Sign in

Isabelle Boutron

@isabelleboutron.bsky.social
370 followers 193 following 3 posts

Prof of Epidemiology at University Paris Cité Director of the Centre for Research in Epidemiology and Statistics (CRESS) Head of the METHODS team within the CRESS Director of Cochrane France

PostsRepliesMedia
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 12/09/2025
@theaacr.bsky.social found that 23% of abstracts in manuscripts and 5% of peer-review reports submitted to its journals in 2024 contained text that was probably generated by large language models (#LLMs) www.nature.com/articles/d41... #AI #metaresearch
nature.com
AI tool detects LLM-generated text in research papers and peer reviews
Authors and peer reviewers are failing to disclose the use of LLMs despite journal policies limiting their use.
044
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 05/09/2025
In the #PubMedCentral-OA dataset, 34% (981 of 2898) of citation quotations were erroneous. #LLMs (@GeminiApp @GPT4oGPT) can be trained to detect citation errors with moderate accuracy, according to @uofilsystem.bsky.social researchers #AI
Automated verification of citations could help journals and peer reviewers identify questionable citation practices and reduce propagation of misinformation, improving the trustworthiness of scientific evidence.
031
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 05/09/2025
A pilot study testing the ability of #MachineLearning models trained on well-annotated datasets to automate detection of hype in biomedical research writing (eg ‘groundbreaking', ‘revolutionary’) showed 70-80% accuracy vs human detection peerreviewcongress.o...
The annotation process underscored the subjective nature of assessing promotional language, particularly for context-dependent adjectives like emerging and latest, and the need for refined constructs to capture gradations of promotional language. Despite these limitations, the pilot study indicates the potential for machine learning models trained on well-annotated datasets to contribute to the automated detection of hype. Future steps include modifying the annotation systems and experimenting with large language models under zero/few-shot regimes.
051
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 05/09/2025
Methods to detect #LLM-generated #PeerReview: in ms, add command to LLM to: 1. Watermark (insert a random start string, fake citation, or technical term) 2. Hidden prompt (insert white-colored text, different language, font manipulation) @cmu.edu
arxiv.org
Detecting LLM-Generated Peer Reviews
The integrity of peer review is fundamental to scientific progress, but the rise of large language models (LLMs) has introduced concerns that some reviewers may rely on these tools to generate...
042
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 05/09/2025
Comparing #LLM vs human #PeerReview of 5 @bmj.com mss, LLM reviews matched or exceeded humans on key elements of identifying strengths/weaknesses, commenting on writing, organization, and Tables and Figures, and constructiveness peerreviewcongress.o...
LLM-generated reviews matched or exceeded human reviewers on a few key dimensions of review quality. A fuller analysis will shed more light on the potential value of LLM peer reviews and how they could complement human peer reviewers’ work.
053
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 05/09/2025
#ZakKohane on #AI in #PeerReview: the surge in scientific publication is straining the conventional review system beyond capacity. @ai.nejm.org piloting AI-augmented fast track review: manuscripts w high prior of being good gets assigned to #GPT5 + a human, disposition reviewed by editorial team!
084
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
Full abstract at
peerreviewcongress.org
Quantifying and Assessing the Use of Generative AI by Authors and Reviewers in the Cancer Research Field - Peer Review Congress
Daniel S. Evanko,1 Michael Di Natale1 Objective This study assessed the ability to reliably detect the use of generative artificial intelligence (genAI) by authors and reviewers in the field of cancer research, quantified this usage over time, and measured the impact of a change in policy on use of genAI by reviewers. Design In this Read more...
041
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
Detection of #AI-generated text at 10 @theaacr.bsky.social journals increased Q1 '23 after public release of ChatGPT; a policy prohibiting its use slowed detections in reviewer comments. Presence in mss was assoc'd w a higher rejection rate before peer review @evanko.bsky.social #cancer
162
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
Full abstract at
peerreviewcongress.org
Notifying Authors That They Have Cited a Retracted Article and Future Citations of Retracted Articles: The RetractoBot Randomized Controlled Trial - Peer Review Congress
Nicholas J. DeVito,1 Christine Cunningham,1 Ben Goldacre1 Objective Continued citation of retracted articles is an ongoing issue.1 RetractoBot examines whether informing authors that they cited a retracted paper reduces future citations to those articles.2 Design This was a parallel-group, 2-group, superiority trial. We identified and randomized retracted articles in PubMed published since 2000. The study Read more...
052
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
#RetractoBot auto-emails authors when papers they've cited are retracted. An RCT comparing it vs no notice showed no diffs in 1y citations @bengoldacre.bsky.social @ndevito1.bsky.social @bennettoxford.bsky.social @ox.ac.uk @oxprimarycare.bsky.social www.retracted.net/ cc: @retractionwatch.com
The effect of our intervention was not statistically significant (mean citation rate, −0.007; 95% CI, −0.055 to 0.041) and held for all prespecified sensitivity analyses.
1114
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
Full abstract at
peerreviewcongress.org
How a Questionable Research Network Manipulated Scholarly Publishing - Peer Review Congress
Leslie D. McIntosh,1 Hélène Draux,1 Elizabeth Smee,1 Cynthia Hudson Vitale2 Objective To understand the broad impact of one questionable network on publishing, including the publishers, countries, and institutions involved and affected by the network’s activity. Design We examined the Pharmakon Neuroscience Research Network (PNN), a questionable entity listed in funding statements, acknowledgments, and author affiliations Read more...
032
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
The #Pharmakon Neuroscience Network, involving 361 authors from 40 countries in 123 articles/56 journals from 12 publishers 2019-2025, appears to have grown too rapidly to have developed naturally @fauxsci.bsky.social @helenedraux.bsky.social @digital-science.com (see also: doi.org/10.48550/arX...)
The PNN involved 56 journals across 12 publishers, with Springer Nature (n = 29), Elsevier (n = 26), and Bentham Science Publishers (n = 25) having the most articles involved out of the total (n = 123). The involved
authors were affiliated with 40 countries and 232 organizations.
142
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
Scanning electron microscope image (SEM) metadata did not match the SEM manufacturer or model listed in the text in 21.2% of 11.3K materials science and engineering articles, a potential indicator of irreproducibility. @reeserichardson.bsky.social Read the full report at journals.plos.org/pl...
Unexplained textual similarities (eg, the same unlikely typo appearing in dozens of articles) common to many of these articles suggest the involvement of paper mills, organizations that mass produce, sell authorship on, and publish fraudulent scientific manuscripts at scale.
132
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 03/09/2025
Among 2078 retracted articles flagged for problematic image manipulation by @retractionwatch.com, gel blots were the most frequently cited image type (52%); image duplication was most common retraction cause (88%) @phillcardenuto.bsky.social @loyolachicago.bsky.social @unicampoficial.bsky.social
Gel blots (eg, Western blots) were the most frequently cited image type in problematic retractions, appearing in 1074 articles (51.68%). Between-article image reuse, where an image and its associated data are duplicated across different publications, was the most common context of misuse, identified in 1241 cases (59.72%). Notably, 982 retractions (47.28%) were attributed to paper mills. Image duplication was the predominant cause of retraction, accounting for 1827 cases (87.92%). Only 1 retraction was attributed to computer-or artificial intelligence–generated manipulation.
164
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 06/08/2025
Unraveling Spin & Selective Reporting in Medical #AI Research: A Cross-Sectional #MetaResearch Study from #UNSWSydney researchers is a poster presentation all 3 PRC days Register to stop by, ask questions, say hello! Learn more and register at peerreviewcongress.org @jama.com @bmj.com
peerreviewcongress.org
International Congress on Peer Review and Scientific Publication
Enhancing the quality and credibility of science.
032
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 07/08/2025
Authorship and Contributorship Criteria and Practices at Annals of African Surgery from EIC James Kigera and AAS colleagues is a poster presentation all 3 days of the PRC Register to stop by, ask questions, say hello! Learn more at peerreviewcongress.org #AfricanScience @jama.com @bmj.com
peerreviewcongress.org
International Congress on Peer Review and Scientific Publication
Enhancing the quality and credibility of science.
021
Reposted by Isabelle Boutron
Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 09/08/2025
Development of a Tool for Addressing #COIs in Trials (TACIT) for Use in Systematic Reviews from @alundh.bsky.social @isabelleboutron.bsky.social @cochranedkcebmo.bsky.social @upcite.bsky.social is a PRC poster presentation Register to stop by, ask the authors questions! peerreviewcongress.org
peerreviewcongress.org
International Congress on Peer Review and Scientific Publication
Enhancing the quality and credibility of science.
043
Reposted by Isabelle Boutron
CRESS UMR1153 @cressumr1153.bsky.social · 12/06/2025
Two modules of the International Summer School in Public Health came to their conclusion yesterday. @cressumr1153.bsky.social and Institut Paris Public Health. After two days of intensive exchanges, workshops and teaching, these modules came to a close in a constructive and collaborative spirit.
011
Reposted by Isabelle Boutron
Christian Cao @christiancao.bsky.social · 12/06/2025
A special shout out to: @rohitarorayyc.bsky.social @paullusla.bsky.social @jzsang.bsky.social for working tirelessly to make this dream happen <3 And our advisors: @isabelleboutron.bsky.social David Moher @geochurch.bsky.social @nikbobrovitz.bsky.social
121
Isabelle Boutron @isabelleboutron.bsky.social · 04/06/2025
Excellent opportunity to learn innovative design, to interact with outstanding researchers in the field of epidemiology and statistics!!! The international summer school of the @cressumr1153.bsky.social in the centre of Paris
030
Reposted by Isabelle Boutron
CRESS UMR1153 @cressumr1153.bsky.social · 04/06/2025
Retour sur la 2ᵉ journée de l’École d’Été en Santé Publique du @cressumr1153.bsky.social & de l'Institut Paris Public Health ! Une journée animée autour d'ateliers pratiques et échanges pluridisciplinaires sur les grands enjeux de santé publique. @inserm.fr @upcite.bsky.social @univ-spn.bsky.social
021
Reposted by Isabelle Boutron
CRESS UMR1153 @cressumr1153.bsky.social · 19/05/2025
On March 20, Astrid Chevance of the METHODS team at @cressumr1153.bsky.social and Luz Ascarate (philosopher) organized an interdisciplinary study day entitled “Suffering and pain”. cress-umr1153.fr/en/rethinkin... @inserm.fr @upcite.bsky.social @univ-spn.bsky.social @inrae-france.bsky.social
cress-umr1153.fr
Rethinking the role of suffering in healthcare: Reflections on the interdisciplinary study day of March 20, 2025 - CRESS - Centre de Recherche en Epidémiologie et Statistiques
021
Reposted by Isabelle Boutron
CRESS UMR1153 @cressumr1153.bsky.social · 02/06/2025
L’École d'été internationale en Santé Publique organisée par @cressumr1153.bsky.social et l'Institut Paris Public Health débute aujourd'hui ! Du 02 au 13 juin, deux semaines de formation de haut niveau en Santé Publique. @upcite.bsky.social @univ-spn.bsky.social @inserm.fr @inrae-france.bsky.social
021
Reposted by Isabelle Boutron
Florian Naudet @floriannaudet.bsky.social · 15/05/2025
"French trial sponsors are urged to bolster clinical trial transparency": STAT News covers the recent French report urging that study results be published in a registry. I was very happy to be interviewed and provide some context.
statnews.com
French trial sponsors are urged to bolster clinical trial transparency
A French government working group recommended a sweeping plan to publicize study data and issue guidelines for reporting results on a timely basis.
121
Reposted by Isabelle Boutron
Hôpital Hôtel-Dieu - AP-HP @hoteldieuparis.bsky.social · 13/05/2025
#SemainedelaRechercheClinique 🔬 | @isabelleboutron.bsky.social mène des travaux visant à améliorer la conception, la transparence et l'interprétation des essais cliniques. Découvrez sa vision⬇️ @ap-hp.bsky.social @upcite.bsky.social @cochranefrance.bsky.social @cressumr1153.bsky.social @inserm.fr
072
Reposted by Isabelle Boutron
CRESS UMR1153 @cressumr1153.bsky.social · 12/05/2025
Pierre-Yves Ancel, co-founding member of @cressumr1153.bsky.social, looks back at the history of the center created in 2014. An ambitious project to foster interdisciplinarity in response to public health challenges. youtu.be/a4tv4VY5uE8 👉 Subscribe for more videos! @upcite.bsky.social
youtu.be
Portrait du CRESS - Pierre-Yves Ancel
YouTube video by CRESS UMR1153
011
Reposted by Isabelle Boutron
Florian Naudet @floriannaudet.bsky.social · 12/05/2025
New post on ResToRes's website "Massive collaboration sharpens tools for identifying problematic trials". It is about the recent publication of INSPECT-SR Stage 2 findings in The Journal of Clinical Epidemiology. restores.univ-rennes.fr/highlights/m...
031
Reposted by Isabelle Boutron
CRESS UMR1153 @cressumr1153.bsky.social · 22/04/2025
'Early bird' rates extended! To allow as many people as possible to experience the unique and enriching International Summer School in Public Health we've decided to extend our early bird rates until May 19, 2025, offering a learning opportunity open to everyone! cress-umr1153.fr/en/summer-sc...
cress-umr1153.fr
International Public Health Summer School: From June 2 to June 13, 2025 - CRESS - Centre de Recherche en Epidémiologie et Statistiques
111
Reposted by Isabelle Boutron
Gary Collins @gscollins.bsky.social · 29/04/2025
NEW PAPER: Updated SPIRIT-2025 for reporting protocols of randomised trials is now available in the @BMJ.com, @JAMA.com, @thelancet.bsky.social, @PLoS.org, and @natmedicine.bsky.social. —> www.bmj.com/content/389/... #openscience #transparency #medsky #statssky #episky
12622
Reposted by Isabelle Boutron
Florian Naudet @floriannaudet.bsky.social · 18/04/2025
🔦 Super happy to highlight a great event by the French Reproducible Research Network! 🎥 Recordings, 🖥️ slides & 📝 notes of the 2025 meeting are now online (in French)! 🔗 www.canal-u.tv/chaines/rfrr... #Reproducibility #OpenScience #MetaResearch #RestoRes
053
Reposted by Isabelle Boutron
CRESS UMR1153 @cressumr1153.bsky.social · 17/04/2025
Read our paper in JAMA Internal Med with a great editorial. Wonderful collaboration with @gcabanac.cpesr.fr Retracted papers are included in meta-analyses published in HIF journal. Inclusion of the retracted studies changed effect estimates. jamanetwork.com/journals/jam...
jamanetwork.com
Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions
This systematic review and meta-analysis identifies reports of systematic reviews that included retracted studies in their meta-analyses, and assesses the impact of these retracted studies on the resu...
065
Reposted by Isabelle Boutron
The BMJ @bmj.com · 17/04/2025
The CONSORT statement has been updated to reflect recent methodological advancements and user feedback. This article describes the rationale for each checklist item and provides published examples of good reporting www.bmj.com/content/389/...
A person looking at data
02611
Reposted by Isabelle Boutron
Journal of Clinical Epidemiology @jclinepi.bsky.social · 17/04/2025
Assessing the Coverage of PubMed, Embase, OpenAlex and Semantic Scholar for Automated Single Database Searches in Living Guideline Evidence Surveillance: A Case Study of the International PCOS Guidelines 2023 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
jclinepi.com
Assessing the Coverage of PubMed, Embase, OpenAlex and Semantic Scholar for Automated Single Database Searches in Living Guideline Evidence Surveillance: A Case Study of the International PCOS Guideli...
Living guideline maintenance is underpinned by manual approaches towards evidence retrieval, limiting long term sustainability. Our study aimed to evaluate the feasibility of using only PubMed, Embase...
096
Reposted by Isabelle Boutron
Gary Collins @gscollins.bsky.social · 15/04/2025
Watch this space, as updated guidance for protocols of randomised trials (SPIRIT-2025) will be published in a couple of weeks.
132
Reposted by Isabelle Boutron
ruthtunn.bsky.social @ruthtunn.bsky.social · 15/04/2025
CONSORT 2025 has landed! Including, among other changes, new items on reporting: ⚕️patient and public involvement 💉intervention delivery ☠️harms ❓missing data handling 👐data sharing 💰author conflicts of interest ...and an enhanced emphasis on open science practices. New website: consort-spirit.org
consort-spirit.org
Home | consort-spirit.org
052
Reposted by Isabelle Boutron
Brennan Kahan @brennankahan.bsky.social · 15/04/2025
NEW: CONSORT 2025 now published! Some notable changes: -items on analysis populations, missing data methods, and sensitivity analyses -reporting of non-adherence and concomitant care -reporting of changes to any study methods, not just outcomes -and lots of other things www.bmj.com/content/389/...
bmj.com
CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials
Critical appraisal of the quality of randomised trials is possible only if their design, conduct, analysis, and results are completely and accurately reported. Without transparent reporting of the met...
01510
Reposted by Isabelle Boutron
JAMA @jama.com · 14/04/2025
Authors, editors, reviewers, and other potential users should use CONSORT 2025 when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent. Learn more in this Special Communication. ja.ma/3Yyu0Hh
Image shows PDF.
02620
Reposted by Isabelle Boutron
The BMJ @bmj.com · 15/04/2025
Well designed and properly executed randomised trials are considered the most reliable evidence on the benefits of healthcare interventions. This update to the CONSORT guidelines includes new changes to the checklist www.bmj.com/content/389/...
24120
Reposted by Isabelle Boutron
rboussageon.bsky.social @rboussageon.bsky.social · 15/04/2025
The new version is great! Congratulations to the whole team and to @isabelleboutron.bsky.social
051
Reposted by Isabelle Boutron
Isabelle Boutron @isabelleboutron.bsky.social · 08/04/2025
Expand your knowledge on "Systematic reviews and meta-analyses of interventions". From June 10th to 11th, 2025, I will be speaking at the CRESS International Summer School in Paris. Hands-on sessions! REGISTER NOW! cress-umr1153.fr/en/summer-sc... I look forward to seeing you there!
cress-umr1153.fr
International Public Health Summer School: From June 2 to June 13, 2025 - CRESS - Centre de Recherche en Epidémiologie et Statistiques
032
Isabelle Boutron @isabelleboutron.bsky.social · 08/04/2025
Expand your knowledge on "Systematic reviews and meta-analyses of interventions". From June 10th to 11th, 2025, I will be speaking at the CRESS International Summer School in Paris. Hands-on sessions! REGISTER NOW! cress-umr1153.fr/en/summer-sc... I look forward to seeing you there!
cress-umr1153.fr
International Public Health Summer School: From June 2 to June 13, 2025 - CRESS - Centre de Recherche en Epidémiologie et Statistiques
032
Reposted by Isabelle Boutron
Paul Guinnessy @paulguinnessy.bsky.social · 19/10/2023
“We believe we found an undocumented way of cheating with citation counts,” Cabanac tells Retraction Watch. “It’s original because it doesn’t require fraudsters to alter the version of record, meaning the PDF or HTML version of the paper.” retractionwatch.com/2023/10/09/h...
retractionwatch.com
How thousands of invisible citations sneak into papers and make for fake metrics
In 2022, Guillaume Cabanac noticed something unusual: a study had attracted more than 100 citations in a short span of less than two months of being published.  Cabanac, a computer scientist a…
044
Isabelle Boutron @isabelleboutron.bsky.social · 01/04/2025
Read our paper in JAMA Internl Med with a great editorial. Wonderful collaboration with @gcabanac.cpesr.fr Retracted papers are included in meta-analyses published in HIF journal. Inclusion of the retracted studies changed effect estimates. doi.org/10.1001/jama... doi.org/10.1001/jama...
doi.org
Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions
This systematic review and meta-analysis identifies reports of systematic reviews that included retracted studies in their meta-analyses, and assesses the impact of these retracted studies on the resu...
0249
Reposted by Isabelle Boutron
Florian Naudet @floriannaudet.bsky.social · 01/04/2025
New research in JAMA Internal Medicine reveals how much retracted studies skew results in meta-analyses, with sometimes significant changes in effect estimates once these studies are excluded. By @isabelleboutron.bsky.social @gcabanac.cpesr.fr et al. jamanetwork.com/journals/jam...
jamanetwork.com
Validate User
1138
Reposted by Isabelle Boutron
Pat Savage @patrickesavage.bsky.social · 17/03/2025
Looks cool, and nice to see this shout out to Registered Reports
The Registered Reports approach, where a study is evaluated by reviewers and accepted or rejected by a journal on the basis of introduction, methods and analysis plan, before any data are gathered, gets rid of the biases due to p-hacking, HARKing and publication bias, making it possible to interpret statistics sensibly. It also leads to improved methods overall, because independent reviewers offer feedback at a point when it can be helpful. As far as I know, the Registered Reports model has not been adopted by biomedicine, but could, I think, transform the field to make it more rigorous.
0105
Reposted by Isabelle Boutron
Cochrane France @cochranefrance.bsky.social · 21/02/2025
🚬 Les #cigarettesélectroniques peuvent‐elles aider les personnes à arrêter de #fumer, et ont‐elles des effets indésirables lorsqu'elles sont utilisées à cette fin ? 🔗 t.ly/QiVqd 📚 MàJ revue #Cochrane (90 études, 29 044 personnes) #cochranereview #santépublique #tabagisme #vape #sevragetabagique
011
Reposted by Isabelle Boutron
Journal of Clinical Epidemiology @jclinepi.bsky.social · 21/02/2025
Corrigendum to ʻMethodological systematic review recommends improvements to conduct and reporting when meta-analyzing interrupted time series studies’. Journal of Clinical Epidemiology 145 (2022) 55–69 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
jclinepi.com
Corrigendum to ʻMethodological systematic review recommends improvements to conduct and reporting when meta-analyzing interrupted time series studies’. Journal of Clinical Epidemiology 145 (2022) 55–6...
In the original article, the supplementary file included our revisions as tracked changes arising from the peer-review process. Attached is an updated supplementary file where the tracked-changes have...
033
Reposted by Isabelle Boutron
Florian Naudet @floriannaudet.bsky.social · 21/02/2025
Hey @ugentopenscience.bsky.social you have been added to the meta-research and open science starting pack 2.
141