RNA is increasingly recognized as a key therapeutic target , driving the development of RNA-based therapeutics for a broad spectrum of diseases. RNA-binding proteins (RBPs) play a fundamental ro…

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

Like all canonical PUF proteins, C. elegans FBF-2 binds to specific RNAs via tripartite recognition motifs (TRMs). Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless b...