This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

The new EMBO Members and Associate Members are recognized for their outstanding achievements in the life sciences

Research and Innovation Bill 2023: Open Letter to Minister Simon Harris

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these m...

The All-Ireland Chromatin Consortium was established in 2021 to foster collaborations between researchers located across the whole of Ireland, promote scientific exchange, and to facilitate networking...

Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum’s expansion during human evolution, yet they remain largely unexplored. In this study, we com...

Tournière et al. uncover the biological roles of sex chromosome dosage compensation, showing it is broadly dispensable except in the respiratory system during metamorphosis, where X chromosome dose de...

Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Abstract. Cytosine DNA methylation patterns vary widely across eukaryotes, with its ancestral roles being understood to have included both transposable ele

Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

Chordin-mediated BMP shuttling is the candidate mechanism for generating bilateral symmetry in the cnidarian-bilaterian ancestor.

Larvae of jellyfish and corals have specialized sensory cells with shared features potentially linked to settlement regulation.

npj Regenerative Medicine - Neuronal activation in the axolotl brain promotes tail regeneration

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

Lebedeva et al. show that unlike Bilateria, the embryo of the cnidarian Nematostella specifies its endomesoderm in the β-catenin-negative domain. In contrast, subsequent β-catenin-dependent axial patt...

We’re thrilled to announce the launch of openRxiv as an independent nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openRxiv ensures that r...