Six years in, all the evidence points in one direction

God save us from economists who think they can competently talk about biology

God save us from economists who think they can competently talk about biology

Understanding how molecular structure encodes biological function remains a grand challenge in drug discovery. Here, we present PubCheF-1, a deep learning model that predicts literature-derived biolog...

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

“The history of medicine is full of examples where we didn't invent the underlying mechanism. We discovered it, understood it, and then engineered it into something useful.” —Peter Attia

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating in...

New findings suggest subtle differences at the beginning of RNA molecules can affect how cells distinguish viral threats from harmless cellular RNA.

Blomqvist et al. show that protein kinase R (PKR) condensation on dsRNA exposed at MERS-CoV or ZIKV viral replication complexes initiates its activation. The NS4a protein encoded by MERS-CoV inhibits ...

SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...

In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC gl…

Job Posting Title: Postdoctoral Fellow ---- Hiring Department: Molecular Biosciences ---- Position Open To: All Applicants ---- Weekly Scheduled Hours: 40 ---- FLSA Status: Exempt ---- Earliest Start ...

Breathe easy. It appears our microbial ancestors used oxygen, too.

In this podcast I speak to Simon about his important research into the causes of bladder cancer, as well as his life and career.Story from Kidney Research UK about Simon's important breakthrough: http...

It has been said that “Energy and persistence conquer all things” (Benjamin Franklin). Viral persistence refers to the ability of some viruses to establish long-term infections rather than being clear...

Argonautes are ancient proteins with well-characterised functions in cell-autonomous gene regulation and genome defence, but less clear roles in non-cell-autonomous processes. Extracellular Argonautes...

A model for hit-and-run viral carcinogenesis in the bladder.

The BK virus, which up to 80% of the population get infected with during childhood, can drive the development of bladder cancer down the line.

Bats are reservoirs for many viruses that frequently cause epidemics in humans and animals. It is thus critical to better understand their immune system and mechanisms of antiviral immunity. Despite a...

Author Summary/ Importance Polyomavirus infections, mostly benign but potentially fatal for immunocompromised individuals, undergo acute and long-term persistent infections. Typically, polyomavirus-as...

Hsc70-4 localizes to the cell surface of Drosophila cells, binds to exogenous dsRNA, and mediates its internalization.

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

Although much is known of the molecular mechanisms of virus infection within cells, substantially less is understood about within-host infection. Such knowledge is key to understanding how viruses tak...