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Thaís Dal’Sasso

@thaisdalsasso.bsky.social
164 followers 145 following 11 posts

Computational and systems biology 👩🏻‍💻, adaptive evolution 🧬, plant-microbe interactions 🪴 | Postdoc @envgenlab.bsky.social‬

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Thaís Dal’Sasso @thaisdalsasso.bsky.social · 04/09/2026
Thrilled to share the final version of our manuscript! 🎉 @estukenbrock.bsky.social and I investigated the secretome of the barley pathogen #Zymoseptoria passerinii and asked what its protein structures could tell us about #effector evolution. 🔗 link.springer.com/article/10.1... 🧶👇🏻
link.springer.com
Conserved protein folds underpin the diversification of secreted proteins in a fungal pathogen - BMC Microbiology
Background During host colonization, fungal plant pathogens secrete effector-like proteins that alter host cell physiology and target plant-associated microbes. However, rapid evolution and low sequen...
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PLOS Biology @plosbiology.org · 27/08/2026
How do #antimicrobial peptides embedded within larger #proteins arise? This study by @titas10.bsky.social @biobarber.bsky.social @caitlinkowa.bsky.social &co resurrects ancient antimicrobial proteins, revealing their origins and diversification. 🧪 #AcademicSky #evolution plos.io/3SonQtD
Reconstructing the emergence of antimicrobial function in mammalian lactoferrin.
(A) Structure of the N-terminal lactoferricin region of lactoferrin (PDB: 1lfg), enriched with positively charged amino acids. (B) Phylogenetic tree of reconstructed ancestral lactoferrin homologs (AncTF and AncLF) with extant human transferrin (hTF, PDB: 3qyt), human lactoferrin (hLF, PDB: 1lfg), and bovine lactoferrin (bLF, PDB: 1blf) illustrated with surface electrostatic potentials. Structures of ancestral proteins were predicted using AlphaFold2. AncTF represents the last common ancestor of mammalian transferrin and lactoferrin, after which the first lactoferrin ancestor (AncLF1) arose by gene duplication. AncLF2 is the common ancestor of hLF and bLF, while AncLF3 represents a bLF ancestor.
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Omar Kamileen @omarkamileen.bsky.social · 20/08/2026
www.science.org/doi/10.1126/...
science.org
Genomes of Poaceae relatives reveal key metabolic innovations preceding the evolution of grasses
The grass family (Poaceae) has immense economic and ecological importance and exhibits distinctive metabolic traits, including dual starch and lignin biosynthetic pathways. We sequenced the genomes of...
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FeM - Funghi e Micologia @funghimicologia.bsky.social · 26/07/2026
NOD-like receptor genes undergo diversity-enhancing evolution in a fungal species complex academic.oup.com/gbe/advance-...
academic.oup.com
NOD-like receptor genes undergo diversity-enhancing evolution in a fungal species complex
Abstract. Fungi harbor diverse arrays of genes encoding NOD-like receptors (NLRs), key intracellular immune proteins found in plants, animals, and bacteria
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Gitta Coaker @gittacoaker.bsky.social · 25/07/2026
www.science.org/doi/10.1126/...
science.org
Programmable design of synthetic plant immune receptors for pathogen protein recognition
The limited diversity and recognition scope of natural plant immune receptors impede resistance breeding against rapidly evolving pathogens. Here we report programmable design of synthetic plant immun...
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 09/07/2026
COMPARATIVE GENOMIC ANALYSIS OF CORE AND ACCESSORY GENES IN RUST FUNGI REVEALS PATHOGENICITY-ASSOCIATED GENE FAMILIES IN Phakopsora pachyrhizi www.biorxiv.org/content/10.64898/20…
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New Phytologist @newphyt.bsky.social · 02/07/2026
Gene regulatory networks to decipher tomato multi-pathogen interactions Multari et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
GENIAL framework. Summary of the main steps of the framework to infer and analyze GRN.
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Plant Science Spotlight @plant-sci.bsky.social · 13/06/2026
🌱🧬Pathogens manipulate the apoplast by controlling pH, water & nutrients. Plants fight back with oxidative bursts, toxins & hydrolases. Adapted pathogens disarm these defenses & hide from detection Molecular arms race outside the cell @annualreviews.bsky.social www.annualreviews.org/content/jour...
annualreviews.org
Extracellular Antagonists: Offense and Counter-Defense in the Apoplast
Extracellular interactions are pivotal in the plant–pathogen arms race. Fungal, bacterial, and oomycete pathogens manipulate the apoplast to control pH, water soaking, sugar levels, and nutrient avail...
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Mauricio Contreras @mpcontreras.bsky.social · 04/06/2026
Molecular mimicry of a pathogen virulence target by a plant immune receptor | Science www.science.org/doi/10.1126/...
science.org
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 30/05/2026
Everything you wanted to know about the protein chemistry behind how amino-acid changes affect the cellular abundance of proteins from @tkschulze.bsky.social Effects of residue substitutions on the cellular abundance of proteins doi.org/10.7554/eLif...
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Eva Stukenbrock @estukenbrock.bsky.social · 28/05/2026
Many pathogens that infect wild plants are close relatives of crop pathogens. Important model systems for studying plant diseases. Check out the special issue on wild plant pathosystems published in the Philosophical Transactions B: royalsocietypublishing.org/rstb/issue/3...
royalsocietypublishing.org
Volume 381 Issue 1951 | Philosophical Transactions of the Royal Society B | The Royal Society
Influential themed journal issues across the life sciences.
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MPI for Evolutionary Biology @mpi-evolbio.bsky.social · 27/05/2026
Congratulations to Prof. Eva Stukenbrock on her appointment to the Leopoldina. Her research on fungal pathogens helps us better understand evolution and protect crops. www.evolbio.mpg.de/3882989/eva-... #EvolutionaryBiology #Leopoldina
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Eva Stukenbrock @estukenbrock.bsky.social · 13/04/2026
So diverse and yet conserved. Check out opinion paper by Leonhard Pachinger @leopach.bsky.social on antimicrobial effectors produced by fungal pathogens: www.sciencedirect.com/science/arti...
sciencedirect.com
Antimicrobial effectors of plant-associated fungi: multipurpose proteins with fast-evolving surfaces and structurally conserved cores
Plants are exposed to a variety of devastating pathogens, causing significant yearly yield losses. In order to facilitate infections, plant pathogens …
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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 15/05/2026
Screen 1M random protein sequences to discover that biology-like folds are accessible from random sequences with surprising frequency www.biorxiv.org/content/10.6...
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Riccardo Baroncelli @riccardobaroncelli.bsky.social · 15/05/2026
Thrilled to see this finally out!! Our new work suggests #Starships helped #Colletotrichum acquire the genes needed to infect lupin. A glimpse into how fungal pathogens emerge through horizontal transfer and genome reshaping. biorxiv.org/content/10.6... #Fungi #Genomics #Pathogenicity #evolution
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Mariana Schuster @marischuster.bsky.social · 09/05/2026
A highly recommended read for all plant people :)
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Jana Sperschneider @jsperschneider.bsky.social · 07/05/2026
📢 EffectorGeneP is finally here! Stop missing small, single-exon or orphan genes from your favourite pathogen genome. Current tools only annotate 15%-78% of effector genes, EffectorGeneP finds 95% - including the large AvrSr26 family in stem rust. #Bioinformatics 📖 www.biorxiv.org/content/10.6...
biorxiv.org
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Molecular Biology and Evolution @molbioevol.bsky.social · 25/02/2026
Robbins, Liu & Kelly present RECUR, a method for identifying recurrent amino acid substitutions from multiple sequence alignments that is fast, easy to use, and scalable to thousands of sequences. 🔗 doi.org/10.1093/molbev/msag036 #evobio #molbio #compbio
doi.org
RECUR: identifying recurrent amino acid substitutions from multiple sequence alignments
Abstract. Identifying recurrent changes in biological sequences is important to multiple aspects of biological research—from understanding the molecular ba
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Eva Stukenbrock @estukenbrock.bsky.social · 26/02/2026
@thaisdalsasso.bsky.social is applying new tools to address the evolution and functional diversification of secreted proteins of fungal plant pathogen. Preprint here: www.biorxiv.org/content/10.6...
biorxiv.org
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Thaís Dal’Sasso @thaisdalsasso.bsky.social · 24/02/2026
Happy to have contributed to this! We investigated the #evolution of a virulence-associated gene family across Dothideomycetes, revealing duplication and loss events, including lineage-specific expansions in a crop pathogen. 🧬 #FungalGenomics 👉 DOI: doi.org/10.1007/s002...
doi.org
Evolutionary History and Diversification of M35 Metalloproteases in Dothideomycetes: A Phylogenomic Overview and Case Study in Corynespora cassiicola - Current Microbiology
Deuterolysin metalloproteases (M35s), a family of zinc-dependent proteolytic enzymes, function as key virulence factors in bacteria and fungi. In plant-pathogenic fungi, these proteins induce host cel...
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Thaís Dal’Sasso @thaisdalsasso.bsky.social · 26/01/2026
Congrats @marco-guerreiro.bsky.social. @estukenbrock.bsky.social and colleagues on this exciting study linking codon optimization and adaptive translation to lifestyle transitions in a group of fungi.
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Qiyun Zhu @zhuqiyun.bsky.social · 11/12/2025
The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource
nature.com
Scikit-bio: a fundamental Python library for biological omic data analysis - Nature Methods
Nature Methods - Scikit-bio: a fundamental Python library for biological omic data analysis
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Environmental Genomics Lab @envgenlab.bsky.social · 05/12/2025
Wishing you all happy holidays. 🎄🎁 Greetings from the Environmental Genomics Group. 🇲🇽🇫🇷🇧🇷🇵🇹🇵🇪🇷🇸🇮🇷🇩🇰🇩🇪🤗
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Thaís Dal’Sasso @thaisdalsasso.bsky.social · 05/11/2025
🎉 Our new paper is out! We assembled a telomere-to-telomere genome 🧬 of Sporisorium scitamineum and showed how two smut strains with contrasting virulence deploy distinct early-infection programs on resistant and susceptible sugarcane genotypes. DOI: doi.org/10.1186/s128...
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Thaís Dal’Sasso @thaisdalsasso.bsky.social · 24/09/2025
Had a great time organizing & teaching the MadFungi transcriptomics workshop. We spent three amazing days on RNA-seq for plant–microbe interactions and had great conversations with brilliant MSc/PhD students! 🌱🍄 #RNAseq #PlantMicrobeInteractions #Bioinformatics #PlantPathology
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The Tattooed Professor @schwessinger.bsky.social · 21/09/2025
Important read if you use LLMs for science knowledge discovery around plants "What Large Language Models Know About Plant Molecular Biology" www.biorxiv.org/content/10.1.... As per usual LLMs appear to propagate biases.
biorxiv.org
What Large Language Models Know About Plant Molecular Biology
Large language models (LLMs) are rapidly permeating scientific research, yet their capabilities in plant molecular biology remain largely uncharacterized. Here, we present MoBiPlant, the first compreh...
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Eli Thynne @elithynne.bsky.social · 24/08/2025
Really happy this is out in preprint - Congratulations to @graemekettles.bsky.social @zymohaider.bsky.social, and everyone involved for their hard work completing this study! It examines a Z. tritici effector that is a molecular mimic of plant LRRs, and suppresses PTI www.biorxiv.org/content/10.1...
biorxiv.org
Molecular mimicry of plant cell-surface immune receptors by fungal secreted leucine-rich repeat proteins
Leucine-rich repeat (LRR) receptor-like kinases (LRR-RLKs) are important plant immunity proteins. The wheat pathogen Zymoseptoria tritici produces many virulence effectors during infection; however, m...
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Rodrigo Reis @rodrigoreislab.com · 25/08/2025
Dolly (@dollymehta.bsky.social‬) developed a pipeline to screen for conserved #RNA structures across genomes. She then applied it ~14,000 #plastid genomes and identified nearly 60 conserved structures. doi.org/10.1101/2025...
doi.org
Genome-wide identification of conserved RNA structure in plastids
The systematic discovery of functional RNA structure directly from sequence remains a central challenge in genomics. Plastid genomes, with their deep evolutionary history and extensive data availabili...
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Thaís Dal’Sasso @thaisdalsasso.bsky.social · 20/08/2025
Great talk this afternoon by Joy Bergelson at #ESEB2025! 🌱 She showed how a small number of NLRs in Arabidopsis can recognize P. syringae, and how a protein interaction model can help explain ETI responses.
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Team Thomma @teamthomma.bsky.social · 24/07/2025
📣 Happy to see the journal publication 📄 of our work on Starships 🚀 in Verticillium fungi: terrific work led by @yukiyosato.bsky.social rdcu.be/exBSp
rdcu.be
Starship giant transposons dominate plastic genomic regions in a fungal plant pathogen and drive virulence evolution
Nature Communications - Giant transposons, known as ‘Starships’, mediate horizontal gene transfer between fungal genomes. Here, Sato et al. show that Starships occupy genome regions...
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Genetics Society of America @genetics-gsa.bsky.social · 16/07/2025
In #GENETICS, @3rdreviewer.bsky.social‬ and @smishra677.bsky.social‬ show it is possible to estimate recombination solely using the allele frequency spectrum and provide a genealogical interpretation of the results, showing how #MachineLearning can provide insights into biology. buff.ly/emixz9W
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Dani Stevens, Ph.D. @danimstevens.bsky.social · 16/07/2025
#2025ISMPMI 📣 In silico screening of PRR-epitope interactions is now possible! Here, we developed mamp-ml to predict their immunogenic outcomes without structural context. Let's accelerate engineering plant receptors for robust resistance! 🚀🌱 Small 🧵 www.biorxiv.org/content/10.1...
biorxiv.org
mamp-ml: A deep learning approach to epitope immunogenicity in plants
Eukaryotes detect biomolecules through surface-localized receptors, key signaling components. A subset of receptors survey for pathogens, induce immunity, and restrict pathogen growth. Comparative gen...
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Nature Reviews Microbiology @natrevmicro.nature.com · 30/06/2025
New online! A genomic perspective on fungal diversity and evolution
nature.com
A genomic perspective on fungal diversity and evolution
Nature Reviews Microbiology, Published online: 30 June 2025; doi:10.1038/s41579-025-01195-6In this Review, Mondo and Grigoriev explore the central role of omics approaches to investigate the biology and evolution of fungi and understand phylogeny and how traits evolved over time within the fungal kingdom.
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Thaís Dal’Sasso @thaisdalsasso.bsky.social · 16/05/2025
Admixture’s impact on Brazilian population evolution and health | Science www.science.org/doi/10.1126/...
science.org
Admixture’s impact on Brazilian population evolution and health
Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who...
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Nature Reviews Genetics @natrevgenet.nature.com · 18/04/2025
FYI: New online! Transcriptomics in the era of long-read sequencing
nature.com
Transcriptomics in the era of long-read sequencing
Nature Reviews Genetics, Published online: 28 March 2025; doi:10.1038/s41576-025-00828-zAdvances in long-read sequencing are driving the implementation of these technologies for transcriptome profiling. The authors provide a comprehensive guide to long-read RNA sequencing, including experimental and computational tools, current applications, challenges and opportunities.
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Justin Blumenstiel @bdelloid.bsky.social · 26/04/2025
The rest of Mendel's alleles characterized! So, out of 7 traits, 3 caused by TE insertions!!! (though apparently there are two different green alleles, one cause by a TE insertion, but another a promoter deletion allele) www.nature.com/articles/s41...
nature.com
Genomic and genetic insights into Mendel’s pea genes - Nature
Characterization of the genetic architecture underlying the 7 pairs of contrasting traits studied by Mendel and the over 70 additional agronomic traits in pea (Pisum sativum) reveals their m...
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Stu West @stuwest.bsky.social · 08/01/2025
Comparative genomics needs to use phylogenetic methods: why, how and common questions www.nature.com/articles/s41... @annadewar.bsky.social @lauriebelch.bsky.social
nature.com
A phylogenetic approach to comparative genomics - Nature Reviews Genetics
Controlling for phylogeny is essential in comparative genomics studies, because species, genomes and genes are not independent data points within statistical tests. The authors review the application ...
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