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Alex Palazzo

@ribonucleicacids.bsky.social
909 followers 645 following 291 posts

Professor of Biochemistry at the University of Toronto. Studies mRNA processing, mRNA nuclear export, mRNA translation, genomic evolution, junk DNA, junk RNA. www.palazzolab.com

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Reposted by Alex Palazzo
Plaschka lab @plaschkalab.bsky.social · 08/10/2026
After excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6)
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Matt Olm @mattolm.bsky.social · 07/10/2026
My final postdoc project is out today in Nature! We show microbes co-migrated with humans out of Africa; three independent methods agree, and timing matches archaeological / genetic evidence (Fig. 4c). Seeing Fig. 4c for 1st time was one of my most memorable "eureka" moments! doi.org/10.1038/s415...
doi.org
Prehistoric global migration of vanishing gut microbes with humans - Nature
Microbial species disappearing from industrialized populations have evolved with humans over millennia and migrated worldwide with them—this may have consequences for human health.
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Alex Palazzo @ribonucleicacids.bsky.social · 06/10/2026
I think this is the key point that "critics" are missing. The helical nature of DNA is not what makes the structure important. It's base pairing. Without info from Donohue, Franklin (and W&C) would have never figured out the base-pairing problem.
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Reposted by Alex Palazzo
Matthew Cobb @matthewcobb.bsky.social · 06/10/2026
They succeeded partly by luck (e.g.unlike Franklin they were told which were the correct form of the bases – had she tried to find base pairing she would have failed) and because they had each other to argue with. Franklin was on her own; that she made such progress is a mark of her ability.
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Alex Palazzo @ribonucleicacids.bsky.social · 05/10/2026
The main importance of the DNA structure was not that it was a helix, but rather that the strands are held together by base-pairing. Franklin would have struggled to get this as the structures of each base in the textbooks (at the time) were wrong. Watson & Crick were told this by Jerry Donohue.
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Reposted by Alex Palazzo
Dr. Sarah Parcak @indyfromspace.bsky.social · 05/10/2026
I was so excited to contribute to this. with so many wonderful friends and colleagues. My ?, at #99 "Is humanity doomed by our nature to inequality and war?" www.nytimes.com/2026/10/05/s...
nytimes.com
What Are the Biggest Questions in Science Today? 100 Scientists Weigh In.
We asked 100 scientists about unsolved problems in their fields. They sent back provocations — on the origins of life, the possibilities for human progress and much more.
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Alex Palazzo @ribonucleicacids.bsky.social · 05/10/2026
A great example how curiosity-driven research drives innovation.
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Reposted by Alex Palazzo
Carl T. Bergstrom @carlbergstrom.com · 03/10/2026
I have absolutely wondered about this. Amazing.
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Paul Byrne @theplanetaryguy.com · 02/10/2026
This will never stop blowing my mind. A 12-year sequence of real telescope images of a star 133 lightyears away. And around it, four planets slowly orbiting. Four real exoplanets, each more massive than Jupiter, imaged as they move around their host star.
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Jennifer Ouellette @jenlucpiquant.bsky.social · 01/10/2026
Tiny image sparks big backlash in Nikon photo contest. Dr Ning Xu denies he broke the rules of Nikon's annual Small World In Motion contest. www.bbc.co.uk/news/article...
bbc.co.uk
Tiny image sparks big backlash in Nikon photo contest
Dr Ning Xu denies he broke the rules of Nikon's annual Small World In Motion contest.
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Alex Palazzo @ribonucleicacids.bsky.social · 29/09/2026
When 1/3 of the population worships a golden calf, that is to be expected.
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Reposted by Alex Palazzo
Will Ratcliff @wcratcliff.bsky.social · 28/09/2026
New paper out with @kaylastoy.bsky.social: academic.oup.com/evlett/advan...
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Epigenetics Podcast @epigeneticspod.bsky.social · 28/09/2026
In the most recent episode we speak with @robklose.bsky.social, Professor of Genetics at the University of Oxford, about how CpG islands help control gene expression and chromatin regulation during development. #podcast #epigenetics Listen here: activemotif.com/podcasts-rob...
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Reposted by Alex Palazzo
Carl Zimmer @carlzimmer.com · 27/09/2026
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
nyti.ms
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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Alex Palazzo @ribonucleicacids.bsky.social · 25/09/2026
Great thread. Mosquitos, plasmodium, isoleucine and globin genes.
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Reposted by Alex Palazzo
Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Ricard Solé @ricardsole.bsky.social · 24/09/2026
What if the origin of life was not a single transition, but a cascade of them? This paper by J. Aguirre & co offers a systems view of how complexity may have emerged across chemical, informational & ecological levels. @manlius.bsky.social @brionesci.bsky.social www.sciencedirect.com/science/arti...
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Alex Palazzo @ribonucleicacids.bsky.social · 24/09/2026
You gotta love this guy!
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Reposted by Alex Palazzo
Joachim Goedhart @joachimgoedhart.bsky.social · 24/09/2026
Thanks for sharing this version, to me the most stunning part is the region where the cilia seem to appear (out of nowhere?)
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Reposted by Alex Palazzo
Simon Cleary @simoncleary.bsky.social · 24/09/2026
Even if it were ok to add AI-generated details in the lower half of the movie, what we are now told is a section of one ciliated cell is way too wide to be based on real images of one cell.
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Reposted by Alex Palazzo
Nature @nature.com · 23/09/2026
Nature research paper: The gene-regulatory evolution of the human skeleton go.nature.com/46GUxG8
go.nature.com
The gene-regulatory evolution of the human skeleton - Nature
Massively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements (CREs), revealing how differences in CREs have shaped the composition of human skeletal tissue.
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Reposted by Alex Palazzo
Maksim Kalutskii @maksimkalutskii.bsky.social · 23/09/2026
Excited to share our new preprint! 📜 Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end. Spoiler: IDRs 🧵 1/n www.biorxiv.org/content/10.6...
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Christophe 🔬 Leterrier @christlet.bsky.social · 22/09/2026
This is the updated part. Looks like the movie is an AI-generated fluorescence image from a non-labeled acquisition technique. No indication that the Small World jury and organizers have requested and verified the raw data (as mentioned as a possibility in the competition rules)
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 22/09/2026
Nikon's response to me on Linked in: "We’ve updated our detailed article with insights from the winner, which may answer some of your questions. We encourage you to check out the link to dive deeper into the technical details" 1/n www.nikonsmallworld.com/masters-of-m...
nikonsmallworld.com
Ning Xu: Studying Disease through Motion
Updated: September 22, 2026Welcome to Masters of Microscopy: The People Behind the Lens, where we showcase and celebrate the individuals at the heart of the Nikon Small World competitions. They are sc...
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Alex Palazzo @ribonucleicacids.bsky.social · 22/09/2026
I'm looking for someone with a ".edu" email to access a database for us. Apparently, our Canadian university email addresses (which end with a ".ca") triggers an automatic flag stating "this is not an educational email". We emailed the database, but have not received a response.
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Alex Palazzo @ribonucleicacids.bsky.social · 21/09/2026
We've used Bindcraft1 with great success. Looking forward to this update.
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Reposted by Alex Palazzo
Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
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James Talarico @jamestalarico.bsky.social · 11/09/2026
This is the interview Trump’s FCC doesn’t want you to see. We’re not just going up against the most corrupt politician in Texas. We’re going up against this entire corrupt system.
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Florian Mayer @florianmayer.bsky.social · 11/09/2026
Excited to share our preprint on Ignicoccus cell divison: only the inner membrane divides, progeny cells accumulate in cell clusters and pop-out! www.biorxiv.org/content/10.6... Great work with the labs: @buzzbaum.bsky.social @curiousdina.bsky.social @anja1.bsky.social @tbharat-lab.bsky.social
biorxiv.org
The life cycle of an archaeon with multiple membranes
Many prokaryotes are diderms. They divide using an FtsZ division ring to simultaneously constrict physically coupled inner and outer membranes to form daughter cells with two membranes. Currently, onl...
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Reposted by Alex Palazzo
Philippe Batut @philippebatut.bsky.social · 10/09/2026
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇
science.org
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...
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Reposted by Alex Palazzo
Anton Goloborodko @golobor.bsky.social · 03/09/2026
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
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mareikejordan.bsky.social @mareikejordan.bsky.social · 04/09/2026
Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social www.biorxiv.org/content/10.6...
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Gary Stevenson @garyseconomics.bsky.social · 04/09/2026
Why governments are poorer now
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Molecular Cell @cp-molcell.bsky.social · 03/09/2026
A conserved mechanism of membrane fusion in nuclear pore complex assembly
dlvr.it
A conserved mechanism of membrane fusion in nuclear pore complex assembly
Fischer et al. uncover a fundamental mechanism of membrane fusion during nuclear pore complex (NPC) assembly. Brl1 and Brr6 form ring-shaped, membrane-remodeling complexes that interact and bridge the nuclear envelope at NPC-assembly sites to mediate fusion. This pathway is conserved in humans via the metazoan fusogen CLCC1.
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
That's it. A huge thanks to co-author Tina Yi Qiu. And a shout out to the "TE ecology community" who heard early versions of this perspective in a couple of talks that I gave to them in the past year. Paper link (open access): febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Big picture: complexity in eukaryotes may be less a triumph of selection than a side effect of weak selection + tolerated mess. We even see it in real time in the rewiring of XIST regulation across primates. 🐒 12/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
The secret ingredient? Buffering e.g., chaperones, RNA QC, & the nucleus, which prevents junk RNA from reaching ribosomes. Just like trash collection, these QC systems soak up the cost of messiness, letting genomes TOLERATE tons of junk — the raw material for tomorrow's new parts. 11/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Model 3: Spandrels. Some junk is a byproduct of something useful (like unstable ncRNAs made just because a nearby gene promoter is firing). Selection maintains the useful thing, which keeps the byproduct around long enough to maybe, eventually, become useful itself. Free real estate. 🏗️ 10/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Model 2: Constructive Neutral Evolution. No positive selection needed! Junk accidentally overlaps an existing function → the original decays → now you're STUCK depending on the junk. Complexity with zero fitness benefit. It's less "survival of the fittest," more "survival of the entangled." 🪢 9/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Model 1: the classic. Junk DNA gets a lucky mutation, becomes useful, selection keeps it. Real, but RARE under weak selection. Bottom line: the benefit has to be big to beat the drift barrier and be sensed by selection. 8/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
To keep our reasoning honest, we borrow the logic of Markov chains: picture each stage from junk → function as a "state," with transitions between them. The rule: where you go next depends only on where you are NOW, not where you might end up. No cheating with the future. ⛓️ 7/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Importantly, activity ≠ function. ENCODE, we're looking at you. 👀 6/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Others who have tried to answer this problem commit three main errors : 1) Invoking selection for a function that doesn't yet exist 2) Assuming that a part's function explains why it appeared 3) Assuming that because a sequence DOES something biochemically, that's WHY it's there 5/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Our answer: most new parts don't arise BECAUSE they're useful. They arise as junk, drift around, and only later get roped into doing something. Selection has no foresight. It cannot reward a function that doesn't exist yet. 4/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Here's the paradox. Eukaryotes are complex, yet we evolve under WEAK selection (small population sizes = selection is inefficient). Natural selection is supposed to build complexity. So how do genomes that selection can barely police end up with the most parts? 🤔 3/n
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Where do new functional parts in eukaryotic genomes actually come from? The textbook answer is "natural selection." But for eukaryotes like us, that answer is mostly wrong.
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
Earlier in the week, our perspective (actually labelled an "Innovational Perspective") came out in FEBS Letters. At the time I had no time to piece together a thread, but I have some time today so here we go ... 1/n
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Max Planck Institute of Biochemistry @mpibiochem.bsky.social · 02/09/2026
Ten years ago, our director, Stefan Jentsch, passed away. A memorial symposium will be held in his honour on October 23. Many of his former colleagues and friends will be in attendance. Would you like to join? Please register until October 1: ❕https://eveeno.com/256035281 #Ubiquitin #Symposium
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Alex Palazzo @ribonucleicacids.bsky.social · 02/09/2026
I love it! My vote is for yeast based on that spread alone! On a serious note, anyone working on basic biological problems in humans should always read the yeast literature if their process is conserved. The yeast field is typically 5-10 years ahead in identifying all of the critical components.
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Alex Palazzo @ribonucleicacids.bsky.social · 31/08/2026
Very proud of our new perspective that was just published: From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity In it, (I think) we give the most comprehensive account of how new genomic parts emerge. doi.org/10.1002/1873...
doi.org
FEBS Press
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non-funct...
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