iiinova — where your digital self keeps evolving

Parker Denz, PhD

@parkerjdenz.bsky.social

589 followers 199 following 0 posts

PhD in Biomedical Sciences | Ohio State alumni

Posts Replies Media

Reposted by Parker Denz, PhD

Jacob Yount @yountlabosu.bsky.social · 16/04/2025

A minireview from @parkerjdenz.bsky.social just out in @mbio.bsky.social! We explore why studies on IFITM3 SNPs and viral disease severity often conflict. Summary: IFITM3 matters most during infections with emergent viruses, when adaptive immunity is lacking. journals.asm.org/doi/10.1128/...

journals.asm.org

IFITM3 variants point to a critical role in emergent virus infections | mBio

The interferon-induced transmembrane protein (IFITM) family includes five IFITMs in humans (IFITM1, 2, 3, 5, and 10). Each of these displays antiviral activity when overexpressed, but only IFITMs 1, 2...

092

Reposted by Parker Denz, PhD

Jacob Yount @yountlabosu.bsky.social · 29/01/2025

🚨Our new preprint! IFITM3 KO mice accelerated SARS-CoV-2 Beta & Omicron adaptation, preserving human-relevant traits & enabling comparative pathology/transcriptomics in mice. 🫁🦠🧬🥼 With @parkerjdenz.bsky.social, @adforu.bsky.social & team. 🔗 www.biorxiv.org/content/10.1...

Lung sections from mice infected with mouse-adapted SARS-CoV-2 variants stained for viral nucleoprotein. MA10 and beta variants show diffuse staining patterns throughout the lung while omicron infection results in infection that is mostly restrained to the large airways.

0216

Reposted by Parker Denz, PhD

Jacob Yount @yountlabosu.bsky.social · 30/10/2024

🚨🚨 Our latest paper shows that IFITM3 deficiency lowers the minimum virus dose threshold for influenza and also enhances adaptation of the virus to a new species.🦠🫁 Major implications for preventing new pandemics. 😷 Proud of first author Parker Denz!👨‍🔬 www.nature.com/articles/s41...

nature.com

Innate immune control of influenza virus interspecies adaptation via IFITM3 - Nature Communications

This study highlights that IFITM3 deficiency lowers the minimum infectious dose of influenza virus, enhances adaptation of influenza viruses to a new host species, and broadly increases infection of h...

12310