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Portugues Lab

@portugueslab.bsky.social
555 followers 316 following 40 posts

Official account of the Portugues Lab @Cornell (previously @TUM), studying all things sensorimotor in larval zebrafish.

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Portugues Lab @portugueslab.bsky.social · 24/09/2026
The Department of Neurobiology and Behavior at Cornell University is hiring! Come and do cutting edge research on the neural basis of natural behaviors at NBB (nbb.cornell.edu). No animal too small, no behavior too strange! Apply here: academicjobsonline.org/ajo/jobs/32592
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Benjamin Judkewitz @benjulab.bsky.social · 05/03/2026
First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...
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Adrien Peyrache @apeyrache.bsky.social · 11/02/2026
New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP
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Portugues Lab @portugueslab.bsky.social · 08/02/2026
We propose that behavioral alignment is a general principle that should be considered when understanding sensorimotor representations. Read the study here: doi.org/10.64898/202...
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Portugues Lab @portugueslab.bsky.social · 08/02/2026
We check this behavioral alignment principle by measuring behavior in larval zebrafish and showing that we can predictively account for visual encoding throughout the brain: population codes represent visual stimuli according to the optomotor responses they elicit.
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Portugues Lab @portugueslab.bsky.social · 08/02/2026
Normative theories such as efficient coding have constrained representations from the sensory input side. Here, we propose that representations to sensory stimuli should be similar when they elicit similar behaviors.
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Portugues Lab @portugueslab.bsky.social · 08/02/2026
Have you ever wondered how the brain should represent the sensory world in order to generate behavior? Read our new preprint: work by Shuhong Huang shuhonghuang.bsky.social with our long-standing collaborator James Fitzgerald at Northwestern.
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Nature @nature.com · 09/01/2026
Nature research paper: Plastic landmark anchoring in zebrafish compass neurons go.nature.com/4qP4HwB
go.nature.com
Plastic landmark anchoring in zebrafish compass neurons - Nature
Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.
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Portugues Lab @portugueslab.bsky.social · 07/01/2026
6/6: Although the habenula-IPN is conserved across vertebrates, in mammals it is thought that anchoring to visual scenes occurs at the level of retrosplenial cortex and postsubiculum. Mystified? Read the paper here: rdcu.be/eX1L4 Congrats Ryosuke! (@ryosuketanaka.bsky.social)
rdcu.be
Plastic landmark anchoring in zebrafish compass neurons
Nature - Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.
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Portugues Lab @portugueslab.bsky.social · 07/01/2026
5/6: The study shows that the anchoring of the HD system to the visual scene in this little fish occurs in the habenula-IPN pathway, using a similar architectural motif to what has been observed in flies.
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Portugues Lab @portugueslab.bsky.social · 07/01/2026
4/6: This requires that neurons that were originally tuned to opposite headings and inhibited each other, shift their relative tuning, as required by the underlying ring attractor structure, indicating a high level of plasticity that can map landmark position to heading in an all-to-all manner.
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Portugues Lab @portugueslab.bsky.social · 07/01/2026
3/6: The relation between landmark position and heading varies across animals and is experience-dependent. In fact, if you show two identical landmarks, neurons tuned to one heading acquire two preferred (and out-of-phase) headings.
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Portugues Lab @portugueslab.bsky.social · 07/01/2026
2/6: This study shows that the heading direction (HD) network in larval zebrafish can use visual cues, both landmarks and optic flow, to track orientation in visual environments. Landmark tracking requires an intact projection from the “visual” habenula to the interpeduncular nucleus (IPN).
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Portugues Lab @portugueslab.bsky.social · 07/01/2026
1/6: New publication from the lab: “Plastic landmark anchoring in zebrafish compass neurons” by Ryosuke Tanaka (@ryosuketanaka.bsky.social) and Ruben is available here: rdcu.be/eX1L4
rdcu.be
Plastic landmark anchoring in zebrafish compass neurons
Nature - Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.
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Sachin Sethi @sethisachin.bsky.social · 06/01/2026
www.cell.com/cell/fulltex... We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -
cell.com
Neuronal calcium spikes enable vector inversion in the Drosophila brain
In the fly central complex, PFNa neurons switch from firing classical sodium spikes when depolarized to firing non-canonical T-type calcium spikes when hyperpolarized. This bidirectional spiking allow...
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Portugues Lab @portugueslab.bsky.social · 02/01/2026
n/n: The method recapitulates what we know from fly central complex anatomy and then predicts that the zebrafish HDN is also a three-ring shifter network! Interested in the details? Read the paper with our friends from Munich here: www.biorxiv.org/content/10.6...
biorxiv.org
A multi-ring shifter network computes head direction in zebrafish
From insects to fish to mammals, many species have an internal compass: a set of recurrently connected neurons that combine motor feedback, vestibular signals, and external cues to compute the animal’...
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Portugues Lab @portugueslab.bsky.social · 02/01/2026
4/n: Siyuan developed a framework that is able to distinguish shifter networks from velocity-modulated synaptic networks. The key point is that shifter networks require neurons that have conjunctive heading and angular velocity responses, whereas the alternative does not.
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Portugues Lab @portugueslab.bsky.social · 02/01/2026
3/n: In fly, functional work, supported by the impressive connectome, show that its HDN is a shifter network made up of three rings: a central ring that encodes heading and two rings that shift the bump CW or CCW. What happens in zebrafish? Structure from function is much trickier there.
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Portugues Lab @portugueslab.bsky.social · 02/01/2026
2/n: Heading direction networks (HDNs) are biological instantiations of ring attractors (RAs), but there are different classes of RAs that incorporate angular velocity signals in different mechanistic ways.
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Portugues Lab @portugueslab.bsky.social · 02/01/2026
1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.
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Dinu F Albeanu @dinanthos.bsky.social · 15/12/2025
Adam Kampff’s passion for understanding and explaining the world was unmatched. Living by example and not ever compromising on his dreams, Adam was uncanny in making people realize they can learn and understand anything and everything. Keep his dream alive! In his own words: tinyurl.com/ye29csw3
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Yvette Fisher @yvetteefisher.bsky.social · 15/12/2025
*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️
Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(n/n) The parallels with insect navigation systems suggest deep conservation of spatial computation principles across evolution. Thanks to the team! For more read the full paper: www.nature.com/articles/s41...
nature.com
Visual motion and landmark position align with heading direction in the zebrafish interpeduncular nucleus - Nature Communications
How are various visual signals integrated in the vertebrate brain for navigation? Here authors show that different spatial signals are topographically organized and align to one another in the zebrafi...
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(9/n) This work reveals how vertebrate navigation circuits organize multiple spatial signals (heading direction, visual motion, and landmarks) in aligned topographic maps, enabling flexible integration for navigation.
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(8/n) This shows the habenula specifically provides landmark information to anchor the heading system to visual scenes.
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(7/n) Habenula ablations revealed: - Visual motion responses in the IPN persist without habenular input - Landmark representations in the IPN require intact habenula - The heading direction network continues to function normally in darkness without habenular input
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(6/n) But here's the surprise: using targeted ablations, we found the habenula's role is highly specific.
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(5/n) Critically, this striped organization aligns with how HD is represented in the same regions - suggesting the IPN as an integration site for spatial signals. Where do these visual signals come from? The habenula contains neurons responding to both directional motion and landmark position.
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(4/n) What we found reveals a striking organizational principle 👇 In the dorsal IPN, both directional motion AND landmark position are topographically organized in parasagittal stripes (running front-to-back).
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(3/n) We wanted to address a fundamental question in navigation: how do animals integrate visual cues like optic flow (indicating traveling direction) and landmarks (for anchoring position) with their internal sense of heading direction?
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(2/n) We discovered that navigationally relevant visual signals are topographically organized in the interpeduncular nucleus (IPN) and aligned with the heading direction signal.
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(1/n) We are excited to share our new paper in Nature Communications, by Hagar Lavian (@hlavian.bsky.social) and team, revealing how the zebrafish brain integrates visual navigation signals! www.nature.com/articles/s41...
nature.com
Visual motion and landmark position align with heading direction in the zebrafish interpeduncular nucleus - Nature Communications
How are various visual signals integrated in the vertebrate brain for navigation? Here authors show that different spatial signals are topographically organized and align to one another in the zebrafi...
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Emilie Macé @mace-lab.bsky.social · 11/09/2025
Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/
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Misha Ahrens @mishaahrens.bsky.social · 08/09/2025
Preprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...
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BonnBrain Conference @bonnbrainconf.bsky.social · 08/09/2025
Application is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!
Flyer advertising the BonnBrain Conference 2026, "From Genes to Circuits and Behavior".
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Siddharth Jayakumar @siddjakes.bsky.social · 02/09/2025
Excited to share our latest!! Thanks to everyone involved especially @neurovenki.bsky.social!
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Isaac Bianco @isaacbianco.bsky.social · 23/08/2025
Latest from the lab. Beautiful work from Joanna Lau and a fantastic collaboration with James Fitzgerald. www.cell.com/current-biol...
cell.com
Supraspinal commands have a modular organization that is behavioral context specific
Lau et al. use calcium imaging and statistical modeling to comprehensively survey reticulospinal activity during diverse locomotor behaviors. They find that a small set of functional modules act combi...
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Portugues Lab @portugueslab.bsky.social · 25/07/2025
Indeed, it is interesting to think how far one could push this analogy and to speculate how the joint constraints of genetics and environmental statistics contribute to this architecture.
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Portugues Lab @portugueslab.bsky.social · 23/07/2025
@natrevneuro.nature.com just published a beautiful cover for the issue that includes the recent review on analogies in the visual system of vertebrates and invertebrates (@ryosuketanaka.bsky.social). Read it here doi.org/10.1038/s415... Science and Art, what could be better?
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Wyart Lab @wyartlab.bsky.social · 02/07/2025
Let's share @etlunsford.bsky.social's work : to survive, animals avoid drifting involuntarily in their environment. While humans rely on visual & vestibular cues, birds & fish need to sense complex flow changes of the external fluid (air/water) around them to select motor actions. How do they do?(1)
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Fumi Kubo @fumikubo.bsky.social · 10/06/2025
Preprint Alert! How does the brain distinguish different types of optic flow? We combined CaMPARI2 labeling with single-cell RNA-seq (CaMPARI-seq) to dissect visual circuits in zebrafish. Read the full study here 👉 www.biorxiv.org/content/10.1...
biorxiv.org
Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors
Optic flow processing is critical for the visual control of body and eye movements in many animals. Rotational and translational binocular optic flow patterns need to be clearly distinguished to induc...
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Portugues Lab @portugueslab.bsky.social · 05/06/2025
Unfortunately I cannot be there this year (I am jealous), but it is great to see the familiar location and the same dedication to sharing and enjoying science by the TENSS family: Raul, Florin, Priyanka, the TAs: Sriram, Anna Maria, and Fred back there looking out the window.
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Portugues Lab @portugueslab.bsky.social · 23/05/2025
Are you interested in visual systems? How are they similar or different across species? Read the review by Ryosuke @ryosuketanaka.bsky.social and Ruben published today in @natrevneuro.nature.com. It is available here: rdcu.be/enlpC
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Benjamin Judkewitz @benjulab.bsky.social · 12/05/2025
Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...
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Markus Meister @mameister4.bsky.social · 21/05/2025
If you're planning a course with mathematical methods content, or use such methods in your own work, please take a look at "Mathematics in Biology", by Meister, Lee, and Portugues, published at MIT Press. 1/2 @portugueslab.bsky.social mitpress.mit.edu/978026204940...
mitpress.mit.edu
Mathematics in Biology
Biology has turned into a quantitative science. The core problems in the life sciences today involve complex systems that require mathematical expression, ye...
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Andrew Pruszynski @andpru.bsky.social · 02/05/2025
I bought this book and its great! Highly recommend to have around the lab.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 20/04/2025
Algorithmic dissection of optic flow memory in larval zebrafish www.biorxiv.org/content/10.1101/202…
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Max Planck Institute for Neurobiology of Behavior – caesar @mpinb.mpg.de · 15/04/2025
🧠 Interested in a postdoc in neuroscience? Our Department of Computational Neuroethology is hiring for two exciting projects: 🔬 Retinal circuitry evolution 🐟 Mechanistic cognition in Danionella cerebrum mpinb.mpg.de/en/research-... 📅 Apply by May 13 via the Max Planck #PostdocProgram #Neuroethology
mpinb.mpg.de
Research Focus - MAX PLANCK INSTITUTE FOR NEUROBIOLOGY OF BEHAVIOR — CAESAR
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Cedric Feschotte @cedricfeschotte.bsky.social · 16/04/2025
Cornell’s new homepage: RESEARCH MATTERS 🔬🔭🧪⚗️🧬💪😍 www.cornell.edu
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Portugues Lab @portugueslab.bsky.social · 03/04/2025
Rheotaxis: the movement through a body of water against the current
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