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SFB 1453 NephGen

@sfb1453.bsky.social
111 followers 143 following 25 posts

NephGen brings together scientists who use genetic evidence and innovative transdisciplinary approaches to prevent and treat kidney diseases.

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JCI insight @insight.jci.org · 20/03/2026
Revealing lysine-specific histone demethylase 1a as a new target for kidney diseases Tobias B. Huber & team show LSD1 regulates kidney development, and its dysfunction disrupts key kidney cells, leading to cyst formation in mouse and organoid models: doi.org/10.1172/jci....
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SFB 1453 NephGen @sfb1453.bsky.social · 12/03/2026
Today we are celebrating #WorldKidneyDay20Years 🎉 #WorldKidneyDay
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SFB 1453 NephGen @sfb1453.bsky.social · 03/03/2026
Together with four other Freiburg CRCs, @sfb1453.bsky.social joined the @friasunifreiburg.bsky.social workshop to discuss "What it takes to build and lead successful interdisciplinary research initiatives" If you want to know more check out the great summary by our CRC 1597 colleagues t1p.de/wlkqd
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Reposted by SFB 1453 NephGen
Christophe Wirth @chriswir.bsky.social · 16/01/2026
Happy to share our paper in the frame of the @sfb1453.bsky.social project that got published in @jmolbiol.bsky.social Tremendous work from @emymrikov.bsky.social and others, on how the scaffold protein PDZK1 interacts with the urate transporter URAT1. ⬇️ www.sciencedirect.com/science/arti...
sciencedirect.com
Molecular Determinants of Selective and High-affinity Binding of the Scaffold Protein PDZK1 to the Urate Transporter URAT1
The renal solute carrier URAT1 (SLC22A12) is essential for urate homeostasis, with loss-of-function linked to renal hypouricemia, nephrolithiasis and …
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Reposted by SFB 1453 NephGen
Dr. Peter Walentek (Walentek Lab) @walenteklab.bsky.social · 06/01/2026
Good start for 2026: Our work on mucociliary progenitors and how FOXI1 regulates them as well as ionocyte specification is now out and open access. tinyurl.com/Bowden-Engel... Congrats to all authors and thanks to @dfg.de @cibss.bsky.social @sfb1453.bsky.social @for5547.bsky.social for support!
tinyurl.com
Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms
The transcription factor Foxi1 regulates ionocytes across species and organs and it is associated with several human diseases, but its function in epidermis remains unclear. This study shows that low ...
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SFB 1453 NephGen @sfb1453.bsky.social · 11/12/2025
Congratulations to NephGen PIs Melanie Börries and Sven Diederichs and their groups on their practise changing publication in @natgenet.nature.com 👏👏 #MedSky #OncoSky rdcu.be/eUbf3
rdcu.be
Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations
Nature Genetics - Saturation mutagenesis screening examines 11,520 point mutations in the kinase domains of FGFR1, FGFR2, FGFR3 and FGFR4, identifying their activating and resistance properties to...
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SFB 1453 NephGen @sfb1453.bsky.social · 10/12/2025
NephGen speaker Anna Köttgen attendend the first ERA Science Meeting in November to further improve precision medicine in genetic kidney diseases #NephSky #MedSky See link for more details 👇 www.linkedin.com/posts/europe...
linkedin.com
✨ On November 27–28, the first ERA Science Meeting took place in Barcelona, Spain 🧬 This exclusive, invitation-only event brought together leading experts to shape a roadmap for implementing… | Euro...
✨ On November 27–28, the first ERA Science Meeting took place in Barcelona, Spain 🧬 This exclusive, invitation-only event brought together leading experts to shape a roadmap for implementing precisi...
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SFB 1453 NephGen @sfb1453.bsky.social · 09/12/2025
A new exciting and highly collaborative @sfb1453.bsky.social paper by NephGen groups Börries, Schell, and Kühn in @pnas.org Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS www.pnas.org/doi/10.1073/...
pnas.org
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. Limited treatment options lead to renal failure in ...
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Reposted by SFB 1453 NephGen
Christoph Schell, MD,PhD @nephpath.bsky.social · 30/11/2025
www.science.org/doi/10.1126/...
science.org
Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease
Proteinuria causes ciliary elongation and actin cytoskeleton remodeling, revealing a key mechanism in kidney disease progression.
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SFB 1453 NephGen @sfb1453.bsky.social · 12/11/2025
Pascal Schlosser and Matthias Wuttke, our @sfb1453.bsky.social representation and speakers at this year's #kidneywk
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SFB 1453 NephGen @sfb1453.bsky.social · 06/11/2025
Congratulations to @sfb1453.bsky.social PI Tobias Hermle and his team for their groundbreaking work on slit diaphragm architecture. Go check it out 👇 rdcu.be/eOzXF
rdcu.be
The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture
Nature Communications - The slit diaphragm is a key component of the glomerular filter. This study reveals that the slit diaphragm of Drosophila nephrocytes exhibits a fishnet architecture,...
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Reposted by SFB 1453 NephGen
s-monteiromartins.bsky.social @s-monteiromartins.bsky.social · 28/10/2025
Our study on the genetic determinants of kidney structure is available online in Kidney International as a pre-proof! We used a CNN to derive kidney sub-volumes from MRIs and performed a GWAS to uncover their genetic determinants. Thanks to all involved! #CKD #Imaging #DeepLearning #GWAS
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SFB 1453 NephGen @sfb1453.bsky.social · 27/10/2025
A massive shoutout to our @sfb1453.bsky.social colleague Nora Scherer from Anna Köttgen's group for receiving the @dgfn.bsky.social Rainer-Greger-Award for her outstanding dissertation! Congratulations and so well deserved!!! 🎉👏
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SFB 1453 NephGen @sfb1453.bsky.social · 12/10/2025
We are delighted that our external advisory board member @ksusztak.bsky.social will be receiving this year’s Homer Smith Award at Kidney Week 2025. www.kidneynews.org/view/journal... Congratulations Katalin, so well deserved! 👏👏💐
kidneynews.org
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SFB 1453 NephGen @sfb1453.bsky.social · 07/10/2025
Brilliant presentations by our NephGen PIs Anna Köttgen, Ulla Schultheiss, Michael Köttgen and Sven Diederichs in the @sfb1453.bsky.social session at this year's Annual Meeting of the @dgfn.bsky.social #Nephrologie #dgfn
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Reposted by SFB 1453 NephGen
American Journal of Kidney Diseases @ajkd.bsky.social · 30/08/2025
Association of Serum Afamin Concentrations With Kidney Failure in Patients With CKD: Findings From the German CKD Cohort Study bit.ly/4fWGYES #OpenAccess #VisualAbstract
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SFB 1453 NephGen @sfb1453.bsky.social · 22/08/2025
Super cool project! Maybe it's time for a NephGen comic? 🤔
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SFB 1453 NephGen @sfb1453.bsky.social · 11/07/2025
Thank you to everyone who joined this years' EUKISS Summer School!!! 🎉🙏 It was an amazing meeting with lovely people, impressive science and hopefully many future collaborations and projects. 😍 See you next year in Aachen! #EUKISS25 #EUKISS
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Reposted by SFB 1453 NephGen
Dr. Peter Walentek (Walentek Lab) @walenteklab.bsky.social · 28/05/2025
Huge congratulations to Dr. Magdalena Brislinger-Engelhardt for defending her PhD thesis today 👏👏👏🥳🥳🥳
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SFB 1453 NephGen @sfb1453.bsky.social · 28/05/2025
Registration for this year’s EUKISS summer school in Freiburg, Germany, is now open! Join us in July for two days of discussions around the basis of kidney functions and their relevance for kidney disease! Registration & program ➡️ www.eukiss.org
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Reposted by SFB 1453 NephGen
Oleg Borisov @olegborisovphd.bsky.social · 26/05/2025
🧬 Looking forward to presenting at the #ESHG2025! Our GWAS & EWAS studies of 10,000+ individuals reveal how genetics & epigenetics regulate trace element metabolism. Visit our poster P18.057.D today at 4pm! Huge thanks to @sfb1453.bsky.social, @zkutalik.bsky.social, and all collaborators involved!
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SFB 1453 NephGen @sfb1453.bsky.social · 26/05/2025
Congratulations to the CIBSS team for this outstanding achievement! So well deserved!!! 🎉👏👏
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Reposted by SFB 1453 NephGen
Cristian Pattaro @cpattaro.bsky.social · 24/03/2025
Wondering whether you should read the great kidney disease genetic scorecard paper by @hongbo919.bsky.social @ksusztak.bsky.social on 2.2Mio people? Here 👇 rdcu.be/eejuB Matthias Wuttke at @sfb1453.bsky.social and I report some highlights for you (and recommend reading the original work) #nephgen
rdcu.be
GWAS scorecard prioritizes kidney genes using coding and regulatory variants
Nature Reviews Nephrology - Based on genome-wide association study data from 2.2 million individuals, a functional prioritization scorecard integrates classical omics with allele-specific gene...
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Robert Grosse @ grosselab @grosselab.bsky.social · 06/03/2025
please re-post! we are looking for a PhD candidate: www.uniklinik-freiburg.de/en/career/jo...
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SFB 1453 NephGen @sfb1453.bsky.social · 13/03/2025
Today is #WorldKidneyDay! #MedSky #NephSky #StandUpforScience
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SFB 1453 NephGen @sfb1453.bsky.social · 28/02/2025
#RareDiseaseDay #NephSky #MedSky
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Reposted by SFB 1453 NephGen
Sebastian Preissl @sebpreissl.bsky.social · 25/02/2025
🚨2 fully funded postdoc positions for 6 years 🚨 Are you interested in gene regulation, cardiovascular diseases or aging? Join our team in beautiful Graz, Austria! Postdoc in Bioinformatics 🖥️ tinyurl.com/3ufv767b Postdoc in functional genomics and models (e.g. organoids) 🧪 tinyurl.com/4ucahvzn
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Reposted by SFB 1453 NephGen
Uniklinik Freiburg @uniklinik-fr.bsky.social · 14/02/2025
Freiburger Forschende zeigen, wie seltene „Nonstop-Mutationen“ die Proteinbildung stören und die Entstehung von #Nierenkrebs fördern können. Erkenntnisse bieten Potenzial für bessere Diagnosen und Therapien. Link zur Studie: t1p.de/ytfs3 #Medizin #Forschung
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Reposted by SFB 1453 NephGen
Communications Biology @commsbio.nature.com · 18/02/2025
This study challenges the idea that KDM5D in male cells functions equivalently to the second KDM5C allele in female cells, implicating an interplay between KDM5C mutation and Y chromosome loss in ccRCC development in men. @sfb1453.bsky.social www.nature.com/articles/s42...
nature.com
KDM5C and KDM5D mutations have different consequences in clear cell renal cell carcinoma cells - Communications Biology
This study challenges the idea that KDM5D in male cells functions equivalently to the second KDM5C allele in female cells and implicates an interplay between KDM5C mutation and Y chromosome loss in cc...
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SFB 1453 NephGen @sfb1453.bsky.social · 13/02/2025
Congratulations to @sfb1453.bsky.social PIs Athina Ganner, Elke Neumann-Haefelin, Ian Frew, and Sven Diedierichs and their teams! 👏👏👏 Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation www.science.org/doi/10.1126/...
science.org
Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation
Extending a protein at its end affects its stability, but also its translation efficiency and even selection of its start.
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SFB 1453 NephGen @sfb1453.bsky.social · 11/02/2025
For NephGen every day is International #WomenInScienceDay 🔬👩‍🔬🎉 #WomenInScience #WomenInSTEM #February11
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Reposted by SFB 1453 NephGen
Dr. Peter Walentek (Walentek Lab) @walenteklab.bsky.social · 22/01/2025
Join us for the fantastic annual @cshlnews.bsky.social #Xenopus cell & developmental Biology course. Deadline for application is Jan 31st. meetings.cshl.edu/courses.aspx...
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SFB 1453 NephGen @sfb1453.bsky.social · 10/01/2025
And another brand new publication for @sfb1453.bsky.social: Published by Ian Frew and his group in collaboration with Anna Köttgen, Melanie Börries and Natalie Köhler in @kidneyint.bsky.social 🎉🎉🎉 #NephSky www.kidney-international.org/article/S008...
kidney-international.org
DEFINE_ME
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SFB 1453 NephGen @sfb1453.bsky.social · 02/01/2025
What a nice way to start the new year! Check out our article on the influence of rare #genetic variants on human #metabolism in the current issue of Nature Genetics rdcu.be/d5ov1 Thanks to all collaborators and funders, @dfgpublic.bsky.social
rdcu.be
Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits
Nature Genetics - Gene-based rare variant aggregation study with the levels of 1,294 plasma and 1,396 urine metabolites from paired specimens of 4,737 participants reveals graded effects of rare,...
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SFB 1453 NephGen @sfb1453.bsky.social · 19/12/2024
Our amazing @sfb1453.bsky.social speaker and leading PI of #nakogesundheitsstudie Freiburg Anna Köttgen gave an interview to the #BadischeZeitung 👏 👏 www.badische-zeitung.de/diese-frau-l...
badische-zeitung.de
Diese Frau leitet in Freiburg die bekannteste Gesundheitsstudie Deutschlands
Anna Köttgen ist eine führende Expertin in der Genetischen Epidemiologie und Spezialistin für Nieren- und Stoffwechselerkrankungen. Sie leitet die Nako-Gesundheitsstudie in Freiburg und der Region und...
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Dr. Peter Walentek (Walentek Lab) @walenteklab.bsky.social · 06/12/2024
While we're at it: We are looking for 2 postdocs. One with experience in dev. Biol (pref. With mouse experience) and one with bioinformatics / modeling / multi-omics experience. Exceptional PhD candidates will be also considered for the project via IMPRS @mpi-ie.bsky.social recruitment.
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SFB 1453 NephGen @sfb1453.bsky.social · 17/12/2024
Check out our newest joint publication by @sfb1453.bsky.social PIs Anke Schumann, Christoph Schell @nephpath.bsky.social, Oliver Schilling and Michael Köttgen in #ScientificReports‍ 👩‍🔬👨‍🔬🔬🎉. #NephSky @uniklinik-fr.bsky.social @uni-freiburg.de rdcu.be/d3UXF
rdcu.be
Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias
Scientific Reports - Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias
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SFB 1453 NephGen @sfb1453.bsky.social · 16/12/2024
NephGen follows the blue butterfly now! Looking forward to sharing and discussing all the latest news about nephrology, kidney physiology and pathology, cilia, epidemiology and much more 🥳🧐
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