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Soham Mukhopadhyay

@sohambio.bsky.social
182 followers 162 following 34 posts

Plant Pathogen Interaction | Plant Galls | Postdoctoral Fellow & Adjunct Faculty @unm.edu | Associate Editor @MPMI | 🌐 soham.science | Try biosearch.chat

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Reposted by Soham Mukhopadhyay
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 24/09/2026
AlphaFold Database is expanding into pandemic preparedness. Together with NVIDIA, DeepMind, EBI et al. we exhaustively predicted ~1.7 million homo- & heterodimers across 2,812 viral proteomes, resulting in 8,028 high-confidence predictions. 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
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Sadaf Shadan @sshadan.bsky.social · 16/09/2026
Plants use the hormone salicylic acid (SA) to fight infection, but how it activates gene expression remained unclear. Two studies @nature show that the mechanism involves interaction between SA receptor NPR1 and a component of the transcriptional machinery. shorturl.at/7PymL & shorturl.at/Iy4oY
shorturl.at
Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors - Nature
Nature - Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors
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Torii Lab @stomata-tweets.bsky.social · 17/08/2026
New paper! Amphibious plant, H. difformis, reprograms C3 to potential C4 photosynthesis underwater, highlighting its amazing plasticity of carbon assimilation machineries for aquatic environment. Congrats, Hongwei & the team🥳🌿🐸! academic.oup.com/hr/advance-article/doi/10.1093/hr/uhag230/8708086
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Jorge Hernández-García @jorgehg.bsky.social · 13/08/2026
Our latest views on deep ARF evolution are finally out in New Phytologist! nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com
AUXIN RESPONSE FACTORs: from transcription factors to auxin effectors
Molecular evolution of AUXIN RESPONSE FACTOR (ARF) effector function.
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rnett42.bsky.social @rnett42.bsky.social · 10/08/2026
Plants can synthesize mimics of the insect molting hormone 20-hydroxyecdysone (20E) to defend against pests. In this preprint, we discover that two plant families independently evolved biosynthetic gene clusters to make 20E. Amazing team effort by my lab! www.biorxiv.org/content/10.6...
biorxiv.org
Convergent biosynthesis of insect molting hormones in plants
Insect herbivores have driven plants to evolve complex chemical defenses, including mimics of the arthropod molting hormone 20-hydroxyecdysone (20E). Many distantly related plants produce 20E, suggest...
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Soham Mukhopadhyay @sohambio.bsky.social · 28/07/2026
👏🏼👏🏼 this is how it should be done
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Reposted by Soham Mukhopadhyay
bioRxiv Plant Bio @biorxiv-plants.bsky.social · 03/06/2026
The demonstration of a single origin for nodule evolution, with nodule engineering in a non-nodulating species www.biorxiv.org/content/10.64898/20…
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Science Magazine @science.org · 28/05/2026
Researchers have identified superparamagnetic macrophages in the livers of rock pigeons to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation. scim.ag/4nTQ3nq
How animals sense Earth’s magnetic field is one of biology’s enduring mysteries. Researchers have now identified superparamagnetic macrophages in the livers of rock pigeons (Columba livia) to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation.

Photo: Andreas Teichmann/laif/Redux
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Soham Mukhopadhyay @sohambio.bsky.social · 22/05/2026
Excited to see the structurally conserved nucleoside hydrolase like fold that we found (elifesciences.org/articles/105...) to be conserved among biotrophs now being experimentally validated to target EDS1 !! Link to the preprint - www.biorxiv.org/content/10.6...
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Team_Zuccaro @algazuccaro.bsky.social · 20/05/2026
Proud to share our new paper on how prion-like fungal effectors target plastids and modulate host metabolism during root symbiosis. Exciting collaborative work uncovering PEPSI effectors and the interaction of one of them with DXR in plants. www.biorxiv.org/content/10.6... bsky.app/profile/eell...
biorxiv.org
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Mauricio Contreras @mpcontreras.bsky.social · 20/05/2026
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
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Adam Steinbrenner @adsteinbrenner.bsky.social · 13/05/2026
We are excited to release the BAT!🦇🚨 We've used this phylogenetic analysis pipeline in our lab for years, and grad Ben Sheppard now presents a Github release and preprint. I run BAT analyses almost daily. It makes exploring gene families routine, customizable, and fun🧵
pipeline logo
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Dan Kliebenstein @spicybotrytis.bsky.social · 23/04/2026
Hey #MPMI crowd, we are having trouble finding co-proteome papers looking into the host and pathogen proteome at the same time. I know they must exist but can’t find them. Any suggestions?
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Daniel Croll @danielcroll.bsky.social · 03/04/2026
Resequencing hundreds or thousands of individuals from the same species has become routine... but processing all those genomes efficiently? Still a headache! Here's my solution that used to be lab-internal but that I am happy to share: crolllab.github.io/genomepanel_...
crolllab.github.io
Home – genomepanel_nf
Nextflow pipeline for reference genome mapping, SNP calling and quality checks on large genome panels
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Nitzan Tal @nitzantal.bsky.social · 06/03/2026
Very excited to see this work out today! Discovering viral immune antagonists directly from predicted protein structures. 🤩 www.science.org/doi/10.1126/... Huge thanks to the amazing collaborators! 🤗
science.org
Structural modeling reveals phage proteins that manipulate bacterial immune signaling
Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and bioph...
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Jean Greenberg @jeantgreenberg.bsky.social · 05/03/2026
@ismpmi.bsky.social
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Chenxin Li, PhD @chenxinli2.bsky.social · 04/03/2026
Plant weirdness. After injecting agro rhizogenes into the stem of Kalanchoe, they start sprouting roots from stem after few weeks later.
Close up of a Kalanchoe stem where white roots emerging from needle holes Emerged roots are green fluorescent as the agro strain injected carries a green fluorescent marker. Close up of the green fluorescent roots emerging from the stem.
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cornellcovercrops.bsky.social @cornellcovercrops.bsky.social · 28/02/2026
Is the lesson from this that, if ones reasoning is freed from the pull of gravity, one can still publish with MDPI?
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Eva Stukenbrock @estukenbrock.bsky.social · 26/02/2026
@thaisdalsasso.bsky.social is applying new tools to address the evolution and functional diversification of secreted proteins of fungal plant pathogen. Preprint here: www.biorxiv.org/content/10.6...
biorxiv.org
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Katharina Hoff @katharinahoff.bsky.social · 16/02/2026
What we more recently learnt about Tiberius: the models trained on softmasked genomes are very sensitive to how the genome was masked for inference. It seems safer to use models trained on unmasked genomes. #genomeannotation #geneprediction github.com/Gaius-August...
github.com
GitHub - Gaius-Augustus/Tiberius: Tiberius is a deep learning gene finder.
Tiberius is a deep learning gene finder. Contribute to Gaius-Augustus/Tiberius development by creating an account on GitHub.
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Wangsheng Zhu @wangshengzhu.bsky.social · 12/09/2025
Out in @NaturePlants. We discover that the fungal pathogen Fusarium graminearum secretes an apoplastic effector that disrupts the N-glycosylation of a maize immune receptor, thereby inducing its degradation via selective autophagy. Very proud of the team~ doi.org/10.1038/s414...
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Ksenia Krasileva @kseniakrasileva.bsky.social · 23/02/2026
Out in New Phytologist! The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat cv. Kronos 🌾 chromosome-scale genome, high-conf annotations, manually curated 1000+ NLRs, ~3000 remapped datasets 🔗 doi.org/10.1111/nph.... #Plants #Genomics #FunctionalGenomics
doi.org
The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos
Triticum turgidum cv Kronos is a tetraploid wheat cultivar that underpins one of the most widely used community platforms for functional genomics. Over the past decade, researchers have generated c. ...
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Yasin Dagdas @plantophagy.bsky.social · 23/02/2026
the estimated 1 billion biochemical reactions that occur every second in every cell of our bodies 🤯
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The Arabidopsis Information Resource (TAIR) @tairnews.bsky.social · 19/02/2026
🎉📣 #TAIR12, the latest reannotation of the Arabidopsis thaliana genome, is now available under accession number PRJEB100887 on ENA and NCBI! Thank you all the volunteer researchers whose hard work has made this possible! #plantscience #plantbiology 🧪 bit.ly/3ZHtneT
bit.ly
Announcing the publication of TAIR12: Consult the fully reannotated genome on the European Nucleotide Archive - Phoenix Bioinformatics
TAIR (The Arabidopsis Information Resource), together with our nonprofit host Phoenix Bioinformatics, is pleased to announce the public release of TAIR12
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Maddy Seale @maddyseale.bsky.social · 13/02/2026
Out in @science.org this week, two fungal enzymes synthesise DHHA, which controls cell wall porosity and turgor in plant pathogenic fungi www.science.org/doi/10.1126/... #mycology #plantscience
science.org
Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi
Many plant pathogenic fungi penetrate host surfaces mechanically, using turgor pressure generated by specialized infection cells called appressoria. These appressoria develop semipermeable cell walls ...
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Team Thomma @teamthomma.bsky.social · 14/02/2026
📣 Our latest story just dropped on bioRxiv:: A structurally unique effector shared between Verticillium dahliae and Fusarium oxysporum is involved in cotton defoliation and virulence on other hosts www.biorxiv.org/content/10.6... 🧵
biorxiv.org
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Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · 06/02/2026
Thrilled to announce that I am joining the Editorial Board of Molecular Plant–Microbe Interactions as a Senior Editor! 🌱🦠 Grateful for the opportunity to serve this vibrant research community and help amplify impactful science 👏 🔗 apsjournals.apsnet.org/page/mpmi/ed...
apsjournals.apsnet.org
MPMI Editorial Board
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Soham Mukhopadhyay @sohambio.bsky.social · 02/02/2026
😮😮
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John Lovell @jotlovell.bsky.social · 30/01/2026
This article is now published! academic.oup.com/nargab/artic... We’ve added a few new analyses. First off, we show that, while gene presence absence variation (PAV) scales with evolutionary distance in both plants and animals, the base level and rate of accrual are both twice as high in plants.
academic.oup.com
Evolutionary and methodological considerations when interpreting gene presence–absence variation in pangenomes
Abstract. While graph-based pangenomes have become a standard and interoperable foundation for comparisons across multiple reference genomes, integrating p
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Ksenia Krasileva @kseniakrasileva.bsky.social · 31/01/2026
📣 Our lab is seeking a postdoc to study mutation mechanisms in fungi using cutting-edge sequencing + computational biology. No active posting/grant right now, but we’re excited to host postdoc fellowship applicants in our comparative immunology team. Interested? Reach out DM email. krasilevalab.org
krasilevalab.org
Krasileva Lab – Research Lab
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Dan Kliebenstein @spicybotrytis.bsky.social · 15/01/2026
Ever wondered if diverse plant species respond similarly when infected by the same exact pathogen? Infect different asterids and rosids with the same Botrytis genotypes and teh short answer, quite differently. www.biorxiv.org/content/10.6... @annajomu.bsky.social @ccaseys.bsky.social (1/3)
biorxiv.org
A multi-plant transcriptomic atlas reveals conserved and lineage specific defense architectures in response to Botrytis cinerea
Generalist pathogens pose a challenge to plant immunity by infecting diverse hosts while harboring extensive intraspecific genetic variation. Whether evolutionary distant plant lineages rely on a shar...
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Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · 05/01/2026
Although it went online in 2025, here is our second paper of 2026! 🎉 Bravo to @jiaxuwu.bsky.social for leading this (possibly) controversial, but much-needed, analysis. Enjoy! Now out in the January 2026 issue of Trends in Genetics. 🔗 www.cell.com/trends/genet...
cell.com
Déjà vu in clubroot resistance: same genes, new names
Despite decades of clubroot research, only three resistance (R) genes have been validated. However, many of the ‘new’ R genes are, in fact, identical to or allelic with these three. In this forum arti...
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 06/01/2026
Towards a quantitative view of NLR evolution in genome space -- check out where we think the field of #NLR #evolution research is heading in this review led by Luzie Wingen and Aurélien Tellier. ecoevorxiv.org/repository/v... #plantscience
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Nature Plants @natplants.nature.com · 10/12/2025
Comment in @nature.com: "Food will be more affordable — if we double funds for agriculture research now" www.nature.com/articles/d41... A global drop in public and private investment in agricultural science in the past four decades is partly to blame for high food prices, an analysis reveals.
nature.com
Food will be more affordable — if we double funds for agriculture research now
A global drop in public and private investment in agricultural science in the past four decades is partly to blame for high food prices, an analysis reveals.
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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n
quinlanlab.org
Intro to Bedder – The Quinlan Lab
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Andreas P.M. Weber 🌾🌱🧬 @apmweber.bsky.social · 26/11/2025
AI model Helixer predicts eukaryotic genes ab initio, directly from a plain text FASTA file. No RNA-seq. No protein homology. No repeats, hints, or curated evidence. Raw genome → accurate gene models. Deep learning + HMM, published in @natmethods.nature.com www.nature.com/articles/s41...
nature.com
Helixer: ab initio prediction of primary eukaryotic gene models combining deep learning and a hidden Markov model - Nature Methods
By leveraging both deep learning and hidden Markov models, Helixer achieves broad taxonomic coverage for ab initio gene annotation of eukaryotic genomes from fungi, plants, vertebrates and invertebrat...
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Stephen Turner @stephenturner.us · 18/11/2025
gggenomes: A Grammar of Graphics for Comparative Genomics thackl.github.io/gggenomes/ #Rstats
thackl.github.io
A Grammar of Graphics for Comparative Genomics
An extension of ggplot2 for creating complex genomic maps. It builds on the power of ggplot2 and tidyverse adding new ggplot2-style geoms & positions and dplyr-style verbs to manipulate the…
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Nature Biotechnology @natbiotech.nature.com · 14/10/2025
Rewriting the code of plant immunity go.nature.com/475WgV7
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Soham Mukhopadhyay @sohambio.bsky.social · 12/10/2025
Just when you thought plant galls couldn't be of any more shapes! Such cool findings! "Dasineura asteriae Reprograms the Flower Gene Expressions of Vegetative Organs to Create Flower-Like Gall in Aster scaber" onlinelibrary.wiley.com/doi/10.1111/...
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Alex McClelland @alexjmcclelland.bsky.social · 10/10/2025
1/13 Thankfully, both you and your plants have a lot of sophisticated ways to fight off invading pathogens. In our new preprint, we describe a new way in which animals and plants share a common strategy to ward off harmful bacteria. www.biorxiv.org/content/10.1...
biorxiv.org
A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen
Plants secrete a variety of proteases as a defense response during infection by microbial pathogens. However, the relationship between their catalytic activities and antimicrobial functions remains la...
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Maite Saura @maitesaura.bsky.social · 10/09/2025
New preprint! 🐛 Root-knot nematodes hijack root cells, turning them into feeding sites and making plants very sick. Using a cross-species scRNA-seq approach we mapped this process and show how this knowledge can be used to engineer resistant crops.🌱 A summary🧵 : www.biorxiv.org/content/10.1...
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Yasin Dagdas @plantophagy.bsky.social · 04/09/2025
“from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.”
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Zoe Bernasconi @zoebernasconi.bsky.social · 01/09/2025
Check out our new pre-print! ✨ We cloned AvrWTK4, the first wheat powdery mildew effector recognised by a tandem kinase protein, and show that an HMA-like integrated domain in WTK4 acts as pathogen decoy. Discover the whole story on bioRxiv ⬇️
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James Lingford @jameslingford.bsky.social · 02/09/2025
Fantastic review on methodological developments in protein structural phylogenetics academic.oup.com/gbe/article/...
academic.oup.com
Protein Structural Phylogenetics
Abstract. Protein structural phylogenetics is an interdisciplinary branch of molecular evolution that (i) uses 3D structural data to trace evolutionary his
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Soham Mukhopadhyay @sohambio.bsky.social · 01/09/2025
a new clubroot susceptibility gene discovered through GWAS
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Sophien Kamoun @kamounlab.bsky.social · 28/08/2025
First a pentamer, then a hexamer… now an octamer! The riddle of the enigmatic CCG10-NLR immune receptor family cracked open 🔥 Congrats Guanghao @GuanghaoGuo He Zhang @mhz1989 Selva @M__Selvaraj et al. #NLRbiology #plantsci #immunology
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Soham Mukhopadhyay @sohambio.bsky.social · 26/08/2025
Today's going exceptionally well 😅. Our paper describing the screening of Arabidopsis natural accessions against a Canadian clubroot pathotype is out now!
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Soham Mukhopadhyay @sohambio.bsky.social · 26/08/2025
Glad to see this out! We discussed the confusion around the ever-growing list of clubroot resistance genes and what truly qualifies as the novel ones. The clubroot community needs a consistent nomenclature to keep track of the real progress. @jiaxuwu.bsky.social , @edelplopez.bsky.social
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Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · 26/08/2025
Happy to see this out! @jiaxuwu.bsky.social, @sohambio.bsky.social & I tackle the growing confusion in clubroot resistance gene naming. We call for a common nomenclature and a shared database to speed up durable resistance 🧬 🥦 Thank you @cp-trendsgenetics.bsky.social for a great editorial process!
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