao-luo.bsky.social · 20/11/2025
So excited to have been part of this work with @timkimd.bsky.social and everyone in @carlosbrody.bsky.social’s lab! Thanks @racheltompa.bsky.social for the wonderful write-up!
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Thomas Luo @thomas-zhihao-luo.bsky.social · 20/11/2025
Thanks, Adrian! I’m excited to be starting a lab at the University of Utah (theluolab.org)! We’re recruiting at all levels. If you’re excited about neural computation, large-scale multi-region recordings, and machine learning, let’s talk! And yes, the mountains are as incredible as they say!
theluolab.org
Luo Lab
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Constantinople lab @constantinoplelab.bsky.social · 17/11/2025
Who wore it better? Our new paper shows that rat OFC supports Bayesian inference of hidden states! With neural correlates of inferred state transitions at the level of single neurons and population-level latent factors. www.sciencedirect.com/science/arti...
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Mitchell Ostrow @neurostrow.bsky.social · 10/11/2025
Our next paper on comparing dynamical systems (with special interest to artificial and biological neural networks) is out!! Joint work with @annhuang42.bsky.social , as well as @satpreetsingh.bsky.social , @leokoz8.bsky.social , Ila Fiete, and @kanakarajanphd.bsky.social : arxiv.org/pdf/2510.25943
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Sophie Caron @thecaronlab.bsky.social · 30/10/2025
1/ Hello Drosophila-philists and braino-maniacs! 👋🪰🧠🧪 The Caron lab has a new preprint, and it is about 🥁🥁🥁 democracy! Neuro-democracy, to be precise. So: drop EVERYTHING and listen up — a 🧶! www.biorxiv.org/content/10.1...
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Jason Shepherd @jasonsynaptic.bsky.social · 20/10/2025
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
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Princeton Neuroscience Institute @princetonneuro.bsky.social · 30/09/2025
With the help of AI, Princeton’s @thomas-zhihao-luo.bsky.social and @carlosbrody.bsky.social can now pinpoint the exact moment a rat makes up its mind — just by reading its brain activity 🧠🐀 pni.princeton.edu/news/2025/wh...
pni.princeton.edu
When a rat makes up its mind, these neuroscientists know
Scientists can now freeze-frame the exact moment an animal makes up their mind and commits to a choice — simply by looking at their brain activity
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Julie Charlton @juliecharlton.bsky.social · 22/09/2025
🛑 Attention researchers who train freely-moving rodents! Jess Breda and I developed a protocol for training center-port nose fixation 61% faster than a previous curriculum while keeping violation rates low. Preprint here: www.biorxiv.org/content/10.1...
biorxiv.org
FixGrower: An efficient and robust curriculum for shaping fixation behavior in rodents
Center-port fixation is a common prerequisite for many freely-moving rodent tasks in neuroscience and psychology. However, typical protocols for shaping this behavior are non-standardized and ineffici...
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Carlos Brody @carlosbrody.bsky.social · 22/09/2025
Thank you @nancyrmack.bsky.social and @princetonneuro.bsky.social for a great explainer about our paper! pni.princeton.edu/news/2025/wh...
pni.princeton.edu
When a rat makes up its mind, these neuroscientists know
Scientists can now freeze-frame the exact moment an animal makes up their mind and commits to a choice — simply by looking at their brain activity
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Ulises Pereira-Obilinovic @ulisespereirao.bsky.social · 20/09/2025
Friday’s AIND JC lead by Shawn Olsen and I on the Brody lab preprint ran 90+ min, unusual. Nice paper, spirited discussion. Make a clear argument that to grasp behavior we need multiregional, multi-neuron, simultaneous single-trial data. Below quotes from the paper. www.biorxiv.org/content/10.1...
biorxiv.org
Brain-wide coordination of decision formation and commitment
Neural correlates of a subject’s upcoming choice in decision making tasks are remarkably widespread throughout the brain, but how these brain-wide signals are coordinated remains unknown. Do brain reg...
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Carlos Brody @carlosbrody.bsky.social · 19/09/2025
What happens in your brain when you make up your mind? Postdoc (soon faculty at U. of Utah) @thomas-zhihao-luo.bsky.social and ex-grad student (now Shanahan Fellow at Allen Institute) @timkimd.bsky.social have some answers in this new paper out in Nature! www.nature.com/articles/s41... 🧵 1/6
nature.com
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Thomas Luo @thomas-zhihao-luo.bsky.social · 17/09/2025
How does the brain decide? 🧠 Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc. After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up. rdcu.be/eGUrv
nature.com
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
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Tatiana Engel @engeltatiana.bsky.social · 25/06/2025
Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables. www.nature.com/articles/s41...
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Gabriel Stine @gabrielmstine.bsky.social · 23/06/2025
Our paper on NHP neuropixels is finally out in Nat Neuro! These probes have already been transformative and will usher in a new era of primate neuroscience. I am extremely proud to have played a very small role in this project. I can't wait to see what our community discovers. tinyurl.com/54u3hrj8
tinyurl.com
Large-scale high-density brain-wide neural recording in nonhuman primates - Nature Neuroscience
Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.
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Julie Fabre @juliefabre.bsky.social · 13/06/2025
🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds. pip install and play around with our toy dataset: 🔗 github.com/Julie-Fabre/...
github.com
GitHub - Julie-Fabre/bombcell: Automated quality control, curation and neuron classification of spike-sorted electrophysiology data
Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell
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Hannah Payne @hannahpayne.bsky.social · 11/06/2025
My latest Aronov lab paper is now published @Nature! When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️ The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar bit.ly/3HvWSum
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Grace Telford @ogtelford.bsky.social · 11/06/2025
Delighted that the first paper from our Cy2 JWST program was published today, reporting the discovery of molecular hydrogen in the 3% Solar metallicity galaxy Leo P. This was a very fun project with @karinsandstrom.bsky.social strom.bsky.social and fabulous co-authors! www.nature.com/articles/s41...
nature.com
Molecular hydrogen in the extremely metal- and dust-poor galaxy Leo P - Nature
Observations from the JWST MIRI-MRS instrument reveal the detection of rotational emission from molecular hydrogen near the only O-type star in the 3% solar metallicity galaxy Leo P, providing confirm...
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Brian DePasquale @briandepasquale.bsky.social · 10/06/2025
Tired of your boring old DDM? Check out recent work by grad student @ryguy.io that introduces a *state-dependent* DDM using an underlying HMM. We find mice change their speed-accuracy strategy from trial to trial! Code provided! (in Julia of course!)
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Carlos Brody @carlosbrody.bsky.social · 08/05/2025
we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please share and re-share so we get more great stories in there!
publicusaresearchbenefits.com
Searchable database of tangible benefits that federally-funded research gave us.
A crowd-sourced site. Health and Well-being. National Security. Prosperity.
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Nicole Rust @nicolecrust.bsky.social · 06/05/2025
Calling all science advocates!! Carlos Brody+ are creating a searchable database of tangible science benefits, and they need you. publicusaresearchbenefits.com They are asking for suggestions - from brief to lengthy. The database is state-searchable, so all 50 states. Please spread the word!
publicusaresearchbenefits.com
Searchable database of tangible benefits that federally-funded research gave us.
A crowd-sourced site. Health and Well-being. National Security. Prosperity.
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Stand Up for Science! @standupforscience.net · 02/05/2025
(2/3) MAKE NOISE: 1. Share your story. Post how NSF funding has impacted your research or your life. Use #WithoutNSF to raise your voice. 2. Share your story on the Federal Freeze Tracker to help lawmakers and the public understand what’s at stake: docs.google.com/forms/d/e/1F...
docs.google.com
Federal Funding Freeze: Share Your Story
Trump's funding freeze is causing chaos and harming Americans. Share your story to build the movement.
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Thomas Luo @thomas-zhihao-luo.bsky.social · 05/04/2025
So impressed by this amazing new paper answering a fundamental question about the brain:
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Thomas Luo @thomas-zhihao-luo.bsky.social · 05/04/2025
I'll be at the Philadelphia event!
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Chris Zimmerman @czimmerman.bsky.social · 03/04/2025
How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later? Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala. 📄: nature.com/articles/s41...
nature.com
A neural mechanism for learning from delayed postingestive feedback - Nature
Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.
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NPR @npr.org · 28/03/2025
Secretary of State Marco Rubio said that his department has revoked the student visas of hundreds of students so far, with plans to cancel more.
npr.org
Trump administration advances immigration crackdown on foreign student protesters
Secretary of State Marco Rubio said that his department has revoked the student visas of hundreds of students so far, with plans to cancel more.
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Julie Charlton @juliecharlton.bsky.social · 27/03/2025
Out today in PNAS! We asked how Bayesian inference is implemented in macaque prefrontal cortex www.pnas.org/doi/10.1073/...
pnas.org
Bayesian inference by visuomotor neurons in the prefrontal cortex | PNAS
Perceptual judgments of the environment emerge from the concerted activity of neural populations in decision-making areas downstream of the sensory...
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Marino Pagan @marinopagan.bsky.social · 21/03/2025
1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!
nature.com
Individual variability of neural computations underlying flexible decisions - Nature
Behavioural experiments to study decision-making in response to context-dependent accumulation of evidence provide testable models that are consistent with the heterogeneity in neural signatures among...
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Anne Urai @anne-urai.bsky.social · 17/03/2025
I think about this a lot. Thanks @behrenstimb.bsky.social for the wonderfully 90s-vibe blog full of wisdom! users.fmrib.ox.ac.uk/~behrens/Sta...
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Mark Histed @markhisted.org · 10/03/2025
Hi friends, If you haven't seen it already, I was part of a mess this week — about science in the United States, and about NIH research aimed at understanding things like Alzheimer's, schizophrenia, autism, and depression. 🧪 Thread with some details. 🧠📈 🧠🤖 1/10
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Thomas Luo @thomas-zhihao-luo.bsky.social · 07/03/2025
Standing up for science here at the New Jersey State House!
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Stand Up for Science! @standupforscience.net · 04/03/2025
Want to learn why some neuroscientists are Standing Up for Science on March 7th? ⬇️☀️ Thank you to @thetransmitter.bsky.social for the feature! #standupforscience2025
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Maxime Beau @maxime-beau.bsky.social · 01/03/2025
I am very proud to announce that my PhD paper finally came out in Cell! In this *very* collaborative study, we develop and release a deep-learning approach to predict neuron type identity from their electrical signature. doi.org/10.1016/j.ce... 1/16 🧵
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Dr. Cate Peña @cate-cholamine.bsky.social · 26/02/2025
It’s happening, New Jersey! It’s time to rally for science!
Stand up for Science rally
March 7th noon-2pm
Trenton, NJ State Capitol Plaza
standupforscience2025.org
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Nancy Kanwisher @nancykanwisher.bsky.social · 28/01/2025
Academic workers across the country are organizing to call on our congressional representatives on Thursday, 1/30, at 3pm ET / 12pm PT to demand these restrictions be lifted immediately. There will be a training over zoom at the beginning of the event. Join us! form.jotform.com/250226137228...
form.jotform.com
Join researchers across the country in fighting restrictions on the NIH
Please click the link to complete this form.
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Markus Meister @mameister4.bsky.social · 17/12/2024
The unbearable slowness of being: Humans still clock in at just 10 bits/s. Even after peer review :) Share link: authors.elsevier.com/a/1kHVa3BtfH.... ArXiv: arxiv.org/abs/2408.10234
authors.elsevier.com
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Blake Richards @tyrellturing.bsky.social · 21/11/2024
1/ I work in #NeuroAI, a growing field of research, which many people have only the haziest conception of... As way of introduction to this research approach, I'll provide here a very short thread outlining the definition of the field I gave recently at our BRAIN NeuroAI workshop at the NIH. 🧠📈
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