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Katharina Hoff

@katharinahoff.bsky.social
849 followers 1.6K following 363 posts

Genome annotation geek at University of Greifswald, always interested in friendly scientific collaboration. Developer of BRAKER, GALBA, MakeHub and other Gaius-Augustus tools.

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Katharina Hoff @katharinahoff.bsky.social · 18h
I am still very excited about the unsupervised gene prediction approach Vipsania, made by @masta.bsky.social , Richard Krieg & Joscha Diehl. So excited that I made you a little web service. You can now run Vipsania via your web browser. bioinf.uni-greifswald.de/vipsania/
bioinf.uni-greifswald.de
Vipsania Web Server - Unsupervised Ab Initio Gene Prediction
Vipsania - unsupervised ab initio eukaryotic gene prediction web server (pretrained models, no finetuning)
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Katharina Hoff @katharinahoff.bsky.social · 01/10/2026
I needed a fast tool that finds the stop codons used within a eukaryotic metagenomic bin. Here comes Scribonia: github.com/Gaius-August...
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SPP 2349 Gevol @gevol.bsky.social · 29/09/2026
🎓🪲We would like to offer our warmest congratulations to Dr Zoe Länger on successfully completing her PhD. We were delighted to have you as a PhD student in our GEvol Group. We wish you all the best for the future.🐞
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Ulrich Hammes @uhammes.bsky.social · 24/09/2026
We’re looking for a new colleague in Würzburg! 🌱 W3 Professorship in Plant Metabolism 💊 Chair of Pharmaceutical Biology 🧪 Head of the Metabolomics Core Unit jobs.zeit.de/jobs/univers... Please spread the word! Questions? Feel free to contact me. www.biologie.uni-wuerzburg.de/en/about-the...
biologie.uni-wuerzburg.de
W3_Pflanzenmetabolismus - FACULTY OF BIOLOGY
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Gitta Coaker @gittacoaker.bsky.social · 22/09/2026
Assistant Professor position at University of Michigan. Applicants in all areas of cellular/molecular biology in prokaryotes, plants, and animals are encouraged to apply. lsa.umich.edu/mcdb/news-ev...
lsa.umich.edu
MCDB Solicits Applications for an Assistant Professor | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)
The faculty position will be tenure track with a university year appointment starting August 25, 2027 or January 1, 2028. Apply now through October 1, 2026.
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Katharina Hoff @katharinahoff.bsky.social · 22/09/2026
When we worked on the Argiope bruennichi genome, there were those odd sequences. A contamination? No: a symbiont. doi.org/10.1093/fems... thx to @miamynta.bsky.social @uhl-lab.bsky.social and Larissa Busch & everyone else. Great to see it published!
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Theresa Heyd @theresaheyd.bsky.social · 20/09/2026
Es war eigentlich eine ganz normale Arbeitswoche, aber die Erlebnisse, die ich allein in den letzten Tagen mit Men In Academia hatte, könnten mal wieder ein ganzes unterhaltsames Buchkapitel füllen.
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Rob Waterhouse @rmwaterhouse.bsky.social · 17/09/2026
ERGA's COST Action is gathering momentum ahead of the kick-off meeting in Brussels 🟣 CONSENSA: Consensus Standards for Applied Biodiversity Genomics 🔵 Read about it here: www.cost.eu/actions/CA25... 🟢 ERGA members - make sure to apply in order to be eligible for grants, awards, meetings, and more!
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Rob Waterhouse @rmwaterhouse.bsky.social · 17/09/2026
Produced a #genome of a European species? Publishing a Genome Report for the assembly? Benefitted from ERGA @ergabiodiv.bsky.social resources or networking? If so, consider listing the Genome Report in the ERGA Collecion riojournal.com/topical_coll... Learn more: www.youtube.com/watch?v=pO6d...
riojournal.com
The European Reference Genome Atlas (ERGA) Community Genome Reports
The European Reference Genome Atlas (ERGA) is a pan-European initiative that aims to facilitate the generation of high-quality reference genomes for the continent’s biodiversity as part of the g...
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Admirable Women @admirablewomen.bsky.social · 14/09/2026
Biochemist Dr. Ida Stephens Owens mapped how human genes control drug metabolism. The first Black woman to earn a PhD from Duke (1967), she spent ~50 years at NIH. She identified the UGT1A gene complex, decoding how enzymes detoxify drugs & harmful toxins. She was born #OTD in 1939.🧵 #WomenInSTEM
A charming photograph of American biochemist Dr. Ida Stephens Owens (1939–2020), renowned for her groundbreaking research on drug-detoxifying enzymes and human genetics, posing in a laboratory setting. Standing from the waist up, she is turned slightly to the right, looking forward with a warm, confident smile that lights up her face. She has short, curly black hair and wears a delicate gold chain necklace with a small round pendant, and a ring on her finger. She is dressed in a casual, short-sleeved beige knit top. Her forearms rest on a surface in the foreground, with one hand loosely holding a pink folder or pamphlet. Behind her, a brightly illuminated laboratory reveals her research environment, featuring a tall shelf tightly packed with colorful textbooks, alongside structured racks holding assorted glass beakers and scientific equipment. The overall composition balances her approachable, dignified expression with the busy backdrop of her historic, decades-long career at the National Institutes of Health.
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beckybart.bsky.social @beckybart.bsky.social · 10/09/2026
The Department of Plant and Microbial Biology at UC Berkeley currently has two open Assistant Professor positions (aprecruit.berkeley.edu/JPF05382 & aprecruit.berkeley.edu/JPF05522). Interested individuals are welcome to apply to one or both searches.
aprecruit.berkeley.edu
Assistant Professor - Plant Responses to Environmental Changes - Department of Plant and Microbial Biology
University of California, Berkeley is hiring. Apply now!
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Mario Stanke @masta.bsky.social · 10/09/2026
With his program, Vipsania, Richard Krieg has shown, that it is possible to do unsupervised deep gene finding with masked language modeling The trick: use an HMM in the middle of the deep-learning architecture that knows the grammar of gene structures. preprint: www.biorxiv.org/content/10.6...
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Yun S. Song @yun-s-song.bsky.social · 09/09/2026
We are thrilled to share that our GPN-Star manuscript is now published and freely available: doi.org/10.1038/s415... (1/n)
doi.org
Predicting genome-wide functional constraints with GPN-Star - Nature
GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species...
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Theresa Heyd @theresaheyd.bsky.social · 10/09/2026
🎓🎓🎓 Last chance to apply: full professorship in English Literature, Heidelberg University, deadline September 15 🎓🎓🎓
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Boas Pucker @bpucker.bsky.social · 07/09/2026
Andreas Weber is kicking off #BT2026 @ruhr-uni-bochum.de with very important messages about the roles of communities for excellent science @plantsciencedbg.bsky.social
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ERGA - European Reference Genome Atlas @ergabiodiv.bsky.social · 04/09/2026
"Turning today’s genomes into analysis-ready resources requires species-dense sampling anchored in natural history collections" www.nature.com/articles/s41... 💥 Congratulations to ERGA members involved in developing this thoughtful review! #biodiversity #genomics
nature.com
Species-dense genomics through natural history collections - Nature Reviews Genetics
Large-scale genome initiatives are transforming biodiversity genomics, but genomes remain taxonomically sparse and difficult to compare across species. Kapli and colleagues argue that natural history ...
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Rob Waterhouse @rmwaterhouse.bsky.social · 04/09/2026
Sponsorship for 3 students in #genomics, evolutionary biology, ecology, and related fields with ambitions in innovation and entrepreneurship to attend Integrating Scales in Planetary Biology 2026 in Uppsala, Sweden. Deadline: 14 September 2026 docs.google.com/forms/d/e/1F...
docs.google.com
GenomeVault Student Sponsorship · Integrating Scales in Planetary Biology 2026
In collaboration with SciLifeLab, we are sponsoring 3 students in genomics, evolutionary biology, ecology, and related fields with ambitions in innovation and entrepreneurship to attend Integrating Sc...
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Earth BioGenome Project 🌍 @ebpgenome.bsky.social · 02/09/2026
🐦🧬 What does it take to complete the genome of a songbird? The Vertebrate Genomes Project has produced the first complete, fully phased reference genome of the zebra finch (𝘛𝘢𝘦𝘯𝘪𝘰𝘱𝘺𝘨𝘪𝘢 𝘨𝘶𝘵𝘵𝘢𝘵𝘢). Getting there took more than simply generating more sequence. #T2T #VGP #Genomics #GenomeAssembly
A male zebra finch with a bright red-orange beak, orange cheek patch, striped chest, and spotted brown wings. Text asks, “What does it take to complete the genome of a songbird?” and explains that the Vertebrate Genomes Project produced the first truly complete, fully diploid, fully phased reference genome of the zebra finch (Taeniopygia guttata).A male zebra finch standing on rocky ground. Text explains that bird genomes are relatively small, but some of their tiniest chromosomes are difficult to sequence. The complete zebra finch genome revealed 7 macrochromosomes, 21 microchromosomes, and 11 tiny dot chromosomes.
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Ana Conesa @anaconesa.bsky.social · 02/09/2026
🎉 New paper from our lab in Nature Comms! We compare 2 strategies—Join & Call vs Call & Join—across PacBio and ONT data, tissues, and 6 lrRNAseq transcript reconstruction tools. Take away: 👉Join & Call 4 novel isoforms 👉Call & Join 4 2 obtain highly replicated signals. www.nature.com/articles/s41...
nature.com
Handling biological replicates in long-read RNA sequencing data by joining or not joining - Nature Communications
When combining long-read RNA sequencing data from multiple samples, transcripts can be identified either before or after merging. This study shows that neither approach is universally optimal and prov...
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Rob Waterhouse @rmwaterhouse.bsky.social · 02/09/2026
We welcome rigorous implementation papers and case studies focused on cyberinfrastructure, data pipelines, repository architectures, interoperability frameworks, semantic technologies, FAIR-aligned workflows, and reproducible computational environments onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com
Ecology and Evolution Call for Papers: Cyberinfrastructure and Data Management in Ecology and Evolution
Ecology & Evolution is a broad open access journal welcoming research in ecology, evolution, and conservation science, and providing a forum for evidence-based views.
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Katharina Hoff @katharinahoff.bsky.social · 02/09/2026
This talk by @anaconesa.bsky.social was most inspiring. So glad I attended that session.
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Katharina Hoff @katharinahoff.bsky.social · 02/09/2026
Stop by poster G43 today at #ECCB2026 to learn about eukaryotic gene prediction with deep learning and evidence. I will also gladly tell you about the Vipsania genome foundation model developed by Richard Krieg, Joscha Diehl & @masta.bsky.social . Looking for a PhD student from 04/2027!
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European Conference on Computational Biology @eccb-europe.bsky.social · 01/09/2026
This morning we remembered four computational biology pioneers, who the world sadly lost over the past year. Thank you to all speakers for your moving tributes at ECCB. #ECCB2026 #Bioinformatics
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Katharina Hoff @katharinahoff.bsky.social · 31/08/2026
github.com/Gaius-August...
github.com
GitHub - Gaius-Augustus/Vipsania: Unsupervised Deep Gene Finding
Unsupervised Deep Gene Finding. Contribute to Gaius-Augustus/Vipsania development by creating an account on GitHub.
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Katharina Hoff @katharinahoff.bsky.social · 31/08/2026
A revolution in annotating protein coding genes in eukaryotes: Richard Krieg, Joscha Diehl & @masta.bsky.social developed Vipsania, a genome foundation model with integrated HMM-layer: www.biorxiv.org/content/10.6... 🎉💐 So impressive work! Congratulations!
biorxiv.org
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Rob Waterhouse @rmwaterhouse.bsky.social · 30/08/2026
If you did not receive this month's newsletter from the 🄴🅄🅁🄾🄿🄴🄰🄽 🅁🄴🄵🄴🅁🄴🄽🄲🄴 🄶🄴🄽🄾🄼🄴 🄰🅃🄻🄰🅂 community @ergabiodiv.bsky.social then your member registration may have lapsed, register again or reach out to the ERGA secretariat for help www.erga-biodiversity.eu/post/erga-ne... #biodiversity #genomics
erga-biodiversity.eu
ERGA News #40 - August 2026
NewsEnd of Term: Thank You to Our Chair and Vice Chairs!As we approach the end of the current 3-year term, we want to thank our Chair Rob Waterhouse and Vice Chairs, Ann Mc Cartney and Olga Vinnere Pe...
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Rob Waterhouse @rmwaterhouse.bsky.social · 30/08/2026
Produced a #genome of a European species? Publishing a Genome Report for the assembly? Benefitted from ERGA @ergabiodiv.bsky.social resources or networking? If so, consider listing the Genome Report in the ERGA Collecion riojournal.com/topical_coll... Learn more: www.youtube.com/watch?v=pO6d...
riojournal.com
The European Reference Genome Atlas (ERGA) Community Genome Reports
The European Reference Genome Atlas (ERGA) is a pan-European initiative that aims to facilitate the generation of high-quality reference genomes for the continent’s biodiversity as part of the g...
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Rob Waterhouse @rmwaterhouse.bsky.social · 29/08/2026
Presentation at #Quest4Orthologues on DupyliCate from Shakunthala Natarajan, from lab of @bpucker.bsky.social, ERGA Council member for Germany @ergabiodiv.bsky.social
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Rob Waterhouse @rmwaterhouse.bsky.social · 29/08/2026
Great to see both ERGA @ergabiodiv.bsky.social and #arthropods featuring at #Quest4Orthologues in #Lausanne today! #biodiversity #genomics Talk from Odile Lecompte, University of Strasbourg #Myriapoda - only 4 of the publicly available #genomes have annotations at INSDC databases
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Rob Waterhouse @rmwaterhouse.bsky.social · 29/08/2026
#Quest4Orthologues #QfO 2026 kicks off in #Lausanne today - a long tradition & great community #genomes #genes #orthologues #paralogues @unil.bsky.social @sib.swiss
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Rob Waterhouse @rmwaterhouse.bsky.social · 30/08/2026
Day 2 of #Quest4Orthologues @unil.bsky.social with @katharinahoff.bsky.social highlighting the huge proportion of #genomes currently lacking gene annotations @ebpgenome.bsky.social @ergabiodiv.bsky.social
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Dr. Katharine Dickson @metaomicsnerd.bsky.social · 29/08/2026
I was today years old when I learned an astonishing amount of commercial bioinformatics is just respectable open source software wearing an enterprise trenchcoat.
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Katharina Hoff @katharinahoff.bsky.social · 28/08/2026
Off to a new adventure: first, Quest for Orthologs 9 qfo2026.unil.ch, then ECCB eccb2026.org . Exciting!!!
qfo2026.unil.ch
Quest for Orthologs 9
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Janina Rinke @jannelrinke.bsky.social · 02/07/2026
Excited to share that our paper on Horizontal Gene Transfer is now out in its final form in @gigascience.bsky.social! 🥳 By analysing 163 high-quality ant genomes, we show that HGT from bacteria is widespread across the ants and likely has adaptive functions! doi.org/10.1093/giga... 🐜📸: Alex Wild
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Greifswald Mire Centre @greifswaldmoor.bsky.social · 19/08/2026
Es gibt Reis 🍚, Baby! 🎶 ( Helge Schneider) Es gibt Jobs, Baby! (GMC) 💼💚 Noch 7 offene Stellen im Moor- & Klimaschutz 🔬 u.a. zu • Biodiversität • Datenmanagement • Experimentelle Pflanzenökologie • Landschaftsökonomie • Bibliothek & Technik 👇
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 31/07/2026
Pls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342
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Pável Matos @pavelmatosm.bsky.social · 31/07/2026
Please share: Full-time PhD position on Butterfly Evolution at High Elevations 🦋⛰️ The project aims to understand the evolution and adaptation of Andean white butterflies using genomics. DEADLINE: September 11, 2026 More info: pavelmatos.wordpress.com/join-us/
pavelmatos.wordpress.com
Join us
Opportunities Below are the positions currently open in our lab. Open PhD position (full time) Comparative and Population Genomics of Butterflies at High Elevations. The project aims to understand …
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Rebecca R Helm @rebeccarhelm.bsky.social · 29/07/2026
Stalked jellyfish are a super rare group of jellies that don't float, but instead anchor themselves to the seafloor using a special 'foot.' To move, they do cartwheels, holding onto the seafloor using sticky pads between their pompom tentacles. 🧪🌿🌊
Pompom tentacles of a staurozoa, by Wkaela robinson from Wikimedia commons Photo by Minette Layne from wikimedia commons, showing the pompom tentacles up close
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Katharina Hoff @katharinahoff.bsky.social · 27/07/2026
Tiberius predicts genes in eukaryotic genomes via our web service bioinf.uni-greifswald.de/tiberius/ #genomeannotation #geneprediction #eukaryotes
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Thomas Mock @thomasmock.bsky.social · 22/07/2026
W3 Professorship (tenured) @geomarkiel.bsky.social (GEOMAR, Germany) in Marine Experimental Benthic Ecology www.berufungen.uni-kiel.de/de/dateien/o...
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Katharina Hoff @katharinahoff.bsky.social · 23/07/2026
Last course for this summer: finished! A ❤️ for my students! This was possibly the most exhausting semester I ever had - but also with very, very nice students!
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Earth BioGenome Project 🌍 @ebpgenome.bsky.social · 22/07/2026
🎥🧬 Every living thing has a story. Every genome helps us read it. The Catalan Initiative for the Earth BioGenome Project is building high-quality reference genomes for the biodiversity of the Catalan-speaking territories. Cada ésser viu conté una història. Watch the video ⬇️ lnkd.in/gcfWsMDS
English Alt Text:
A great cormorant stands on the ground in a natural habitat, facing left with its long bill extended. The background is softly blurred, while bilingual English and Catalan text overlays introduce the message that every living thing has a story and highlight the Catalan Initiative for the Earth BioGenome Project.

Català (Text alternatiu):
Un corb marí gros dret en un entorn natural, mirant cap a l'esquerra amb el bec llarg estès. El fons és desenfocat i la imatge inclou text superposat en anglès i català que transmet que cada ésser viu té una història i presenta la Iniciativa Catalana per a l'Earth BioGenome Project.Photo 2 (Bearded Vulture)

English Alt Text:
A bearded vulture perches on a rocky outcrop with its wings partially spread, showing its striking black, cream, and rust-colored plumage. Bilingual English and Catalan text explains that every genome tells a story and that every species carries millions of years of evolutionary history in its DNA.

Català (Text alternatiu):
Un trencalòs està posat sobre una roca amb les ales parcialment obertes, mostrant el seu característic plomatge negre, crema i ataronjat. La imatge inclou text en anglès i català que explica que cada genoma explica una història i que cada espècie conserva milions d'anys d'història evolutiva en el seu ADN.
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Gabriel Schaaf @gabrielschaaf.bsky.social · 22/07/2026
Please share! 🌱🤖 Permanent W2 Professorship in crop & plant sciences @ PhenoRob, University of Bonn. Especially encouraged: crop genome engineering, sustainable pest control, or sustainable disease control. Expertise in one area is enough. Apply by Sept. 30, 2026. www.uni-bonn.de/en/universit...
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Kenneth Dumack @dumack.bsky.social · 22/07/2026
New preprint! 🧵 Best #Cercozoa genome alert! For a decade, I’ve studied protist ecology through questions like who eats whom. But beyond “they eat this, they eat that,” what do #protists do to their environment, biochemically speaking? #protistsonsky @huesnaoeztoprak.bsky.social
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Katharina Hoff @katharinahoff.bsky.social · 14/07/2026
I love the many big birds in this area. Listening to an owl right now…
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