Reposted by Robert HillMCB Graduate Program at Dartmouth @mcbdartmouth.bsky.social · 10/04/2026🎉 Congratulations to the newly-minted Dr. Alicia Pietramale from the @bobalhill.bsky.social Lab! 🥳 011
Robert Hill @bobalhill.bsky.social · 09/04/2026New work from Maryanne Barasa et al shows that CX3CR1 deletion results in delayed microglial engagement and clearance of dying cortical neurons! 2Phatal continues to help us uncover important cell-cell interactions in vivo. www.biorxiv.org/content/10.6... 0104
Robert Hill @bobalhill.bsky.social · 06/03/2026Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/... 1309
Reposted by Robert HillDartmouth Arts and Sciences @dartmouthartsci.bsky.social · 26/01/2026A #Dartmouth study in Nature Communications reveals that immune cells in the brain use a surprising two-step process to power their search-and-destroy missions: the brain’s emergency responders arrive powered by sugar, then build roads to recruit reinforcements for longer-term damage control.fas.dartmouth.eduBrain Immune Cells Travel Light, Then Call for Backup | Faculty of Arts and SciencesA Dartmouth study shows the brain’s emergency responders arrive powered by sugar, then build roads to recruit reinforcements. 072
Robert Hill @bobalhill.bsky.social · 23/01/2026New preprint from Xhoela Bame et al shows that dying oligodendrocytes stick around for weeks to months without mitochondria! This happens after single cell DNA damage or when mitochondrial Fis1 is deleted in oligodendrocytes. www.biorxiv.org/content/10.6... 092
Robert Hill @bobalhill.bsky.social · 15/12/2025Alicia Pietramale et al. discovered a disconnection between microglial processes that surveil or respond to acute damage and those that contain mitochondria. Cytoskeletal components and metabolic enzymes underlie these differences. Final version just published! www.nature.com/articles/s41... 1173
Reposted by Robert HillSoni Lacefield @lacefieldlab.bsky.social · 27/08/2025My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438 @dartmouthbcb.bsky.social @futurepislack.bsky.socialapply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 16777
Reposted by Robert HillAmanda Amodeo @aaamodeo.bsky.social · 14/08/2025My Department (Biology) at @dartmouthartsci.bsky.social is hiring this year! We have an opening for a Tenure Track Cell and/or Molecular biologist (broadly defined). Please share with your trainees/labmates/friends and reach out if you have questions. apply.interfolio.com/171625apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 15777
Robert Hill @bobalhill.bsky.social · 18/07/2025We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy. www.nature.com/articles/s44... 24311
Reposted by Robert HillKlingenstein Philanthropies @klingensteinorg.bsky.social · 05/06/2025Thank you @antferrui.bsky.social and @bobalhill.bsky.social for presenting their research at the recent Klingenstein Fellowship Awards in Neuroscience Conference. 📷 : SimonProPhoto 042
Reposted by Robert Hilllyons-lab.bsky.social @lyons-lab.bsky.social · 14/05/2025For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...nature.comActivity-driven myelin sheath growth is mediated by mGluR5 - Nature NeuroscienceEmploying pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop... 14722
Robert Hill @bobalhill.bsky.social · 19/03/2025Yasmine Kamen's paper that establishes procaspase-3 as a marker for new oligodendrocytes was officially published and featured in This Week in The Journal. Congrats to Yasmine and co-authors! www.jneurosci.org/content/45/1... 0100
Reposted by Robert HillEthan Hughes @ethanhugheslab.bsky.social · 18/01/2025New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠 www.nature.com/articles/s41...nature.comIncomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature CommunicationsRemyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n... 26026
Reposted by Robert HillEduardo Zimmer @erzimmer.bsky.social · 05/12/2024What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇 www.science.org/doi/full/10....science.orgAstrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivoAstrocytes and microglia have specialized roles and display a coordinated response during corpse removal in the live brain. 1347
Robert Hill @bobalhill.bsky.social · 15/11/2024New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions. www.biorxiv.org/content/10.1... 0235