Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. Limited treatment options lead to renal failure in ...

Proteinuria causes ciliary elongation and actin cytoskeleton remodeling, revealing a key mechanism in kidney disease progression.

Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and intercellular communication dynamics a...

Scientific Reports - Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

Angplt4 deficiency in podocytes and renal tubule cells is protective in diabetes.

The role of the focal adhesion protein KANK1 in cancer progression is not yet clearly understood. Here the authors find that KANK1 competes with the polarity protein Scribble at cell-cell junctions fo...