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Alexandros Bousios

@abousios.bsky.social
134 followers 146 following 11 posts

Plants, genome biology, TEs, epigenetics, @ University of Sussex www.sussex.ac.uk/lifesci/bousioslab

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Reposted by Alexandros Bousios
Polina Novikova @pnovik.bsky.social · 04/03/2026
I am happy to announce the launch of a new Arabidopsis genomics resource! Check out arabidopsislyrata.org Now you can easily look at the natural genetic variation across the entire species range of A. lyrata and A. arenosa.
arabidopsislyrata.org
Home | Alyrata Resource
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Alexandros Bousios @abousios.bsky.social · 06/02/2026
Come join our lab in Sussex, UK for a PhD on TEs, on centromeres, on the genome ecosystem! Exciting times for TE:genome dynamics given the rate of T2T sequencing. Please circulate! www.findaphd.com/phds/project...
findaphd.com
Evolutionary dynamics of transposable elements in the genome ecosystem of eukaryotes at University of Sussex on FindAPhD.com
PhD Project - Evolutionary dynamics of transposable elements in the genome ecosystem of eukaryotes at University of Sussex, listed on FindAPhD.com
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André Marques @amarques.bsky.social · 21/01/2026
📢 Three new #bioRxiv preprints from our team on holocentric chromosomes. Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
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Ian Henderson @hendersi.bsky.social · 11/11/2025
FastGA -> ALNview; step into the centromeric matrix! github.com/thegenemyers Probably the best dot plot software on the planet...
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 10/08/2025
Wonderful (and humble) essay on mentorship by Brandon Gaut, on occasion of Brandon receiving the inaugural Mentorship Award of @genetics-gsa.bsky.social. I hope this will be widely read! academic.oup.com/genetics/art...
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André Marques @amarques.bsky.social · 28/07/2025
Happy to share our new work with exciting findings, incl. different centromere organisations and all kinds of weird polyploids giving rise to the mysterious carnivorous sundews! Great word led by my postdoc Laura in collaboration with @plantgenomes.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Contrasting centromere structures in carnivorous sundews uncover a dynamic evolutionary trajectory shaped by polyploidy and chromosomal remodeling
Sundews (Drosera) are carnivorous plants that capture prey using mucilage-producing glands with both secretory and absorptive functions. Within a remarkably diverse clade that includes the Venus flytr...
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Alexandros Bousios @abousios.bsky.social · 22/07/2025
Our new preprint on somatic TE transposition in A. thaliana is out! It looks like TEs jump like crazy! Led by the amazing @heenaa02.bsky.social and with Hans-Wilhelm Nuetzmann from Exeter www.biorxiv.org/content/10.1...
biorxiv.org
Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana
Background The movement of transposable elements (TEs) in somatic cells generates genetic and phenotypic diversity across the soma of individual organisms. This process is especially important in plan...
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heenaa02.bsky.social @heenaa02.bsky.social · 22/07/2025
6/ 🙏 Huge thanks to the amazing collaborators and co-authors who made this work possible! 🧑‍🔬 Basile Leduque, Leandro Quadrana, Keith Slotkin, Alexandros Bousios (@abousios.bsky.social) & Hans-wilhelm Nuetzmann
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heenaa02.bsky.social @heenaa02.bsky.social · 22/07/2025
5/ 💻 Surprise package! We developed a custom pipeline, deNOVOEnrich, to profile somatic TE insertions from TEd-seq short-read data. Using split-read mapping, we pinpoint new somatic insertions at base-pair resolution 🧬🔍 Check it out: github.com/hAmbreen02/d...
github.com
GitHub - hAmbreen02/deNOVOEnrich: Identification of de novo transposon insertion sites from targeted sequencing data
Identification of de novo transposon insertion sites from targeted sequencing data - hAmbreen02/deNOVOEnrich
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heenaa02.bsky.social @heenaa02.bsky.social · 22/07/2025
4/ 🔥 Somatic insertion hotspots of the EVADE transposon are enriched at environmentally responsive genes 🌄 - including Resistance gene and biosynthetic gene clusters. Is stress guiding TE activity, or are TEs tuning stress responses? Somatic genome plasticity 🧬
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heenaa02.bsky.social @heenaa02.bsky.social · 22/07/2025
3/ 🧬 Our work shows somatic TE activity in Arabidopsis is non‑random and family‑specific. Different TE families prefer distinct genomic niches - is it driven by underlying epigenetic code, or are they avoiding conflict in a shared genome ecosystem? 🤔
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heenaa02.bsky.social @heenaa02.bsky.social · 22/07/2025
2/ Combining distinct experimental conditions, we traced a roadmap of expected TE movement in somatic cells 🌿, capturing ~200K new TE insertions across multiple families in the process.
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heenaa02.bsky.social @heenaa02.bsky.social · 22/07/2025
1/📢News from TE diary - Somatic transposition in Arabidopsis is more explosive than we imagined! Thrilled to share our latest findings - TEs make new somatic insertions en masse, reshaping the somatic genome🧬with surprising frequency🍃 @abousios Hans-Wilhelm Nuetzmann www.biorxiv.org/content/10.1...
biorxiv.org
Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana
Background The movement of transposable elements (TEs) in somatic cells generates genetic and phenotypic diversity across the soma of individual organisms. This process is especially important in plan...
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 21/07/2025
1/2 Somatic TE transposition in plants is getting traction again (70 years after McClintock's discovery of "controlling elements")! A very large collection of somatic TE insertions in A. thaliana described by Ambreen et al.(www.biorxiv.org/content/10.1...).
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 21/07/2025
2/2 See also @movillome.bsky.social's paper from my lab on using PacBio long-read sequencing to discover somatic TE insertions with high sensitivity and specificity in an unbiased manner -- an excellent complement to powerful short-read based enrichment methods (www.biorxiv.org/content/10.1...)
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André Marques @amarques.bsky.social · 18/06/2025
1/7 I am very excited to announce our🌹NEW PAPER OUT IN 𝑁𝐴𝑇𝑈𝑅𝐸!🌹 𝐃𝐑𝐈𝐕𝐄 𝐓𝐎 𝐒𝐔𝐑𝐕𝐈𝐕𝐄: Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis With the Ritz and Kovařík labs we show a potential role for centromeres on 𝘙𝘰𝘴𝘢 𝘤𝘢𝘯𝘪𝘯𝘢 bizarre reproduction! www.nature.com/articles/s41...
nature.com
Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature
Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.
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Nature @nature.com · 18/06/2025
Nature research paper: Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis go.nature.com/407PRGm
go.nature.com
Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature
Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.
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Cedric Feschotte @cedricfeschotte.bsky.social · 30/04/2025
💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n
pnas.org
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...
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Schneeberger Lab @labschneeberger.bsky.social · 16/04/2025
📢 Excited to share our work out now in @nature.com! 📢 We present the phased pan-genome of tetraploid European potato, based on 10 historical cultivars representing 85% of European potato diversity. Learn more below! 🔗 www.nature.com/articles/s41... 1/7
nature.com
The phased pan-genome of tetraploid European potato - Nature
A haplotype-resolved pan-genome of autotetraploid European potato founder lines shows high nucleotide diversity at remarkably low haplotype diversity, which is probably the result of hybridization eve...
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Sergio Cruz-León @sergiocruzleon.bsky.social · 11/04/2025
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv
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Maya Voichek @mayavoichek.bsky.social · 17/03/2025
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte
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Marc Somssich @somssich.bsky.social · 12/03/2025
This Editorial by Brandon S. Gaut and Claudia A. M. Russo provides some nice insight into how #SocietyJournals work, and why it pays for Scientists to publish with #SocietyOwned Journals. 👇 A Message From the Editors-in-Chief academic.oup.com/mbe/article/... #PlantScience #SciencePublishing
academic.oup.com
A Message From the Editors-in-Chief
We have been Co-Editor-in-Chiefs of Molecular Biology and Evolution (MBE) for 2 years now. In that time, we have learned a great deal about the science of
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Matthias Benoit @mattbnt.bsky.social · 05/03/2025
🚨New paper published in @nature.com! Using pan-genetics across the Solanum genus🍅🥔🍆we reveal why gene duplications🧬are major contingencies in crop engineering. My postdoc work in the Lippman lab @CSHL, collab. with @katiejenike.bsky.social @mikeschatz.bsky.social chatz.bsky.social and many others!
nature.com
Solanum pan-genetics reveals paralogues as contingencies in crop engineering - Nature
Gene duplication and subsequent paralogue diversification are major obstacles to genotype-to-phenotype predictability.
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Genetics Society UK @gensocuk.bsky.social · 28/02/2025
Join us for the first seminar in a new series by @IntlGeneticsFed! "Biodiversity Genomics – African & European Perspectives" 📅 March 4, 2025 at 12:00 GMT 🔗 Register now: forms.office.com/r/e1MgVyfCvs
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Alexandros Bousios @abousios.bsky.social · 18/02/2025
Another piece to add in the emerging golden era of centromere research. Our review of centrophilic transposons in plants @annualreviews.bsky.social with @hendersi.bsky.social and Tetsuji Kakutani. www.annualreviews.org/content/jour...
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Ian Henderson @hendersi.bsky.social · 18/02/2025
Centrophilic Retrotransposons of Plant Genomes www.annualreviews.org/content/jour... new review @annualreviews.bsky.social from @abousios.bsky.social, Tetsuji Kakutani, and myself on my favourite type of mobile genetic element
annualreviews.org
Centrophilic Retrotransposons of Plant Genomes | Annual Reviews
The centromeres of eukaryotic chromosomes are required to load CENH3/CENP-A variant nucleosomes and the kinetochore complex, which connects to spindle microtubules during cell division. Despite their ...
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John Innes Centre @johninnescentre.bsky.social · 13/02/2025
PRESS RELEASE - Professor Uauy appointed as Director of the John Innes Centre Following an international search, we are delighted to announce that Professor @cristobaluauy.bsky.social has been appointed as the next Director of the John Innes Centre. www.jic.ac.uk/press-releas... @ukri.org
jic.ac.uk
Professor Uauy appointed as Director of the John Innes Centre | John Innes Centre
Following an international search, Professor Cristóbal Uauy has been appointed as the next Director of the John Innes Centre. Professor Uauy is internationally recognised for his significant…
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Elena Rivas @rivaselenarivas.bsky.social · 17/02/2025
We present Rfam-based RNA structural alignments and other structure-based inputs for RNA 3D structure prediction by deep learning. www.biorxiv.org/content/10.1...
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Zhigui Bao 鲍志贵 @zbao.bsky.social · 23/01/2025
Happy to share our recent work about 🥔 pangenome. With HiFi and HiC together, we explore the 31 accessions genome of clonal propagation crops. Not surprisingly, large haplotype diversity hidden on the genome. Lots of breakpoints are TEs. www.nature.com/articles/s41... 1/7
nature.com
Leveraging a phased pangenome for haplotype design of hybrid potato - Nature
A phased pangenome of potato constructed from 60 wild and cultivated haplotypes shows that substantial hybridization occurred during domestication and enables identification of many putative dele...
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Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 09/01/2025
Postdoc jobs in the Gaut lab! Brandon isn't on here, so I can be frank: he is fantastic. I did my postdoc with him and he is not only an amazing scientist but one of my favorite humans. I would have happily stayed in his lab forever if that was feasible. recruit.ap.uci.edu/JPF08999 #plantscijobs
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André Marques @amarques.bsky.social · 07/01/2025
Happy to share our Tansley insight published in @newphyt.bsky.social nph.onlinelibrary.wiley.com/doi/epdf/10.... #plantscience #chromosome #centromere #meiosis
nph.onlinelibrary.wiley.com
Centromere diversity and its evolutionary impacts on plant karyotypes and plant reproduction
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Alexandros Bousios @abousios.bsky.social · 06/01/2025
Beautiful collaboration led by Tetsuji Kakutani and Sayuri Tsukahara on unravelling the fine changes that can make a centrophobic TE become centrophilic and vice versa! The devil is in the details for these TEs. www.nature.com/articles/s41...
nature.com
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis - Nature
An Arabidopsis long terminal repeat retrotransposon integrates de novo into regions occupied by centromere-specific histone variant, showing the impact of centromeric chromatin on transposable element...
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Ian Henderson @hendersi.bsky.social · 06/01/2025
Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana biorxiv.org/content/10.1... new work from us on centromere inheritance and organisation @matt-naish.bsky.social @plantevolution.bsky.social @genomeevolution.bsky.social
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 27/12/2024
Announcing a curated collection of long-read genomes for Arabidopsis thaliana: The 1001 Genomes Plus Project. Currently 453 unique accessions/almost 600 assemblies. Interested in contributing? Please contact us! #plantscience www.biorxiv.org/content/10.1...
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