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Quantitative Biosciences Institute, UCSF

@qbi-ucsf.bsky.social
78 followers 21 following 84 posts

Transforming our understanding of biology and disease through collaborative, quantitative research.

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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 24/09/2026
Most kinase inhibitors target one binding site. A new Nature study from UCSF introduces a framework for designing “bitopic” inhibitors that engage two, demonstrating the approach with PonatiLink-2. Learn more: qbi.ucsf.edu/qbi-highligh...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 21/09/2026
SEMINAR CANCELLATION: The QBI seminar with Forest White, scheduled for September 23, has been cancelled. We apologize for any inconvenience and appreciate your understanding.
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 16/09/2026
Join us at UCSF 09/23 for a seminar with Forest White, Prof. of Biological Engineering at MIT to learn about signaling, MHC peptide presentation, cancer progression and therapeutic response. Learn more & sign up: qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 11/09/2026
This October, QBI brings together scientists from around the world for the "Molecular Mechanisms of Aquatic Organisms" symposium at UCSF! Submit an abstract to present an oral or poster presentation. Submit by Sept. 29! Learn more: qbi.ucsf.edu/events/molec...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 03/09/2026
Join us @UCSF on 9/22 for a Science Art Club Social, inspired by the world of aquatic organisms! Create, connect, and explore the intersection of science & art. No artistic or scientific experience needed—just bring your curiosity and creativity. Details: qbi.ucsf.edu/events/art-s...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 27/08/2026
Scientists at UCSF studied 100 autism risk genes and found that many patient-derived mutations disrupt core biological processes; a discovery that opens new avenues for future interventions. Learn more about the study published in Science today. qbi.ucsf.edu/qbi-highligh...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 20/08/2026
What happens after you submit a manuscript?? Join us on 8/24 for a behind-the-scenes look at scientific publishing with Yuan Allegretti, Scientific Editor at Cell Systems. Bring your questions! More details & registration: qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 11/08/2026
We’re delighted to welcome Brad Schneider as QBI’s new Chief Operating Officer. With 20+ years in infectious disease, global health, and AI biosecurity, Brad will help strengthen our operations and translate our science into real-world impact. Read more: go.shr.lc/4cAQwX0
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 10/08/2026
Last week, QBI’s annual Internship Symposium brought together our summer researchers to share their work! We’re so proud of this year’s cohort and grateful to community members who helped make it all possible! ✨ Revisit event details & browse more photos: qbi.ucsf.edu/events/inter...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 10/08/2026
This September, researchers from California and Germany will gather in Berlin for a QBI–FUB @freieuniversitaet.bsky.social symposium exploring the molecular mechanisms of neuropsychological & neurodevelopmental disorders, with a focus on autism. Learn more & register: qbi.ucsf.edu/events/qbi-f...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 24/07/2026
The 2026 QBI Hackathon showcased what's possible when developers and scientists collaborate to solve biomedical challenges through open science. Our biggest edition yet! Learn more about projects, browse the open-source repositories, and explore photos: qbi.ucsf.edu/hackathon2026
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 22/07/2026
Join us on July 31 @UCSF for a seminar with Ron Shamir of @telavivuni.bsky.social on AI-driven approaches to Parkinson’s disease assessment, polygenic risk prediction, and future QBI/UCSF–Tel Aviv University collaborations in computational biology and drug discovery! qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 26/06/2026
A new Molecular Cell study led by Hayarpi Torosyan, Natalia Jura & Klim Verba @ucsanfrancisco.bsky.social, maps how PI3Kα, a key cancer-linked signaling protein, is activated at the cell membrane: qbi.ucsf.edu/qbi-highligh...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 25/06/2026
Join us for a talk with Prof. Patrick Barth on July 1! He will discuss how proteins function as dynamic molecular systems and how computational + deep learning approaches can be used to model and engineer protein motion. More info: qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 12/06/2026
A new iScience study led by researchers from QBI, University of Ghana, Yemaachi Biotech, and UCLA identifies a mechanism linking HIV infection to increased cervical cancer risk even in individuals receiving antiretroviral therapy: qbi.ucsf.edu/qbi-highligh...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 04/06/2026
We're pleased to welcome Andy Kilianski @andykilianski.bsky.social as QBI's Chief Science & Technology Officer. Learn more about Andy's background and the role he'll play as QBI continues to expand its translational science and technology initiatives: go.shr.lc/4v1N5zK
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 02/06/2026
On June 10, Raphaël of @pasteur.fr will talk about how phages adapt to new hosts using DNA-based “variation systems” that rapidly reshuffle key proteins involved in host recognition...and more! Hope you can join us. Learn more & register: qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 21/05/2026
One week to go until QBI, UAlberta, & Gladstone bring together researchers across fields for this dynamic symposium. Trainees: join the Trainee Collaboration Prize. Build project ideas, connect with collaborators, and compete for a $500 prize! qbi.ucsf.edu/events/qbi-u...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 14/05/2026
A new Cell Host & Microbe study from QBI, Gladstone, and Icahn Mount Sinai maps virus–host interactions in humans & bats. A single change in SARS-CoV-2 Orf9b alters immune targeting across species, helping explain why bats tolerate viruses humans don’t. Learn more: qbi.ucsf.edu/qbi-highligh...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 12/05/2026
We’re excited to welcome John Young as QBI’s Chief Strategy Officer. With experience across pharma R&D, #InfectiousDisease, pandemic preparedness, & public-private partnerships, John will help advance QBI’s mission to move discoveries closer to patients. Read more here: go.shr.lc/4dkGVmK
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 08/05/2026
Join the next Pre-Hackathon Meet & Greet Mixer at UC Santa Cruz next week! Details and sign up: qbi.ucsf.edu/events/hacka...
qbi.ucsf.edu
QBI - QBI Pre-Hackathon Mixer UCSC
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 05/05/2026
QBI UCSF, UAlberta & Gladstone present: a joint symposium on May 29! We will explore how molecular and computational approaches are reshaping neuro-inflammation research. There will be posters + a trainee collaboration initiative. Learn more and register: qbi.ucsf.edu/events/qbi-u...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 23/04/2026
Looking for your next big challenge? Join our Hackathon 2026 Pre-Hackathon Mixers and connect before the main event in June. Meet collaborators, pitch ideas, and start building your team early. April 27 — UC Berkeley May 14 — UC Santa Cruz June 11 — UCSF qbi.ucsf.edu/hackathon-de...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 21/04/2026
Join us on April 23 for a seminar with Dr. Christopher Overall, who will discuss how SARS-CoV-2 uses key enzymes to disable defenses, spread between cells, and avoid detection -- insights that could shape future antivirals. More details: qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 20/04/2026
A new Cell paper authored by Ujjwal Rathore, Eli Dugan, and colleagues reveals a comprehensive map of how HIV interacts with human proteins in primary immune cells, opening exciting new doors for HIV drug discovery. Learn more: qbi.ucsf.edu/qbi-highligh...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 15/04/2026
Join us April 22 for a seminar with Janet Iwasa, a leader in 3D molecular animation at University of Utah. From research to storytelling, her work transforms how we understand cells - and even how scientists build hypotheses. See you there! Learn more & register: qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 09/04/2026
The start time for the April 13 QBI Seminar featuring Mehdi Bouhaddou has been changed. New time: April 13, 2026, at 1:00 PM (previously 2:00 PM). Event details: qbi.ucsf.edu/events/semin... We appreciate your understanding and hope you can still join us.
qbi.ucsf.edu
QBI - What Do Viruses, Wildfires, and Coral Reefs Have in Common? Phosphorylation.
Mehdi Bouhaddou is an Assistant Professor in the Department of Microbiology, Immunology, and Molecular Genetics and co-affiliated with the Institute for Quantitative and Computational Biosciences at UCLA.
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 06/04/2026
Join us on April 14 for a Systems Biology for Infectious Diseases Workshop! Learn network biology, multi-omics & computational modeling through influenza, coronavirus & antimicrobial resistance case studies. Register by April 10: qbi.ucsf.edu/events/sysbi...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 03/04/2026
How do cells respond to their environment? Mehdi Bouhaddou provides a fascinating cross-disciplinary perspective on biology, disease, and adaptation! Join us on April 13 to hear about it: qbi.ucsf.edu/events/semin...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 17/03/2026
10 years ago, the Quantitative Biosciences Institute was established at UCSF.✨ Revisit the original announcement from 2016: www.ucsf.edu/news/2016/03...
ucsf.edu
Archive: UCSF Establishes Quantitative Biosciences Institute
UCSF announced the establishment of the Quantitative Biosciences Institute (QBI), to drive forward the application of computation, mathematics, and statistics toward a deeper understanding of complex ...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 17/03/2026
Excited to highlight new work from Rezo Therapeutics. Their collaboration with NVIDIA advances AI approaches to predict higher order protein complexes and uncover disease relevant interactions. The work builds on research from the lab of QBI Director Nevan Krogan. rezotx.com/predicting-a...
rezotx.com
Predicting and Verifying Novel Higher-Order Protein Complexes In Silico With NVIDIA | Rezo
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 03/03/2026
As the top-funded unit within the School of Pharmacy, QBI proudly supports UCSF’s mission to lead in research excellence and help drive breakthroughs from the lab to real-world therapies. pharmacy.ucsf.edu/news/2026/02...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 26/02/2026
On March 13, QBI welcomes two leaders from @genentech.bsky.social for a seminar: Jennie Lill & Tess Branon! "Deciphering Disease Dynamics, Supporting Drug Discovery, & Empowering ML with transformative proteomic technologies" Register to join us: qbi.ucsf.edu/seminar-jenn...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 24/02/2026
Join us for the next Infectious Diseases & Human Health Symposium by @gladstoneinst.bsky.social and QBI: "Sex Differences in Immunity and Diseases" on February 27! Learn more & register: qbi.ucsf.edu/sex-differen...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 02/02/2026
Join us on Feb 6 at UCSF for a talk by Christian Freund of @freieuniversitaet.bsky.social on Dynamic States in the Peptide Exchange of MHC Class I Molecules. From immune signaling to neurobiology ... plus great science, refreshments & community. Don’t miss it! Register: qbi.ucsf.edu/christianfre...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 23/01/2026
Check out an overview of our HIV Accessory and Regulatory Complexes Center’s systems biology approach to HIV discovery, featured in a UCSF School of pharmacy article with commentary from HARC program manager Zelda Love! pharmacy.ucsf.edu/news/2026/01...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 12/01/2026
Join us for an evening exploring how science is reshaping our understanding of the brain. ✨ Flash talk by Dr. Matthew State ✨ Conversation with journalist Victoria Colliver ✨ Open audience Q&A The Night of Science-making science relevant and deeply human. Register: qbi.ucsf.edu/night-of-sci...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 05/01/2026
Kick off 2026 with us! Meet Søren Brunak of the University of Copenhagen on Jan 8 at UCSF. He turns massive biological datasets into insights advancing medicine, biotechnology, and health. Join us in hearing from a leading voice in the field. Learn more & register: qbi.ucsf.edu/seminar-brunak
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 05/01/2026
Looking back on 2025, we’re proud to reflect on the milestones, discoveries, and collaborations that made the year remarkable. Explore our timeline for some key moments from last year and join us as we continue the journey in 2026! qbi.ucsf.edu/YearInReview...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 24/11/2025
We’re welcoming Kevin Lou as a QBI Fellow! In his Q&A, he shares what inspired his journey into chemical biology, why QBI is the right place to pursue his vision, and how quantitative approaches are shaping the future of drug discovery. Read more: qbi.ucsf.edu/kevin-lou-qb...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 10/11/2025
APOE4, the strongest genetic risk for Alzheimer’s, disrupts the recycling centers of nerve cells, laying the foundation for toxic protein accumulation. A new study led by Einar Krogsaeter & Danielle Swaney sheds light on early cellular stress in AD. Read more: www.tandfonline.com/doi/full/10....
tandfonline.com
Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction
APOE4 is the primary risk factor for Alzheimer disease (AD). Early AD pathological events first affect the neuronal endolysosomal system, which in turn causes neuronal protein aggregation and cell ...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 07/11/2025
What happens when a chromosome breaks & how do cells put it back together? Jim Haber @brandeisuniversity.bsky.social will be at UCSF next week to share how scientists learned to watch DNA repair in real time & what that reveals about how cells maintain genetic stability. qbi.ucsf.edu/seminar-haber
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 06/11/2025
Join us on November 13 for a seminar with Dr. Rafael Couñago of UNC on leveraging AI models to accelerate chemical probe discovery for Target 2035! Learn more & register for his talk: qbi.ucsf.edu/seminar-coun...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 05/11/2025
How does AI meet molecular structure to reveal the roots of health & disease? Join us for a QBI seminar with Dr. Arun Prasad Pandurangan of University of Cambridge on November 12 at UCSF Mission Bay! Learn more & register: qbi.ucsf.edu/seminar-pand...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 28/10/2025
How do cells control what enters and exits the nucleus? A study maps the nuclear pore complex in unprecedented detail, solving a decades-old mystery and offering insights into cancer, Alzheimer’s, and ALS: www.pnas.org/doi/10.1073/...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 24/10/2025
We look forward to welcoming Dr. @andykilianski.bsky.social, Program Manager at ARPA-H for a seminar hosted by James Fraser. Learn about how ARPA-H is investing in bold, transformative research to shape the future of health in the United States: qbi.ucsf.edu/seminar-kili...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 20/10/2025
AI is powering new frontiers in drug discovery, but success still depends on good data and biological insight. This @cenmag.bsky.social piece features our director, Nevan Krogan, among voices exploring the real promise and pitfalls of AI in biomedicine. cen.acs.org/physical-che...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 19/09/2025
Join us for the next Infectious Diseases & Human Health Mini-Symposium by @gladstoneinst.bsky.social and QBI: “Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories" on 9/23. Learn more & register: qbi.ucsf.edu/givi-mini-sy...
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 19/09/2025
New QCRG-AViDD study: SARS-CoV protein Orf9b shape-shifts to block our immune defenses by binding to mitochondria’s Tom70. Lipids & mutations tweak how efficiently it works -revealing new insights into coronavirus immune evasion. Learn more: doi.org/10.7554/eLif...
doi.org
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.
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Quantitative Biosciences Institute, UCSF @qbi-ucsf.bsky.social · 11/09/2025
The HARC Center supports scientists through Mentored Scientist and Collaborative Developmental Awards, fostering HIV research and training opportunities. Check out this year’s awardees and the projects they’re working on! 🔬✨https://bit.ly/HARCawards2025
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