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Steffen Scholpp

@scholpplab.bsky.social
2.6K followers 2.7K following 163 posts

I am a cell and developmental biologist at the Living Systems Institute (LSI) in Exeter. We work on spreading Wnt signals and characterising cytonemes in zebrafish embryos, human neurons, and cancer using high-res imaging and mathematical modelling.

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Steffen Scholpp @scholpplab.bsky.social · 17/09/2026
How does a Wnt cytoneme contact become a productive signalling site? Emma Cooper and colleagues find focal Ca²⁺ transients at cytoneme contacts and link Ca²⁺ availability to contact stability and Wnt/β-catenin signalling. www.biorxiv.org/content/10.6... #Wnt #Cytonemes #CellBiology
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Steffen Scholpp @scholpplab.bsky.social · 23/07/2026
A fantastic start to our first @wellcometrust.bsky.social Cytoneme Network Workshop @lsiexeter.bsky.social, bringing together our Exeter and Manchester teams. Excited to uncover the unifying principles of contact-mediated signalling of Wnt, Notch, & Dpp in Drosophila, fish & mice. Cytonemes rock!
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Reposted by Steffen Scholpp
Developmental Biology @devbiol.bsky.social · 22/07/2026
#DBfeature A tribute to Gail R Martin, mouse geneticist and mentor extraordinaire (April 12, 1944 - Feb 9, 2026) By Alexandra Joyner doi.org/10.1016/j.ydbio.2026.05.007
Gail Martin looking at the camera, sitting on a bench in front of a lily pad pond in her garden in Berkeley. Photo from Brigid Hogan.
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Steffen Scholpp @scholpplab.bsky.social · 14/07/2026
Back where it all started! Great to visit my old PhD lab and catch up with Michael. Fascinating to see the impressive progress in brain regeneration research using #zebrafish. Thanks for the warm welcome and inspiring discussions. Always a pleasure to come back!
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Steffen Scholpp @scholpplab.bsky.social · 12/07/2026
Fantastic presentations of PhD students, postdocs, ECRs, and PIs from all the zebrafish groups in Exeter at #EZM2026 - well done everyone! Exeter is becoming a central hub for research using zebrafish as a model organism in the UK and Europe. #LSIZebrafsihHub @lsiexeter.bsky.social @exeter.ac.uk
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Steffen Scholpp @scholpplab.bsky.social · 08/07/2026
Exeter is making waves at #EZM2026! Fantastic to see so many brilliant Exeter posters from development & disease to imaging&gene editing; great science & great people. From the West Country to Europe: Exeter is becoming a real zebrafish hotspot. Come say hi! @exeter.ac.uk @lsiexeter.bsky.social
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Steffen Scholpp @scholpplab.bsky.social · 08/07/2026
No better way to head to #EZM2026 than with a freshly published success! Our eLife paper is now out: elifesciences.org/articles/107.... We show optimised prime editing in zebrafish for precise DNA substitutions and insertions. Huge thanks to the fantastic team #Zebrafish #GenomeEditing #eLife
elifesciences.org
Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish
Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.
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Steffen Scholpp @scholpplab.bsky.social · 09/06/2026
The LSI Zebrafish Hub is very excited to welcome Prof Alex Schier - @schierlab.bsky.social - from the @biozentrum.unibas.ch for our Joint LSI/Biosciences Distinguished Seminar @lsiexeter.bsky.social tomorrow! Please come along & join us! #zebrafish #developmentalbiology @zebrafishrock.bsky.social
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Steffen Scholpp @scholpplab.bsky.social · 06/06/2026
After months of experiments, failed injections, unexpected results, and those rare moments when everything suddenly works - our manuscript is finally submitted. Read our newest story about a journey of tiny vesicles carrying big biological messages, now in bioRxiv. www.biorxiv.org/content/10.6...
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Steffen Scholpp @scholpplab.bsky.social · 26/05/2026
It was a pleasure to showcase our most recent data on cytonemes to the cell biology community in Bristol, including a long discussion about morphogen distribution mechanisms. Zebrafish cell biology rocks!
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Reposted by Steffen Scholpp
Roberto Mayor Lab @mayorlab.bsky.social · 16/05/2026
PL retweet. Developmental Biology Course (Quintay). More information: biodesarrollo.unab.cl
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Steffen Scholpp @scholpplab.bsky.social · 19/05/2026
Today’s lab meeting came with proper birthday celebrations for our two birthday girls and, thanks to Jess, not one but two cakes. A very strong experimental design: double cake input, significantly improved lab morale output. Cake really does make all data sweeter.
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Steffen Scholpp @scholpplab.bsky.social · 14/05/2026
Wonderful PhD Day @lsiexeter.bsky.social today - full of great science, interdisciplinary projects, lively discussions and lots of laughter. Huge congratulations to our PhD students Jess Bansey and Lizzy Sears for winning Best Talk & Best Flash Talk Award. Very proud of you both! 👏 #PhDLife #ECRs
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Steffen Scholpp @scholpplab.bsky.social · 07/05/2026
Very happy to share that I have joined the Heidelberg CRC/SFB 1324 “Mechanisms and Functions of Wnt Signalling” as a DFG Mercator Fellow. Looking forward to linking our work @lsiexeter.bsky.social with @cosheidelberg.bsky.social. Wonderful to hear Gemma's excellent presentation on cytonemes.
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Steffen Scholpp @scholpplab.bsky.social · 16/03/2026
How many fish researchers fit into a tiny elevator? Answer; apparently all of us! Unexpected outcome: massively improved team spirit! 🐟📸
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Reposted by Steffen Scholpp
Matthew Freeman @mjafreeman.bsky.social · 16/12/2025
Breaking... Very good news. A first step towards...? www.theguardian.com/world/2025/d...
theguardian.com
UK to rejoin EU’s Erasmus student exchange programme
Exclusive: British students will be able to participate in EU-wide scheme from January 2027, sources say
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Reposted by Steffen Scholpp
Chris Lintott @chrislintott.bsky.social · 29/01/2026
We should party.
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Steffen Scholpp @scholpplab.bsky.social · 04/02/2026
Important changes in the UKRI funding landscape. Thanks, Matt, for the update.
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Steffen Scholpp @scholpplab.bsky.social · 20/01/2026
We are delighted to launch the Centre for Cellular Life, a new partnership between the @lsiexeter.bsky.social and SKLMB, Tsinghua University. Interdisciplinary science will drive collaborative research, researcher mobility and doctoral training to tackle how cells function in health and disease.
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Steffen Scholpp @scholpplab.bsky.social · 22/12/2025
Back in my old uni city. Where the memories are strong, the coffee tastes familiar, and the colleagues somehow look the same 😄
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Steffen Scholpp @scholpplab.bsky.social · 15/12/2025
End-of-year lab meeting powered by Jellycat-style cake creatures 🐟🧁. Smiling faces, great results, and a lot to celebrate from 2025. Here is to the same momentum in 2026 (and more cake from Lizzy et al.). 🍰
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Steffen Scholpp @scholpplab.bsky.social · 12/12/2025
Great to see our collaboration between @tsinghuauniversity.bsky.social and the @lsiexeter.bsky.social taking shape after a fantastic visit to Beijing. We have established a strong foundation for joint research projects starting in 2026. Thanks to Li Yu and Fan Zhou for the excellent organisation.
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Reposted by Steffen Scholpp
LSI-Exeter @lsiexeter.bsky.social · 28/11/2025
Looking for a PhD? 3 days left to apply for a fully funded China Scholarship Council & University of Exeter studentship! Join the Living Systems Institute—where Maths, Physics, Bio and Biomed meet—and carry out cutting-edge interdisciplinary research. tinyurl.com/y3ufdnxf @exeter.ac.uk
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Reposted by Steffen Scholpp
LSI-Exeter @lsiexeter.bsky.social · 25/11/2025
Last chance to apply for one of the LSI PhD projects intake Sept 2026! Deadline tomorrow, 26.11.2025, noon. www.exeter.ac.uk/research/ins... @exeter.ac.uk @lsiexeter.bsky.social
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Chrissy Hammond @hammofish.bsky.social · 14/11/2025
We’ve got a couple of PhD projects open. Including one with the lovely @adamgrieve.bsky.social and @scholpplab.bsky.social on Rhbdl proteins in #zebrafish which is open to UK and international students tinyurl.com/fishprotease
tinyurl.com
Funded PhD SWBio DTP- (STANDARD) Brains, Blades, and Zebrafish: Dissecting Rhomboid Protease Roles in Neuronal Development and Signalling at University of Bristol on FindAPhD.com
PhD Project - Funded PhD SWBio DTP- (STANDARD) Brains, Blades, and Zebrafish: Dissecting Rhomboid Protease Roles in Neuronal Development and Signalling at University of Bristol...
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Steffen Scholpp @scholpplab.bsky.social · 10/11/2025
Thrilled to share that we have been awarded a Wellcome DA to explore cytoneme-based cell communication in development! A fantastic collaboration with Kyle @kylewedgwood.bsky.social at @lsiexeter.bsky.social, and Hilary Ashe & Cerys Manning at Manchester - exciting times ahead! tinyurl.com/2ytm6y2w
tinyurl.com
Exeter researchers awarded £3.5M to uncover how cells communicate during development
Researchers at the Living Systems Institute (LSI), University of Exeter, have been awarded a £3.5 million Wellcome Discovery Award to investigate how cells exchange information to coordinate the forma...
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Steffen Scholpp @scholpplab.bsky.social · 30/10/2025
🚨 Exciting opportunity for 🇨🇳 students! Apply for a PhD scholarship via CSC to join my lab @UniofExeter studying cytoneme-mediated cell communication 🧫🐟 All projects are in collaboration with top Chinese universities: Tsinghua, Zhejiang & Kunming 🌏 📅 Deadline: 1 Dec 2025 携手探索细胞交流的奥秘,让科学没有距离!加油!💪🇨🇳✨
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Dr. Jey McCreight 🏳️‍⚧️🧬 @jeymccreight.bsky.social · 16/10/2025
As a science communicator who built my professional career out of understanding "Science Twitter": I'm confident Bluesky will be the scientific community's social media home for a while Tell your friends at #ASHG25 to get over here, whether they're on X or not!
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Steffen Scholpp @scholpplab.bsky.social · 10/10/2025
Deadline approaching – 15 Oct! A brilliant PhD opportunity for all keen zebrafish enthusiasts, gene jockey and microscopy aficionados 🐟🧬🔬 If you find joy in embryos, lasers, and watching cells do clever things — this is your moment.
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Steffen Scholpp @scholpplab.bsky.social · 08/10/2025
Such sad news. An amazing scientist, an amazing person, and a wonderful and inspiring lecturer. Will be greatly missed. www.cam.ac.uk/research/new...
cam.ac.uk
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
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Steffen Scholpp @scholpplab.bsky.social · 01/10/2025
Back from the London Zebrafish Research Network — a truly inspiring afternoon. Many thanks to @cvagenapantoula.bsky.social, @kkalyviotis.bsky.social and Eleni for putting together such an interactive programme, full of excellent talks - Tim 👏 - and great discussions. Zebbie research at its best!
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Steffen Scholpp @scholpplab.bsky.social · 25/09/2025
Want to help prevent aggressive NF1 cancers using cutting-edge models? The GW4 BioMed2 MRC DTP is offering a fully funded 4-year PhD @lsiexeter.bsky.social @exeter.ac.uk to develop a humanised zebrafish model for NF1 resilience. Apply by 20 Oct 2025 www.exeter.ac.uk/study/fundin... #PhD #biomed
exeter.ac.uk
PhD:GW4 BioMed2 MRC DTP Studentship | University of Exeter
  The GW4 BioMed2 MRC DTP is offering up to 17 funded studentships across a range of biomedical disciplines, with a start date of October 2026.
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Steffen Scholpp @scholpplab.bsky.social · 19/09/2025
A huge thank you to everyone who made #UKZF2025 possible 🙌🐟 From inspiring talks and posters to lively discussions and community spirit — your energy and contributions turned this meeting into a real success. 💙✨
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Steffen Scholpp @scholpplab.bsky.social · 12/09/2025
All the hard work during the workshop at #UKZF2025 🐟💡 was rewarded with a joyful gala dinner — science, community & celebration coming together in style ✨🥂
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Steffen Scholpp @scholpplab.bsky.social · 11/09/2025
One of the best parts of #UKZF2025 🐟✨ — old friends reconnecting, new colleagues meeting for the first time, all sharing ideas and energy to drive science forward together 💡🤝
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Steffen Scholpp @scholpplab.bsky.social · 10/09/2025
Day 1 of #UKZF2025 is here! 🎉🐟 The conference kicks off in Exeter & Exmouth — packed with science, networking, and community. Let’s dive in! 🚀 @izfs.bsky.social @zebrafishrock.bsky.social @lsiexeter.bsky.social @zebrafishhusbandry.bsky.social
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Steffen Scholpp @scholpplab.bsky.social · 10/09/2025
What started as a small idea has grown into a buzzing UKZF2025 — and now we’re treated to an incredible line-up of super science talks from our brilliant UK ECRs! 🐟✨ #UKZF2025
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Steffen Scholpp @scholpplab.bsky.social · 10/09/2025
🐟🎟 Long queues at the #UKZF2025 registration desk this morning — thank you all for your patience and enthusiasm! The buzz is real, and we’re so excited to get started 🚀
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Steffen Scholpp @scholpplab.bsky.social · 10/09/2025
It’s all coming together beautifully — #UKZF2025 is really taking shape 🐟✨ We can’t wait to share this vibrant meeting with you all!
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Steffen Scholpp @scholpplab.bsky.social · 10/09/2025
🚨 Final bits are falling into place for #UKZF2025 🎉 The organisers are buzzing with excitement and can’t wait to welcome the zebrafish community to Exeter & Exmouth TODAY 🐟✨
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Steffen Scholpp @scholpplab.bsky.social · 02/09/2025
Interested in zebrafish as a disease model for NF1? We are seeking a motivated PhD student to join our team and become an expert in high-resolution imaging/precise genome editing in collab with AZ. gw4biomed.ac.uk/establishing... @lsiexeter.bsky.social @zebrafishrock.bsky.social @izfs.bsky.social
gw4biomed.ac.uk
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Steffen Scholpp @scholpplab.bsky.social · 01/09/2025
Why do some people with #NF1 develop aggressive nerve tumours while others don’t? 🧬🐟 Join us to explore genetic resilience in zebrafish, uncover protective pathways & discover new strategies to prevent cancer. gw4biomed.ac.uk/establishing... @lsiexeter.bsky.social
media.tenor.com
a cartoon drawing of a fish wearing sunglasses and a lightning bolt
ALT: a cartoon drawing of a fish wearing sunglasses and a lightning bolt
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Steffen Scholpp @scholpplab.bsky.social · 30/07/2025
Team BBQ yesterday: sun, sizzle, and seriously good food! But also bittersweet as we said goodbye (for now) to two fab members 😢. Lucy is off on maternity leave to grow a tiny scientist. Eloise is swapping pipettes for passport stamps. We’ll miss them both-but remember, our lab door is always open!
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Steffen Scholpp @scholpplab.bsky.social · 23/07/2025
Huge congratulations to our brilliant graduates: one newly minted PhD, a sharp MSc, and two stellar BScs! You all looked majestic in your gowns — a well-earned symbol of your hard work, late nights, and scientific curiosity. Serious achievements, bright futures. @lsiexeter.bsky.social @exeter.ac.uk
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Steffen Scholpp @scholpplab.bsky.social · 20/06/2025
Power presentation of Bertram about the beauty of cryo EM at the #LSIOpenDay. @lsiexeter.bsky.social
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Steffen Scholpp @scholpplab.bsky.social · 17/06/2025
Time is running out to present your latest #Zebrafish research at ZFUK25 tinyurl.com/mw7r3nbn in Exeter. This is your chance to share your work, connect with the community, and contribute to cutting-edge discussions. The deadline for abstract submission is rapidly approaching: 30th June 2025!
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Steffen Scholpp @scholpplab.bsky.social · 11/06/2025
Thrilled to announce a seminar featuring Prof. Hilary Ashe, a leading Cell & Developmental Biologist from @UoM_BioSci! Discover her lab's latest findings on spatiotemporal gene expression & cell communication in #Drosophila @lsiexeter.bsky.social
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Carol Yang @yhcarolyang.bsky.social · 10/06/2025
Carer's Awards, funded by the Genetics Society, are available to support 3 participants of the First UK Zebrafish Meeting with caring responsibilities. @gensocuk.bsky.social More info at exeter.ac.uk/ukzfmeeting
exeter.ac.uk
UK Zebrafish Meeting | University of Exeter
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Steffen Scholpp @scholpplab.bsky.social · 09/06/2025
Excellent presentation of the function of cytonemes in neural crest specification from Gemma Sutton GW4 Imaging workshop @lsiexeter.bsky.social @gw4alliance.bsky.social Cytoneme biology rocks!
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Steffen Scholpp @scholpplab.bsky.social · 05/06/2025
My next stop is CRUK Scotland in Glasgow. Thanks to Owen Sansom @cruk-si.bsky.social for hosting me. The @wntuk.bsky.social community is just awesome—great people, excellent research!
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