La molécule la plus couramment utilisée pour traiter les infections sanguines causées par Staphylococcus aureus n’est pas le meilleur choix et on dispose d’au moins deux autres alternatives tout aussi...

To address the growing problem of overprescribing for seniors, a new Canadian guideline is calling for routine medication reviews. In Canada, roughly two in three adults age 65 or older take five or m...

Global tuberculosis incidence map highlighting endemic regions in 2025 (adapted from WHO data).

Immortal time bias is a spurious or exaggerated protective association that commonly arises in naive analyses of observational data. It occurs when people receive the intervention because they survive...

This randomized clinical trial tested whether a 4-week pulse and taper vancomycin regimen was superior to a 2-week pulse regimen for preventing recurrence among patients with a first episode or first ...

We identified a substantial burden of invasive SDSE, dominated by the emergent stG62647 lineage. The contrasting epidemiology between species in the different Australian regions, during COVID-19 NPIs,...

A recent multicenter randomized clinical trial (RCT) of steroids for severe Pneumocystis jirovecii pneumonia (PCP) in patients without HIV failed to demonstrate a significant benefit in its primary ou...

Each time a man stands up for an ideal, or acts to improve the lot of others, or strikes out against injustice, he sends forth a tiny ripple of hope.Robert F. Kennedy, Senior

Fluoroquinolones (FQs) are valuable given their broad-spectrum activity...

Systemic inflammatory biomarkers coupled with physiological data from wearable biosensors provided rich and objective data from which to train machine learning algorithms to predict systemic inflammat...

This systematic review and meta-analysis evaluates the association between interventions to reduce potentially inappropriate prescribing for older primary care patients and changes in the number of me...

Meningitis remains a major global health threat, with an estimated 2.5...

Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, with significant morbidity and mortality. CDI predominantly affects adults, with community-acquired cases o...

This stepped-wedge cluster randomized trial of long-term care home residents assesses the efficacy of an evidence-based electronic decision support tool for deprescribing potentially inappropriate med...