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Séamus Holden 🔬🦠🧫

@seamusholden.bsky.social
2.9K followers 1.3K following 119 posts

Professor of Microbial Biophysics, University of Warwick. Interested in all things bacterial cell envelope, cell biophysics and super-resolution microscopy. holdenlab.github.io

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Reposted by Séamus Holden 🔬🦠🧫
Matthew Freeman @mjafreeman.bsky.social · 5h
I wrote something (as did Mehul Malik) More importantly, @royalsociety.org has just launched a series: a practical guide to starting your PI career royalsociety.org/blog/2026/10...
royalsociety.org
The first member of your team: recruiting a postdoc | Royal Society
Matthew Freeman contributes to the 'Practical advice for an independent research career' essay series.
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Ricardo Henriques @henriqueslab.bsky.social · 14/10/2026
⚙️ Physicists, engineers, computer scientists (066/BI/2026): build a smart microscope that spots infection events live with neural networks, fixes the cell at that moment with NanoJ-Fluidics and images it at about 20 nm. euraxess.ec.europa.eu/jobs/472471
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Ricardo Henriques @henriqueslab.bsky.social · 14/10/2026
🧫 Biologists (065/BI/2026): how do bacteria get into human cells? Study cell entry with a natural model, the midbody remnant, a bacterium-sized particle released at every division, using AI-guided microscopes, and compare it with S. aureus. euraxess.ec.europa.eu/jobs/472468
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Ricardo Henriques @henriqueslab.bsky.social · 14/10/2026
🔬🚀 A head start on your PhD! Two ERC-funded fellowships for Master's graduates at ITQB NOVA, Lisbon: seven months in our lab (Dec 2026 to Jun 2027) to start your research and build a strong 2027 FCT PhD application with us. Apply by 27 Oct 👇 henriqueslab.org/pages/recruitment
Poster split by a diagonal: a fluorescent human cell in cyan and magenta on the left, a laser bench with green, cyan and red light on the right. Start your PhD with us: two fellowships for Master's graduates at ITQB NOVA, 065/BI/2026 (biology) and 066/BI/2026 (engineering). Apply by 27 October.
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 13/10/2026
Cool new super-res imaging tools for bacteria from @michriscopy.bsky.social lab! A simple platform for in situ DNA-PAINT optimization enables improved multiplexed super-resolution imaging in Gram-negative bacteria www.biorxiv.org/content/10.6...
biorxiv.org
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Jean-Yves Tinevez @jytinevez.bsky.social · 05/10/2026
We have a position open in our core facility in the @pasteur.fr . Please share it and / or apply! forum.image.sc/t/research-e...
forum.image.sc
Research engineer in Bioimage Analysis. Institut Pasteur, Image Analysis Hub - 2026
Dear all Below is an announcement for a permanent position as a Research Engineer in the Institut Pasteur, Paris. There is a flyer attached at the bottom. We are looking ideally for a Bioimage An...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 02/10/2026
Considering a PhD in 2027? Applications for Gates Cambridge Scholarships @gatescambridge.bsky.social are now open for October 2027 PhD entry (deadline: 14 October 2026). Learn more about PhD study at the LMB: mrclmb.ac.uk/careers-and-...
mrclmb.ac.uk
PhD Students | MRC Laboratory of Molecular Biology
PhD Students Budding scientists from all over the world undertake postgraduate research at the LMB. Our students are creative and innovative, driving the su ...
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Institut Jacques Monod @ijmonod.bsky.social · 01/10/2026
✍️ The Bonazzi Lab published a new article 📖 @natcomms.nature.com 📃Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up 🔗 www.nature.com/articles/s41...
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Robin Bisson @robinbisson.bsky.social · 30/09/2026
The Labour Party conference didn’t deliver any surprises on R&D, but it was possible to feel which way the wind is blowing I sat down with Emily Darlington MP to talk about it. As an adviser during the New Labour years, both on science and within the Treasury, she had some important insights
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Ákos T Kovács @evolvedbiofilm.bsky.social · 30/09/2026
The phenotypic landscape of the model firmicute Bacillus subtilis PNAS from Carol A. Gross www.pnas.org/doi/10.1073/...
pnas.org
The phenotypic landscape of the model firmicute Bacillus subtilis | PNAS
Firmicutes are gram-positive bacteria with important roles in human health, disease, and industry. However, more than a quarter of genes in the mod...
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Freya Harrison @friendlymicrobe.bsky.social · 30/09/2026
This will be a brilliant post with a super team #MicroSky
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026
Today's winning Biology All email--in fact this is a contender for best this year
Hi all,

We received a package with no name to GSB 2144 with 80 sheep brains in it. If you are expecting this package, please reach out and we can coordinate the pickup!

Best wishes,
Jenna
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Erin Purcell @erinpurcell.bsky.social · 24/09/2026
'We have replaced the danger of mouth-pipetting with the danger of a generation of scientists spending their most productive years writing grants that will not be funded. This is its own form of danger, just slower and less honest than the phenol.' Onion-level satire with a side of 'oooof.'
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Steve Russell @steverus.bsky.social · 24/09/2026
We’re recruiting to an assistant/associate professorship in Pathogen Genetics- come and join us. www.cam.ac.uk/jobs/assista...
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 18/09/2026
Intriguing preprint on effects of cyclic di-AMP on Strep pneumo cell division, looking forward to reading properly www.biorxiv.org/content/10.6... I wonder this is related to effect of ci-di-AMP on turgor #microsky
biorxiv.org
Cyclic di-AMP signalling affects cell division and penicillin susceptibility in Streptococcus pneumoniae
Resistance to β-lactam antibiotics in the human pathogen Streptococcus pneumoniae is mainly attributed to the acquisition of mutated versions of pbp2x , pbp2b and pbp1a , encoding functional penicilli...
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 18/09/2026
Really impressing MINFLUX tracking of molecular motors www.nature.com/articles/s41... #bioimaging
nature.com
Characterizing dynamics of productive dynein stepping by MINFLUX - Nature Structural & Molecular Biology
Slivka et al. track dynein’s microtubule-binding domain with minimal fluorescence photon flux, revealing transient backward ‘dips’ before steps. These dips represent microtubule release upon ATP bindi...
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 18/09/2026
Really neat natural language based microscope control software from @jonasries.bsky.social lab www.biorxiv.org/content/10.6... #bioimaging
biorxiv.org
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Reposted by Séamus Holden 🔬🦠🧫
Charlotte Walker @charlottewalker.bsky.social · 28/10/2023
Someone sent me this meme about peer reviewer comments and it is 👌🏻 #PhDSky #AcademicSky
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Cllr Dr Alex Powell @apowelllaw.bsky.social · 15/09/2026
All eyes on Brighton. These actions are hideous. But they also suggest serious issues at the institution, are we about to see the first institution go bust? Without government action, this decimation of our universities will continue to and accelerate. Where is the Prime Minister?
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James Connolly @ruamicro.bsky.social · 14/09/2026
Are you a motivated researcher interested in bacteria-host interactions? We have postdoc position available in my lab to join our Wellcome Trust funded collaborative team. We will study the role and regulation of the enigmatic sphingolipids in E. coli. Please share. www.jobs.ac.uk/job/DSX115/r...
jobs.ac.uk
Research Assistant/ Associate in Bacteria-Host Interactions at Newcastle University
Explore an exciting academic career as a Research Assistant/ Associate in Bacteria-Host Interactions. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
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Freya Harrison @friendlymicrobe.bsky.social · 03/09/2026
It's taken 12 years and a lot of work from many fantastic people, but we have published an analysis of how our reconstruction of Bald's eyesalve kills bacteria. This was driven by @tosinorababa.bsky.social & Jess Furner-Pardoe through their PhD work #MicroSky journals.asm.org/doi/10.1128/... [1/n]
Jess in the lab, holding an onion and a garlic bulb and talking; Tosin in the lab holding a petri dish and inspecting it; two glass bottles labelled "eyesalve 33/6/14"
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Christophe 🔬 Leterrier @christlet.bsky.social · 02/09/2026
Really cool! Smaller than GFP and reversibly binding last-generation rhodamine dyes. De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles www.cell.com/cell/fulltex... Congrats @bohuang.bsky.social @rhodamine110.bsky.social @mullinslab.bsky.social et al
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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EMBO @embo.org · 24/08/2026
Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027. Deadline: 6 January 2027 meetings.embo.org/event/27-cell-div… #EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪
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Susan Schlimpert @s-lab.bsky.social · 25/08/2026
It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social ! Deadline: Jan 6, 2027. #Bacdiv27
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BWJones @bwjones.bsky.social · 19/08/2026
An excellent thread by @doctorow.pluralistic.net on defining AI simply as a technology that is currently in a massive overhype cycle. But this overhype is doing real damage to our lives, environment, and sense of society. The sooner we contextualize it as another technology, we can regain sanity.
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Dave Baltrus 🦦 @surtlab.bsky.social · 19/08/2026
+1 for my own inherent biased viewpoint actually aligning with data
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 22/07/2026
Jobs: My fantastic membrane biologist colleague Satyajit Mayor (warwick.ac.uk/fac/sci/med/...) has a really exciting single molecule #biophysics PDRA position currently advertised based at @warwickmed.bsky.social warwick-careers.tal.net/vx/lang-en-G...
warwick-careers.tal.net
Research Fellow in Membrane Biophysics (111600-0526) - University of Warwick
Title: Research Fellow in Membrane Biophysics (111600-0526). Application Deadline: . Position Type: Fixed Term
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James Connolly @ruamicro.bsky.social · 10/07/2026
Fantastic opportunity to join a brilliant lab and wider collaborative team!
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Graham Dellaire @docdellaire.bsky.social · 15/06/2026
🔥Kind of a big advance in CryoEM - www.science.org/doi/10.1126/...
science.org
Laser phase plate improves structure determination of small proteins by cryo-EM
Phase plates can in principle overcome the poor image contrast in electron cryo–microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous desi...
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Freya Harrison @friendlymicrobe.bsky.social · 15/06/2026
Hey #MicroSky, can anyone tell me offhand whether Klebsiella pneumoniae ATCC13883 has rough or smooth LPS please? My searches are failing. Thank you :)
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Christophe 🔬 Leterrier @christlet.bsky.social · 15/06/2026
Banker-type hippocampal neuron culture world championship
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 01/06/2026
I don't know sorry. But SunJin lab have been very quick to respond to enquiries, and to send out free samples
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 01/06/2026
We tested a different dimension iSpacer for time lapse imaging of Bacillus subtilis and observed good growth. The only difference of this new product is a more convenient size for 25x25mm coverslips, we will of course test it but I am pretty confident it should work well too.
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 01/06/2026
Update on GeneFrame alternative for bacterial imaging. After discussion with us and others, SunJin lab have how launched a substitute for timelapse imaging in geneframes www.sunjinlab.com/product/ispa... Dimensions are very similar, price is reasonable ($105 for 250) #microsky
sunjinlab.com
iSpacer 0.3mm – SUNJIN LAB
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 21/05/2026
Still some time to apply for this faculty position at Warwick!
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Prof Paula Salgado @pssalgado.bsky.social · 12/05/2026
Just over a week left to apply for this #PhD #studentship on S-layers and #AMR! Please share and if you want to know more, get in touch!
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Exciting Instruments @ei-science.bsky.social · 05/05/2026
🤔 Still wondering how smFRET works in practice - and how it complements your current techniques? Our handbook shows when and why to use it alongside existing methods to add dynamic, single-molecule insight. Download: buff.ly/CxuqL1A #smFRET #biophysics #biochemistry
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Prof Paula Salgado @pssalgado.bsky.social · 29/04/2026
🧫 #AMR #PhD open @newcastleuni.bsky.social! How does #Cdifficile protein "armour" help it resist antimicrobials? Join me and @henrikstrahl.bsky.social to find out using: 🔬 #Structuralbiology, #microbiology #microscopy #genetics 📅 Deadline 20 May 2026 #PhD #PhDLife Pls share! (UK home only)
findaphd.com
C. difficile S-layer’s role in antimicrobial resistance at Newcastle University on FindAPhD.com
PhD Project - C. difficile S-layer’s role in antimicrobial resistance at Newcastle University, listed on FindAPhD.com
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 22/04/2026
Priority areas: - Biomedical microbiology and infectious disease #microsky - Biomedical cellular disease or immunity pathways. - Environmental biology or Environmental microbiology - Plant/crop science including phenomics, plant physiology, genetics/breeding or virology. Deadline: 31 May 2026
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 22/04/2026
There's more - we also have a broad call for 6 Assistant Professors in @warwicklifesci.bsky.social www.nature.com/naturecareer...
nature.com
Assistant Professor x6 - Coventry, West Midlands (GB) job with The University of Warwick | 12858563
The School of Life Sciences (SLS) wishes to appoint six excellent and ambitious early career principal investigators
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 22/04/2026
Relevant areas include but are not limited to Physics of Life (PoL), Engineering Biology, Bioelectricity, Cellular Metabolisms, and Biomanufacturing. #biophysics #syntheticbiology #biotechnology #bioengineering #EngineeringBiology Deadline 31 May 2026
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 22/04/2026
Join us! We are recruiting an Associate/ Assistant Professor in quantitative, systems and engineering biology (QSEB) @warwicklifesci.bsky.social . warwick-careers.tal.net/vx/lang-en-G...
warwick-careers.tal.net
Associate Professor or Assistant Professor in Quantitative, Systems and Engineering Biology (111546-0426) - University of Warwick
Title: Associate Professor or Assistant Professor in Quantitative, Systems and Engineering Biology (111546-0426). Application Deadline: . Position Type: Permanent
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Christophe 🔬 Leterrier @christlet.bsky.social · 22/04/2026
A review on Super-resolution Structured Illumination Microscopy (SIM) to study endocytosis: pubs.acs.org/doi/10.1021/... Featuring our live-cell SIM of proximal axons showing frozen clathrin-coated pits within clearing of the spectrin mesh (doi.org/10.1126/scie...)
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Brian Cook @bcryo.bsky.social · 23/03/2026
1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 23/03/2026
I may also have a withered self portrait in my attic 😄
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 11/03/2026
Neat paper from Schwille lab. They demonstrate constriction of synthetic vesicles using important components of the bacterial cell division machinery, FtsZ and FtsN. They induce strong constriction of Z-rings in vesicles just by adding the cytoplasmic domain of FtsN www.nature.com/articles/s41...
nature.com
Optimizing spatial organization of FtsZ rings for large-scale constriction in synthetic cells - Nature Communications
Spatially regulated membrane constriction is an important milestone in reconstituting minimal cell division. Here the authors engineer a truncated system where the cytosolic domain of FtsN forms large...
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 11/03/2026
3D-MINSTED nanoscopy and protein tracking in densely labelled living cells www.biorxiv.org/content/10.64898/20…
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Ellie Boardman @ellieboardman.bsky.social · 24/02/2026
Come work with us in Oxford! www.jobs.ac.uk/job/DQL601/p...
jobs.ac.uk
Postdoctoral Research Associates in the Molecular Analysis of Bacterial Outer Membrane Biogenesis at University of Oxford
An opportunity for an academic position as a Postdoctoral Research Associates in the Molecular Analysis of Bacterial Outer Membrane Biogenesis is available, as advertised on jobs.ac.uk. Apply now and ...
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