Reposted by SchottdorfLabSebastian Michelmann @s-michelmann.bsky.social · 03/09/2026Thrilled to share this with the world! In this work led by Zihan Bai, we asked how episodic memory interacts with working memory and found evidence for a tight integration between the two systems. Zihan walks you through it in his thread 🧵🧠 🔥 04011
Reposted by SchottdorfLabDr. Becca @docbecca.bsky.social · 26/08/2026My behavioral neuroscience lab at Northeastern is looking to recruit two new research techs! Job description and link to apply is here: northeastern.wd1.myworkdayjobs.com/careers/job/...northeastern.wd1.myworkdayjobs.comLaboratory Technician - The Shansky LabAbout the Opportunity Job Summary The Shansky Lab is seeking a full-time technician to conduct National Institutes of Health (NIH)-funded behavioral neuroscience research. The position includes lab ma... 44058
SchottdorfLab @schottdorflab.bsky.social · 25/08/2026New preprint from the lab: We reproduced our 2p data in the accumulating towers task with e-phys and found low-dimensional neural manifolds in the frontal cortex that were aligned timepoint-by-timepoint with the hippocampus. www.biorxiv.org/content/10.6...biorxiv.orgThe geometry of knowledge in the hippocampal-prefrontal systemDecision making is associated with frontal brain circuits and spatial navigation with the hippocampus. In addition, recent work in spatial decision making tasks found single neurons in both areas enco... 0175
Reposted by SchottdorfLabEmily A. Aery Jones @emilyaeryjones.bsky.social · 01/04/2026My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13nature.comEntorhinal cortex represents task-relevant remote locations independently of CA1 - Nature NeuroscienceNeurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar... 67729
Reposted by SchottdorfLabAaron Milstein @neurosutras.bsky.social · 27/03/2026Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP. www.cell.com/cell-reports...cell.comCellular and subcellular specialization enables biology-constrained deep learningGalloni et al. introduce “dendritic target propagation”: a Dale’s law-compliant learning algorithm for cortical microcircuits with soma- and dendrite-targeting inhibition and realistic connectivity co... 49435
Reposted by SchottdorfLabMark Histed @markhisted.org · 27/03/2026“Facilitatory surrounds resembled naturalistic continuations of the optimal center stimulus” Excellent: this physiology data supports our recent finding using patterned stimulation—together suggesting that visual cortex neurons go beyond the classical RF and reflect the structure of natural vision. 1296
Reposted by SchottdorfLabRebecca Jordan @beckyjordan.bsky.social · 05/03/2026First preprint from the lab! Using intracellular recordings & analysis of 2-photon imaging data, we show that spiking & neuromodulatory input during experience drive a reorganization of visuomotor inputs in V1 layer 2/3 neurons, consistent with enhanced visuomotor cancellation - bioRxiv link below. 17423
Reposted by SchottdorfLabSpencer LaVere Smith @spencerlaveresmith.bsky.social · 27/02/2026Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday 311627
Reposted by SchottdorfLabBenjamin Cowley @benjocowley.bsky.social · 26/02/2026DNN models of the brain are getting bigger. Are we replacing one complicated system in vivo with another in silico? In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony. It turns out these compact models are surprisingly small! rdcu.be/e5H8Grdcu.beCompact deep neural network models of the visual cortexNature - Parsimonious deep neural network models can be used for prediction of visual neuron responses. 412947
Reposted by SchottdorfLabLoren Looger lab @loogerl.bsky.social · 25/02/2026hey team! I need advice! If there were theoretically an organization whose sole purpose was to systematically identify and break nuisance and stupid IP in the biomedical space, creating shareware equivalents, what would be the highest value targets? e.g., AAV serotypes, antibodies, CRISPR, 1/n 4127
Reposted by SchottdorfLabPeter Rupprecht @ptrrupprecht.bsky.social · 17/02/2026Interested in deep learning-based spike inference with Cascade? We re-implemented the code in Torch -previously in Tensorflow - for better compatibility. Blog: gcamp6f.com/2026/02/17/c... GitHub: github.com/PTRRupprecht...gcamp6f.comCascadeTorch: a PyTorch version of Cascade for spike inferenceI’m glad to share a PyTorch-based implementation of spike inference from calcium imaging data: CascadeTorch, now available on GitHub. The original Cascade repository remains fully supported. … 2194
Reposted by SchottdorfLabSoledad Gonzalo Cogno @soledad-gcogno.bsky.social · 17/02/2026Applications are now open for the summer school: 𝐌𝐚𝐭𝐡𝐞𝐦𝐚𝐭𝐢𝐜𝐚𝐥 𝐌𝐞𝐭𝐡𝐨𝐝𝐬 𝐢𝐧 𝐂𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 🧠 Apply before March 15: www.compneuronrsn.org 📍 Located in beautiful Eresfjord 🇳🇴 🗓️ Between July 6-24 Supported by the @kavlifoundation.org In collaboration with @kavlintnu.bsky.socialcompneuronrsn.orgMathematical Methods in Computational NeuroscienceSummer school in Eresfjord, Norway (July 8th - 26th, 2024) 06329
Reposted by SchottdorfLabJulie Charlton @juliecharlton.bsky.social · 07/02/2026@sebastianseung.bsky.social Did you follow through on your plan to visit Epstein island? 3225
Reposted by SchottdorfLabNicole Rust @nicolecrust.bsky.social · 07/02/2026Here’s a trainee sticking their neck out to ask a fair and important question. Admiration! (And obviously, follow @juliecharlton.bsky.social). 1172
Reposted by SchottdorfLabJulie Charlton @juliecharlton.bsky.social · 07/02/2026Hey @eboyden3.bsky.social care to explain? 4406
Reposted by SchottdorfLabJens-Bastian Eppler @j-b-eppler.bsky.social · 03/02/2026New @pnas.org paper out 🎉 “Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning” 👉 doi.org/10.1073/pnas... What drives representational drift in neural populations? Here’s the short version. 👇 🧪🧠 1/5doi.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 2388
Reposted by SchottdorfLabCatrina Hacker @catrinahacker.bsky.social · 05/01/2026🚨 New preprint! Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question. www.biorxiv.org/content/10.6... 🧵 (1/10) 🧠🟦 🧠💻biorxiv.orgNeural representations of visual memory in inferotemporal cortex reveal a generalizable framework for translating between spikes and field potentialsTranslating neurophysiological findings requires understanding the relationship between common measures of brain activity in animals (spiking activity) and humans (local field potentials, LFP). Prior ... 211534
Reposted by SchottdorfLabIan Oldenburg @ianoldenburg.bsky.social · 01/12/2025With Masashi launching his new lab, we’ll be recruiting a new postdoc in the Oldenburg Lab. Work: high-precision multiphoton holography, neural coding, motor cortex circuits, all-optical physiology. If you’re interested, just reach out. 034
Reposted by SchottdorfLabIan Oldenburg @ianoldenburg.bsky.social · 01/12/2025Proud to share that my first postdoc, Masashi Hasegawa, will be starting his own lab as a Chica and Heinz Schaller Research Group Leader at Heidelberg University! He’ll be continuing our holography-based work on cortical circuits. Phenomenal scientist, even better human. 1122
SchottdorfLab @schottdorflab.bsky.social · 01/12/2025*Fully funded PhD student positions available to discover what changes in 🧠 when we learn something new.* You think virtual reality + laser scanning microscopy are cool? You like 💻 and 🐭? Come join us! Apply either through www.udel.edu/academics/co... or www.udel.edu/academics/co... 0104
Reposted by SchottdorfLabTatiana Engel @engeltatiana.bsky.social · 24/10/2025Our work with @pawa-pawa.bsky.social is out in Nature Machine Intelligence! The choice of activation function affects the representations, dynamics, and circuit solutions that emerge in RNNs trained on cognitive tasks. Activation matters! www.nature.com/articles/s42...nature.comSingle-unit activations confer inductive biases for emergent circuit solutions to cognitive tasks - Nature Machine IntelligenceRecurrent neural networks are widely used to model brain dynamics. Tolmachev and Engel show that single-unit activation functions influence task solutions that emerge in trained networks, raising the ... 04211
Reposted by SchottdorfLabSven Dorkenwald @sdorkenw.bsky.social · 15/10/2025Excited to share more widely: I am starting the Dorkenwald Lab at MIT (McGovern Institute + BCS) in January 2026. We study the organizational principles of neuronal circuits using connectomics. And we are hiring postdocs & tech associates! dorkenwaldlab.com/joinmcgovern.mit.eduMIT’s McGovern Institute and Department of Brain and Cognitive Sciences welcome new faculty member Sven Dorkenwald - MIT McGovern InstituteThe McGovern Institute and the Department of Brain and Cognitive Sciences are pleased to announce the appointment of Sven Dorkenwald as an assistant professor starting in January 2026. A trailblazer i... 2407
Reposted by SchottdorfLabSpencer LaVere Smith @spencerlaveresmith.bsky.social · 09/10/2025Even colleagues who should know better are claiming that we are halting animal research. No, we're not. Now this NYT opinion piece appears (gift link) www.nytimes.com/2025/10/08/o... You can't just move everything to cell culture, organoids, and computers. Even this NYT piece admits that. 1/3 193
Reposted by SchottdorfLabMarius Schneider @mariusschneider.bsky.social · 23/09/2025🚨Our NeurIPS 2025 competition Mouse vs. AI is LIVE! We combine a visual navigation task + large-scale mouse neural data to test what makes visual RL agents robust and brain-like. Top teams: featured at NeurIPS + co-author our summary paper. Join the challenge! Whitepaper: arxiv.org/abs/2509.14446arxiv.orgMouse vs. AI: A Neuroethological Benchmark for Visual Robustness and Neural AlignmentVisual robustness under real-world conditions remains a critical bottleneck for modern reinforcement learning agents. In contrast, biological systems such as mice show remarkable resilience to environ... 33820
SchottdorfLab @schottdorflab.bsky.social · 03/10/2025From the popular series "Figures that look like Kraftwerk Albums". Fig. 3 in Georgopoulos et al. Science 1986. Contributions of individual neurons to a shared coding direction in state space — pubmed.ncbi.nlm.nih.gov/3749885/ 070
SchottdorfLab @schottdorflab.bsky.social · 01/10/2025Using calcium imaging with single cell resolution across brain areas while mice solve two VR navigation problems, we discovered that neural manifolds can change in size based on working memory demands! Check out Mika Diamanti's amazing work: www.biorxiv.org/content/10.1...biorxiv.orgWorking memory expands shared task representations in cortexCognition is thought to emerge from the flexible organization of neural activity, yet how this organization reconfigures across behaviors varying in cognitive load remains unclear. We investigated how... 052
Reposted by SchottdorfLabbioRxiv Neuroscience @biorxiv-neursci.bsky.social · 30/09/2025Working memory expands shared task representations in cortex www.biorxiv.org/content/10.1101/202… 032
Reposted by SchottdorfLabThomas Luo @thomas-zhihao-luo.bsky.social · 17/09/2025How does the brain decide? 🧠 Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc. After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up. rdcu.be/eGUrvnature.comTransitions in dynamical regime and neural mode during perceptual decisions - NatureSimultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura... 1325097
Reposted by SchottdorfLabSam McDougle @actlab.bsky.social · 15/09/2025Thrilled that our new review "Motor Working Memory" is now in press at TiCS! @cp-trendscognsci.bsky.social @cellpress.bsky.social By me + Hanna Hillman We argue that a dedicated research program on 'working memory for movements' is long overdue Link: authors.elsevier.com/a/1lmMX4sIRv... 69837
Reposted by SchottdorfLabKanaka Rajan @kanakarajanphd.bsky.social · 12/09/2025(1/8) New paper from our team! Yu Duan & Hamza Chaudhry introduce POCO, a tool for predicting brain activity at the cellular & network level during spontaneous behavior. Find out how we built POCO & how it changes neurobehavioral research 👇 arxiv.org/abs/2506.14957 15415
SchottdorfLab @schottdorflab.bsky.social · 05/09/2025Our latest project find shared representations while controlling for confounds is out www.biorxiv.org/content/10.1... Check @s-michelmann.bsky.social 's thread for the executive summary. Code in python and matlab: github.com/s-michelmann... — Now is play time 👨💻biorxiv.org| bioRxivbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 082
Reposted by SchottdorfLabSebastian Michelmann @s-michelmann.bsky.social · 05/09/2025🚀Excited to share our project: Canonical Representational Mapping for Cognitive Neuroscience. @schottdorflab.bsky.social and I propose a novel multivariate method to isolate neural representations aligned with specific cognitive hypotheses 🧵https://www.biorxiv.org/content/10.1101/2025.09.01.673485v1 17730
Reposted by SchottdorfLabAmerica's Lab @americas-lab.bsky.social · 21/05/2025Wonder what kind of innovations publicly funded science has generated? Look no further than the device you may be reading this post on! Touchscreens started as a NSF funded thesis project at the University of Delaware. Learn more at: publicusaresearchbenefits.com/examples/202...publicusaresearchbenefits.comTouchscreensAn NSF-funded graduate fellowship changed smartphones all over the world 064
Reposted by SchottdorfLabAmerica's Lab @americas-lab.bsky.social · 24/05/2025we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please re-post so we get more great stories in there!publicusaresearchbenefits.comSearchable database of tangible benefits that federally-funded research gave us.A crowd-sourced site. Health and Well-being. National Security. Prosperity. 0811
Reposted by SchottdorfLabKanaka Rajan @kanakarajanphd.bsky.social · 28/03/2025Big showing from the Rajan Lab at @cosynemeeting.bsky.social! We have posters on everything from multi-agent social foraging to neuromodulated neural networks. Catch us in Poster Sessions 2 & 3 🧠🤖 #Cosyne2025 #NeuroAI #CompSci #neuroskyence 0369
Reposted by SchottdorfLabMatthijs van der Meer @mvandermeer.bsky.social · 27/03/2025New opinion paper in @cp-trendsneuro.bsky.social with Dan Bendor, where we argue that rodent studies provide only marginal support for the idea that replay supports real-time decisions (e.g. planning). Fictive learning and memory tagging are more consistent w/evidence. www.cell.com/trends/neuro...cell.comAwake replay: off the clock but on the jobHippocampal replay is widely thought to support two key cognitive functions: online decision-making and offline memory consolidation. In this review, we take a closer look at the hypothesized link bet... 15523
Reposted by SchottdorfLabThe Transmitter @thetransmitter.bsky.social · 20/02/2025Scientific data and independence are at risk: We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political interference. By @neuralreckoning.bsky.social #neuroskyence www.thetransmitter.org/policy/scien...thetransmitter.orgScience must step away from nationally managed infrastructureScientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political… 18636
SchottdorfLab @schottdorflab.bsky.social · 16/02/2025Do you want to build your own two photon microscope for in vivo imaging? We have made our design open: With complete building instructions, bill of materials, CAD designs — and even the optics simulations. Now peer reviewed: journals.plos.org/plosone/arti... 030
Reposted by SchottdorfLabPeter Rupprecht @ptrrupprecht.bsky.social · 13/02/2025How to guide a micropipette into mouse hippocampus using two-photon microscopy - great protocol paper by Kevin Gonzalez and the Losonczy Lab: www.nature.com/articles/s41... 0102
Reposted by SchottdorfLabHHMI @hhmi-science.bsky.social · 13/02/2025Read more: www.janelia.org/news/mapmaki...janelia.orgMapmaking in the mind: new research details how the brain builds mental maps of the worldTo see how cognitive maps form in the brain, researchers used a Janelia-designed, high-resolution microscope with a large field of view to image neural activity in thousands of neurons in the 031
Reposted by SchottdorfLabChristopher Langdon @cmlangdon.bsky.social · 12/02/2025(1/5) Excited to share my work with @engeltatiana.bsky.social , out now in Nat Neuro! We show that RNNs use low-d latent circuit mechanisms for cognitive tasks. We find that context-dependent decisions in both RNNs and PFC arise from latent inhibitory mechanisms. www.nature.com/articles/s41...nature.comLatent circuit inference from heterogeneous neural responses during cognitive tasks - Nature NeuroscienceThe latent circuit model identifies low-dimensional mechanisms of task execution from heterogenous neural responses. This approach reveals a latent inhibitory mechanism for context-dependent decisions... 24615
Reposted by SchottdorfLabPeter Rupprecht @ptrrupprecht.bsky.social · 31/01/2025Cool experimental design by @simwieg.bsky.social's lab with optogenetics + calcium imaging: how place cells in CA1 are affected by stimulation of contralateral CA3. They observe less an induction of place fields but somewhat random shifts of existing place fields: www.biorxiv.org/content/10.1... 182
Reposted by SchottdorfLabNicole Rust @nicolecrust.bsky.social · 28/01/2025This is legit - the organizers (including unions) are organizing. When I ask those in the know what we can do that will actually matter, the answer includes collective action of this type. I'm joining @nancykanwisher.bsky.social and all the others for this Thurs 3p ET effort. I hope you do too! 410557
Reposted by SchottdorfLabMick Craig @mickcraig.bsky.social · 20/01/2025With the death of Twitter is the loss of years of cool papers. Let's start again #NeuroSkyence! What paper are you most proud of? This isn't my biggest or most cited, but the one I 🥰 most: www.jneurosci.org/content/35/8.... I found a type of gamma in CA1 that didn't involve PV baskets or PYRs 🤓 1444
Reposted by SchottdorfLabTobias Rose @trose-neuro.bsky.social · 08/01/2025Let's see if bluesky = 2016NeuroTwitter: Two-Photon optophys people: Are you using a denoising step in your pipelines? If yes which? 393
Reposted by SchottdorfLabJens-Bastian Eppler @j-b-eppler.bsky.social · 06/01/2025Our new preprint: We found that during representational drift co-activation of neuron pairs is predictive of future effective connectivity. Drift is - in parts - just Hebbian plasticity. But we also need a stochastic process to account for our observations. doi.org/10.1101/2025...doi.orgRepresentational drift reflects ongoing balancing of stochastic changes by Hebbian learningRecent evidence indicates that even under stable environmental and behavioural conditions responses to sensory stimuli undergo continuous reformatting over the course of days, a condition described as... 0228
Reposted by SchottdorfLabThe Transmitter @thetransmitter.bsky.social · 02/01/2025Our first book, “Thinking about neuroscience: Essays from the field," highlights what some of our contributing editors, including @nicolecrust.bsky.social, Anthony Zador and @russpoldrack.bsky.social, think the field should prioritize over the next few decades. Check it out here: bit.ly/40iSUfxbit.lyThe Transmitter booksThe Transmitter’s first book, “Thinking about neuroscience: Essays from the field,” features a rich collection of writing from researchers Nicole Rust, Anthony Zador and many more. 061
SchottdorfLab @schottdorflab.bsky.social · 24/11/2024Have you ever wondered how and why learning abstract things can literally change how we see the world? We'll start digging into this beginning Jan 1 2025 at @udelaware.bsky.social's department of Psychological & Brain Sciences! More infos on schottdorflab.com 050