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Sara McArdle

@saramcardle.bsky.social
1.5K followers 644 following 84 posts

Staff Scientist at the La Jolla Institute Microscopy and Histology Facility. I love cat videos and microscopy images and I believe that Matlab is better than Python :)

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Reposted by Sara McArdle
San Diego Zoo Wildlife Alliance @sandiegozoo.bsky.social · 30/09/2026
Just a lil guy and his mulberry branch 🪾
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Reposted by Sara McArdle
Faine Greenwood @faineg.com · 30/09/2026
GOAT OR BIRD????
This is even better than the
"what color is this dress" dress.
Goat?
or Bird?
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Sara McArdle @saramcardle.bsky.social · 10/09/2026
Today is that LAST DAY to register for the Multiplex Image Analysis meeting! Remote and in-person registration is available. See the program and register here: quantitativebioimaging.com/miacp2026/ September 15-16, San Diego, CA.
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Reposted by Sara McArdle
Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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derek guy @dieworkwear.bsky.social · 13/08/2026
I enjoyed this. ordinaryabundance.com
ordinaryabundance.com
Ordinary Abundance
A walk through a modern apartment, through the eyes of the people for whom everything in it was new.
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Sara McArdle @saramcardle.bsky.social · 04/08/2026
If you see this, quote the energy you bring to Bluesky
Tiny kitten hugging a large potato
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Sara McArdle @saramcardle.bsky.social · 29/07/2026
2 more days to submit an abstract to the QBI Multiplexing conference! Come to beautiful San Diego to discuss all things multiplex immunofluorescence. Registration is still open for those who want to attend but not speak.
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Sara McArdle @saramcardle.bsky.social · 24/06/2026
There is still time to register for the QBI Multiplex Image Analysis and Computational Pathology workshop! Details below.
Multiplex immunofluorescence image of a human tonsil. There are 2 germinal centers (red circles with scattered orange and blue cells) on a field of green and purple T cells. There are bright pink elongated macrophages marking the tissue edge.
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Reposted by Sara McArdle
Yasin Dagdas @plantophagy.bsky.social · 23/06/2026
I will arrive at your therapeutic area with a molecule so chiral, so offensive to your multi-parameter optimization algorithm, that your model will flag it as “not drug-like.” It will then proceed to work, in vivo. inpreparation.substack.com/p/go-ahead-a...
inpreparation.substack.com
Go Ahead and Use AI to Design Drugs. It Will Only Help Me Dominate You.
A message of support for my fellow drug hunters
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Joachim Goedhart @joachimgoedhart.bsky.social · 16/06/2026
From Segmentation to Pipelines: AI-Assisted Bioimage Analysis with Python 21-24 September 2026, Erasmus MC Rotterdam (The Netherlands) Application deadline: 25 July 2026 More information & signing up: courses.microscopie.nl?event_id=527
courses.microscopie.nl
NL-BioImaging Advanced Image Analysis for Biologists 2026
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Sara McArdle @saramcardle.bsky.social · 15/06/2026
Announcing a Multiplex Image Analysis and Computational Pathology workshop through the Quantitative BioImaging Society Talks on cell segmentation and phenotyping, data normalization, spatial analysis, and more! Hosted by @lji.org in San Diego, CA, Sept. 15-16 quantitativebioimaging.com/miacp2026/
quantitativebioimaging.com
Multiplex Image Analysis & Computational Pathology - QBI Society
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Alex Wild @alexwild.bsky.social · 09/06/2026
25 minutes of Photuris tremulans fireflies in Tennessee's smoky mountains.
Portrait orientation photograph of a meadow in thick forest viewed over a split rail fence, with a small hut at center. Hundreds of glowing yellow orbs light up the scene.
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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Jan Rosenow @janrosenow.bsky.social · 19/05/2026
The world’s largest sand battery got through Finland’s harshest winter in years. 2,000 tonnes of sand, heated to 500-600°C by cheap power, feeding district heating in Pornainen. And it worked. Result from one install: oil down 100%, emissions down 70%. Industrial process heat is the real prize.
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Meade Krosby @meadekrosby.bsky.social · 12/05/2026
More about the Cowlitz Tribe's beaver relocation program, which is among the largest in the West. "Beavers are amazing ecosystem engineers and create high-quality, complex wetland habitats that support biodiversity and ecosystem properties that can help buffer projected impacts of climate change.”
columbian.com
Check out baby beavers on ‘Kit Cam’ thanks to Cowlitz Indian Tribe
The Cowlitz Indian Tribe recently launched a new livestream featuring a mother beaver and four kits born April 16 as they wait to be relocated.
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Sara McArdle @saramcardle.bsky.social · 01/05/2026
Birdsky! I need advice. This little bird has been sitting unnaturally still near my back door, and didn't even move when my kid excitedly banged on the glass. It's def alive, but I think not healthy? Is there anything I can do to help it?
A brown bird that might be a dove sitting on a mat behind a glass door.
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Sara McArdle @saramcardle.bsky.social · 07/04/2026
I just called my reps with @5calls.org, you should too: 5calls.org
5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
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Reposted by Sara McArdle
Alex Spahn 🌋🌪️☄️ @spahn711.bsky.social · 06/04/2026
Absolutely incredible Nutella ad.
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Brian Northan @truenorth-ia.bsky.social · 22/03/2026
Last week I shared results showing large variability between Imaris/Arivis/Aivia vs Python/ImageJ/CellProfiler. Much was due to small code issues (x/y swaps, microns vs pixels). After fixing, results are much closer—no big log-scale gaps. Some variability remains, but large errors weren’t real.
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Sara McArdle @saramcardle.bsky.social · 11/03/2026
Well this is maddening
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The Washington Post @washingtonpost.com · 07/03/2026
Love is in the air at Edinburgh zoo. Pebbling marks the start of the breeding season for Gentoo penguins. Kids at Edinburgh Children's Hospital Charity painted pebbles for the penguins to choose from and present to their mates.
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Cheshire @thatsregrettab1.bsky.social · 06/03/2026
Cool, useful, project. www.sciencedetective.org/scientific-d...
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Brett "Solidarity 2026" Banditelli @banditelli.org · 07/02/2026
Good morning from the harbor seal factory! We got several working harbor seal families ready to challenge the establishment! Here you can see a mother teaching their baby about the union. Get em started young! #UnionsForAll #SealSky 🦭 🦑
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Sara McArdle @saramcardle.bsky.social · 03/02/2026
Videos are now available from the 2025 QuPath Training Course, from @iamichaelnelson.bsky.social, @zmikulski.bsky.social, and myself. Watch for multiplex tutorials! For image analysis inspiration! Or just watch to hear me speak like an overcaffeinated squirrel! www.youtube.com/playlist?lis...
youtube.com
From Samples to Knowledge 2025: QuPath Training Course - YouTube
Recordings of the 2-day hands-on workshop at the La Jolla Institute for Immunology in February 2025. To follow along please use QuPath 0.6.0 or later.
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Jennifer Waters @jencwaters.bsky.social · 06/01/2026
🔬 🖥️ Applications are open for the CSHL course Quantitative Imaging: From Acquisition to Analysis (April 6–21, 2026)! An intensive, hands-on course covering advanced fluorescence microscopy and quantitative image analysis using open-source tools. 🗓️ Apply online by Jan 30, 2026
meetings.cshl.edu
Quantitative Imaging: From Acquisition to Analysis
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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MDI Biological Laboratory @mdibl.org · 10/12/2025
Quantitative Fluorescence Microscopy 2026: Registration Open! An international course in #fluorescence #microscopy and imaging for advanced grad students, postdoc trainees, imaging core managers and researchers who are incorporating the technology into their laboratories. 🧪 🐟🎸 🍎 👩‍🔬 🌎 🖥️ 🧬
mdibl.org
Quantitative Fluorescence Microscopy 2026
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Dr. Stephanie @punkrockscience.bsky.social · 08/12/2025
Holy CRAP. Retired engineer takes random pics of *kids*, without consent or attribution, bins them into “autistic” or “not autistic”, and uploads that “data” for free on Kaggle. Well over a HUNDRED papers are published, 38 in Springer Nature, 25 in IEEE, using it. And no reviewers objected? WTF.🧪
thetransmitter.org
Springer Nature retracts, removes nearly 40 publications
The dataset contains images of children’s faces downloaded from websites about autism, which sparked concerns at Springer Nature about consent and reliability.
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Taskmaster @taskmaster.tv · 04/12/2025
XXL NEWS! Greg and Alex are coming to America in January 2026 to spread the word of the Taskmaster. Shows in Chicago, Boston, Philadelphia, Washington D.C. and New York! Sign up to the mailing list for pre-sale access. taskmaster.tv/taskmaster-l...
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Sara McArdle @saramcardle.bsky.social · 02/12/2025
Science works
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Erik Angner @erikangner.com · 27/11/2025
"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se
Infographic with AI slop published in Nature Scientific Reports
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Randall Munroe @xkcd.com · 26/11/2025
Fifteen Years xkcd.com/3172/
Comic. Panels up to the 10-year point are grayed out. New panels since the Ten Years comic, which chronicles the first ten years of PERSON 1's journey with cancer: (1) [two people in bed] PERSON 1 (woman): One more chapter? PERSON 2 (man): Don’t we both have to get up early? PERSON 1: Nnnnnggggh PERSON 2: Sure, good point. (2) [many people wearing masks, walking while looking at graphs on their phones] (3) [birds landing on people] PERSON 2 in beanie and scarf: Hah! They like *my* seeds best. PERSON 1 in scarf holding phone with a bird sitting on it: Wait, how do I take a picture of this one? (4) [two people rowing boats with tree landscape] (5) [Person 1 carries overflowing stack of things to Person 2 in bed] PERSON 1: I brought you honey lemon tea, more pillows, a cinnamon roll, Tylenol, another blanket, a– PERSON 2: It was just Appendicitis, I’m really– PERSON 1: *It is my turn to take care of you and I am going to do it right!* (6) [Two people in car] (7) [still in car) PERSON 1: Oh my god. PERSON 2: Oh my god. (8) [car driving] PERSON 1: Pull over! PERSON 2: I am! (9) [both people get out of car] (10) [Large colored panel of aurora borealis over water with both people looking on] (11) [Person 1 sits against tree while Person 2 lies on the ground] PERSON 1: Fifteen years. No sign of the cancer. (12) I *am* having some weird symptoms. Joint pain. Fatigue. I think I’m losing my close-up vision. PERSON 2: Yeah. Me too. (13) PERSON 2: I think we’re getting old. (14) PERSON 1: I guess that’s okay. PERSON 2: It’s all I wanted.
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 20/11/2025
Python notebook from a two year old paper: Oh, no, I cannot run, there is a slight mismatch of a logging library. ImageJ plugin from 2001 running on Quantum Java 51 in 2078: Your 100 petabyte temporal hologram was successfully thresholded.
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Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 13/11/2025
Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)
A fluorescent embryo on black text, with the words 
Halfway to I2K: Virtual Tutorials on Image Analysis
November 17-19, 2025
Virtual Conference for beginners to developers
i2kconference.org
Image Credit - "Sweet Embryo",Travis D. Carney, BINA Image Contest 2024
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Barack Obama @barackobama.bsky.social · 30/10/2025
California – this Election Day, vote yes on Prop 50. California’s Prop 50 says that if Republicans are going to abuse the system to try and hang onto power, we’re going to counteract that abuse and create a level playing field in the midterm elections. Make a plan to vote yes on Prop 50.
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Sara McArdle @saramcardle.bsky.social · 19/10/2025
Took my daughter to one of the San Diego No Kings rallies, because even she knows that you have to stand up and say No to bullies.
A 5 year old girl in a green dress at a protest with approximately 20 other people visible. There were hundreds there in total.
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🦋💔🇺🇸SEB🇺🇸💔🦋 @sebastiangarof5.bsky.social · 10/10/2025
Wouldn’t it be cool if this photo of Obama receiving his Noble Peace Prize went viral today? 🔄
Obama  receiving his Noble Peace Prize
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Sara McArdle @saramcardle.bsky.social · 08/10/2025
I'm thrilled to share that our work studying microglia morphological changes in early Alzheimer's in mice is up! www.biorxiv.org/content/10.1...
biorxiv.org
Unmasking Early Microglial Remodeling in an Alzheimer's Disease Mouse Model
Early neuroimmune remodeling is a critical yet understudied component of Alzheimer's disease (AD) pathogenesis. To investigate microglial contributions to AD development prior to overt plaque depositi...
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Merriam-Webster @merriam-webster.com · 01/10/2025
We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.
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Anna Bower @annabower.bsky.social · 29/09/2025
While I’m at it: You guys know what to do!! youtu.be/jPCJIB1f7jk?...
youtu.be
Lip Sync Battle - Tom Holland
YouTube video by Comedy Central Latinoamérica
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Sara McArdle @saramcardle.bsky.social · 05/09/2025
Happy Fluorescence Friday! Rainbow Z projection of lymph node follicular dendritic cells.
A psychedelic-looking image of what a network of cells (follicular dendritic cells in a lymph node).
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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 04/09/2025
Who say what now?!! BLUEY THE MOVIE?!! #bluey #myChildWillBeTooOldButIllStillGo www.bluey.tv/blog/date-an...
media.tenor.com
two cartoon animals hugging each other with the word seduff on the bottom right
ALT: two cartoon animals hugging each other with the word seduff on the bottom right
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Sara McArdle @saramcardle.bsky.social · 07/08/2025
I got this in my head and I couldn't focus on work until it existed. Microscopy image file alignment chart, based on how I feel if you give me an image to analyze:
D&D style alignment chart for microscopy images.

Lawful good: .ome.tiff
Lawful neutral: .png
Lawful evil: .jpg
Neutral Good: .tiff
Neutral: .pdf
Neutral Evil: .mrxs
Chaotic Good: .h5
Chaotic Neutral: .ppt
Chaortic Evil: .jpg.avi.tiff
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Stefania Marcotti @lankylaste.bsky.social · 06/08/2025
Ready to automate your #microscopy #imageanalysis tasks? Applications are now open for our next "Introduction to Image Analysis" training course, in London at the @crick.ac.uk on October 27th-28th, 2025! 🔬💻 More info ⬇️ www.crick.ac.uk/whats-on/int...
crick.ac.uk
Introduction to image analysis
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Morgan Carter @morgancarterphd.bsky.social · 25/06/2025
It's not just #NIH. It's not just #NSF. It's not just #NASA. The whole scientific community has to make clear that all science across fed agencies is being destroyed in the US. We can't just ask for our particular piece of the pie. The whole pie is being thrown out - saving your bit won't work.
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Ben Collins @bencollins.bsky.social · 11/06/2025
Every flashbang could instead be a meal for a poor kid. Every hotel room for a National Guardsman deployed to fire at our neighbors could house a homeless vet. Every "less-than-lethal" bullet pulled from a journalist's eye could be already needed healthcare for anyone else. All of this is a choice.
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Abby Polter @ampolter.bsky.social · 15/05/2025
It's not that we might lose our jobs. It's that all of it will disappear or mutate beyond recognition. I worry we're not talking or thinking enough about this deeper sadness hiding behind our immediate anxieties and it's this heaviness that has us all at a breaking point.
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Steve Lieber @stevelieberart.bsky.social · 07/05/2025
Cleansing the timeline with video from the Cincinnati Zoo & Botanical Garden.
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BioVoxxel (Jan Brocher) @biovoxxel.de · 23/04/2025
🚀 Tired of manual image analysis or scared of scripting? Our self-paced “ImageJ Macro Scripting for Automatic Image Analysis” course makes automation easy—no coding experience needed! Start from scratch & build pro-level macros. www.biovoxxel.de/individual-w... #ImageJ #MacroScripting
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Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 08/04/2025
Bioimaging and bioimage analysis friends, some help if you have 2-3 mins; for a paper, we're trying to estimate the number of biologists trained in open source software or tools in the last ~5 years. (1/2) #bioimaging #microscopy #bioimageanalysis
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ABC 10News @abc10news.bsky.social · 14/04/2025
WATCH: Elephants at the San Diego Zoo Safari Park react to Monday's 5.2 magnitude earthquake that shook San Diego County. The elephants formed an "alert circle" meant to protect the young and the entire herd from any threats, according to the San Diego Zoo Wildlife Alliance.
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