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Brian DePasquale

@briandepasquale.bsky.social
1.7K followers 462 following 66 posts

science. briandepasquale.github.io

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Reposted by Brian DePasquale
Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 21/09/2026
The person who thinks that he has the ability to decide which science to fund out of hundreds of subfields is exactly the person who should not make that decision. There is a reason that expert committees of scientists review and give recommendations for funding. No one person can know all of it.
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PLOS Biology @plosbiology.org · 11/09/2026
Mosquitoes use CO2 to sense if humans are nearby. Chih-Ying Su explores a @plosbiology.org study showing that CO2-sensing neurons in #mosquitoes can amplify each other’s signals, creating a neural echo chamber 🧪 Paper: plos.io/4cFCPpV Primer: plos.io/4h9FSIy
Comparative circuit architecture of CO2- and odor-sensing OSNs in mosquitoes and flies. Left: Insect olfactory sensory neurons (OSNs) expressing the same receptor converge onto a single glomerulus (circle) in the antennal lobe, where they synapse onto projection neurons (PNs). This study focuses on two circuit motifs: recurrent OSN-to-OSN connections (for signal amplification) and feedforward OSN-to-PN connections (for information relay). Middle: OSNs also synapse onto inhibitory local neurons (LNs) When multiple OSNs are co-activated, they recruit local neurons to mediate global lateral inhibition for divisive normalization. In mosquitoes, both CO2- and odor-sensing OSNs express GABA receptors (likely at their axonal terminals), rendering them susceptible to this inhibition. Only CO2-sensing OSNs exhibit strong recurrent connections, which amplify their output signal and protect it from divisive normalization. Right: Strong recurrent connectivity is observed among mosquito CO2-sensing OSNs, but is absent in either CO2- or odor-sensing OSNs of fruit flies.
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Alison Gopnik @alisongopnik.bsky.social · 11/09/2026
An especially clear and insightful piece on AI from Melanie Mitchell Misleading Metaphors and Real Risks aiguide.substack.com/p/misleading...
aiguide.substack.com
Misleading Metaphors, Real Risks
What To Fear from AI Agents and How to Reclaim Our Human Agency
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Itai Yanai @itaiyanai.bsky.social · 31/08/2026
Advice for new PhD students: choose a mentor who is committed to your training, not just your project. The most important product of your PhD - even more important than the science - is YOU, a newly trained scientist.
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I-270, Exit 1 @i270exit1.bsky.social · 14/08/2026
This plan will make peer review less transparent and more confusing to applicants and program staff. Y'all killed it on the OMB proposal, you know what to do here. Comment deadline is October 13.
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Nina Miolane @ninamiolane.bsky.social · 22/07/2026
Our review on superposition in AI & brains is published in @nature.com #Machine #Intelligence 🌐 Neural networks encode concepts in superposition. We can recover them in 3 steps: identifiability, compressed sensing, interpretability. W/ @david-klindt.bsky.social O'Neil Reizinger & Maurer 🌟
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The Transmitter @thetransmitter.bsky.social · 09/07/2026
AI may soon enable researchers to generate high-quality science at a previously unimaginable speed. The effects for researchers will be as disruptive as industrial mass production was for artisan manufacturers, writes @kenneth-harris.bsky.social. #neuroskyence www.thetransmitter.org/artificial-i...
thetransmitter.org
Mass-produced science is coming. What happens to scientists?
Artificial intelligence may soon enable researchers to generate high-quality science at a previously unimaginable speed.
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Adam Weinstein @adamweinstein.bsky.social · 07/07/2026
I'm so disillusioned, I almost don't even care who gets the FIFA Peace Prize next year
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Amanda @onidagirl.bsky.social · 07/07/2026
Friday: FIFA announces, after further consideration, the game was a 4-6 win by USMNT, knocking Belgium out of the tournament and paving the way for the U.S. team to face Spain instead. 🙃
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Mark D Humphries @markdhumphries.bsky.social · 01/07/2026
At Cosyne, Chris Olah from Anthropic told us that neuroscientists had “3-4 years left to make a contribution” Why was not clear. Perhaps he was hinting at the below graph accompanying today’s Claude Science launch. Apparently we’ll all be obsolete soon.
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Machine Learning in Science @mackelab.bsky.social · 26/06/2026
New paper: We recast automated scientific model discovery with LLMs as Bayesian inference! LLMs write code and carry domain knowledge, great for proposing models. The key idea: discovery is inference, not just generation. What distribution of models explains the data? 🧵 arxiv.org/abs/2602.18266
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Brian DePasquale @briandepasquale.bsky.social · 17/06/2026
Thanks to everyone for contributing their comments! I really enjoyed seeing the diversity of takes — an important conversation at a critical moment!
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Reposted by Brian DePasquale
The Transmitter @thetransmitter.bsky.social · 16/06/2026
Hear from Larry Abbott, @neurograce.bsky.social, @gjorjulijana.bsky.social, @neural-reckoning.org, @talmo.bsky.social, @neurokim.bsky.social and @tonyzador.bsky.social on what that tectonic change will bring to the field.
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Brian DePasquale @briandepasquale.bsky.social · 17/06/2026
How can AI change theoretical neuroscience? Technologies separate us from the mechanics of computation. Are we liberated to focus on the big picture or abandoning the substrate of thought? Born from an ongoing experiment in my lab about balancing these technologies for research and training
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Sarah Wood @sarahwood.bsky.social · 13/06/2026
I had no idea men played soccer, too! Good for them! Go boy soccer!! ⚽️
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Brian DePasquale @briandepasquale.bsky.social · 11/06/2026
🚨 New preprint from the lab! 🚨 We introduce BiXformer, a bidirectional cross-attention transformer for disentangling inter-regional neural dynamics. Recordings from multiple regions superimpose feedforward & feedback signals 🔁, offset in time, making it difficult to tease these signals apart. 🧠 🔁
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Kevin J Miller @kevinjmiller.bsky.social · 03/06/2026
Computational models are a key part of science but discovering new ones is hard! DataDIVER discovers concise models from data, which surface new mechanistic ideas and clear predictions for future experiments From Google Deepmind Neuroscience Lab + collaborators www.biorxiv.org/content/10.6...
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buhaririinstitute.bsky.social @buhaririinstitute.bsky.social · 03/06/2026
FY27 Focused Research Programs Spotlight: "AI for Characterizing and Designing Biomolecular Interactions" Learn more about this FRP: spr.ly/63323B8Y3sz
AI for Characterizing and Designing Biomolecular Interactions
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Brian DePasquale @briandepasquale.bsky.social · 31/05/2026
🚨New Preprint🚨 from amazing PhD student @ryguy.io! We augmented the classic DDM to account for state-dependent changes in decision strategy and found a clear improvement. Applied to a novel 24 hour dataset we found support for circadian influence on decisions and more! Check out thread and paper!
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Jennifer Ouellette @jenlucpiquant.bsky.social · 11/05/2026
National Academy of Sciences experts denounce Trump’s NSF board purge www.scientificamerican.com/article/nati...
scientificamerican.com
National Academy of Sciences experts denounce Trump’s NSF board purge
In an open letter, thousands of researchers criticized the White House’s firing of the research agency’s board as ‘an alarming attack’ on U.S. science
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Friedemann Zenke @fzenke.bsky.social · 06/05/2026
1/7 New paper accepted as ICML spotlight arxiv.org/abs/2605.03517! We unify self-supervised learning (SSL) algorithms (e.g., contrastive, VICReg, stopgrad) via latent distribution matching (LDM), which matches an induced latent distribution to an explicit latent model.
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Datta Lab @dattalab.bsky.social · 29/04/2026
Excited to see our paper describing a stereotyped receptor map for smell (led by @davidhbrann.bsky.social ) out in the world! See below for short thread with open access link to paper www.nytimes.com/2026/04/29/s...
nytimes.com
Scientists Unveil ‘Long Lost’ Map for Smell
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Aadi Prasad @aaprasad.bsky.social · 28/04/2026
maybe besides the point but didnt Lebos et al show that good models can recover interpretable models of orbital mechanics like 5 years ago? arxiv.org/abs/2202.02306
arxiv.org
Rediscovering orbital mechanics with machine learning
We present an approach for using machine learning to automatically discover the governing equations and hidden properties of real physical systems from observations. We train a "graph neural network" ...
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Jacob Aron @jjaron.bsky.social · 27/04/2026
Scrap all of this wasted time and effort and just award grants randomly. The article briefly suggests and dismisses this but I think it would solve a lot of problems with science funding. If you're overwhelmed with good submissions, you're already choosing randomly and just not admitting it.
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Brian DePasquale @briandepasquale.bsky.social · 27/04/2026
Film you've watched more than six times with a gif. Hard mode: no Star Trek, Star Wars, LOTR, DC, Marvel, Disney, Pixar, Spielberg, Cameron, Wachowskis, or Ghibli:
media.tenor.com
a close up of a man with the word rocky on the bottom right
ALT: a close up of a man with the word rocky on the bottom right
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Mary Kenney @marykgames.com · 20/04/2026
One of the hardest + most important things to learn as a creative. Stop waiting to make your “opus” — keep going, get better
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Mohammed AlQuraishi @moalquraishi.bsky.social · 13/03/2026
New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9
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Carl T. Bergstrom @carlbergstrom.com · 15/04/2026
Johnny Knoxville says Ed Witten should be more careful when talking about physics.
Vance Says the Pope Should Be More Careful When Talking About Theology

The vice president, who is Catholic, took issue with Pope Leo XIV’s statement that disciples of Christ are “never on the side of those who once wielded the sword and today drop bombs.”
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Jeremiah Cohen @jeremiahycohen.bsky.social · 13/04/2026
Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
biorxiv.org
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Ronen Tamari @ronentk.me · 12/04/2026
Interesting piece claiming that the asymmetry between writing acceleration and review acceleration is breaking science. Essentially Brandolini’s law (The amount of energy needed to refute bs is an order of magnitude bigger than that needed to produce it) applied to science publishing >
arxiv.org
Publish and Perish: How AI-Accelerated Writing Without Proportional Verification Investment Degrades Scientific Knowledge
Artificial intelligence tools are accelerating manuscript production far faster than peer review capacity can expand. Applying the theory of constraints from manufacturing science, we formalize this a...
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Mina Kimes @minakimes.bsky.social · 10/04/2026
I can't stop laughing at this post. It's perfect.
A guy asking ChatGPT to review a series of fart sound effects and getting a serious kiss ass response that calls it atmospheric
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Brian DePasquale @briandepasquale.bsky.social · 10/04/2026
Fix for next 11th hour grant push — Dr Robby tells me to Dr the f**k up 🔥
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Erin Rich @erinlrich.bsky.social · 02/04/2026
Wow!
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Dan Goodman @neural-reckoning.org · 01/04/2026
This is satisfyingly niche. Shots fired by the chemical reaction networks community. arxiv.org/abs/2603.12060
arxiv.org
Chemical Reaction Networks Learn Better than Spiking Neural Networks
We mathematically prove that chemical reaction networks without hidden layers can solve tasks for which spiking neural networks require hidden layers. Our proof uses the deterministic mass-action kine...
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Sam Gershman @gershbrain.bsky.social · 31/03/2026
Among the frustrating aspects of the funding situation in the U.S. is that the strategic response is to apply for more grants, with the result that the equilibrium success rate is pushed lower (up to a point). Scientists get less while spending more time writing grants rather than doing science.
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Ashley Juavinett, PhD @ashleyjuavinett.bsky.social · 30/03/2026
The question of if and how we should be integrating AI into programming and neuroscience education is an ever-present one in my mind. Here are my current set of thoughts, driven by an undercurrent of *you need to talk with students about it* regardless of how you personally use AI, or not.
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elia ayoub @ayoub.bsky.social · 28/03/2026
The difference between these two is racism
Russia plans to illegally annex lands it invaded, even as its military falters.

Israel Plans to Control Large Parts of Southern Lebanon, Defense Minister Says
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gavin jones @ecologyofgavin.bsky.social · 15/03/2026
“In our culture, preferring an algorithm to a trainee feels like a betrayal of the academic mission.” That’s because it is. www.science.org/content/arti...
science.org
Why I may ‘hire’ AI instead of a graduate student
“It can competently perform a lot of the work I need immediately,” this professor writes
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Research Corporation for Science Advancement @rescorp.org · 13/03/2026
The 2nd meeting of #Scialog: Neurobiology and Changing Ecosystems has begun in Tucson! Special welcome to all our new Fellows. Cosponsored with @allenphilanthro.bsky.social, the Frederick Gardner Cottrell Foundation, and @kavlifoundation.org.
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Benjamin Cowley @benjocowley.bsky.social · 26/02/2026
DNN models of the brain are getting bigger. Are we replacing one complicated system in vivo with another in silico? In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony. It turns out these compact models are surprisingly small! rdcu.be/e5H8G
rdcu.be
Compact deep neural network models of the visual cortex
Nature - Parsimonious deep neural network models can be used for prediction of visual neuron responses.
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Joshua Weitz @joshuasweitz.bsky.social · 07/03/2026
The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302
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Science Magazine @science.org · 03/03/2026
Many of the scientists Jeffrey Epstein courted were already well-established and well-funded. So why didn’t they all just say no? Science talked with three who did just that. Here’s how Epstein approached them, and why they refused to have anything to do with him. ⬇️ scim.ag/40qbXnv
scim.ag
Meet three scientists who said no to Epstein
The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”
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Kyle Cranmer @kylecranmer.bsky.social · 03/03/2026
Knuth on Claude code! www-cs-faculty.stanford.edu/~knuth/paper...
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Brian DePasquale @briandepasquale.bsky.social · 20/02/2026
Truly honored to be recognized by the Sloan Foundation. Major thanks to my research collaborators, students, and my many amazing mentors over the years
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Stephan Saalfeld @herrsaalfeld.bsky.social · 17/02/2026
This is work that we presented at last year's #Cosyne workshop on #GNN s sites.google.com/bu.edu/gnnwo.... Better late than never. You can reproduce everything with the associated notebooks. I think it's a good start to learn how to use GNNs to infer something about NNs. arxiv.org/abs/2602.13325
arxiv.org
Graph neural networks uncover structure and functions underlying the activity of simulated neural assemblies
Graph neural networks trained to predict observable dynamics can be used to decompose the temporal activity of complex heterogeneous systems into simple, interpretable representations. Here we apply t...
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Nanthia Suthana @suthanalab.bsky.social · 16/02/2026
The biggest problem holding neuroscience back right now isn’t data or tools, thanks in large part to the BRAIN Initiative. It’s fragmentation across species. I wrote this to hopefully spark discussion around an issue that can only be solved as a community👇 www.thetransmitter.org/animal-model...
thetransmitter.org
Neuroscience has a species problem
If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle.
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Atika Syeda @atika-syeda.bsky.social · 05/02/2026
Excited to share “Orofacial behaviors, not eye movements, govern neural activity in mouse visual cortex” www.biorxiv.org/content/10.6... Summary below...
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Maria Geffen @geffenlab.bsky.social · 31/01/2026
A special year for the Cajal Course in Computational Neuroscience: the BRAIN Prize winners Haim Sompolinsky and Larry Abbott will join us as keynote speakers. And we will bring you the same great roster of instructors as every year. Applications are now open! cajal-training.org/on-site/comp...
cajal-training.org
The Brain Prize Course - Computational and Theoretical Neuroscience - CAJAL
[…]
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Akilla Cooper @akelacooper.bsky.social · 23/01/2026
Reupping this cause it’s evergreen and I feel better knowing someone out there called him out like this
A screenshot of an opinion by Oliver Kornetzke from August 18th, 2025. There’s a photo of a tired, bloated Donald trump over the opinion that reads: behold. The festering carcass of American rot shoved into an ill fitting suit: the sleeves of economy, man, the cowardice of a draft dodger, the gluttony of a parasite, the racism of a clansman, the sexism of a back alley creep, and the greed of a hedge fund ghoul – all spray painted orange and paraded like a prize hog at a country fair. Not a president. Not even a man. Just the diseased distillation of everything this country swears it isn’t but has always been – arrogance dressed up as exceptionalism, stupidity passed off as common sense, cruelty sold as toughness, greed, exalted as ambition, and corruption worship like gospel. It is America’s shadow made flesh, a rotting pumpkin idol, proving that when a nation kneels before money, power, and spike, it doesn’t just lose its soul – it shits out this bloated, obscenity, and calls it a leader.
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Gatsby Computational Neuroscience Unit @gatsbyucl.bsky.social · 15/01/2026
📢 Applications open on 19 Jan for the 7-week #Mathematics #SummerSchool in London. You will develop the maths skills and intuition necessary to enter the #TheoreticalNeuroscience / #MachineLearning field. Find out more & register for the information webinar 👉 www.ucl.ac.uk/life-science...
Applications for 2026 entry to the Gatsby Bridging Programme (7-week maths summer school) will open on 19 Jan and close on 16 Feb. Designed for students who wish to pursue a postgrad research degree in theoretical neuroscience or foundational machine learning but whose degree programme lacks a strong maths focus. Applications from students in underrepresented groups in STEM strongly encouraged. A small number of bursaries available.
Register for the information webinar on 23 Jan.
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