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Brian Carrick @bcarrick.bsky.social · 25/02/2026

Congrats to all the winners - and a special shout out to my PhD mentor, Judith Kimble, for receiving the Thomas Hunt Morgan Medal for lifetime achievement in genetics!!

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Reposted by Brian Carrick

Lori Passmore @lapassmore.bsky.social · 27/09/2025

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

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Brian Carrick @bcarrick.bsky.social · 06/09/2025

It was great to be able to present my PhD work at #EMBLProtein! Thanks to the organizers for the opportunity.

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Brian Carrick @bcarrick.bsky.social · 03/09/2025

Great start to the EMBL translation control meeting with a keynote from @lapassmore.bsky.social. Excited for all the science to come. #EMBLProtein

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Brian Carrick @bcarrick.bsky.social · 01/08/2025

Incredibly honored to be a Shurl and Kay Curci Fellow of the Life Sciences Research Foundation. Thanks to Marv and Judith for their support during my PhD and @lapassmore.bsky.social for her backing and mentorship in my postdoc work. lsrf.org/current-fell...

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Reposted by Brian Carrick

Chris Lapointe @lapointelab.bsky.social · 02/05/2025

A fun collaboration with @rasilab.bsky.social led by Rachael Bakker. We used an RNA base editor to analyze at scale how substitutions within an RNA or RNA-binding protein affect binding. doi.org/10.1101/2025...

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Brian Carrick @bcarrick.bsky.social · 16/04/2025

Happy to see this work published in RNA, and thanks to the editors for the interview/Meet the First Author Feature! Surprisingly, we found that mutating an RNA binding protein's ability to bind RNA did not remove all biological function. #RNAsky #RNAbiology. rnajournal.cshlp.org/content/31/5...

rnajournal.cshlp.org

The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

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Brian Carrick @bcarrick.bsky.social · 03/01/2025

It was great working with Chen Qiu, Traci Hall, and all the other authors on this project! Using a combination of structural, biophysical, and in vivo stem cell analyses, we investigated how an RBP and a partner regulate adjacent binding elements in a critical RNA. #RNAsky #RNAbiology rdcu.be/d5pER

rdcu.be

A higher order PUF complex is central to regulation of C. elegans germline stem cells

Nature Communications - PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and...

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Brian Carrick @bcarrick.bsky.social · 26/10/2024

I’m excited to share this story. We found that mutating an RNA binding protein’s ability to bind RNA did not remove all biological function, but when combined with a mutation that affects protein interactions, the RBP no longer functioned. www.biorxiv.org/content/10.1...

biorxiv.org

The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA

Like all canonical PUF proteins, C. elegans FBF-2 binds to specific RNAs via tripartite recognition motifs (TRMs). Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless b...

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Brian Carrick @bcarrick.bsky.social · 29/01/2024

First Bluesky post, and I'm so excited to share our latest work, online today! We found a protein-protein interaction interface on a Pum/Puf protein mediates binding to a specific subset of RNA targets, and in turn affects only one of its functions in stem cells. 1/2 www.cell.com/developmenta...

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