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Hongbo Liu

@hongbo919.bsky.social
31 followers 43 following 1 posts

Dissecting aging and disease mechanisms | Epigenome, Disease Genetics, Aging, Functional Genome | Asst. Prof. @UR_Med | Alumni @KSusztak Lab @PennMedicine

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Reposted by Hongbo Liu
Cristian Pattaro @cpattaro.bsky.social · 24/03/2025
Wondering whether you should read the great kidney disease genetic scorecard paper by @hongbo919.bsky.social @ksusztak.bsky.social on 2.2Mio people? Here 👇 rdcu.be/eejuB Matthias Wuttke at @sfb1453.bsky.social and I report some highlights for you (and recommend reading the original work) #nephgen
rdcu.be
GWAS scorecard prioritizes kidney genes using coding and regulatory variants
Nature Reviews Nephrology - Based on genome-wide association study data from 2.2 million individuals, a functional prioritization scorecard integrates classical omics with allele-specific gene...
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Reposted by Hongbo Liu
Simone Sanna-Cherchi 🧬 @genetickidneydoc.bsky.social · 09/02/2025
Not only an awesome paper! But it also saves me a long pubmed search to look for something to present at Journal Club this week :) Thank you twice @ksusztak.bsky.social !! In these surreal times, science still shows us a way forward. #Nephsky #Medsky #Genetics #science
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Reposted by Hongbo Liu
University of Rochester School of Medicine and Dentistry @urochestersmd.bsky.social · 13/02/2025
New #URochesterResearch in @science.org unlocks the mysteries of “junk” DNA. Researchers led by @ksusztak.bsky.social of @pennmedicine.bsky.social pooled 32 types of genetic data to link mutations in non-coding (or junk) DNA to their functions. www.science.org/doi/10.1126/...
science.org
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and...
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Reposted by Hongbo Liu
Katalin Susztak @ksusztak.bsky.social · 07/02/2025
🎇Our new paper in @ScienceMagazine : Kidney Multiome-Based Genetic Scorecard Reveals Convergent Coding and Regulatory Variants. @Hongbo919Liu science.org/doi/10.1126/...
science.org
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and...
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