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Reposted by @markhoro.bsky.social

Joanna Moncrieff @joannamoncrieff.bsky.social · 22/07/2025

Remember the 2024 Henssler review claiming only 1 in 6 have antidepressant withdrawal symptoms & 1 in 30 severe symptoms? Here we show it was based on highly unreliable data & can't be used to assess withdrawal effects @ploederl.bsky.social @markhoro.bsky.social 1/n www.cambridge.org/core/journal...

cambridge.org

Evidence on antidepressant withdrawal: an appraisal and reanalysis of a recent systematic review | Psychological Medicine | Cambridge Core

Evidence on antidepressant withdrawal: an appraisal and reanalysis of a recent systematic review - Volume 55

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markhoro.bsky.social @markhoro.bsky.social · 05/09/2025

To err is human. To leave out that you take money from 20 drug companies, were part of the original panel aimed to downplay withdrawal effects, to call for guidelines to be updated based on 10 week studies well that is divine. I think that's how the saying goes.

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Reposted by @markhoro.bsky.social

Martin Plöderl @ploederl.bsky.social · 26/08/2025

1. Are there robust subdistributions in antidepressant response? Should we dismiss the average efficacy as best estimation of efficacy? Our new paper is out (uncorrected proofs yet) where we tried to replicate the previously found trimodal subdistributions using data from the STAR*D trial.

sciencedirect.com

Large responses to antidepressants or methodological artifacts? A secondary analysis of STAR*D, a single-arm, open-label, non-industry antidepressant trial

To replicate Stone et al.'s (2022) [1] finding that the distribution of response in clinical antidepressant trials is trimodal with large, medium-effe…

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markhoro.bsky.social @markhoro.bsky.social · 13/12/2024

Wide-ranging discussion with Dr Alex Curmi psychiatrist and podcaster in the UK about withdrawal, “biological depression” and what drugs can and can’t do: bit.ly/3ZS642W bit.ly/3ZQVBol

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Reposted by @markhoro.bsky.social

Therapeutics Initiative (TI) @drug-evidence.bsky.social · 22/11/2024

Our MOST-VIEWED #Deprescribing webinar ever 👇🏽 Antidepressant withdrawal effects & how to safely 🛑 them ti.ubc.ca/antidepressa... ✅ Maudsley approach to deprescribe #antidepressants ✅ Hyperbolic tapering ✅ Distinguishing withdrawal effects Speaker: @markhoro.bsky.social #medsky #pharmsky

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markhoro.bsky.social @markhoro.bsky.social · 10/12/2024

Useful blog from the National Clinical Director for Prescribing at NHS England about antidepressant deprescribing flagging overprescription, the need for services and the helpfulness of the Maudsley Deprescribing Guidelines bit.ly/41syj9t

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markhoro.bsky.social @markhoro.bsky.social · 06/12/2024

Powerful account from @JoeTudor_ of how understanding his depression was caused by what was happening in his life and not the chemicals in his head gave him hope and the opportunity to move forward

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markhoro.bsky.social @markhoro.bsky.social · 05/12/2024

It’s a pity that Prof Kendrick is advocating for more money to be spent on his CBT phoneline for patients stopping antidepressants when his trial showed that did not help people to stop the drugs. Money better spent on a helpline for tapering problems bit.ly/4ihUBk9

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markhoro.bsky.social @markhoro.bsky.social · 28/11/2024

The most important findings of the REDUCE trial by Prof Kendrick was that about 60% patients who did not need to be on antidepressants were unable to stop with current approaches to tapering. 2 patients required urgent care Outlined here: bit.ly/3Zq8cym

bit.ly

Hidden Costs: The Clinical and Research Pitfalls of Mistaking Antidepressant Withdrawal for Relapse

One of the commonest stories encountered in psychiatric practice is a patient reporting that their withdrawal symptoms after stopping an antidepressant were misdiagnosed by a clinician as either a rel...

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markhoro.bsky.social @markhoro.bsky.social · 28/11/2024

We just published a short editorial Hidden Costs: The Clinical and Research Pitfalls of Mistaking Antidepressant Withdrawal for Relapse bit.ly/3Zq8cym with @drjamesdaviesbskys.bsky.social

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Reposted by @markhoro.bsky.social

Martin Plöderl @ploederl.bsky.social · 20/11/2024

Still no correction published for this meta-analysis about cariprazine for major depression. SE conflated with SD. Only 4 studies, the outlier is obvious, even more so as the original study findings were p>.05 but the CI in the forest plot clearly doesn't cover the null pubpeer.com/publications...

pubpeer.com

PubPeer - Adjunctive Cariprazine for Major Depressive Disorder: A Syst...

There are comments on PubPeer for publication: Adjunctive Cariprazine for Major Depressive Disorder: A Systematic Review and Meta-Analysis (2024)

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