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Frank Harrell

@f2harrell.bsky.social
7.9K followers 146 following 1.6K posts

Professor of Biostatistics Vanderbilt University School of Medicine Consultant, clinical trials/drug development hbiostat.org fharrell.com

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Reposted by Frank Harrell
Emi Tanaka @emitanaka.org · 13h
I’m pleased to announce that Vol 18 Issue 3 of The R Journal is out now! 🥳 Free & open access, R journal is made possible by our volunteer editors, reviewers + contributing authors. Thank you all! journal.r-project.org/issues/2026-3/ 🧵 20 articles 👇 #rstats journal.r-project.org/issues/2026-3/
journal.r-project.org
The R Journal: Volume 18/3
Articles published in the September 2026 issue
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Lisa Kammerman, Ph.D. @kammerman.com · 23/09/2026
I spent 24 years at FDA reviewing the statistics in NDA and BLA submissions. Now I write The Significant Difference: what FDA's reviewers see, and what sponsors need to know. Short, practical, from the reviewer's side of the table. www.thesignificantdifference.com
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Michael Friendly @datavisfriendly.bsky.social · 24/09/2026
Could be a game changer for diverging color palettes
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Retraction Watch @retractionwatch.com · 24/09/2026
Investigative records paint the picture of a professor who took financial and personal advantage of his students for years – from manipulating them into paying him rent to making them clean up after his dog – and grew vengeful when they spoke out about his alleged crimes.
retractionwatch.com
Tennessee researcher heads to court amid claims of theft, forgery and revenge
In May 2025, Tennessee authorities were preparing to arrest a university math professor for allegedly soliciting university donations from his students and pocketing the money.  Middle Tenness…
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Frank Harrell @f2harrell.bsky.social · 12/09/2026
I've been going back and forth between the Zed and Cot editors and have found that I prefer Cot for most things. For the one language I needed syntax highlighting for (Typst) that was not built-in to Cot, Claude quickly wrote the Cot plug-in needed.
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Retraction Watch @retractionwatch.com · 12/09/2026
Weekend reads: The afterlife of retracted articles; ADA denies it censored opinions; a ‘twisted phantasmagory’ of ghostwriting
retractionwatch.com
Weekend reads: The afterlife of retracted articles; ADA denies it censored opinions; a ‘twisted phantasmagory’ of ghostwriting
If your week flew by — we know ours did — catch up here with what you might have missed. The week at Retraction Watch featured: Editors of higher education journal coauthor editorial with fake refe…
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Frank Harrell @f2harrell.bsky.social · 12/09/2026
Nice paper about ordinal regression and why computing sample means on ordinal data is usually a good idea. #StatsSky #Statistics
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Retraction Watch @retractionwatch.com · 09/09/2026
Five researchers at Norway’s national gender incongruence clinic are appealing a university committee’s finding they committed “gross negligence” and scientific misconduct after the group published studies using the medical records of more than 1,000 minors.
retractionwatch.com
Researchers appeal misconduct finding over studies of trans youth
Oslo University Hospital Five researchers at Norway’s national gender incongruence clinic are appealing a university committee’s finding they committed “gross negligence” and scientific misconduct …
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Anna Nagurney @annanagurney.bsky.social · 06/09/2026
What a wonderful article about an inspiring collaboration of female mathematicians across the ages. Thanks to @nytimes.com for publishing it www.nytimes.com/2026/09/06/s...
nytimes.com
The 92-Year-Old Mathematician and the Teenage Apprentice
Joan Birman thought her major discoveries were behind her. Then came an email from a young neighbor — a girl who knew little but wanted to learn.
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Frank Harrell @f2harrell.bsky.social · 07/09/2026
Nice to see coverage of Bayes and ethics --
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Frank Harrell @f2harrell.bsky.social · 05/09/2026
Excellent @nathanihoff.bsky.social - not only are doubly robust procedures' confidence intervals not robust but point estimates may not be worth the effort. Hope you can compare w/ flexible semiparametric models, which give further advantages to one-step modeling approaches. fharrell.com/post/cpm
fharrell.com
The Unifying Capabilities of Cumulative Probability Semiparametric Models – Statistical Thinking
Ordinal semiparametric regression models in the cumulative probability model (CPM) family, of which proportional odds, proportional hazards, and probit regression are examples, contain virtually all r...
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Vincent Arel-Bundock @vincentab.bsky.social · 04/09/2026
Big news! 🎉 𝚖𝚊𝚛𝚐𝚒𝚗𝚊𝚕𝚎𝚏𝚏𝚎𝚌𝚝𝚜 1.0.0 for #Rstats is out. It’s a big number and it feels like a big step. I wrote a blog on the challenges of interpreting statistical models, SPEED, cool new features, the future, and a 5 year package development and writing odyssey. arelbundock.com/posts/margin...
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Helen Kennedy @helenkennedy.com · 02/09/2026
All white, all male. This was unacceptable so recently.
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David Colquhoun @davidcolquhoun.bsky.social · 30/08/2026
I find it hard to believe that a company like #Google doesn't stick to official names on its maps. They were obscenely quick to respond to the random musings of the tangerine tyrant. Very disappointing
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Stats For Bios @statsforbios.bsky.social · 25/08/2026
Reread my blog post on the biggest problem in statistics. On re-read, I still don't think it is terrible (other than the typos and things). So I'll repost. timcdlucas.github.io/the-biggest-...
timcdlucas.github.io
The Biggest Problem In Statistics
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Lana 🌺 ❤️💛💚💙💜 @mahalomalama.bsky.social · 25/08/2026
No caption required…
5 Supreme Court Judges Raising The Confederate Flag While Trampling Over Paper That Says, Voting Rights Act
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Etienne Bacher @etiennebacher.bsky.social · 24/08/2026
#rstats I'm glad to announce Jarl 0.6.0! Jarl is a very fast R linter, written in Rust. This release brings many improvements and fixes. See the blog post: www.etiennebacher.com/posts/2026-0... And the full changelog: jarl.etiennebacher.com/changelog 🧵 to highlight some features below (1/5)
etiennebacher.com
Jarl 0.6.0 | Etienne Bacher
Personal website of Etienne Bacher: blog posts about R, research, and software.
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Frank Harrell @f2harrell.bsky.social · 25/08/2026
American Journal of Obstetrics & Gynecology should be ashamed.
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Retraction Watch @retractionwatch.com · 25/08/2026
A rapidly increasing number of published articles rely on analyses produced via the TriNetX platform. However, TriNetX users don’t get full access to the information in the platform, muddying the truthfulness of any analyses of the data and compromising the integrity statements offered by authors.
retractionwatch.com
Guest post: The uncomfortable truth an explosion of papers reveals about authors’ access to data
wildpixel/iStock The involvement of independent academic researchers in examining data and conducting analyses is central to producing trustworthy research. Because of this, many journals require a…
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Frank Harrell @f2harrell.bsky.social · 23/08/2026
The gold standard for producing PDF documents (especially books and journal articles) has been LaTeX. @typst.app re-engineered the entire process in an incredibly elegant extensible way. On my MacOS LaTeX (TexLive) takes 9.1GB of disk space. Typst takes 43MB. Not a misprint.
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Frank Harrell @f2harrell.bsky.social · 21/08/2026
1/2 This is cool! The main reason that html is not a complete solution (and why the R tinytable package is also important) are that pdf is required for (1) manuscript submission to journals and book publishers (2) documents sent to government agencies, e.g. #Statistics appendices for FDA. #RStats
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Mickaël CANOUIL, Ph.D. @mickael.canouil.fr · 20/08/2026
If you want to try Gribouille (still in development) for your graphics using the grammar of graphics. I would love some feedback (or bug reports). m.canouil.dev/gribouille/
m.canouil.dev
Gribouille
Create elegant graphics with the Grammar of Graphics for Typst.
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Frank Harrell @f2harrell.bsky.social · 20/08/2026
The more I use @typst.app for producing pdf files (haven't gotten much into html production yet) the more I love it. I'm finishing, with Claude's help, major updates to the #RStats Hmisc and rms packages that add full Typst support.
Typst output of R rms package lrm model fit
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The R Foundation @r-foundation.bsky.social · 19/08/2026
We invite #RStats users to contribute to a fund dedicated to helping the family of Tomáš Kalibera following his untimely death in April. Find out more and donate here: www.r-project.org/foundation/k...
r-project.org
R: Tomáš Kalibera Family Fund
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Frank Harrell @f2harrell.bsky.social · 16/08/2026
Highly interesting and important reads, as always.
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Daniel Lakens @lakens.bsky.social · 15/08/2026
New Blog post: Which Data Repository Should you Use? In light of OSF closing down, I compare Zenodo, Dataverse, ResearchBox, PsychArchive, and local repositories on six important dimensions. If you want to know which to pick: It depends! daniellakens.blogspot.com/2026/08/whic...
daniellakens.blogspot.com
Which Data Repository Should You Use?
The Center for Open Science has announced that from November 16, 2026, no new projects can be created on the Open Science Framework. After F...
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Andrew Vickers @vickersbiostats.bsky.social · 07/08/2026
Can everyone stop using the term "real world data" and just be precise about setting, participants and interventions? grandroundsinurology.com/the-reality-...
grandroundsinurology.com
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Aki Vehtari @avehtari.bsky.social · 13/08/2026
All four books I've co-authored are freely available online for non-commercial use: - Bayesian Workflow at avehtari.github.io/Bayesian-Wor... Links to other three books are in the quoted post 👇 (too many books to fit in one post!)
avehtari.github.io
Bayesian Workflow book: Website – Bayesian Workflow book
Website for the Bayesian Workflow book by Gelman, Vehtari, McElreath, et al. — case studies, code, and exercises in R and Stan.
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Frank Harrell @f2harrell.bsky.social · 11/08/2026
What a great review of current Quarto collaboration options by @nrennie.bsky.social
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Frank Harrell @f2harrell.bsky.social · 10/08/2026
When not assuming a normal distribution is it worthwhile to parametrically fit a distribution? Or better to just go with the empirical cumulative distribution function (ECDF) and its generalization - cumulative prob. ordinal regression? New blog article: fharrell.com/post/ecdf #Statistics #StatsSky
fharrell.com
Parametric Models vs. Empirical Distributions and Ordinal Regression – Statistical Thinking
A primary goal of this article is to compare the accuracy of empirical cumulative distribution functions (ECDFs) and their logical extensions—cumulative probability ordinal regression models—with that...
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Andrew Vickers @vickersbiostats.bsky.social · 10/08/2026
Generally assumed population-based PSA screening = increased overdiagnosis. But already lots of PS testing going on. In a modeling study, we show organized screening would reduce PSA tests, overdiagnsosis compared to current disorganized approach onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Effect of Implementing Population‐Based Prostate‐Specific Antigen Screening on Testing Rates and Prostate Cancer Overdiagnosis in England: A Statistical Modelling Study
We undertook a statistical modeling study to determine the effect of implementing population-based prostate-specific antigen (PSA) screening in England on overdiagnosis and PSA testing rates in compa...
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Andrew Gelman et al. @statmodeling.bsky.social · 07/08/2026
How to avoid the “clean data, clean model” trap when teaching statistics and data science statmodeling.stat.columbia.edu/2026/08/07/h...
statmodeling.stat.columbia.edu
How to avoid the “clean data, clean model” trap when teaching statistics and data science | Statistical Modeling, Causal Inference, and Social Science
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Paul Pharoah @paulpharoah.bsky.social · 08/08/2026
This story explains exactly why there is no similarity between the USA under Trump and 1930s Germany. No similarity at all. @larryandpaul.bsky.social youtu.be/z2IdtjKUsX0?...
youtu.be
⚠️ Why Trump Is NOTHING Like Hitler - #BrokenNews
YouTube video by Larry & Paul
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Frank Harrell @f2harrell.bsky.social · 07/08/2026
Believe it or not these are all special cases of cumulative probability ordinal regression as discussed at fharrell.com/post/cpm: #Statistics #StatsSky
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Frank Harrell @f2harrell.bsky.social · 28/07/2026
Another new blog article, elaborating on ordinal regression within the cumulative probability model family. One general model contains an amazing array of special cases used all the time. Do we need to keep teaching special cases&assuming so much? www.fharrell.com/post/cpm/ #Statistics #StatsSky
fharrell.com
The Unifying Capabilities of Cumulative Probability Semiparametric Models – Statistical Thinking
Ordinal semiparametric regression models in the cumulative probability model (CPM) family, of which proportional odds, proportional hazards, and probit regression are examples, contain virtually all r...
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Frank Harrell @f2harrell.bsky.social · 27/07/2026
New blog article proposing a general statement of the fundamental question a standard RCT should answer and providing robust and powerful statistical methods to answer it: www.fharrell.com/post/rctmod/ #Statistics #StatsSky #EpiSky #clinicaltrial #rct #pharma @stephensenn.bsky.social
fharrell.com
Statistical Models Answer the Fundamental Clinical Question and Provide Clinical Trial Estimands – Statistical Thinking
Specific goals and estimation targets for randomized clinical trials have still not been well defined for general outcome variables. Proponents of causal inference calculus have claimed to define goal...
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Retraction Watch @retractionwatch.com · 25/07/2026
Weekend reads: Young girl’s death after gene therapy never made public; FDA retracts lettuce test result; ADA delays editorial publication after controversy
retractionwatch.com
Weekend reads: Young girl’s death after gene therapy never made public; FDA retracts lettuce test result; ADA delays editorial publication after controversy
If your week flew by — we know ours did — catch up here with what you might have missed. The week at Retraction Watch featured: Exclusive: A couple’s daughter died after they paid more than $…
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Vincent Arel-Bundock @vincentab.bsky.social · 21/07/2026
Here's a useful page with a **ton** of common tasks in #RStats, done with parallel syntax for tidyverse vs. data.table vs. base. arelbundock.com/posts/dt_tb_... #rdatatable #tidyverse
arelbundock.com
data.table vs. base vs. dplyr | Vincent Arel-Bundock
Academic website and blog of Vincent Arel-Bundock.
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Retraction Watch @retractionwatch.com · 18/07/2026
Weekend reads: Private info in ‘most’ arXiv preprints; why did George Church decline authorship; 28 misconduct cases in China
retractionwatch.com
Weekend reads: Private info in ‘most’ arXiv preprints; why did George Church decline authorship; 28 misconduct cases in China
If your week flew by — we know ours did — catch up here with what you might have missed. The week at Retraction Watch featured: ‘Disappointed’: Cochrane journal asked researchers to publish article…
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Peg Duthie @plduthie.bsky.social · 17/07/2026
The Middle TN Chapter of the American Statistical Association @amstatnews.bsky.social is hosting a half-day applied improv course in Nashville, Friday 8/14 8:30am-12:30pm w/lunch and parking included. No experience required; sign up by July 22 for 10% discount. www.eventbrite.com/e/fundamenta...
eventbrite.com
Fundamentals of Applied Improvisation for (Bio)statisticians
This half-day course introduces applied improvisation as a novel way to pursue interpersonal skills as a quantitative scientist.
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Cameron Patrick @cameronpat.bsky.social · 17/07/2026
the most surprising thing about this is that Twitter never tried this first
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Frank Harrell @f2harrell.bsky.social · 14/07/2026
What an incredible resource!! I've added a link to it from hbiostat.org/data and hbiostat.org/bbr/ancova. How did you find this Darren? Having ready-to-analyze #RStats RDS files is wonderful. #rct #Statistics #StatsSky
hbiostat.org
Datasets
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Alexander Gibson @alexdgibson.bsky.social · 10/07/2026
🚨 Protocol -> preregistration -> preprint -> publication 🚨 125 clinical prediction model articles developed on unreliable data on stroke and diabetes. Since preprinting our results 7 articles have been retracted. doi.org/10.1186/s129...
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Frank Harrell @f2harrell.bsky.social · 12/07/2026
It is so sad to lose Norm. I learned so much from him-one of the few researchers/teachers credentialed in both comp sci and #Statistics; he used that dual expertise to great effect. He contributed greatly to the community&engaged in vigorous and thought-provoking discussions to the end. #RStats
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Frank Harrell @f2harrell.bsky.social · 10/07/2026
I finished translating my CV from a complex mess of LaTeX constructions to a clean and much simpler @typst.app document. Typst handles multiple bibliographies out of the box, among other things. It also instantly processes BibTeX files without creating auxiliary files sub as .bbl.
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Soledad Galli, PhD @solegalli.bsky.social · 10/07/2026
Diagnostic models fail because we optimise sensitivity instead of probability calibration. @f2harrell.bsky.social explains why dichotomising outcomes destroys information and what doctors actually need 📊
youtube.com
UM Division of Biostatistics Seminar Series (2013-14) - Frank Harrell Jr, PhD
For more info and seminars, visit:http://biostat.med.miami.edu
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Frank Harrell @f2harrell.bsky.social · 09/07/2026
Brown University's response to widespread student laziness has been underwhelming
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💙Beebs @blue-rosary52.bsky.social · 08/07/2026
Calling FIFA
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Minnesota Star Tribune @startribune.com · 08/07/2026
Mayo Clinic’s former director of research operations alleges she was sidelined, then terminated, for raising objections over lax standards of studies involving AI.
startribune.com
Former executive accuses Mayo of cutting corners on AI research
Mayo’s former director of research operations alleges she was sidelined, then terminated, for raising objections over lax standards of studies involving AI.
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Solomon Kurz @solomonkurz.bsky.social · 04/07/2026
At a basic level, I think this depends on what you care about. If you want quick pubs for a grade or a promotion, just do t-tests. If you are interested in your data, learn how to fit and interpret ordinal models.
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