Preferential insertion into the late-replicating inactive X explains L1 accumulation in this chromosome

Abstract. L1 retrotransposons are the only protein-coding active transposable elements in the human genome. While typically silenced in normal cells, they are highly expressed in many human epithelial...

At least 19 people in two cities died on Monday in Nepal's worst unrest in decades, authorities said, as police in the capital fired tear gas and rubber bullets at protesters trying to storm parliament in anger at a social media shutdown and corruption.

Distinguishing real biological variation in the form of single-nucleotide variants (SNVs) from errors is a major challenge for genome sequencing technologies. This is particularly true in settings whe...

Nature Methods - This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...

Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.