TiHo researchers induce cell death in 3D mini-tumors and discover that forcing cancer cells to die can also alert the immune system and enhance anti-tumor attack.

Professor Sjoerd van Wijk und Professorin Maren von Köckritz-Blickwede haben in der vergangenen Woche ihre Antrittsvorlesungen an der #TiHo gehalten. Sjoerd van Wijk wurden auf die Professur für Zellbiologie am Institut für Physiologie und Zellbiologie berufen. Maren von Köckritz-Blickwede nahm den Ruf der TiHo auf die Professur für Biochemie an. Sie leitet künftig das Institut für Biochemie. Herzlich willkommen und vielen Dank für die inspirierenden Vorträge! ❤

In a career defined by constant questioning, self-doubt can become an occupational hazard. Now, for the first time, a group of Cambridge scientists reveal the personal struggles they’ve faced – and co...

Aufgrund von Drohungen hat Frauke Brosius-Gersdorf ihre Mitarbeiter gebeten, nicht am Lehrstuhl zu arbeiten. Einen Verzicht auf ihre Kandidatur schließt sie nicht aus.

Aufgrund von Drohungen hat Frauke Brosius-Gersdorf ihre Mitarbeiter gebeten, nicht am Lehrstuhl zu arbeiten. Einen Verzicht auf ihre Kandidatur schließt sie nicht aus.

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent of auto...

Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

World’s largest public biomedical funder “cancels grant meetings”, while WHO pauses recruitment after US withdraws

The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...

Weidel gegen Wagenknecht reloaded: In der Talkshow von Sandra Maischberger umwarb die AfD-Chefin die CDU, nannte Hitler einen Kommunisten und fühlte sich in der Rolle der Stärkeren pudelwohl.

Researchers facing

Amid a deluge of executive actions, the Trump administration has directed federal health agencies to pause external communications, such as regular scientific reports, updates to websites and health a...

On 20 January, President Trump announced the withdrawal of the United States from the World Health Organization (WHO). President Trump shares many of the same concerns about WHO as previous administra...

USP18 is a multifunctional cysteine protease involved in IFN pathways. Here, the authors report chemical probes and chemoproteomics platforms that allow to detect and perturb USP18 activity in complex...

A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.

In this perspective, the authors showcase the importance and need for additional investigation of the ubiquitin-dependent regulation of neurodevelopment. They then propose interdisciplinary approaches...