iiinova — where your digital self keeps evolving

rwsobol @rwsobol.bsky.social · 05/03/2026

5th Anniversary Thematic Collection: Manipulating DNA Repair and the DNA Damage Response to Improve Cancer Therapy url:https://academic.oup.com/narcancer/pages/manipulating-dna-repair @emgsus.bsky.social @weldeiry.bsky.social

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ahellab.bsky.social @ahellab.bsky.social · 10/07/2025

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! www.nature.com/articles/s41... www.science.org/doi/10.1126/...

nature.com

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 09/07/2025

🔔 GP2’s 10th data release is live on the cohort dashboard! It includes a new family file and data discovery report with pairwise kinship estimates, capturing both inferred and reported relationships. 🧪 Learn more: gp2.org/the-components-of-gp2s-10th-data-release/

Blue and green background with white text that reads "GP2 Data Update, Release #10" and a small icon below the text.

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Colin Black @cmblack.bsky.social · 03/07/2025

👇we must resist

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Amarie @humanwolf.bsky.social · 03/06/2025

All of us are in grave danger this year before of this inept fascist takeover

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John Wares @johnwares.bsky.social · 31/05/2025

Remember folks, the budget cuts for NSF and NIH *can still be stopped*. That is a luxury not granted to our agency science colleagues who have or could still lose their jobs from the top down. So - Fight! Speak up! Pay attention!

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Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · 22/05/2025

NSF Physics was cut by 85%, basically wiping out most of its capacity for supporting research. NSF Astronomy was cut by 53% Undergrad education was cut by 71% and research on learning by 79% Graduate education was cut by 100% to ZERO. #GiftLink ⚛️🔭 www.nytimes.com/interactive/...

nytimes.com

Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article)

The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.

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Max Kozlov @maxkozlov.bsky.social · 08/05/2025

A US judge to govt lawyers defending the NIH's grant terminations: "I understand the administration is against DEI. Respectfully, I just don't know what you mean. This isn't a teasing question. There has to be some working definition. This is research to advance healthcare for all our citizens."

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Barbara van Loon @barbaravlb.bsky.social · 28/04/2025

Due to great enthusiasm, we are extending the early bird registration deadline, at a reduced rate, until 25 May. After this date, the rate will increase by 1500NOK (approx. 135USD). We look forward to seeing you in Trondheim! www.endodnadamage.com

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rwsobol @rwsobol.bsky.social · 24/03/2025

Legorreta Cancer Center Newsletter | Spring 2025 createsend.com/t/r-01DBD817...

createsend.com

Cancer Center Newsletter | Spring 2025

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Eric Topol @erictopol.bsky.social · 23/03/2025

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

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Jeremy Berg @jeremymberg.bsky.social · 13/03/2025

Bluetorial: Mentors: The long-serving dean Art Levine was a great leader, first at NIH, and then at the University of Pittsburgh He is a great mentor to me and others and a scientist's scientist (A long palate cleanser for today)

media.tenor.com

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

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🦋❄️🍁Baron🍁❄️🦋 @baron333.bsky.social · 04/03/2025

From Canada 🇨🇦 with love

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Stephanie Kennedy @wordswithsteph.bsky.social · 04/03/2025

“We have to consider the possibility that President Trump is a Russian asset.” Conservative MP Graham Stuart suggested Donald Trump is a Russian asset. Stuart’s comment comes after considering Trump’s betrayal of Ukraine. Trump’s sudden and indefinite suspension of military aid to…

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Fyodor Urnov @urnov.bsky.social · 02/03/2025

Folks, Pubmed is not down - what is down/slow is the DNS that resolves the URL into an IP address (34.107.134.59). On the Mac you need to edit your hosts file to look like this. 1. In Term type: sudo vi /etc/hosts 2. Add the line below 3. Exit vi (see post 2 below) H/t @jstammi.bsky.social‬

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Dan Froomkin/Press Watch/Heads Up News @froomkin.bsky.social · 28/02/2025

Cheers for Washington Post columnist extraordinaire @danamilbank.bsky.social, who writes today that "the single greatest threat to 'personal liberties and free markets' in the United States today" is "President Donald Trump." wapo.st/3DaSKxX (gift link)

wapo.st

Opinion | Here’s the real threat to ‘personal liberties and free markets’

The rapidly spreading authoritarianism coming from this administration threatens all of our freedoms.

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rwsobol @rwsobol.bsky.social · 25/02/2025

For Trump, 3 court losses in 90 minutes - CNN

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Bret Freudenthal @freudlab.bsky.social · 25/02/2025

The 2025/05 NIH Biochemical and Cellular Oncogenesis (BCO) study section meeting that was supposed to happen tomorrow has been rescheduled to a later date, to be determined. Just FYI for folks wondering. This is so disheartening.

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Office of Mayor Michelle Wu 吳弭 @mayorwu.boston.gov · 20/02/2025

The City of Boston is leading 40+ mayors, cities, and counties in an amicus brief against the Trump Administration's drastic and illegal cuts to federal research funding—cuts that will lead to immediate job losses nationwide.

COALITION OF MAYORS ACROSS U.S. FILE AMICUS BRIEF IN OPPOSITION TO TRUMP ADMINISTRATION’S DRASTIC CUTS TO FEDERAL RESEARCH FUNDING
Led by the City of Boston, MA, City of Cleveland, OH, the Metropolitan Government of Nashville and Davidson County, TN, the Mayor of Gainesville, FL, and the Mayor of Salt Lake City, UT, over 40 mayors, cities, and counties argue that NIH cuts will cause job losses, economic disruption, and undermine U.S. competitiveness

BOSTON - Thursday, February 20, 2025 - Late yesterday, Mayor Michelle Wu co-led a coalition of Mayors from across the United States in writing and filing an amicus brief in federal district court in Boston to stop the Trump Administration's drastic and illegal cuts to federal research funding and immediate job losses in cities nationwide. Over 40 mayors, cities, and counties from across the country joined the brief. These cities are home to universities and hospitals that employ hundreds of thousands of Americans in cutting edge medical and scientific research, and the federally-funded research in these communities has made the United States the global leader in scientific discovery. The brief seeks a temporary restraining order against the Trump Administration, alongside the research universities, medical schools, hospitals, and 22 states that are plaintiffs in the three cases filed last week in federal district court.

“For decades, Congress has made a clear choice to use federally-funded research to invest in cities, build a broadly-distributed infrastructure for scientific discovery, create jobs, and drive economic growth in communities across the United States,” said Mayor Michelle Wu. “We join with cities across the country – in red states, purple states, and blue states – to stop this illegal action that will cause layoffs, lab closures, and undermine scientific progress in American cities. I thank Massachusetts Attorney General Andrea Campbell for her leadership on behalf of the research institutions of Boston.”

This amicus brief is in response to the abrupt February 7, 2025 announcement by the National Institutes of Health (NIH) of an immediate reduction in funding for scientific and medical research institutions across the country. Under the NIH’s new policy, which temporarily went into effect on Monday, February 10, payments for indirect costs reimbursed to research universities would be capped at 15%, down from 30-70%. The brief makes clear that NIH funding cuts would devastate research institutions in cities across the county, cause job losses, create severe economic disruption, and undermine a critical pillar of strength and civic pride in cities across the United States. The cuts would also undermine critical medical and scientific research that residents are counting on, including cancer, diabetes, and heart disease, and jeopardize the cities’ and country’s position of global leadership on scientific advancement.
“The Gainesville community depends on this highly efficient, dependable investment of our tax dollars back into our city’s innovation economy,” said Harvey L. Ward, Mayor, City of Gainesville, Florida. “I’m glad to join other mayors in highlighting the vital role NIH funding plays in the lives of everyday hardworking American families.”
“The breadth and diversity of this coalition highlights the devastating and widespread impact of these NIH funding changes, from Alzheimer’s research to cancer clinical trials,” said Jill Habig, Founder and CEO of Public Rights Project. “We’re proud to partner with mayors, cities, and counties in opposing this threat to critical federal funding and the health and vitality of our communities.”
On Monday, February 10th, twenty two states and associations of medical schools, hospitals, and universities, filed three related cases, and secured a temporary restraining order preventing the Trump Administration from slashing the reimbursement rates. That initial order will be revisited this week in a hearing scheduled for Feb. 21.

The Public Rights Project served as amici counsel. The full list of mayors, cities and counties who joined the brief is below.

Local Governments and Mayors

City of Boston, Massachusetts
City of Cleveland, Ohio
Harvey L. Ward, Mayor, City of Gainesville, Florida
Metropolitan Government of Nashville and Davidson County, Tennessee
Erin Mendenhall, Mayor, City of Salt Lake City, Utah
City of Alameda, California
City of Albuquerque, New Mexico
Allegheny County, Pennsylvania
City of Baltimore, Maryland
Emma Mulvaney-Stanak, Mayor, City of Burlington, Vermont
Township of Canton, Michigan
Town of Chapel Hill, North Carolina
City of Chicago, Illinois
Sandra Welch, Mayor, City of Coconut Creek, Florida
City of Columbus, Ohio
City of Easthampton, Massachusetts
Daniel Biss, Mayor, City of Evanston, Illinois
City of Fairfax, Virginia
Harris County, Texas
Ravinder S. Bhalla, Mayor, City of Hoboken, New Jersey
Quinton Lucas, Mayor, Kansas City, Missouri
Indya Kincannon, Mayor, City of Knoxville, Tennessee
City of Madison, Wisconsin
Jeff Silvestrini, Mayor, City of Millcreek, Utah
Anissa Welch, Mayor, City of Milton, Wisconsin
Montgomery County, Maryland
City of New Haven, Connecticut
Dontae Payne, Mayor, City of Olympia, Washington
Adrian O. Mapp, Mayor, City of Plainfield, New Jersey
Sue Noack, Mayor, City of Pleasant Hill, California
City of Pittsburgh and Ed Gainey, Mayor, City of Pittsburgh, Pennsylvania
City of Providence, Rhode Island
John Clark, Mayor, Town of Ridgway, Colorado
City of Rochester, New York
City of Sacramento, California
City and County of San Francisco, California
City of Santa Monica, California
Constantine H. Kutteh, Mayor, City of Statesville, North Carolina
Lisa Brown, Mayor, City of Spokane, Washington
Tishaura O. Jones, Mayor, City of St. Louis, Missouri
City of St. Paul, Minnesota
Dennis R. McBride, Mayor, City of Wauwatosa, Wisconsin

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Stand Up for Science! @standupforscience.net · 21/02/2025

The Trump Administration is maintaining the NIH grant freeze despite lawsuits challenging the order, a Nature article reported today. Science funding in the US is already lagging, leaving researchers in limbo. www.nature.com/articles/d41...

nature.com

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

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