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rboussageon.bsky.social

@rboussageon.bsky.social
27 followers 38 following 113 posts
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Joar Øveraas Halvorsen @joarhalvorsen.bsky.social · 10/09/2026
«Randomization and other forms of experimental control do not detach research from real-world contexts but, rather, reduce systematic error and uncertainty to better isolate causal effects.» 🎯 www.jclinepi.com/article/S089...
jclinepi.com
Randomized, controlled, and real
The growing use of the term “real-world evidence” (RWE) has introduced a classification of clinical research based on its perceived proximity to routine practice rather than its methodological charact...
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rboussageon.bsky.social @rboussageon.bsky.social · 04/09/2026
www.jclinepi.com/article/S089... @floriannaudet.bsky.social
jclinepi.com
The erosion of proof in paradigm transitions: the rise of narrative rationality in health technology assessment
To describe and characterize three partly coexisting evidentiary configurations in drug regulation and health technology assessment (HTA), and to examine the inferential consequences of the progressiv...
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rboussageon.bsky.social @rboussageon.bsky.social · 03/09/2026
Comment transformer un résultat exploratoire en un résultat qui va influencer les décisions (alors qu'il ne devrait pas): c'est simple, faire une méta analyse ! www.bmj.com/content/394/...
bmj.com
There is no evidence (as proof) that semaglutide reduces all-cause mortality
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rboussageon.bsky.social @rboussageon.bsky.social · 10/07/2026
www.bmj.com/content/394/...
bmj.com
There is no evidence (as proof) that semaglutide reduces all-cause mortality
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rboussageon.bsky.social @rboussageon.bsky.social · 08/07/2026
www.sciencedirect.com/science/arti... @ploederl.bsky.social @ioanaacristea.bsky.social @floriannaudet.bsky.social
sciencedirect.com
Efficacy of antidepressants in addition to psychotherapy in major depressive disorder: a systematic review and meta-analysis of randomized clinical trials
Major depressive disorder (MDD) impairs daily functioning and is often treated with psychotherapy, antidepressants (AD), or both. While combined thera…
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Reposted by @rboussageon.bsky.social
Docdu16 @docdu16.eurosky.social · 03/07/2026
www.lequotidiendumedecin.fr/actu-medical...
lequotidiendumedecin.fr
Angine à streptocoque A : une nouvelle étude désavoue l’antibiothérapie en prévention
« La prévention des infections invasives à streptocoques A ne doit pas constituer un motif de prescription d’antibiotiques ». Une nouvelle étude publiée dans l’International Journal of Infectious Dise...
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rboussageon.bsky.social @rboussageon.bsky.social · 16/06/2026
Dear @stephensenn.bsky.social In this link, you write "proof "...and not "evidence"... Why? What is the difference ?
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Damien BARRAUD @damienbarraudmd.bsky.social · 28/05/2026
Poke @fzores.eurosky.social @docdu16.eurosky.social @rboussageon.bsky.social
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Therapeutics Initiative (TI) @drug-evidence.bsky.social · 07/05/2026
‼️We need to talk about #Tramadol 💊 ICYMI: Our #BestEvidence webinar recording featuring the TI's Dr. Jessica Otte Practical info for clinicians considering tramadol for pain: bit.ly/3onIs05 👉More here: ti.ubc.ca/letter131 #MedEd #deprescribing #pain
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rboussageon.bsky.social @rboussageon.bsky.social · 07/05/2026
Et ça continue encore encore pubmed.ncbi.nlm.nih.gov/42067418/
pubmed.ncbi.nlm.nih.gov
[Systematic review of the literature and evaluation of the effectiveness of muscle relaxants in acute low back pain according to REB method] - PubMed
According to the REB method, none of the three molecules demonstrated efficacy in acute low back pain with or without radiculopathy.
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Reposted by @rboussageon.bsky.social
Docdu16 @docdu16.eurosky.social · 26/04/2026
Message de service : prescrire paxlovid (nirmatrelvir - ritonavir) à un patient vacciné contre le covid est une double escroquerie : aux données des essais cliniques et à l'Assurance-Maladie. C'est du charlatanisme escroc. docteurdu16.blogspot.com/2026/04/paxl...
docteurdu16.blogspot.com
Paxlovid : enterrement du paxlovid en grandes pompes (corrompues). Ne pas en donner chez les vaccinés.
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Reposted by @rboussageon.bsky.social
Amanda Kay Montoya @akmontoya.bsky.social · 26/04/2026
Not every solution is meant for every problem, but much of research is framed as confirmatory (i.e., hypothesis testing) and thus should be done in a rigorous manner through RRs. Publication bias drives so much of how we do science that we’ve lost sight of what matters: learning about the world.
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Martin Plöderl @ploederl.bsky.social · 25/04/2026
I think this is a collection of mostly unreliable studies - effect sizes SMD > 1 are too good to be true. www.frontiersin.org/journals/psy...
frontiersin.org
Frontiers | Meta-analysis of the effect of vitamin D on depression
ObjectiveTo investigate the effect of vitamin D supplementation on depressive symptoms by conducting a meta-analysis of randomized controlled trials.MethodsW...
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rboussageon.bsky.social @rboussageon.bsky.social · 24/04/2026
Hi Florian, Ioana, and Martin. Would you be interested in creating a wiki guideline on treatments for depression? @floriannaudet.bsky.social @ioanaacristea.bsky.social @ploederl.bsky.social www.wikiguidelines.org
wikiguidelines.org
Home | WikiGuidelines
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rboussageon.bsky.social @rboussageon.bsky.social · 22/04/2026
We strongly disagree with Guo and colleagues, who suggest an overall benefit from blood pressure targets of less than 120 or 130 mm Hg. www.thelancet.com/journals/lan...
thelancet.com
Benefit–harm trade-offs of intensive blood pressure control versus standard blood pressure control on cardiovascular and renal outcomes: an individual participant data analysis of randomised controlle...
Compared with standard blood pressure control, intensive blood pressure control provides a net benefit between the reduction in cardiovascular events and the increase in adverse events, including rena...
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Reposted by @rboussageon.bsky.social
Martin Plöderl @ploederl.bsky.social · 13/04/2026
Re-analyses of existing data can be super important, as the RIAT initiative shows
academic.oup.com
Good science is not only about data: are you asking the right question?
We have built an extraordinary scientific machine. We can capture data at scale, store data cheaply, and analyse data in ways that were unthinkable even a
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rboussageon.bsky.social @rboussageon.bsky.social · 03/04/2026
@fzores.bsky.social www.bmj.com/content/388/...
bmj.com
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Stephen Senn @stephensenn.bsky.social · 26/03/2026
See onlinelibrary.wiley.com/doi/abs/10.1... and www.senns.uk/You_may_beli... p56
onlinelibrary.wiley.com
Inherent difficulties with active control equivalence studies
A simple model is used to investigate the relevance of ‘competence’ to active control equivalence studies )ACES(. It is shown that to the extent that such trials are successful the results of such tr...
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rboussageon.bsky.social @rboussageon.bsky.social · 26/03/2026
Dear Stephen @stephensenn.bsky.social How do you reconcile Bayesianism with falsificationism ? pubmed.ncbi.nlm.nih.gov/1792462/
pubmed.ncbi.nlm.nih.gov
Falsificationism and clinical trials - PubMed
The relevance of the philosophy of Sir Karl Popper to the planning, conduct and analysis of clinical trials is examined. It is shown that blinding and randomization can only be regarded as valuable for the purpose of refuting universal hypotheses. The purpose of inclusion criteria is also examined. …
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rboussageon.bsky.social @rboussageon.bsky.social · 25/03/2026
1. A comment about this important meta-analysis : bmjopen.bmj.com/content/9/9/...
bmjopen.bmj.com
Benefits and harms of lower blood pressure treatment targets: systematic review and meta-analysis of randomised placebo-controlled trials
Objectives To assess the effect of antihypertensive treatment in the 130–140 mm Hg systolic blood pressure range. Design Systematic review and meta-analysis. Information sources PubMed, CDSR and DAR...
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Reposted by @rboussageon.bsky.social
Martin Plöderl @ploederl.bsky.social · 24/03/2026
Nice to see that our review on fluoxetine and the correspondence it triggered was selected for the editor's choice section in @jclinepi.bsky.social www.jclinepi.com/article/S089... @markhoro.bsky.social @richlyus.bsky.social @joannamoncrieff.bsky.social @rboussageon.bsky.social
jclinepi.com
Editors' choice April 2026
If the history of evidence-informed health-care research tells us anything, it is that interventions that are launched with the most fanfare and media hype should occasion sensible people to start cou...
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rboussageon.bsky.social @rboussageon.bsky.social · 23/03/2026
mentalhealth.bmj.com/content/29/1... The guidelines are therefore consistent with EBM if they have conducted a systematic review and make recommendations based on the" best available evidence", even if that evidence is of low quality.. And that is what I am criticizing:
mentalhealth.bmj.com
Levels of evidence supporting American, European and international guidelines in psychiatry, 2014–2024: a systematic review with quantitative synthesis
Question To what extent are psychiatry guidelines supported by high-level evidence?Study selection and analysis Guidelines from the American Psychiatric Association, European Psychiatric Association, ...
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Martin Plöderl @ploederl.bsky.social · 22/03/2026
10. Overall, even without accounting for biases, results for efficacy and drop-out are sobering and at odds with perferring this drug to treat depression in kids. Considering biases, this drug should not be used. Unfortunately, this was not discussed by Cochrane and also not in guidelines yet.
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Docdu16 @docdu16.eurosky.social · 22/03/2026
Message originel : x.com/anish_koka/s...
x.com
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Florian Naudet @floriannaudet.bsky.social · 19/03/2026
SPIN GRAND CHELEM 🏆 Psilocybin JAMA Psychiatry trial 🍄 a) Positive framing despite negative primary outcome, b) Inconclusive results presented as supportive evidence, c) Safety concerns downplayed with reassuring wording. See the rest of the 🧵 for the verbatim...
jamanetwork.com
Psilocybin in Treatment-Resistant Major Depression
This randomized clinical trial investigates the efficacy and safety of psilocybin, 25 mg, with adjunct psychotherapy in treatment-resistance major depression.
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rboussageon.bsky.social @rboussageon.bsky.social · 18/03/2026
Quel guideline choisir ? Exemple chez le patient à risque CV: @fzores.bsky.social www.cfp.ca/content/72/3...
cfp.ca
Which guidelines from North America and Europe on cardiovascular risk management with statins have high utility in family medicine?
Objective To comprehensively assess the relevance, trustworthiness, and utility of guidelines using the Guideline Trustworthiness, Relevance, and Utility Scoring Tool (G-TRUST); and to describe the va...
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rboussageon.bsky.social @rboussageon.bsky.social · 17/03/2026
Okay, let's start a discussion: what kind of evidence E is necessary to justify an intervention? I am a GP, and I claim to base my practice on E.. @lakens.bsky.social @stephensenn.bsky.social @f2harrell.bsky.social @ploederl.bsky.social @floriannaudet.bsky.social @isabelleboutron.bsky.social
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Martin Plöderl @ploederl.bsky.social · 19/01/2026
About 1/3 of patients would be excluded from clinical trials. However, instead of calling for "real-world" data to complement RCTs, shouldn't we have more real-world (pragmatic) RCTs? And the way keep up defending antidepressants, well...
onlinelibrary.wiley.com
Representation and outcomes of individuals with major depression in routine care who are ineligible for randomized controlled trials: a nationwide register‐based study
Randomized controlled trials (RCTs) are the foundation of current clinical treatment guidelines. However, they may not reflect real-world populations, due to strict eligibility criteria. We determine...
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Reposted by @rboussageon.bsky.social
Frank Harrell @f2harrell.bsky.social · 13/01/2026
FDA drugs and biologics guidance for Bayesian clinical trials is something I've been dreaming of for decades. I am thrilled that this draft has been released!! #Statistics #StatsSky #fda #clinicaltrial #bayes
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rboussageon.bsky.social @rboussageon.bsky.social · 23/12/2025
www.cnge.fr/wp-content/u...
cnge.fr
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rboussageon.bsky.social @rboussageon.bsky.social · 15/12/2025
Je conseille cet article onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
How to survive the medical misinformation mess
Most physicians and other healthcare professionals are unaware of the pervasiveness of poor quality clinical evidence that contributes considerably to overuse, underuse, avoidable adverse events, mi.....
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Reposted by @rboussageon.bsky.social
Martin Plöderl @ploederl.bsky.social · 21/11/2025
No names, unfortunately 😉 bmjopen.bmj.com/content/15/1...
bmjopen.bmj.com
Undisclosed financial conflicts of interest among physician-authors in leading US psychiatry journals: a cross-sectional study
Objective To assess the prevalence and magnitude of undisclosed financial conflicts of interest (COIs) among physician-authors in high-impact US-based psychiatry journals. Design Cross-sectional stud...
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Reposted by @rboussageon.bsky.social
THERAPIES @therapies.bsky.social · 17/11/2025
#Ibuprofene #Ketoprofene #Naproxene #Diclofenac #Douleur #Entorses #LesionsMusculaires #SystemeMusculosquelettique
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THERAPIES @therapies.bsky.social · 07/11/2025
Bon usage du médicament Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires #Recommandations #Antibiotiques #SoinsPrimaires www.em-consulte.com/article/1773...
em-consulte.com
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
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rboussageon.bsky.social @rboussageon.bsky.social · 22/10/2025
academic.oup.com/fampra/artic...
academic.oup.com
Calcium score: what do the most reliable guidelines recommend? An analysis using the G-TRUST tool
AbstractIntroduction. In 2023, cardiovascular disease was the leading cause of death worldwide. Various risk calculation tools based on risk factors can be
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rboussageon.bsky.social @rboussageon.bsky.social · 19/10/2025
Voilà un raisonnement fondé sur les preuves....et une perspective de médecine générale ! Bravo! www.cfp.ca/content/71/1...
cfp.ca
Clinical prudence urged in testing for steatotic liver disease
We read with interest “[Approach to steatotic liver disease in the office. Diagnosis, management, and proposed nomenclature][1]” by Szilagyi and Hilzenrat in the April 2025 issue of Canadian Family Ph...
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Therapeutics Initiative (TI) @drug-evidence.bsky.social · 15/10/2025
@deprescribing.bsky.social @deprescribeus.bsky.social @reeve-research.bsky.social @trudypharmd.bsky.social @frankmoriarty.bsky.social @caden-recad.bsky.social @dremilymcd.bsky.social @doctorsofbc.bsky.social @bcfamilydocs.bsky.social @bcpharmd.bsky.social
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Martin Plöderl @ploederl.bsky.social · 16/10/2025
"About 67% of all antidepressant and antipsychotic treatment episodes in the 700 included patients (mean age = 14.6 years, girls = 67%) were off-label." link.springer.com/article/10.1...
link.springer.com
Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial - Child and Adolescent Psychiatry and Mental Health
Background/Objectives Off-label psychopharmacologic medication use is widespread in child and adolescent psychiatry, but little is known about its associated factors. This study aimed to assess freque...
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Greg Fell @felly500.bsky.social · 13/12/2024
opportunity costs associated with NICE recommendations. Defo the most important h economics paper you will read today, maybe this week, maybe the year so far This is where the primary care budget gets spent A www.thelancet.com/journals/lan...
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rboussageon.bsky.social @rboussageon.bsky.social · 08/10/2025
www.lemonde.fr/sciences/art...
lemonde.fr
« Depuis plusieurs années, on observe une dérive sémantique dans l’évaluation des médicaments »
TRIBUNE. Dans une tribune au « Monde », plusieurs experts appellent à une vigilance lexicale accrue dans les rapports d’évaluation et dans les publications scientifiques afin de ne pas induire en erre...
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Martin Plöderl @ploederl.bsky.social · 04/10/2025
Now also featured by @mad-in-america.bsky.social www.madinamerica.com/2025/10/a-ca...
madinamerica.com
A Call for Evidence-Based, Fear-Free Practice
It is right to criticize MAHA, but poorly researched, fear-based responses by mainstream psychiatry only further mislead the public.
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Reposted by @rboussageon.bsky.social
Martin Plöderl @ploederl.bsky.social · 26/09/2025
17/ Therefore, we dug deeper into the two Lancet NMAs and we indeed could explain the discrepancy after isolating a potential zombie trial. But more later, when this will be published, and we experienced the 4th rejection already (preprint here www.medrxiv.org/content/10.1...)
medrxiv.org
A Re-Appraisal of Three Network Meta-Analyses to Explain the Discrepancy in Findings for the Efficacy of Fluoxetine for the Treatment of Depression in Children and Adolescents
Objective To explain discrepant findings for fluoxetine’s efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recommend...
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Martin Plöderl @ploederl.bsky.social · 26/09/2025
1/32 Fluoxetine's loss of efficacy for the treatment of pediatric depression. 🚨 New paper and pre-print alert 🚨 With great colleagues @floriannaudet.bsky.social @richlyus.bsky.social @markhoro.bsky.social @joannamoncrieff.bsky.social and Gert van Valkenhoef A longer 🧵
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Dr Jessica Otte, 🇨🇦 MD, CCFP, FCFP 🩺🌍🌱 @drotte.medsky.social · 07/10/2025
another TI @drug-evidence.bsky.social + collaborators publication: It is possible to reduce the unnecessary over-use of TSH and related #thyroid tests!!! But it can be a challenge! (DM me to ask how I know!) qualitysafety.bmj.com/content/qhc/... #choosingwisely #overtesting
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Therapeutics Initiative (TI) @drug-evidence.bsky.social · 02/10/2025
🚨 ICYMI: UBC TI Therapeutics Letter 156: Antidepressant withdrawal syndrome – Update 👉 ti.ubc.ca/letter156 Antidepressants can be helpful for some people; but starting or stopping requires care Knowing about types of possible withdrawal problems helps prescribers guide patients in 🛑 more safely
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Martin Plöderl @ploederl.bsky.social · 02/10/2025
In this blog, I take a closer look at how leading psychiatrists responded to MAHA's critical views on psychiatric drugs for children and adolescents. Spoiler: they could have done MUCH better. ploederlm.github.io/blogs/MAHA-r...
ploederlm.github.io
Martin Plöderl - A call for evidence based, fear-free practice
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Martin Plöderl @ploederl.bsky.social · 21/08/2025
This is such important work! www.sciencedirect.com/science/arti...
sciencedirect.com
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project
The aim of the INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project is to develop a tool to identify problematic RCTs …
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Florian Naudet @floriannaudet.bsky.social · 10/07/2025
Interesting. Discontinuation symptoms are not so bit with antidepressants (SMD=0.3). However, 0.3 is the SMD of antidepressant efficacy in MDD... It means that we must also agree to say that antidepressants efficacy is not so big either. And GRADE is likely better for the 2nd claim than the 1st one.
jamanetwork.com
Incidence and Nature of Antidepressant Discontinuation Symptoms
This systematic review and meta-analysis examines the presence and incidence of discontinuation symptoms in individuals who stop taking antidepressants.
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Martin Plöderl @ploederl.bsky.social · 12/07/2025
One more thought: while a statistically significant average diff of 1.8 points on the Hamilton Scale (range 0-52) in similar short-term RCTs is used for justificatin of AD prescriptions, the increase of 1-2 pts on the withdrawal (DESS) scale (range 0-43) seems unimportant. SMD ca. 0.3 for both.
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