Reposted by Roshni PatelHanbin Lee @epigenci.bsky.social · 07/10/2026We then applied the theory to human demography and deduced a provisional estimate of stabilizing selection in humans accounting for LD. The key machinery is Roshni Patel's conditional frequency spectra. With SDEs, this becomes a PDE scheme. 193
Reposted by Roshni PatelHanbin Lee @epigenci.bsky.social · 06/10/2026Now I turn to an old topic I was ranting in social apps for years. What genomic studies refer to as *narrow-sense* heritability is actually *narrow-narrow-sense* heritability that ignores LD. This is larger than narrow sense h2 under stabilizing selection. 163
Reposted by Roshni PatelHanbin Lee @epigenci.bsky.social · 06/10/2026We studied the evolution of genome-wide linkage disequilibrium and its influence on genetic architecture with genetic drift. We found that the Bulmer effect is population size and demography dependent. For nerds: genetic architecture follows from solving PDEs. 15523
Roshni Patel @roshnipatel.bsky.social · 06/10/2026Would love to hear any feedback, and for more reading on the impact of the 2023 NASEM report, check out our preprint surveying early-career researchers, led by @jayatirsharma.bsky.social and @christacaggiano.bsky.social, from earlier this year: www.biorxiv.org/content/10.6...biorxiv.orgRecommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchersDespite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ... 043
Roshni Patel @roshnipatel.bsky.social · 06/10/2026But, this also illustrates the importance of bottom-up change: decades of work by individual researchers across the field have systematically improved our use of population descriptors in human genetics and genomics. We need to continue to invest in these efforts -- ethics and rigor are intertwined! 143
Roshni Patel @roshnipatel.bsky.social · 06/10/2026To be clear, this is good news! Over the last 20 years, human genetics GWAS have consistently followed all 2023 NASEM guidelines more thoroughly. (One notable exception is community engagement, which remains poor.) 132
Roshni Patel @roshnipatel.bsky.social · 06/10/2026Surprisingly, we also find that improvements in the use of population descriptors far predate the publication of the NASEM report -- suggesting these changes are not the result of any single intervention but rather the cumulative effects of tiny shifts in research practices and community norms 111
Roshni Patel @roshnipatel.bsky.social · 06/10/2026Here, we use the recommendations of the NASEM report as a rubric to evaluate the use of pop descriptors. We find that GWAS on datasets from outside the US or UK, or on non-European populations, tend to score better, suggesting these GWAS systematically use pop descriptors more accurately + ethically 112
Roshni Patel @roshnipatel.bsky.social · 06/10/2026This work was motivated by a deep appreciation for the 2023 NASEM report on population descriptors, which at the time felt like a groundbreaking feat: geneticists, sociologists, anthropologists, & ethicists speaking with one voice on the use of race, ethnicity, and ancestry in genetic studies 112
Roshni Patel @roshnipatel.bsky.social · 06/10/2026So excited about this work with @nasalab.bsky.social! Led by Stephanie Gogarten & with help from @daphmarts.bsky.social, we use LLMs as judges to evaluate the use of population descriptors in the entirety of the GWAS Catalog (~4,000 papers published 2007-2025) www.biorxiv.org/content/10.6...biorxiv.orgLarge language model-based bibliometric evaluation of population descriptors in human geneticsAs the use of population descriptors such as race, ethnicity, and ancestry have become increasingly common in modern genetics research, there have been growing calls to critically examine their use. M... 12211
Reposted by Roshni PatelMaitreya Dunham @maitreya.bsky.social · 24/09/2026Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly. 1107105
Reposted by Roshni PatelStand Up for Science! @standupforscience.net · 18/09/2026We scraped through the data and found that 50% of all clinical trials are at risk of being cancelled. 1,026 cancer trials 273 pediatric trials 115 heart disease trials 184 diabetes trials This is unacceptable and inhumane. 415689
Reposted by Roshni PatelDmitri Petrov @petrovadmitri.bsky.social · 17/09/2026We are searching for an Assistant Professor in Evolutionary Biology! Looking for colleagues asking fundamental questions relating to evolutionary processes and drivers of evolutionary patterns. If you think it is you, please do apply! And please repost. facultypositions.stanford.edu/jobs/assista...facultypositions.stanford.eduAssistant Professor in Evolutionary Biology - Stanford University, California, United StatesThe Department of Biology at Stanford University seeks applicants for a tenure-track Assistant Professor in Evolutionary Biology. A successful candidate will conduct research that asks fundamental que... 5151191
Roshni Patel @roshnipatel.bsky.social · 15/09/2026...though of course in aggregate the effect on allele frequency change can be substantial. does that answer your question? or perhaps I'm misunderstanding? 110
Roshni Patel @roshnipatel.bsky.social · 15/09/2026thanks Hanbin! hmm, are you referencing "weak LD at unlinked variants" on p. 5? I think we meant weak in a pairwise sense; under a polygenic model the LD between any two unlinked variants should be very weak 100
Roshni Patel @roshnipatel.bsky.social · 15/09/2026huge compliment considering the total absence of plants in here :) 120
Reposted by Roshni PatelKevin Bird @stairwaytokevin.bsky.social · 15/09/2026Very cool paper and, although still not as cool as plants, a very exciting time to study human genetics and evolution! 1132
Reposted by Roshni PatelAna Ignatieva @anaignatieva.bsky.social · 14/09/2026We are advertising a 3 year postdoc position for a project on ARGs and structural variation! Based at Oxford stats. Closing date noon 12 October, full details here: my.corehr.com/pls/uoxrecru...my.corehr.comJob Details 02529
Reposted by Roshni PatelYun Deng @yundeng.bsky.social · 14/09/2026I am excited to share that I will be joining the Baker Institute for Animal Health and College of Veterinary Medicine at Cornell University as an Assistant Professor next spring! I am grateful to my mentors and colleagues who have supported me throughout this journey. 25714
Roshni Patel @roshnipatel.bsky.social · 14/09/2026These are of course very old questions with tremendous recent progress; we focus mostly on the recent progress and what it offers for the next era of studying human genetics in biobanks. Excited this preprint is out and we'd of course love to hear any thoughts! 12411
Reposted by Roshni PatelJeff Spence @jeffspence.github.io · 14/09/2026@roshnipatel.bsky.social and I wrote about using biobanks to learn about evolution, and how those findings shape interpretations of association studies. We focused on estimating evolutionary constraint and relating relating selection on variants to selection on traits and include open questions. 15325
Reposted by Roshni PatelPeter Ellis @pjie2.bsky.social · 12/07/2026Let biological sex be multifaceted, as all biology is. And when you need to be precise in scientific research, be precise. Say ‘gametic sex’ or ‘chromosomal sex’ or ‘anatomical sex’, or whatever is appropriate to your own work. 130331
Reposted by Roshni PatelChrista Caggiano @christacaggiano.bsky.social · 09/07/2026Working on this project was so fun! ❤️ It's really awesome to work with so many passionate scientists who are all committed to improving our field (despite a climate that might not always be so friendly to that) We'd love any feedback, especially from other trainees and early career researchers! 022
Roshni Patel @roshnipatel.bsky.social · 07/07/2026And, of course, we'd love to hear what others think, esp any authors of the NASEM report in question! (3/3) 030
Roshni Patel @roshnipatel.bsky.social · 07/07/2026But this has yet to materialize in systematic changes to the way we approach graduate student education - which is why we conclude this piece by offering recommendations for everyone with a role in mentoring trainees, from PIs to dept heads to scientific societies. As a new PI I recommend! (2/) 140
Roshni Patel @roshnipatel.bsky.social · 07/07/2026I think this work really underscores that we are at a turning point in human genetics. There is a growing consensus that doing good research in human genetics requires an expanded skillset (including, e.g., one that can navigate the relationship between genetics, ancestry, and pop descriptors) (1/) 1229
Roshni Patel @roshnipatel.bsky.social · 07/07/2026So excited to see this out! It was an absolute joy and honor to work so closely w @jayatirsharma.bsky.social and @christacaggiano.bsky.social on this - both are terrific examples of the kind of interdisciplinary human genetics researchers that we need more of (and will be on the job market soon 👀) 180
Reposted by Roshni PatelJayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026In what has been a labor of love & joyful collaboration, we are super excited to share our preprint on recommendations towards the ethical and accurate use of population descriptors generated from a survey by trainees, for trainees. www.biorxiv.org/content/10.6...biorxiv.orgRecommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchersDespite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ... 12610
Reposted by Roshni PatelCandy Corn of defiance @drlatigo.bsky.social · 30/06/2026I commented yesterday, there’s still time 002
Reposted by Roshni PatelTami Gjorgjieva @tamigj.bsky.social · 18/05/2026Hi Genetics/Comp-Bio community 👋 Interested in mentoring a comp-bio research student in East Africa over the summer? Do you have any experience in bioinformatics, biostats, genome/RNA-seq analyses, ML, or metagenomics? We'd love to have you as a mentor in our new program! 🧵 (1/n) 12323
Reposted by Roshni PatelKevin Bird @stairwaytokevin.bsky.social · 10/05/2026People have got to wake up to how bad the situation in US science is right now 5319129
Reposted by Roshni PatelMax Kozlov @maxkozlov.bsky.social · 06/05/2026When the NIH abruptly terminated thousands of research grants last year, the fallout wasn’t distributed equitably. A new analysis suggests the cuts disproportionately hit women, BIPOC, and LGBTQ+ investigators. My latest for @nature.comnature.comNIH grant cuts disproportionately hit minority and female scientistsA survey reveals sharp divides in who bore the brunt of last year’s spree of grant cancellations by the Trump administration. 46747
Reposted by Roshni PatelKrystal Tsosie @kstsosie.bsky.social · 17/04/2026DNA is not the same as kinship. Our perspective paper argues that treating genetics as the ultimate proof of identity or family can: • erase community-defined relationships • reinforce Western biases • and even cause real harm in policy + research Special Issue: www.cambridge.org/core/journal... 512044
Reposted by Roshni PatelShoumita Dasgupta, PhD @profdasgupta.bsky.social · 18/03/2026🧪 Pathways for future scientists are becoming scarce, threatening a strong and innovative workforce: “We are not simply shrinking budgets. We are shrinking who gets to imagine themselves in science at all.” @jpflores.rbind.io hechingerreport.org/opinion-path...hechingerreport.orgOPINION: We need to expand research experience for college students to HBCUs, regional public universities and community collegesIf we want a scientific workforce capable of addressing the challenges we face, we must invest in scientists long before they become scientists. That means expanding research opportunities, supporting... 067
Reposted by Roshni PatelJenna Norton @jenna-m-norton.bsky.social · 06/03/2026Current NIH leadership want you to think they are using rigorous, consistent & scientific processes to screen studies to align them with agency priorities. But the process that they have put down on paper is a sham. It’s important to know NIH is not following its own guidance. Here’s why: 🧵1/ 4224131
Reposted by Roshni PatelJenna Norton @jenna-m-norton.bsky.social · 06/03/20267/ In reality, my colleagues still inside NIH tell me that their assessments are largely ignored. Once a grant or application is picked up by the tool, they are almost never able to move the grant forward as is - regardless of the scientific justification. 16525
Reposted by Roshni PatelShai Carmi @shaicarmi.bsky.social · 01/03/2026Great perspective by @philipcball.bsky.social. Elementary genetics teaching (HS/college) focuses on Mendelian traits (single gene => single trait). However, it is now clear that polygenicity and pleiotropy are the norm. Curriculum must change accordingly. www.sciencedirect.com/science/arti...sciencedirect.comShould biology put complexity first?The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing dama… 03315
Reposted by Roshni PatelJazlyn Mooney @jazlynmooney.bsky.social · 26/02/2026Excited that our work was featured on the local (Bay Area) news for their Black History month series. Interview with Noah and clips from my interview with @dornsife.usc.edu and CGSI talk in the article below www.nbcbayarea.com/discover-bla...nbcbayarea.comStanford researchers help trace ancestry for African AmericansA group of Stanford researchers is offering a mathematical model to help link family connections up to 410 years ago. 11310
Reposted by Roshni PatelPrinceton University Press @princetonupress.bsky.social · 26/02/2026Sam Trejo and @daphmarts.bsky.social, authors of What We Inherit: How New Technologies and Old Myths Are Shaping Our Genomic Future, write for @livescience.com about new reproductive technologies and the importance of regulation: 012
Reposted by Roshni PatelRebecca Sear @rebeccasear.bsky.social · 17/02/2026Publications which use "national IQ" data still appearing in Springer Nature journals in 2026. Cool cool doi.org/10.1057/s415...doi.orgBeyond GDP: national intelligence quotient as a catalyst for sustainable socioeconomic welfare - Humanities and Social Sciences CommunicationsHumanities and Social Sciences Communications - Beyond GDP: national intelligence quotient as a catalyst for sustainable socioeconomic welfare 46316
Reposted by Roshni PatelJeffrey Ross-Ibarra @jrossibarra.bsky.social · 09/02/2026Fun news! @gcbias.bsky.social and I are teaching a 2-week online population genetics workshop this summer to raise money for the Center for Population Biology at UC Davis. We're trying to gauge interest -- please fill this out if you might be interested! And please share broadly!docs.google.comDavis Summer Population Genomics ProgramWant to learn population genetics? Please fill out this form to indicate your potential interest in a 2-week intensive online summer population genetics course taught by Jeffrey Ross-Ibarra and Graham... 6140168
Roshni Patel @roshnipatel.bsky.social · 30/01/2026I hear you, and: hope, change, etc is non-linear and multi-faceted. I guarantee that the world looks a little bit different to a whole bunch of first year grad students taking notes on scientific activism (it looks different to me, too). 061
Reposted by Roshni PatelColette Delawalla, PhD @cdelawalla.bsky.social · 30/01/2026Someone on LinkedIn just asked me "why scientists should care and mobilize" right now. But the answer is simple: BECAUSE IT IS THE MORALLY RIGHT THING TO DO. People are being killed in the street, our democracy is being eroded, & we are watching the onset of authoritarianism before our eyes. 1/ 515939
Reposted by Roshni PatelJenna Norton @jenna-m-norton.bsky.social · 29/01/2026To the extent that the fate of NIH and ICE funding may continue to be linked, we as scientists may feel forced to choose between protecting our own funding and the safety and wellbeing of our neighbors. This is a false choice. open.substack.com/pub/sciencea...open.substack.comDemanding a Homeland Security bill that reins in lawlessness is the best path for science–even if it stalls NIH fundingThe Senate voted today on a final funding package that included both the National Institutes of Health (NIH) and Immigration and Customs Enforcement (ICE), among many other agencies and institutions. 1268
Reposted by Roshni PatelJoyce Wang @joyce-yiyi-wang.bsky.social · 26/01/2026Relatedly, some cool recent work from @roshnipatel.bsky.social, Jeffrey Spence, @jkpritch.bsky.social et al. dives deep into expectations, based on models of natural selection, for allele frequency in a group B conditional on allele frequency in group A. academic.oup.com/genetics/art... (16/27) 172
Reposted by Roshni PatelJoyce Wang @joyce-yiyi-wang.bsky.social · 26/01/2026Our work on the generalizability of polygenic scores (PGS) from the @arbelharpak.bsky.social Lab is now officially out! We examine the accuracy of PGS predictions at the individual level. We make 3 observations that expose gaps in our understanding of PGS “portability.” rdcu.be/e0LAr (1/27)rdcu.beThree open questions in polygenic score portabilityNature Communications - Genetic predictors of health outcomes often drop in accuracy when applied to people dissimilar to participants of large genetic studies. Here, the authors investigate the... 34119
Reposted by Roshni PatelMax Kozlov @maxkozlov.bsky.social · 22/01/2026🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year. That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027. A wonky bureaucratic problem with big implications. A short 🧵nature.comExclusive: key NIH review panels due to lose all members by the end of 2026Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members. 2322257
Reposted by Roshni PatelNikhil Milind @nikhilmilind.dev · 06/01/2026How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS. In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time! doi.org/10.64898/202... 1/ndoi.orgHigh false sign rates in transcriptome-wide association studiesTranscriptome-wide association studies (TWAS) are widely used to identify genes involved in complex traits and to infer the direction of gene effects on traits. However, despite their popularity, it r... 26626
Reposted by Roshni PatelSasha Gusev @sashagusevposts.bsky.social · 13/12/2025I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.open.substack.comEmbryo selection company Herasight goes all in on eugenics... 612380