CFH is a key mediator of neuronal resilience across the central nervous system in mice and humans.

Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.